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  • dysplasia
  • The adenomatous proliferation is characterized by different degrees of cell dysplasia (atypia or loss of normal differentiation of epithelium) irregular cells with hyperchromatic nuclei, (pseudo)stratified nuclei, nucleolus, decreased mucosecretion, and mitosis. (wikipedia.org)
  • endometrium
  • A similar lesion, villoglandular adenocarcinoma of the endometrium, may arise from the inner lining of the uterus, the endometrium. (wikipedia.org)
  • It is possible to identify the phase of the menstrual cycle by reference to either the ovarian cycle or the uterine cycle by observing histological differences at each phase-for example in the ovarian cycle: The endometrium is the innermost glandular layer and functions as a lining for the uterus, preventing adhesions between the opposed walls of the myometrium, thereby maintaining the patency of the uterine cavity. (wikipedia.org)
  • adenomas
  • The results of immunohistochemistry with an antibody against Snail showed that most adenocarcinomas had positive Snail expression, whereas weak Snail expression was detected in a small number of gastritis and gastric adenomas. (hindawi.com)
  • E-cadherin was not detected in adenocarcinomas that expressed Snail, whereas gastritis and adenomas stained positively for E-cadherin. (hindawi.com)
  • Vimentin expression was seen in adenocarcinomas with positive Snail expression, whereas gastritis and adenomas did not express vimentin. (hindawi.com)
  • cavities
  • It is specifically expressed in the simple epithelia lining the cavities of the internal organs and in the gland ducts and blood vessels. (wikipedia.org)
  • This type II cytokeratin is specifically expressed in the simple epithelia lining the cavities of the internal organs and in the gland ducts and blood vessels. (wikipedia.org)
  • peripheral
  • The peripheral location of adenocarcinoma in the lungs may be due to the use of filters in cigarettes which prevent the larger particles from entering the lung. (wikipedia.org)
  • clarification needed] Deeper inhalation of cigarette smoke results in peripheral lesions that are often the case in adenocarcinomas of the lung. (wikipedia.org)
  • cells
  • MGH shows certain cytomorphologic features from pap smears, such as bi- or tridimensional cellular clusters consisting of glandular cells with vacuolated cytoplasm together with reserve cells with scant cytoplasm. (wikipedia.org)
  • The presence of subnuclear vacuoles is often observed in MGH, whereas squamous metaplasia, stromal foam cells, mitotic activity, vimentin and MIB‐1 expression are rather more often observed in adenocarcinoma. (wikipedia.org)
  • Epithelial cells of the lung and breast both contain keratin-7, but some other glandular epithelia, such as those of the colon and prostate, do not. (wikipedia.org)
  • Several other types of cancer, which collectively represent the majority of the non-adenocarcinomas, can also arise from these cells. (wikipedia.org)
  • lung
  • however, among people who have smoked fewer than 100 cigarettes in their lifetimes ("never-smokers"), adenocarcinoma is the most common form of lung cancer. (wikipedia.org)
  • According to the Nurses' Health Study, the risk of adenocarcinoma of the lung increases substantially after a long duration of previous tobacco smoking, with a previous smoking duration of 30 to 40 years giving a relative risk of approximately 2.4 compared to never-smokers, and a duration of more than 40 years giving a relative risk of approximately 5. (wikipedia.org)
  • The adenocarcinoma has an increased incidence in smokers, and is the most common type of lung cancer seen in non-smokers and women. (wikipedia.org)
  • Some variants are not clearly recognized by the WHO and IASLC/ATS/ERS classification: Enteric adenocarcinoma of the lung Cribriform adenocarcinoma of the lung Adenocarcinoma of the lung tends to stain mucin positive as it is derived from the mucus-producing glands of the lungs. (wikipedia.org)
  • histology
  • Measurement of serum concentrations of CEA, CA19-9 and CA125 can be helpful in monitoring urachal cancer Urachal cancer usually is an adenocarcinoma (about 90%) mostly with mucinous/colloidal histology. (wikipedia.org)
  • epithelial cells
  • We have generated PSA-Cre-ER T2 mice that express the tamoxifen-dependent Cre-ER T2 recombinase selectively in prostatic epithelium, thus allowing us to target floxed genes selectively in epithelial cells of fully differentiated prostate of adult mice and to modulate the number of genetically altered cells. (pnas.org)
