Epitope hla. Medical search. Frequent questions

HLA-DR antigens in rheumatoid arthritis. (wikipedia.org)
The identification of PAP-specific CD8+ T-cell epitopes should provide a means of monitoring the immunological efficacy of vaccines targeting PAP, and these epitopes might themselves be developed as vaccine antigens. (elsevierpure.com)
11 nonamer peptides derived from the amino acid sequence of PAP were used as stimulator antigens in functional ELISPOT assays with peripheral blood mononuclear cells from 20 HLA-A2+ patients with prostate cancer or ten healthy blood donors. (elsevierpure.com)
We propose that this method to first identify epitopes for which there are pre-existing epitope-specific T cells could be used to prioritize MHC class I-specific epitopes for other antigens. (elsevierpure.com)
In the present study various peptides, synthesized according to the binding motifs for both the immunodominant epitope of myelin basic protein (MBP) 85-99, a candidate autoantigen in MS, and Cop 1, differentially inhibited binding of these antigens to disease-associated HLA-DR2 (DRB1*1501) molecules. (ox.ac.uk)
Figure G. Epitope 5037 shared by the HLA C-locus antigens Cw4, Cw6, Cw17, Cw18 and defined by 73A+77N. (mundial-brasil2014.net)
Figure H HLA class II DQB epitope 2007 shared by DQ4,5,6 antigens and define by 52P+55R on the beta chain of the DQ antigens. (mundial-brasil2014.net)
Figure J. Epitope 2018 shared by the alpha chains of the DQ4, 5, 6 antigens and defined by Glutamine (Q) at position 53. (mundial-brasil2014.net)
Figure L. Epitope 2010 shared by the beta chains of DQ antigens DQ4, 5, 6, 8, 9 and defined by 45G+46V. (mundial-brasil2014.net)
Figure N. Epitope 2006 shared by DQB1?03:01 (DQ7), DQB1?03:02 (DQ8), DQB1?03:03 (DQ9) and defined by Proline (P) at position 55 on the beta chains of the DQ antigens. (mundial-brasil2014.net)
It is commonly understood that antibodies bind to HLA antigens. (mundial-brasil2014.net)
The phenomenon of cross-reactivity in HLA testing, often explained as cross-reactive groups (CREGs) of antigens with antibody, can be clearly explained now by public epitopes. (mundial-brasil2014.net)
1. Introduction Sensitization to HLA antigens in organ transplant patients causes graft rejection, according to the humoral theory of transplantation [1]. (mundial-brasil2014.net)
Determining specificity of the anti-HLA antibody has advanced in recent years using recombinant CHMFL-ABL-039 HLA single antigens (SA) coated on color-coded Luminex beads [3]. (mundial-brasil2014.net)
The reactivity of anti-HLA antibodies with HLA antigens and the phenomenon of cross-reactivity has been the subject of investigation for decades. (mundial-brasil2014.net)
others are public epitopes shared by two or more antigens. (mundial-brasil2014.net)
To evaluate whether abnormal T cell recognition may be generated by exposure to exogenous antigens presenting sequence homology with epitopes contained in self HLA alleles, and if such recognition may be part of the mechanisms that fuel inflammation in autoimmune diseases associated with certain HLA alleles. (unina.it)
Immuno-informatic analysis predicted that the identified T-cell antigens (AgA and AgD) bind more number of class I and class II HLA alleles as compared with the reference immuno-dominant antigens ESAT-6 and CFP-10 from the tuberculous mycobacterial species M. tuberculosis. (cdc.gov)
Collectively, our results imply that AgA and AgD are T-cell antigens with a high HLA binding frequency as well as population coverage for HLA alleles. (cdc.gov)
This first report on T-cell antigens and epitopes of M. immunogenum is significant as it is expected to open up avenues for understanding pathogenesis mechanisms and developing T-cell-based immunodiagnostic tools for this poorly investigated occupational lung disease. (cdc.gov)
Furthermore, his research spurred the discovery of H-2 haplotypes, HLA alleles and haplotypes, HLA loci genetic order, the role of histocompatibility antigens in skin graft rejection, and the outcome of kidney allografts. (brighthub.com)
A strong association between fogo selvagem and class II HLA antigens exists. (medscape.com)
Tedopi is composed of synthetic tumoral neo-epitopes (peptide fragments) that target five tumoral antigens, permitting the activation of tumor-specific T-lymphocytes for patients who are HLA-A2 positive. (medscape.com)
The technology uses the human leukocyte antigen (HLA) system, one of the keys for presenting antigens to T-lymphocytes. (medscape.com)
A genetic predisposition has been identified and, in White populations, localized to a shared epitope in the HLA-DRB1 locus of class II histocompatibility antigens. (msdmanuals.com)

