• In the 4th edition of WHO classification of tumors of female reproductive organs, primary villoglandular mucinous adenocarcinoma is defined as a primary invasive glandular epithelial tumor of intestinal type and the synonyms are cloacogenic carcinoma or cloacogenic adenocarcinoma [ 1 ]. (hindawi.com)
  • Epithelial-stromal tumors are classified on the basis of the epithelial cell type, the relative amounts of epithelium and stroma, the presence of papillary processes, and the location of the epithelial elements. (wikipedia.org)
  • May form very large cystic masses, with recorded weights exceeding 25 kg Mucinous tumors are characterized by a lining of tall columnar epithelial cells with apical mucin and the absence of cilia, similar in appearance with benign cervical or intestinal epithelia. (wikipedia.org)
  • The most frequently encountered neoplastic pancreatic cysts include intraductal papillary mucinous neoplasm (IPMN), serous cystadenoma (SCA), mucinous cystic neoplasm with ovarian stroma (MCN), and solid pseudopapillary epithelial neoplasm. (medscape.com)
  • Exocrine cells in benign tumors (accounting for 10% of pancreatic tumors), including the origin of the catheter in the duct epithelial adenoma, intraductal papilloma, serous cystadenoma, mucinous cystadenoma, and originated in the solid and acinar cells cystic tumor. (cancerlive.net)
  • Moreover, siRNA-mediated knockdown of KLF5 blocked the expression of CDX2, MUC2 and villin, but transfection of a KLF5 expression vector into esophageal epithelial cells promoted their transdifferentiation into columnar-like cells, as demonstrated by increased expression of the intestinal markers CDX2, MUC2 and villin. (jcancer.org)
  • Ovarian epithelial tumors are subclassified into several categories based on two criteria: 1) the degree of epithelial proliferation and invasion and 2) the histotype of the epithelium composing the tumor. (biomedcentral.com)
  • Epithelial neoplasms of the ovary are thought to arise either directly or indirectly from the ovarian surface epithelium according to incessant ovulation theory[ 4 ]. (biomedcentral.com)
  • However, there was no correlation between CEA level and cystic mucinous secretions or mucinous epithelial cytoplasm CEA staining, mucin glycoprotein expression, size of lesion, grade of dysplasia or presence of invasive carcinoma. (gastrores.org)
  • The tumors may be entirely benign, as are mucinous cystadenomas or intraductal papillary mucinous adenomas. (medscape.com)
  • Intraductal papillary mucinous neoplasm (IPMN) is a non-invasive mucin-producing neoplasm of the pancreas arising from the main pancreatic duct or side-branches. (utoronto.ca)
  • Histologically, IPMNs are lined by flat or papillary mucinous epithelium of gastric, intestinal, pancreatobiliary, or oncocytic type, exhibiting varying degrees of dysplasia, and surrounded by dense fibrotic stroma. (utoronto.ca)
  • To study the relationship between carcinoembryonic antigen (CEA) level, intraductal papillary mucinous neoplasm (IPMN) subtype, and the presence of invasive carcinoma. (gastrores.org)
  • Intraductal papillary mucinous neoplasm (IPMN) is a substantial subclass of pancreatic pathology, representing 20-50% of cystic pancreatic neoplasms [ 1 - 3 ]. (gastrores.org)
  • The international consensus guidelines for intraductal papillary mucinous neoplasm of the pancreas (IPMN) presented clinical features as indications for surgery. (biomedcentral.com)
  • 1. Adenocarcinoma: papillary, mucoid, trabecular (well-differentiated). (poznayka.org)
  • Microscopically, fungating or polypoid carcinomas are well-differentiated adenocarcinomas, commonly papillary type. (poznayka.org)
  • The epithelium is of variable thickness, being thickest over the tongue where there are also papillary projections which account for its rougher texture. (clinicalgate.com)
  • The endocervix is lined by columnar mucinous epithelium and in continuity with vaginal mucosa, the ectocervix is lined by squamous epithelium. (cytojournal.com)
  • 3Type A tunnel clusters Type A tunnel clusters are characterized by a lobulated proliferation of small,closely packed glands that are lined by columnar mucinous epithelium. (fliphtml5.com)
