AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation Science
EpitheliumEpithelium, CornealSeminiferous EpitheliumEpithelial CellsRetinal Pigment EpitheliumOlfactory MucosaRespiratory MucosaIntestinal MucosaImmunohistochemistryTracheaCorneaBronchiCiliary BodyIn Situ HybridizationMicroscopy, ElectronConjunctivaNasal MucosaRNA, MessengerMetaplasiaCell DifferentiationKeratinsCells, CulturedMicroscopy, Electron, ScanningMorphogenesisOrgan Culture TechniquesMucous MembraneColonMouth MucosaGene Expression Regulation, DevelopmentalEsophagusReverse Transcriptase Polymerase Chain ReactionMice, TransgenicLungMice, Inbred C57BLMammary Glands, AnimalHistocytochemistryRabbitsTongueEye ProteinsEpithelial AttachmentUterusMesodermImmunoenzyme TechniquesLimbus CorneaeFluorescent Antibody Technique, IndirectPrecancerous ConditionsGene ExpressionFallopian TubesCiliaLens, CrystallineRetinaSignal TransductionIntestine, SmallChloridesWound HealingIntestinesChoroidMucinsTight JunctionsEndometriumBarrett EsophagusRespiratory SystemCorneal DiseasesGoblet CellsFluorescent Antibody TechniqueEyeCell DivisionPalateBlotting, WesternCell ProliferationIntercellular JunctionsMice, KnockoutTime FactorsSertoli CellsPulmonary AlveoliStem CellsBasement MembraneMembrane ProteinsCell PolarityEpididymisGene Expression RegulationTestisBruch MembraneCell LineSpermatogenesisLipofuscinMolecular Sequence DataRegenerationChoroid PlexusMicroscopy, ConfocalOdontogenesisGastric MucosaMicrovilliOlfactory Receptor NeuronsMucusSeminiferous TubulesDigestive SystemHyperplasiaCorneal StromaPregnancy
RetinalIntestinal epitheliumRespiratory epitheliumBronchial epitheliumSimple epitheliumEpithelial cellsAirway epitheliaMucosal epitheliumMammary epitheliumCorneal epitheliumOlfactory EpitheliumSquamousDistalCellsColumnarTissuesLungHyperplasiaProteinSensoryHumanInteractionsAtopic asthmaRegulatesGene expressionPathologyCellFunctionsImpact
Retinal12
Intestinal epithelium13
  • Multipotent LGR5 + crypt-based columnar cells typically power intestinal epithelium turnover, but these cells are lost after injury like radiation, according to researchers led by Alex Gregorieff from Mount Sinai Hospital in Toronto. (genomeweb.com)
  • Despite their loss, the intestinal epithelium is able to recover, which has suggested that other cells step in to regenerate the epithelium. (genomeweb.com)
  • Gregorieff and his colleagues exposed mice to 12 Grays of whole-body radiation and isolated single cells from their intestinal epithelium, including their intestinal crypts, for transcriptional profiling to tease out cells involved in epithelial regeneration. (genomeweb.com)
  • Translocation of NWs across the intestinal epithelium was investigated using confocal fluorescence microscopy directly after 24 h of exposure and was observed in 89% of Daphnia exposed to 40 nm NWs and in 11% of Daphnia exposed to 80 nm NWs. (lu.se)
  • A high degree of fragmentation was observed for NWs of both diameters after ingestion by the Daphnia, although 40 nm NWs were fragmented to a greater extent, which could possibly facilitate translocation across the intestinal epithelium. (lu.se)
  • Researchers from the Jan Dobeš laboratory have made a significant discovery uncovering a novel immune response in the intestinal epithelium Furthermore, their study delineates a mechanism that controls this immune response. (cas.cz)
  • "The inspiration for the study emerged in a somewhat humorous fashion, as Jan Dobeš and Tomáš Brabec both independently noticed changes in MHCII in the intestinal epithelium," as detailed by Jan Dobeš. (cas.cz)
  • The study thus introduces a novel immune response and a regulatory mechanism governing the entire system, demonstrating that MHCII in the epithelium, T cells producing granzymes, and the presence of SFB bacteria determine the rate of renewal of the intestinal epithelium. (cas.cz)
  • Our findings show that all three cannabinoids induce autophagy in a dose-dependent manner in fully differentiated CaCo2 cells, a model of mature intestinal epithelium. (lancs.ac.uk)
  • We show that noroviruses can infect and replicate in a 3-dimensional (3-D), organoid model of human small intestinal epithelium. (cdc.gov)
  • In vitro differentiation of small intestinal epithelium that approaches physiologic functionality of the in vivo host may allow for the development of a pathogenesis model for norovirus. (cdc.gov)
  • Representative models of differentiated human intestinal epithelium can be established by growing cells in 3 dimensions (3-D) on collagen-I-coated porous microcarrier beads in rotating-wall vessel (RWV) bioreactors that model the physiologic fluid-shear environment in their respective organs ( 21 - 24 ). (cdc.gov)
  • We present the results of our first attempts to infect a physiologically relevant 3-D small intestinal epithelium model (INT-407) with genogroup I and II human noroviruses. (cdc.gov)
Respiratory epithelium3
  • To describe an in vitro model of human respiratory epithelium in primary cell culture linked with a computer microscope interface that allows evaluation and imaging of living RSV-infected respiratory epithelium. (nih.gov)