The influence of HLA alleles on HIV-1 infection and disease outcome has been studied extensively. (researcher-app.com)
Several HLA alleles are known to be associated with resistance to infection or delayed progression to AIDS after infection. (researcher-app.com)
Similarly, certain HLA alleles are reported to be associated with rapid progression to disease. (researcher-app.com)
Since HLA alleles influence the outcome of HIV infection differentially, selection of epitopes specifically recognized by protective alleles could serve as a rational means for HIV vaccine design. (researcher-app.com)
In this review article, we discuss existing knowledge on HLA alleles and their association with resistance/susceptibility to HIV and its relevance to vaccine design. (researcher-app.com)
Given information about participant's HLA alleles, we attempt to predict vaccine induced T-cell responses at various levels of refinement, based on the current group-testing hierarchical mapping approach. (iucc.ac.il)
For a minority of epitopes (8/34, and generally associated with HLA class I alleles that confer clinical benefit), new variants appeared early and consistently over the first 3 years of infection. (ox.ac.uk)
HLA-B*57 alleles and the closely related HLA-B*5801 are often grouped together because of their similar peptide-binding motifs and HIV disease outcome associations. (ox.ac.uk)
However, we show here that the apparently small differences between HLA-B*57 alleles, termed HLA-B*57 micropolymorphisms, have a significant impact on immune control of HIV. (ox.ac.uk)
1,000 C-clade-infected subjects, a comprehensive analysis of the epitopes presented by these 3 alleles and of the selection pressure imposed on HIV by each response. (ox.ac.uk)
In contrast to previous studies, we show that each of these three HLA alleles is characterized both by unique CD8(+) T-cell specificities and by clear-cut differences in selection pressure imposed on the virus by those responses. (ox.ac.uk)
These findings are consistent with HLA class I alleles mediating effective immune control of HIV through the number of p24 Gag-specific CD8(+) T-cell responses generated that can drive significant selection pressure on the virus. (ox.ac.uk)
To further analyze the association of HLA-DRB1 alleles with disease susceptibility in recent onset rheumatoid arthritis (RA), 167 caucasian RA patients and 166 healthy controls were typed for HLA-DRB1. (biomedcentral.com)
The association of susceptibility to RA with the group of alleles encoding the shared epitope susceptibility sequences (SESS) was confirmed in recent onset RA. (biomedcentral.com)
The prevalence of the immunogenicity of a peptide in the cohort was correlated with the diversity of HLA-II alleles that they could bind. (johnshopkins.edu)
Dr. Amos organized the first World Health Organization Nomenclature Committee, which has been responsible for the naming of HLA specificities and alleles since 1967. (brighthub.com)
Researchers have identified hundreds of different versions (alleles) of the HLA-DRB1 gene, each of which is given a particular number (such as HLA-DRB1 *04:01). (medlineplus.gov)