  • Tumors of this type are also called ovarian adenocarcinoma. (wikipedia.org)
  • Mucinous tumors: Closely resemble their serous counterparts but unlikely to be bilateral Somewhat less common, accounting for about 25% of all ovarian neoplasms In some cases mucinous tumors are characterized by more cysts of variable size and a rarity of surface involvement as compared to serous tumors Also in comparison to serous tumors, mucinous tumors are less frequently bilateral, approximately 5% of primary mucinous tumors are bilateral. (wikipedia.org)
  • As primary ovarian mucinous tumors are usually unilateral (in one ovary), the presentation of bilateral mucinous tumors requires exclusion of a non-ovarian origin, usually the appendix. (wikipedia.org)
  • CDX2 has been useful to establish gastrointestinal origin of metastatic adenocarcinomas and carcinoids and can be especially useful in distinguishing metastatic colorectal adenocarcinoma from tumors of unknown origin. (micro-shop.pl)
  • CDX2 has also been shown to be expressed in mucinous ovarian cancer, bladder adenocarcinoma, cholangiocarcinoma and malignant germ cell tumors of the testes. (micro-shop.pl)
  • Benign and malignant exocrine tumors of the points, mainly from pancreatic ductal cancer epithelium to adenocarcinoma the most common (accounting for more than 90% of pancreatic cancer), squamous cell carcinoma, mucinous carcinoma and acinar cells derived from acinar cells carcinoma, acinar cystadenocarcinoma are rare (accounting for about 10%), the above collectively referred to as pancreatic cancer. (cancerlive.net)
  • Endocrine tumors, including insulinoma, gastrinoma (Zhuoyi syndrome), intestinal peptide tumors (Verner-Morrison syndrome), glucagon tumors, pancreatic somatostatin cell tumor, non-functional islet cell tumors (pancreatic polypeptide tumor). (cancerlive.net)
  • A small proportion of these tumors show large ducts lined by neoplastic cells, the so-called large-duct variant of adenocarcinoma. (coek.info)
  • mucinous and Brenner malignant tumors potentially develop from the Walthard nests. (biomedcentral.com)
  • IT-Ks20.10 represents an excellent marker for certain types of carcinomas such as adenocarcinomas of the colon, transitional cell carcinomas of the bladder and Merkel cell tumors of the skin. (progen.com)
  • Very sensitive detection of intestestinal and gastric foveolar epithelium, urothelial umbrella cells, Merkel cells of epidermis as well as tumors originating therefrom (e.g. primary and metastatic colorectal carcinoma). (progen.com)
  • Adenocarcinomas of breast, lung, endometrium and ovary (non-mucinous) as well as neuroendocrine tumors of the lung are essentially negative. (progen.com)
  • intestinal metaplasia with goblet cells and neuroendocrine cells are present in some cases. (nih.gov)
  • The region of columnar esophageal metaplasia is considered the "cancerization field" in which esophageal adenocarcinoma (EAC) develops [ 3 - 5 ]. (jcancer.org)
  • It is widely accepted that chronic GERD leads to inflammation and ulceration of the esophageal squamous mucosa and that persistent and recurrent inflammation and ulceration may lead to columnar metaplasia and, ultimately, intestinal metaplasia. (jcancer.org)
  • The tumorigenesis progression of GC is involved in multiple stages and develops from normal epithelia, chronic gastritis, atrophic gastritis, intestinal metaplasia, and dysplasia to carcinoma [ 6 , 7 ]. (biomedcentral.com)
  • Malignant cystadenocarcinoma and intramedullary mucinous carcinomas may be further subdivided into noninvasive and invasive types. (medscape.com)
  • Indeed, it has been postulated that the possible mechanisms by which repetitive ovulation could influence the development of ovarian carcinomas include an increased formation of inclusion cysts, repeated bathing of the surface epithelium by an estrogen-rich follicular fluid, excessive production of growth factors or cytokines, and an aberration of the repetitive repair process that follows the trauma to the surface epithelium as a consequence of ovulation. (biomedcentral.com)