  • The polymeric immunoglobulin receptor (PIgR) is a protein involved in the transport of immunoglobulin A (IgA) across mucosal membranes, from the basolateral aspect of epithelial cells to the luminal surface.24,25 PIgR is highly expressed in intestinal epithelial cells and is downregulated in adenocarcinomas of the colon.26 PIgR is not present in normal gastric mucosa. (redorbit.com)
  • bronchioalveolar carcinoma ( bronchiolar carcinoma ) ( bronchioloalveolar carcinoma ) ( bronchoalveolar carcinoma ) a variant type of adenocarcinoma of the lung , with columnar to cuboidal epithelial cells lining the alveolar septa and projecting into alveolar spaces in branching papillary formations. (thefreedictionary.com)
  • Epithelial cells of the lung and breast both contain keratin-7, but some other glandular epithelia, such as those of the colon and prostate, do not. (wikipedia.org)
  • High levels cause the glandular tissues to proliferate and, especially important, they cause the number of and activity of ciliated epithelial cells (that would normally line the fallopian tubes) to increase. (wikipedia.org)
  • carcinomas
  • 27 Expression of PIgR also has been documented in IM of the gastric mucosa and stomach carcinomas, with progressive loss in advanced stages.28 The expression patterns of PIgR in adenocarcinomas of the GE junction and esophagus have not been reported. (redorbit.com)
  • situ
  • Its progression proceeds through a series of defined states, which include prostatic intraepithelial neoplasia (PIN) and prostate adenocarcinoma in situ , followed by locally invasive adenocarcinoma and eventually metastatic cancer. (pnas.org)
  • mucinous
  • Measurement of serum concentrations of CEA, CA19-9 and CA125 can be helpful in monitoring urachal cancer Urachal cancer usually is an adenocarcinoma (about 90%) mostly with mucinous/colloidal histology. (wikipedia.org)
  • invasive
  • The exocrine group is dominated by pancreatic adenocarcinoma (variations of this name may add "invasive" and "ductal"), which is by far the most common type, representing about 85% of all pancreatic cancers. (wikipedia.org)
  • cysts
  • Breast cysts (as occur commonly during pregnancy and at other times) are another example, as are other encapsulated glandular swellings (thyroid, adrenal gland, pancreas). (wikipedia.org)
  • It is characterized by cysts with tubal-type epithelium (e.g. ciliated epithelium) surrounded by a fibrous stroma. (wikipedia.org)
  • glands
  • Some variants are not clearly recognized by the WHO and IASLC/ATS/ERS classification: Enteric adenocarcinoma of the lung Cribriform adenocarcinoma of the lung Adenocarcinoma of the lung tends to stain mucin positive as it is derived from the mucus-producing glands of the lungs. (wikipedia.org)
  • Poorly differentiated adenocarcinoma will not resemble the normal glands (high grade) and will be detected by seeing that they stain positive for mucin (which the glands produce). (wikipedia.org)
  • mitoses
  • 5)mitotic figures are more abundant than usual, but conform to normal patterns and appear in abnormal location within the epithelia, i.e. mitoses are not confined to the basal layers and may appear at all levels and even in surface cells. (studymode.com)
  • transgenic mice
  • To control the cell specificity, the time of occurrence, and the cell extent of targeted somatic mutagenesis in the prostatic epithelium, we have generated PSA-Cre-ER T2 transgenic mice that express the tamoxifen (Tam)-dependent Cre-ER T2 recombinase ( 14 ) under the control of the human PSA promoter. (pnas.org)
  • prostate
  • Various mouse lines aimed at exploring the molecular mechanisms underlying prostate carcinogenesis were generated over recent years by introducing targeted mutations selectively in prostatic epithelium ( 6 , 7 ). (pnas.org)
  • prostate adenocarcinoma often stains with PSA and/or PSAP, while urothelial carcinoma does not. (wikipedia.org)
  • genes
  • Both genes are expressed in glandular epithelia and have dominant alleles (Le and Se, respectively) coding for enzymes with fucosyltransferase activity and recessive alleles (le and se, respectively) that are not functional. (wikipedia.org)
  • metastases
  • Eight to 10 months after PTEN ablation some PINs of the dorsolateral lobe had progressed to adenocarcinoma, but no distant metastases were found up to 20 months after PTEN ablation, indicating that progression to metastasis requires an additional mutation or mutations. (pnas.org)