C ) Multi-epitope proteins with GLA-SE are captured by the Antigen-presenting cells (APCs), and the peptides contained are presented by MHC molecules on the APCs to T lymphocytes in both a class I and a class II pathway. (jci.org)
In this study, we comprehensively screened HLA-A2 restricted MAGE-A3 tumor epitopes and characterized the corresponding TCRs using in vitro artificial antigen presentation cells (APC) system, single-cell transcriptome and TCR V(D)J sequencing, and machine-learning. (thno.org)
This work identified candidate TCRs potentially suitable for TCR-T design targeting HLA-A2 restricted MAGE-A3 tumor antigen. (thno.org)
HLA, human leukocyte antigen. (cdc.gov)
Figure K. Epitope 2002 shared exclusively by the beta chains of the DQ4 antigen and defined by Leucine (L) in position 56. (mundial-brasil2014.net)
Figure M. Epitope 2022 exclusive to DQB1?05:01 chain on the DQ5 antigen and defined by 125S+126Q. (mundial-brasil2014.net)
Advances in testing assays and amino acid sequencing of HLA along with computer software contributed further to the understanding of antibody-antigen reactivity. (mundial-brasil2014.net)
Amino acid sequences of the HLA molecules which greatly contributed to our understanding of antibody and antigen reactivity has been introduced since 1963 [4C12]. (mundial-brasil2014.net)
Overall primary concerns are: extrapolating human clinical studies, seeding durable effective T cell resident memory (Trm), population human leucocyte antigen (HLA) coverage, and the potential for T cell-mediated immune escape. (mdpi.com)
It is also essential for the proper antigen presenting function of HLA-A*0101 (HLA-A1), HLA-A*0801 (HLA-B8) and HLA-B*4402 (HLA-B4402). (ox.ac.uk)
Several environmental, genetic, and immune factors create a "perfect storm" for the development of coeliac disease: the antigen gluten, the strong association of coeliac disease with HLA, the deamidation of gluten peptides by the enzyme transglutaminase 2 (TG2) generating peptides that bind strongly to the predisposing HLA-DQ2 or HLA-DQ8 molecules, and the ensuing unrestrained T cell response. (frontiersin.org)
CeD is triggered by gluten consumption in genetically susceptible individuals carrying certain major histocompatibility complex (MHC) class II human leukocyte antigen (HLA) variants ( 5 , 6 ). (frontiersin.org)
The epidemiology, age distribution, and human leukocyte antigen (HLA) associations distinguish fogo selvagem from nonendemic pemphigus foliaceus. (medscape.com)
The HLA-DRB1 gene is part of a family of genes called the human leukocyte antigen (HLA) complex. (medlineplus.gov)
Together, they form a functional protein complex called the HLA-DR antigen-binding heterodimer. (medlineplus.gov)

In a case-control study involving patients with recent-onset rheumatoid arthritis (RA), we studied interactions between a major environmental risk factor (smoking), major susceptibility genes included in the SE of HLA-DR, and the presence of the most specific autoimmunity known for RA (i.e., antibodies to proteins modified by citrullination). (nih.gov)
Sensitization is almost ubiquitous as anti-HLA antibodies are found in almost all sera of transplant recipients. (mundial-brasil2014.net)
With current knowledge of epitopes, it is more accurate to describe that antibodies bind to their target epitopes on the surface of HLA molecular chains. (mundial-brasil2014.net)
Sensitization is almost ubiquitous as it is evident in the detection of anti-HLA antibodies in the sera of recipientsin one study, almost all patients waiting for regraft of a kidney transplant have anti-HLA antibodies [2]. (mundial-brasil2014.net)
however, it is more accurate to describe the reactivity of the antibody as binding to specific epitopes on the surface of HLA antigensepitopes are conformational amino acid arrangements and are the targets of antibodies. (mundial-brasil2014.net)
Anti-GBM antibodies interact with the GBM glycoproteins, almost exclusively the epitope of the noncollagenous domain (NC1) of the α3 chain of type IV collagen. (medscape.com)