  • Serous carcinomas are thought to be derived from the fallopian tubes through foci of endosalpingiosis, which are inclusion cysts from the tubal epithelium at the ovarian and peritoneal surface. (biomedcentral.com)
  • They showed the classic colorectal (CK20 + , CDX2 + , CK7-) immunostaining profile but, based on various morphologic criteria, they could be distinguished from conventional adenocarcinoma NOS, mucinous, signet ring cell, medullary, goblet cell and undifferentiated carcinomas. (bvsalud.org)
  • Macroscopically, ulcerative carcinomas are poorly-differentiated adenocarcinomas, which invade deeply into the stomach wall. (poznayka.org)
  • Patients with low-grade appendiceal mucinous carcinomas (LAMNs) treated with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) have a favorable prognosis. (rare-cancer.org)
  • The region where there is a transition from squamous to columnar epithelium in cervix is transformation zone. (cytojournal.com)
  • Barrett's esophagus (BE) is an acquired condition in which normal squamous epithelium is replaced with metaplastic columnar epithelium as a consequence of gastroesophageal reflux disease. (jcancer.org)
  • Gastrointestinal mucosa starts off as nascent columnar epithelium that is subsequently patterned to confer regional specific functions. (bvsalud.org)
  • Adenocarcinoma of the cervix is less common than squamous cell carcinoma, although its relative prevalence is increasing. (nih.gov)
  • CDH17 has been shown to be a useful marker for distinguishing between primary urinary bladder adenocarcinoma and urothelial carcinoma with glandular differentiation. (micro-shop.pl)
  • Compared to CDX2 or CK20 alone, the combination of CDX2 and CDH17 is highly sensitive and somewhat specific for colorectal and stomach adenocarcinoma in routine immunohistochemistry, especially in cases with a CK7-/CDX2-/CK20- carcinoma. (micro-shop.pl)
  • In spite of their aggressive biologic behavior, some ductal adenocarcinomas show bland nuclear features, making the distinction of benign lesion from an invasive carcinoma difficult, particularly on small biopsy specimens (Fig. 1). (coek.info)
  • However, as explained below, recent morphologic findings and molecular analyses have demonstrated that each morphologic subtype of ovarian carcinoma might be derived from a Müllerian-type epithelium. (biomedcentral.com)
  • IPMN is thought to represent a precursor lesion to pancreatic adenocarcinoma due to its association with invasive carcinoma [ 5 ]. (gastrores.org)
  • In addition to CEA being used to stratify mucinous vs. non-mucinous lesions, several studies have attempted to correlate pancreatic cyst fluid CEA level and the presence of invasive carcinoma, with discordant results [ 17 , 18 ]. (gastrores.org)
  • BACKGROUND: Invasive stratified mucin-producing carcinoma is a recently recognized adenocarcinoma with distinctive features. (bvsalud.org)
  • Microscopically, early gastric carcinoma is a typical glandular adenocarcinoma, usually well-differentiated. (poznayka.org)
  • Microscopically, it may be an adenocarcinoma or signet-ring cell carcinoma, extensively infiltrating the stomach wall, but due to marked desmoplasia cancer cells may be difficult to find. (poznayka.org)
  • One rare but noteworthy condition associated with mucinous ovarian neoplasms is pseudomyxoma peritonei. (wikipedia.org)
  • In contrast, mucinous cystic neoplasms of the pancreas occur almost exclusively in women, arise in the body/tail, do not communicate with a pancreatic duct, and exhibit dense ovarian-type stroma. (utoronto.ca)
  • Whereas serous cystic neoplasms are benign, IPMNs as well as mucinous cystic neoplasms can progress to invasive adenocarcinoma and require surgical resection. (utoronto.ca)
  • many of these benign yet floridly proliferative lesions have been mistaken for invasive adenocarcinoma. (fliphtml5.com)