  • Our report demonstrating the generation of mature multiciliated cells in respiratory epithelium from iPSCs is a significant advance toward modeling a number of human respiratory diseases in vitro. (ca.gov)
  • ASL glucose concentrations are the net result of diffusion of glucose from blood and interstitial fluid across the respiratory epithelium into the ASL, and removal of glucose from ASL by epithelial glucose transport processes. (ersjournals.com)
Bronchial epithelium3
Simple epithelium4
  • These can be arranged in a singular layer of cells as simple epithelium, either simple squamous, simple columnar, or simple cuboidal, or in layers of two or more cells deep as stratified (layered), or compound, either squamous, columnar or cuboidal. (wikipedia.org)
  • Simple epithelium is a single layer of cells with every cell in direct contact with the basement membrane that separates it from the underlying connective tissue. (wikipedia.org)
  • By layer, epithelium is classed as either simple epithelium, only one cell thick (unilayered), or stratified epithelium having two or more cells in thickness, or multi-layered - as stratified squamous epithelium, stratified cuboidal epithelium, and stratified columnar epithelium,: 94, 97 and both types of layering can be made up of any of the cell shapes. (wikipedia.org)
  • Stratified or compound epithelium differs from simple epithelium in that it is multilayered. (wikipedia.org)
Epithelial cells2
  • However, when taller simple columnar epithelial cells are viewed in cross section showing several nuclei appearing at different heights, they can be confused with stratified epithelia. (wikipedia.org)
  • We isolated four categories of cells from mammary epithelium of female calves: bromodeoxyuridine label retaining epithelial cells (LREC) from basal (LRECb) and embedded layers (LRECe), and epithelial control cells from basal and embedded layers. (frontiersin.org)
Airway epithelia3
  • Generation of multiciliated cells in functional airway epithelia from human induced pluripotent stem cells. (ca.gov)
  • TGF-β1 is a major mediator of airway tissue remodelling during atopic asthma and affects tight junctions (TJs) of airway epithelia. (springer.com)
  • In summary, we demonstrate a role of motile cilia in TGF-β1 sensing and showed that TGF-β1 disturbs TJ permeability of conductive airway epithelia by redistributing CLDN3 from TJs into cell nuclei. (springer.com)
Mucosal epithelium1
Mammary epithelium1
  • Cells which lack ER expression at diagnosis arise from an ER compart- were harvested at 60 - 80% confluency and used as a reference in all hybrid- ment within the mammary epithelium or represent evolution from an izations. (lu.se)
Corneal epithelium2
  • Conclusions: The data suggest PNN's role in the alternative splicing of a specific subset of lncRNAs might have a significant impact on the corneal epithelium. (molvis.org)
  • It was found that between embryonic days E10.5 and E16.5 Pax6 is autonomously required for cells to contribute fully not only to the corneal epithelium, where Pax6 is expressed at high levels, but also to the to the corneal stroma and endothelium, where the protein is detected at very low levels. (ed.ac.uk)
Olfactory Epithelium1
  • Objectives: This article aims to (i) estimate the dose of inhaled nanoparticle s that deposit in the human olfactory epithelium during nasal breathing at rest and (ii) compare the olfactory dose in humans with our earlier dose estimates for rats. (cdc.gov)
Squamous5
  • Look up epithelium or squamous in Wiktionary, the free dictionary. (wikipedia.org)
  • Transitional epithelium has cells that can change from squamous to cuboidal, depending on the amount of tension on the epithelium. (wikipedia.org)
  • Stratified epithelia (of columnar, cuboidal, or squamous type) can have the following specializations: Epithelial tissue cells can adopt shapes of varying complexity (from polyhedral to scutoidal to punakoidal), are tightly packed and form a continuous sheet. (wikipedia.org)
  • Tissues that line the inside of the mouth, the esophagus, the vagina, and part of the rectum are composed of nonkeratinized stratified squamous epithelium. (wikipedia.org)
  • Barrett's esophagus (BE) is an acquired condition in which normal squamous epithelium is replaced with metaplastic columnar epithelium as a consequence of gastroesophageal reflux disease. (jcancer.org)
Distal4
  • A significant fraction of HGSC arises from the tubal epithelium (TE) located in the distal region of Fallopian tube (aka uterine tube or oviduct). (cornell.edu)
  • Current model of the mechanisms controlling glucose concentrations in the surface liquid lining the airway and distal lung epithelium. (ersjournals.com)
  • IPF is characterized by damaged distal lung epithelium with excessive tissue scarring and extracellular matrix remodeling. (lu.se)
  • We found that YT have different interaction partners in the proximal and distal lung epithelium and further identified specific YT interactions in the human fibrotic lung epithelium. (lu.se)
Cells12
  • Epithelium or epithelial tissue is a thin, continuous, protective layer of compactly packed cells with a little intercellular matrix. (wikipedia.org)