Multi-epitopes adjuvanted with GLA-SE are captured and presented by MHC molecules on the APCs to T lymphocytes. (jci.org)
Support for this pattern came from sequencing peptides eluted from purified HLA B8 molecules, where lysines were predominant at positions 3 and 5. (ox.ac.uk)
Synthetic peptides that inhibit binding of the myelin basic protein 85-99 epitope to multiple sclerosis-associated HLA-DR2 molecules and MBP-specific T-cell responses. (ox.ac.uk)
In particular, two peptides with residue K at position P-1, as referred to MBP 85-99, inhibited effectively the binding of both biotinylated MBP 85-99 and Cop 1 to HLA-DR2 molecules as well as IL-2 production by two MBP-specific HLA-DR2-restricted T-cell clones. (ox.ac.uk)
Synthetic copolymers and peptides that inhibit binding of the collagen type II 261-273 epitope to rheumatoid arthritis-associated HLA-DR1 and-DR4 molecules and collagen-specific T cell responses. (ox.ac.uk)
Biochemical in-vitro binding assays and immunogenetic and immunogenicity studies indicated that each of the sixteen immunogenic 15-mer peptides contained two or more partially overlapping epitopes that could bind with high affinity to molecules of different HLAs. (johnshopkins.edu)
Cytotoxic responses of peripheral blood mononuclear cells to 9-mer peptides derived from HLA molecules (DRB1*1101, DRB1*0801, or DPB1*0201) associated with oligoarticular juvenile idiopathic arthritis (JIA) or homologous peptides derived from Epstein-Barr virus (EBV) proteins (Bolfl or Balf2) were analyzed in patients with oligoarticular JIA and in healthy controls matched for HLA-DRB1*1101, DRB1*0801, or DPB1*0201. (unina.it)
We show here that while tapasin is required for HLA-A*0201 (HLA-A2) molecules to bind to TAP, its absence does not block the presentation of HLA-A2-restricted TAP-dependent epitopes to cytotoxic T lymphocytes indicating that, unlike HLA-A1, HLA-B8 and HLA-B4402, HLA-A2 has access to the TAP-dependent peptide pool even in the absence of tapasin. (ox.ac.uk)
Nevertheless, the overall efficiency with which HLA-A2 was loaded with optimal, stabilizing peptides was impaired in the cell line .220, resulting in a significant increase in the fraction of HLA-A2 molecules being released from the ER in a "peptide-receptive" state. (ox.ac.uk)
In this review, we will discuss how tissue destruction in the context of coeliac disease results from the complex interactions between gluten, HLA molecules, TG2, and multiple innate and adaptive immune components. (frontiersin.org)
However, while up to 40% of the general population in Western countries express one of the predisposing HLA molecules, the global prevalence of CeD is just 1% ( 8 ). (frontiersin.org)

Thus, our work creates an adjuvanted platform assembly of peptides resulting in cross presentation of CD8+ T cell-eliciting epitopes in a vaccine that prevents toxoplasmosis. (jci.org)
Moreover, HLA-A2 transgenic mice immunized with a DNA vaccine encoding PAP developed epitope-specific responses for one or more of these three peptide epitopes. (elsevierpure.com)
In this paper we explore the idea of using HLA binding predictors to improve the efficiency of epitope mapping protocols in vaccine trials. (iucc.ac.il)
These epitopes, which are both strongly and frequently recognized, and for which escape involves a high cost to the virus, have the potential to optimize vaccine design. (ox.ac.uk)
The vaccine is effective for patients who express the HLA-A2 gene, which is present in around half of the population. (medscape.com)
They had an HLA-A2 phenotype, as determined by a blood draw to determine whether their immune system could respond to the vaccine. (medscape.com)

We created and tested multi-epitope DNA or protein vaccines with TLR4 ligand emulsion adjuvant (gluco glucopyranosyl lipid adjuvant in a stable emulsion [GLA-SE]) for their ability to protect against Toxoplasma gondii in HLA transgenic mice. (jci.org)
These multi-epitope vaccines increased memory CD8+ T cells that produced IFN-γ and protected mice against parasite burden when challenged with T. gondii. (jci.org)
In addition, we propose that the epitopes identified here could be used to monitor immune responses in HLA-A2+ patients receiving vaccines targeting PAP to identify potentially therapeutic immune responses. (elsevierpure.com)
Nat Biotech 2020), which are now being used to develop novel therapeutic approaches and targets for immunotherapy, such as personal tumor vaccines targeting multiple HLA-associated neoantigens in human tumors (together with Dr. Catherine Wu at DFCI, Ott et al. (massgeneral.org)