  • 2Introduction The distinction between benign proliferative glandular lesions of the endocervixand well-differentiated invasive cervical adenocarcinoma continues to be problematic, ashighlighted by the number of reports in the literature considering this diagnostic issue.Interestingly, the relatively recent recognition of a number of potential mimics ofinvasive adenocarcinoma of the endocervix underscores the likelihood that in the pastmany of these benign yet floridly proliferative lesions have been mistaken for invasiveadenocarcinoma. (fliphtml5.com)
  • For instance, in one institutional review five cases diagnosed asinvasive adenocarcinoma over a 14-year period were reclassified as benign mimics (1).Although a variety of immunoperoxidase stains have been tried, ultimately therecognition of benign pseudoneoplastic glandular lesions of the cervix rests upon theirdistinctive histologic features. (fliphtml5.com)
  • A number of benign processes may mimic adenocarcinoma in situ, invasiveadenocarcinoma or both. (fliphtml5.com)
  • Benign Mimics of Invasive Adenocarcinoma of the Cervix Tunnel Clusters Microglandular Hyperplasia Mesonephric Hyperplasia Endocervical Glandular Hyperplasias Arias-Stella ReactionTunnel Clusters Fluhmann first introduced the term "tunnel cluster" in his description of thehistology of the endocervix (2;3). (fliphtml5.com)
  • Although all morphologic variants of IPMN can progress to cancer, invasive adenocarcinoma originating in gastric-type IPMNs is associated with a significantly worse survival rate than that originating from other types of IPMNs. (medscape.com)
  • In an attempt to identify pancreatic cystic lesions with an increased risk of associated invasive adenocarcinoma, carcinoembryonic antigen (CEA) level has emerged over the last few decades as a tool to assess pancreatic cystic fluid pre-operatively. (gastrores.org)
  • Tunnel clusters have been separated by Fluhmann into two subcategories: Type Aand Type B. Although type A and B tunnel clusters are often intermixed, their distinctionis important as they each pose their own relatively unique problems in the discriminationfrom invasive adenocarcinoma. (fliphtml5.com)
  • Primary villoglandular mucinous adenocarcinoma of the vulva is rare tumor. (hindawi.com)
  • The tumor had a large proportion of mitotic cells and its resemblance to adenocarcinoma of the large intestine was striking. (hindawi.com)
  • CDH17 (Cadherin 17 or LI-cadherin) is a novel oncogene expressed in intestinal epithelium which is involved in tumor invasion and metastasis. (micro-shop.pl)
  • With tumor progression, it evolves into a mucinous adenocarcinoma with a proclivity towards signet ring cells. (bvsalud.org)
  • The high proportion of mitotic cells and resemblance to well-differentiated adenocarcinoma of the large intestine suggested that this neoplasm was adenocarcinoma rather than adenoma. (hindawi.com)
  • Minimal deviation adenocarcinoma (MDA) of mucinous type (adenoma malignum) is considered an extremely well differentiated variant of GAS and is encompassed within the category of GAS. (nih.gov)
  • [ 4 ] IPMN can progress from lower to higher grades of dysplasia and, ultimately, pancreatic ductal adenocarcinoma (PDAC). (medscape.com)
  • Four main histologic subtypes of IPMN have been described: gastric, intestinal, pancreaticobiliary and oncocytic. (gastrores.org)
  • Risk factors for Rem-Panc recurrence were reported to be the presence of high-grade dysplasia in resected specimens, positive surgical margins, and a family history of pancreatic ductal adenocarcinoma (PDAC). (biomedcentral.com)
  • Goblet cell hyperplasia is the precursor lesion of adenomas and dysplasia in the classical colorectal cancer pathway, of sessile serrated adenomas and serrated dysplasia in the serrated colorectal cancer pathway, and of flat and elevated dysplasia and dysplasia-associated lesions or masses in IIBD-associated intestinal cancers. (biomedcentral.com)
  • PATHOLOGY Ductal adenocarcinomas are firm to hard mass lesions that are often poorly defined grossly. (coek.info)
  • During the diagnostic workup for pancreatic cysts, CEA is often utilized to distinguish those pancreatic cystic lesions that are likely to be mucinous [ 13 - 16 ]. (gastrores.org)
