• Specifically, we find that a growth-induced physical instability defines the relative locations of branches within the developing murine airway epithelium in the absence of mesenchyme. (pnas.org)
  • When analyzing the small airway epithelium, though, they did not find significant differences between healthy smokers and nonsmokers, but they did find significant overall upregulation of cancerization genes in smokers with COPD. (medindia.net)
  • Analysis of these genes in the large and small airway epithelia obtained from the same individuals revealed that molecular cancerization occurs more frequently in the large airway epithelium than in the small airway epithelium. (medindia.net)
  • Shaykhiev and colleagues drew the following conclusions: Smoking is associated with acquisition of molecular cancerization features in the large airway epithelium prior to the development of disease, and the large airway epithelium is likely more susceptible to smoking-induced changes than the small airway epithelium, implying that it may be the primary site of molecular alterations leading to lung cancer in smokers. (medindia.net)
  • We sought an optimised method of digestion for the isolation of viable basal cells from murine, and then human, airway epithelium. (bmj.com)
  • We identified a well-defined basal cell population representing 30% of the airway epithelium, consistent with known airway basal cell frequency, which can be isolated by fluorescence-activated cell sorting. (bmj.com)
  • This investigation provides the first systematic determination of the cellular and molecular progression of vocal fold (VF) epithelium development in a murine model. (nih.gov)
  • Development and systematic characterisation of an in vitro otopathogenic infection model of the murine middle ear epithelium as a tool to better understand the complex pathophysiology of Otitis media. (biologists.org)
  • Structure of Murine lingual epithelia and papillae, cell genesis model for filiform and fungiform papillae and Predictions of the cell genesis hypothesis compared with experimental results. (omicsonline.org)
  • Murine esophageal epithelium (EE) consists of layers of keratinocytes. (sciencemag.org)
  • Optimal extraction of murine basal cells involved removal of the epithelium through a dispase/trypsin incubation followed by incubation of tracheal remnants in collagenase to release the remaining basal cells from submucosal glands. (bmj.com)
  • Although hormone induced changes occur in the other tissues and organs of the female reproductive system, the vaginal epithelium is more sensitive and its structure is an indicator of estrogen levels. (wikipedia.org)
  • All epithelia is usually separated from underlying tissues by an extracellular fibrous basement membrane. (wikipedia.org)
  • They are arranged with their long axes parallel to each other, so that their free ends form the surface of the epithelium, while their deeper cuds either rest upon the tissues beneath the epithelium or upon other epithelial cells of different shape which form one or more layers between the columnar cells and the underlying tissue. (molecularstation.com)
  • High frequency microwave electromagnetic radiation from mobile phones and other modern devices has the potential to damage eye tissues, but its effect on the lens epithelium is unknown at present. (stopumts.nl)
  • If a specimen looks stratified, but you can identify cilia, the specimen is pseudostratified ciliated epithelium since stratified epithelium cannot have cilia but may be very rarely found in fetal oesophagus. (bionity.com)
  • The possession of cilia, which are very motile organs, presents a marked departure in specialization from the usual metabolic functions of epithelium. (molecularstation.com)
  • But there are secreting varieties of epithelium possessing a ' cuticle ' which appears to be morphologically anal ogous to the cilia, but in which the fibrils are less highly developed, probably not motile, and, therefore, functionally not the equiva. (molecularstation.com)
  • ciliated epithelium epithelium bearing vibratile, hairlike processes (cilia) on its free surface. (thefreedictionary.com)
  • Using solely a gene-based procedure, PCR amplification of the 16S ribosomal RNA gene coupled with very deep sequencing of the amplified products, the microbes on 20 human vaginal epithelia of healthy women have been identified and quantitated. (pnas.org)
  • We have applied one of these gene-based methods (PCR amplification of a 16S ribosomal RNA gene and very deep sequencing of the PCR products) to the ecological niche of the normal healthy human vaginal epithelium. (pnas.org)
  • Under direct visualization using a speculum, a sterile cryoloop (Hampton Research, Aliso Viejo, CA) was passed across the vaginal epithelium in the posterior vaginal fornix and was immediately plunged into liquid nitrogen and stored at -80°C until use. (pnas.org)
  • Total DNA was prepared by the use of a DNeasy kit, as described by the manufacturer (Qiagen, Valencia, CA). The total DNA from each vaginal epithelium was aliquoted and stored frozen at -80°C until use. (pnas.org)
  • The reverse primer was SDBact1492aA22 ( 4 , 6 ), 5′-TACGGYTACCTTGTTACGACTT-3′, Y = C +T. The primers were added to an aliquot of the total DNA from the vaginal epithelium from any given subject. (pnas.org)
  • The vaginal epithelium is divided into layers of cells, including the basal cells , the parabasal cells, the superficial squamous flat cells , and the intermediate cells. (wikipedia.org)