Here we report the X-ray crystallography structure of a T cell receptor , shared among unrelated individuals (public TCR) in complex with a dominant spike-derived CD8+ T cell epitope (YLQ peptide ). (bvsalud.org)

A ) HLA-A*11:01 transgenic mice immunized with LO protein plus GLA-SE were protected compared with control mice inoculated with PBS when they were challenged with 20,000 T . gondii prugneaud strain (Fluc) luciferase expressing parasites after 4 and 6 days. (jci.org)

HLA-A*0201 presents TAP-dependent peptide epitopes to cytotoxic T lymphocytes in the absence of tapasin. (ox.ac.uk)
Within HIV-1 RT the peptide appears to be the dominant HLA A*0201-restricted epitope. (anaspec.com)
Lack of strong immune selection pressure by the immunodominant, HLA-A 0201-restricted cytotoxic T lymphocyte response in chronic human immunodeficiency virus-1 infection. (anaspec.com)
The HLA-DR1-Dw20 (DRB1*0102) gene is related to susceptibility to fogo selvagem, whereas absence of the HLA-DQw2 (DQB1*0201) allele is linked with resistance. (medscape.com)

The amino acid sequence of the peptide epitope was compared to six other known virus peptides known to be restricted by HLA B8 and a sequence homology was identified, which predicted nonamer and octamer epitope sequences. (ox.ac.uk)
Based on this motif, we identified an octamer epitope from influenza A matrix protein which is presented by HLA-B35. (ox.ac.uk)

HLA-DR1 (DR1) is a HLA-DR serotype that recognizes the DRB1*01 gene products. (wikipedia.org)
Copolymer 1 (Cop 1, poly [Y, E, A, K]) is a random synthetic amino acid copolymer effective in the treatment of relapsing forms of multiple sclerosis (MS), a disease that is linked to HLA-DR2 (DRB1*1501). (ox.ac.uk)
Since 2006, we defined and reported 194 HLA class I unique epitopes, including 56 cryptic epitopes on dissociated HLA class I heavy chains, 83 HLA class II epitopes, 60 epitopes on HLA-DRB1, 15 epitopes on HLA-DQB1, 3 epitopes on HLA-DQA1, 5 epitopes on HLA-DPB1, and 7 MICA epitopes. (mundial-brasil2014.net)
A common epitope in the third hypervariable (positions 67-74) of the DRB1 gene is involved in susceptibility to fogo selvagem. (medscape.com)
The HLA-DRB1 gene provides instructions for making a protein that plays a critical role in the immune system. (medlineplus.gov)
The HLA-DRB1 gene belongs to a group of MHC genes called MHC class II. (medlineplus.gov)
The protein produced from the HLA-DRB1 gene, called the beta chain, attaches (binds) to another protein called the alpha chain, which is produced from the HLA-DRA gene. (medlineplus.gov)
Certain variations in the HLA-DRB1 gene have been linked to an increased risk of developing an autoimmune disorder called autoimmune Addison disease. (medlineplus.gov)
A particular HLA-DRB1 gene variant called HLA-DRB1*04:04 is the most well-known risk factor for autoimmune Addison disease. (medlineplus.gov)
It is not clear how HLA-DRB1*04:04 and other HLA-DRB1 variations are involved in the inappropriate immune response that causes autoimmune Addison disease. (medlineplus.gov)
Variations in the HLA-DRB1 gene have been associated with an increased risk of developing multiple sclerosis. (medlineplus.gov)

In fact, the HLA locus which is the main inherited genetic susceptibility factor for CeD, only accounts for ~ 40% of the genetic variance of the disease. (frontiersin.org)