  • Fifty-four cases (41.9%) had histologically normal appendices, while 75 cases (58.1%) had various histopathologically demonstrable lesions ranging from acute appendicitis (the most frequent with 27%) to neoplasia (one case of mucinous adenocarcinoma). (bvsalud.org)
  • Pathologically, multiple cystic structures consisting of cuboidal epithelium containing mucinous material are seen in the submucosa and may extend to penetrate the muscularis propria. (radiologytoday.net)
  • The common admixture of type A and B tunnelclusters, in combination with the predominantly lobulated architecture, absence ofdesmoplasia and lack of deep, widely infiltrative glands helps distinguish it fromadenoma malignum.Type B tunnel clusters Type B tunnel clusters also have a lobular architecture, but are composed ofdilated glands lined by cuboidal or flattened epithelium and filled with inspissated,mucinous secretions. (fliphtml5.com)
  • Conclusion: right-sided pelvic lesion consistent with ovarian mucinous cystadenomatous-type lesion. (amsj.org)
  • MAP's invasion of intestinal goblet cells may result in the initial pathologic lesion of IIBD and sporadic colorectal cancer. (biomedcentral.com)
  • Pseudomyxoma peritonei (PMP) is a rare, slow growing mucinous ascites, typically associated with primary appendiceal or ovarian neoplasm [1]. (amsj.org)
  • This picture depicts an abdominal CT scan of a 7 year-old boy with a mucinous adenocarcinoma of the ascending colon. (medscape.com)
  • Mesenteric fat, vessels and lymph nodes were resected en block with the ascending colon. (medscape.com)
  • Barrett's esophagus (BE), also defined as columnar-lined esophagus, is a metaplastic condition in which the normal non-keratinizing squamous epithelium of the esophagus is replaced by a columnar mucosal epithelium [ 1 , 2 ]. (jcancer.org)
  • GAS has a much poorer prognosis than HPV-associated cervical adenocarcinoma, with propensity for presentation at advanced stage and wide dissemination to unusual sites such as the ovary, omentum and peritoneum. (nih.gov)
  • Main duct IPMNs often have intestinal-type epithelium, and side-branch IPMNs usually have gastric-type epithelium. (medscape.com)
  • Of the remaining non-HPV associated tumours, the most frequent is gastric-type adenocarcinoma (GAS), which is recognised by the World Health Organization as a form of mucinous adenocarcinoma of the cervix. (nih.gov)
  • Research has demonstrated MAP's ability to invade intestinal goblet cells and cause acute and chronic goblet cell hyperplasia. (biomedcentral.com)
  • PURPOSE: To evaluate the tissue content of neutral and acidic mucins, sulfomucins and sialomucins in colonic glands devoid of intestinal transit after enemas containing sucralfate and n-acetylcysteine alone or in combination. (bvsalud.org)
  • Histologically, most ductal adenocarcinomas are composed of glandlike structures embedded in an abundant desmoplastic stroma. (coek.info)
  • Mucinous material fills the peritoneal cavity, causing enlargement of the abdomen and has been described as "jelly belly", due to its appearance at laparotomy [2]. (amsj.org)
  • Histological differentiation must be made from mucinous adenocarcinoma of the rectum. (radiologytoday.net)
  • It is hypothesized that the epithelium covering the ovarian surface and the peritoneum retains the potential for Müllerian differentiation given the proximity to the coelomic epithelium from which the Müllerian ducts are derived. (biomedcentral.com)
  • Diet-induced obesity led to altered acetylation of lysine 27 on histone H3 (H3K27ac) and to altered monomethylation of lysine 4 on histone H3 (H3K4me1) at numerous loci, with concomitant changes in the expression of genes that were functionally relevant to intestinal cancers. (biomedcentral.com)
  • [8] There are many terms used to describe "APC-associated polyposis condition" including FAP, attenuated FAP, Gardner syndrome, Turcot syndrome, and gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS). (wikipedia.org)
  • Protruding polypoid masses which are inflammatory in origin, soft, yields to palpation, and have a smooth, glistening surface with underlying cystically dilated spaces filled with mucinous secretion. (brainscape.com)