  • On the one hand, similar to endothelial cells, parenchymal epithelia must guide leukocytes to traverse them in order to reach a localized inflammatory focus, for example, in the lung or intestinal mucosa. (hindawi.com)
  • In particular, they noted control crypts had 2.5-fold more LGR5 + CBC cells, as compared to the epithelium, but after radiation, 90 percent of those cells were lost. (genomeweb.com)
  • The dome shaped cells on the transitional epithelium is readily visible. (histology-world.com)
  • Epithelium (surface layer of tissue cells) of vesicomyid clam gill covered with cilia (thin, finger-like projections). (noaa.gov)
  • Using induced pluripotent stem cells (iPSCs), we generated mature multiciliated cells in a functional airway epithelium. (ca.gov)
  • Addgene: Cortical F-actin stabilization generates apical-lateral patterns of junctional contractility that integrate cells into epithelia. (addgene.org)
  • We then attempted to replicate our findings in nasal epithelial samples from two studies of children, while also examining whether our results in nasal epithelium overlap with those from an eQTM analysis in white blood cells from the Puerto Rican subjects. (physiciansweekly.com)
  • We also show that individual conjunctival cells can be sorted and reconstituted by cultivation into a functional conjunctival epithelium that includes mucin-producing goblet cells. (listlabs.com)
  • Keratinocyte growth factor (KGF), moreover, is necessary for the maturation of hiPSC-derived conjunctival epithelium-particularly the goblet cells-indicating key complementary roles of EGF and KGF in directing the differentiation and maturation, respectively, of the human conjunctival epithelium. (listlabs.com)
  • The segregation and near-exclusion of mutant cells from the nasal epithelium mirrored the behaviour of mutant cells in other developmental contexts, particularly the lens, suggesting that common primary defects may be responsible for diverse Pax6-related phenotypes. (ed.ac.uk)
  • Together with mucus-secreting goblet cells within the stratified epithelium, melanocytic cells are found in the basal layer of the conjunctiva. (medscape.com)
Columnar1
Tissues1
Lung7
  • Our understanding of the role of glucose transport in the lung and the mechanisms that regulate glucose movement across the human lung epithelium lags far behind that of the gut and kidney. (ersjournals.com)
  • To investigate possible changes following lung transplantation, the structure and in vitro ciliary beat frequency (CBF) of airway epithelium from the cytology brushings of 9 heart-lung (HLT) and 5 single-lung (SLT) transplant recipients were examined. (soton.ac.uk)
  • YT play a role in fibrotic fibroblasts, but their role is not yet known in the fibrotic lung epithelium. (lu.se)
  • The aim of this thesis project is to develop the tools needed to explore the role of Hippo-YT in fibrotic lung epithelium and to identify the TFs that YT interact with to exert their various functions. (lu.se)
  • We further found the Hippo pathway to be dysregulated in the fibrotic lung epithelium which led to increases in nuclear YT as well as known downstream targets. (lu.se)
  • Interestingly, we found epithelial YT signaling to be actively involved in extracellular matrix remodeling in the fibrotic lung epithelium through modulation of lysyl oxidase expression, a collagen crosslinking enzyme. (lu.se)
  • Right now, the most common theory is that the disease could potentially be triggered by an initial injury to the lung epithelium which in turn induces an abnormal repair pathway, leading to d amage of the lung. (lu.se)
Hyperplasia1
Protein3
  • Glial fibrillary acidic protein is localized in the lens epithelium. (rupress.org)
  • The epithelium of the mouse lens stains intensely with antisera to glial fibrillary acidic protein (GFAP). (rupress.org)
  • A protein co-migrating with GFAP and immunoreactive with antisera to GFAP can be demonstrated in lens epithelium protein extracts by immunoblots. (rupress.org)
Sensory3
  • The saccular macula is an elliptical thickened area of sensory epithelium that lies on the anterior vertical wall of the saccule. (medscape.com)
  • the sensory epithelium lies on the crista ampullaris. (medscape.com)
  • The vestibular sensory epithelium is located on the maculae of the saccule and utricle and the cristae of the semicircular canals. (medscape.com)
Human1
  • Studies of ciliated epithelia of the human genital tract. (bmj.com)
Interactions1
Atopic asthma2
Regulates1
  • Here we review evidence showing that apicobasal polarity regulates the inflammatory response: various polarized epithelia asymmetrically secrete chemotactic mediators and polarize adhesion receptors that dictate the route of leukocyte migration within the parenchyma. (hindawi.com)
Gene expression1
Pathology1
  • Methodology: 15 samples of periapical cyst with most of the epithelial lining represented by the atrophic type and 15 samples with most of the epithelium lining represented by the hyperplastic type were selected, all originating in the Anatomical Pathology Laboratory of the Dental School, Pontificia Universidade Católica of Minas Gerais. (bvsalud.org)
Cell1
Functions2
Impact1
  • However, its impact on TJs of ciliated epithelia is sparsely investigated. (springer.com)