A sequence pattern for peptides presented to cytotoxic T lymphocytes by HLA B8 revealed by analysis of epitopes and eluted peptides. (ox.ac.uk)
The dominant epitope was mapped using recombinant vaccinia viruses that expressed fragments of the NP and then synthetic peptides based on the NP amino acid sequence. (ox.ac.uk)
CTL preparations from four HLA B37-positive donors were shown to recognize a synthetic peptide that corresponded to amino acids 335-349 of the nucleoprotein sequence. (ox.ac.uk)

HLA B8-restricted cytotoxic T lymphocytes (CTL) specific for influenza A virus were generated and shown to recognize the nucleoprotein (NP). (ox.ac.uk)
HLA B37 determines an influenza A virus nucleoprotein epitope recognized by cytotoxic T lymphocytes. (ox.ac.uk)

This unexpected finding demonstrates that immunodominance patterns can be influenced by intracellular events independent of HLA binding motifs. (ox.ac.uk)
These findings suggest that overlapping of HLA binding motifs within a peptide enhances its T-cell immunogenicity and the prevalence of the response in the population. (johnshopkins.edu)

In the current report, we hypothesized that PAP-specific epitopes might be identified by direct identification of pre-existing CD8+ T cells specific for HLA-A2-restricted peptides derived from PAP in the blood of HLA-A2-expressing individuals. (elsevierpure.com)
Identification of a novel HLA-A25-restricted epitope in a conserved region of p24 gag (positions 71-80). (ox.ac.uk)

One antibody targets epitope 2017 (defined by 52H) on the DQA1?02:01 alpha chain and the other targets epitope 2001 (defined by 52L) on the DQB1?02:02 beta chain. (mundial-brasil2014.net)
90-95% of CeD patients carry the HLA-DQ2.5 variant (DQA1*05:01, DQB1*02:01) that confers the highest risk of developing CeD while the remaining patients carry HLA-DQ2.2 (DQA1*02:01, DQB1*02:02) or HLA-DQ8 (DQA1*03, DQB1*03:02) ( 5 , 7 ). (frontiersin.org)

Molecular Basis of a Dominant SARS-CoV-2 Spike-Derived Epitope Presented by HLA-A*02:01 Recognised by a Public TCR. (bvsalud.org)
It seems that healthy family members of patients with fogo selvagem have the dominant allele HLA-DQw2, which may be protective. (medscape.com)

Substitution of this residue with proline (the favored amino acid in this position in B35-associated peptides) considerably enhances binding to HLA-B35 in the T2-B35 cell line, but the peptide is not recognized by the majority of CTL clones and can antagonize recognition of the index peptide. (ox.ac.uk)

A model was made of the HLA B8 molecule and negatively charged pockets predicted, which could accommodate the positively charged side chains of the peptide anchor residues. (ox.ac.uk)

Cross-reactivity risk analysis of the candidates TCRs showed high binding stability to MAGE-A3-Mp4 epitope and low risk of cross-reaction. (thno.org)

A cohort of HLA-A2+ NSCLC donors demonstrated that the number of epitope specific CD8+ T cells increased in NSCLC than healthy controls when measured with tetramer derived from the candidate MAGE-A3 epitopes, especially epitope Mp4 (MAGE-A3: 160-169, LVFGIELMEV). (thno.org)
Using extensive epitope mapping data from a cohort of 12 acutely infected HIV infected individuals, we show that using state-of-the-art HLA binding predictors, significant improvements in mapping efficiency can be obtained. (iucc.ac.il)

We identified the HLA-A2 restricted T cell epitopes from MAGE-A3 that could effectively induce the activation and cytotoxicity of CD8+ T cells using artificial APC in vitro . (thno.org)
CD8+ CTL lines were derived from lymphocytes of two HLA B37-positive donors and used to show that the peptide was represented on virus-infected cells and to determine the probable boundaries of the epitope. (ox.ac.uk)
The closely related, but less protective, HLA-B*58:01 presents similar epitopes, but HLA-B*58:01(+) individuals do not generate CD8(+) T cells targeting the KF11-Gag epitope, which has been linked to low viremia. (ox.ac.uk)
Here we show that HLA-B*58:01 binds and presents KF11 peptide, but HIV-infected HLA-B*58:01(+) cells fail to process KF11. (ox.ac.uk)
Patients with oligoarticular JIA, but none of the healthy controls, had EBV-self HLA cross-reactive T cells. (unina.it)
This track shows putative epitopes for CD4+ and CD8+ T cells whose HLA binding properties cover over 99% for US, European, and Asian populations, for both HLA-I and HLA-II. (ucsc.edu)
T cell immunity is at the center of the disease contributing to the inflammatory process through the loss of tolerance to gluten and the differentiation of HLA-DQ2 or HLA-DQ8-restricted anti-gluten inflammatory CD4 + T cells secreting pro-inflammatory cytokines and to the killing of intestinal epithelial cells by cytotoxic intraepithelial CD8 + lymphocytes. (frontiersin.org)

Their capacity to elicit immune and protective responses was studied using immunization of HLA-A*11:01 transgenic mice. (jci.org)

Six HLA B8-positive influenza immune donors that we have tested respond to this peptide as part of their influenza-specific CTL response. (ox.ac.uk)
Influenza-specific CTL from 10 donors of other HLA types failed to recognize this epitope. (ox.ac.uk)

T cell cytotoxic responses and production of proinflammatory cytokines in response to stimulation with self HLA-derived peptides were found only in patients with oligoarticular JIA, and not in controls. (unina.it)

This is a reverse transcriptase (RT) epitope (Pol residues 476-484). (anaspec.com)

Our findings of HLA-dependent reversion suggest that costs are borne by some escape variants which may benefit the host, a finding contrary to a simple immune evasion paradigm. (ox.ac.uk)

To investigate whether smoking and HLA-DR shared epitope (SE) genes may interact in triggering immune reactions to citrulline-modified proteins. (nih.gov)

The genetic polymorphism that has the greatest impact on immune control of human immunodeficiency virus (HIV) infection is expression of HLA-B*57. (ox.ac.uk)
Human peripheral blood lymphocytes were stained with biotinylated HLA-A,B,C (clone W6/32, filled histogram) or biotinylated mouse IgG2a, κ isotype control (open histogram), followed by SAV-FITC. (biolegend.com)
The HLA complex is the human version of the major histocompatibility complex (MHC), a gene family that occurs in many species. (medlineplus.gov)

Peptides associated with HLA-B35 commonly have a proline or occasionally a serine residue in the P2 anchor position of the peptide, with a tyrosine at the C terminus. (ox.ac.uk)
Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding. (expasy.org)

We identified an environmental factor, smoking, that in the context of HLA-DR SE genes may trigger RA-specific immune reactions to citrullinated proteins. (nih.gov)
The HLA complex helps the immune system distinguish the body's own proteins from proteins made by foreign invaders such as viruses and bacteria. (medlineplus.gov)

Distinct recognition of closely-related HIV-1 and HIV-2 cytotoxic T-cell epitopes presented by HLA-B*2703 and B*2705. (ox.ac.uk)

He organized the First International Histocompatibility Workshop in Durham, North Carolina, which fostered previously unheard-of international collaboration, leading to competitive studies that define the MHC (HLA) complex. (brighthub.com)

Anatomy21

Organisms13

Diseases8

Chemicals and Drugs128

Analytical, Diagnostic and Therapeutic Techniques and Equipment33

Phenomena and Processes57

Disciplines and Occupations1

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Antigens25

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Antigen15

Antibodies6

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Vaccine6

Vaccines4

Cell epitope1

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02014

Octamer epitope2

DRB111

Susceptibility1

Sequence3

Influenza A vir2

Motifs2

Identification2

DQB12

Dominant2

Amino1

Molecule1

Cross-reactivity1

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Investigate1

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27051

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