  • The epithelial cells of the uterus possess some of the same characteristics of the vaginal epithelium. (wikipedia.org)
  • What Is Vaginal Epithelium? (wisegeek.com)
  • Doctors specializing in the female reproductive system, called gynecologists, are required to familiarize themselves with the normal appearance of vaginal epithelium and its cells. (wisegeek.com)
  • A multitude of other diseases can also be indicated by irregularities in the vaginal epithelium. (wisegeek.com)
  • Women with artificial vaginas, resulting from sexual reassignment surgery, will not have vaginal epithelium. (wisegeek.com)
  • A post-op transwoman can definitely have normal vaginal epithelium, depending on the technique used. (wisegeek.com)
  • As such, simple squamous epithelia are seen lining body cavities and capillaries to reduce friction, as well as lining the alveoli of the lung to facilitate gas exchange . (wikidoc.org)
  • Squamous, or flattened, epithelial cells, very thin and irregular in outline, occur as the covering epithelium of the alveoli of the lung and of the glomeruli and capsule of the kidney. (britannica.com)
  • In the fetal lung, the epithelium actively secretes Cl− fluid secretion is a major requirement for normal pulmonary growth and development. (springer.com)
  • In several cases, including the formation of the branched airways of the lung, reciprocal signaling between an epithelium and its surrounding mesenchyme helps generate these spatial patterns. (pnas.org)
  • Airspaces of the lung are lined by an epithelium whose cellular composition changes along the proximal-to-distal axis to meet local functional needs for mucociliary clearance, hydration, host defense, and gas exchange. (jci.org)
  • Here, we review the development of the pulmonary epithelium, its roles in normal lung function, and the cellular and molecular mechanisms regulating epithelial maintenance. (jci.org)
  • Lung, Bronchiole, Epithelium, Bronchiole - Necrosis in a female B6C3F1/N mouse from a subchronic study. (nih.gov)
  • Lung, Epithelium - Necrosis in a male Wistar Han rat from a chronic study. (nih.gov)
  • Lung, Epithelium, Alveolus - Necrosis in a female F344/N rat from a subchronic study. (nih.gov)
  • Lung, Epithelium - Necrosis should be diagnosed and graded whenever present. (nih.gov)
  • Epithelium ( epi- + thele + -ium ) is ane o the fower basic teepes o ainimal tishie , alang wi connective tishie , muscle tishie an nervish tishie . (wikipedia.org)
  • Another unique characteristic of the RPE is the "reversed polarity" of proteins such as the Na,K-ATPase pump, EMMPRIN, and the adhesion molecule N-CAM at the apical surface, rather than at the basolateral surface where these proteins are found in other epithelia ( 6 - 9 ). (mcponline.org)
  • Epithelium , in anatomy, layer of cells closely bound to one another to form continuous sheets covering surfaces that may come into contact with foreign substances. (britannica.com)
  • This article is about epithelium in animal anatomy. (wikipedia.org)
  • In anatomy , squamous epithelium (from Latin squama , "scale") is an epithelium characterised by its most superficial layer consisting of flat, scale-like cells called squamous cell. (wikidoc.org)
  • In animals, outgrowths or ingrowths from these surfaces form structures consisting largely or entirely of cells derived from the surface epithelium. (britannica.com)
  • There is proliferation of the surface epithelium of the ovary. (nih.gov)
  • 1975. Active transport of Na + and Cl− across the canine tracheal epithelium in vitro . (springer.com)
  • 1981. Ion contents and other properties of isolated cells from dog tracheal epithelium. (springer.com)
  • Cigarette smoke inhibition of ion transport in canine tracheal epithelium. (springer.com)
  • 1982. Chloride secretion by canine tracheal epithelium. (springer.com)
  • 1980. Fluid transport across the canine tracheal epithelium. (springer.com)
  • 1979. The effects of sodium substitution and ouabain on ion transport by dog tracheal epithelium. (springer.com)
  • 1979. Localization of Na pumps in the tracheal epithelium of the dog. (springer.com)
  • Create healthcare diagrams like this example called Tracheal Epithelium in minutes with SmartDraw. (smartdraw.com)
  • Tracheal epithelium at the cellular level showing specialized cells and their internal structures. (smartdraw.com)
  • 1968. Electron microscopic observations of the bronchial epithelium of dogs. (springer.com)
  • For each of these same patients, generation of bronchial epithelium in vitro from bronchial biopsy using human bronchial epithelial cells (HBECs) in air-liquid interface (ALI) cultures. (clinicaltrials.gov)
  • Confrontation of the two models of in vitro generation of bronchial epithelium by iPS and ALI in order to validate our model of study of the human bronchial epithelium COPD generated by the iPS. (clinicaltrials.gov)
  • The epithelium of the terminal bronchioles and alveolar ducts (i.e., the centriacinar region) and alveoli are particularly susceptible to injury due to the large surface area and fragility of the alveolar type I cells, the metabolic activity of P450 enzymes in Clara cells, and the generally thinner mucous layer. (nih.gov)
  • The purpose of this review is to analyze some of the current data regarding the regulatory components of the TJ that could potentially affect cellular functions of the salivary epithelium. (hindawi.com)
  • This review discusses basic cellular mechanisms that regulate establishment of the conducting airway and gas exchange systems as well as the functional maintenance of the epithelium during postnatal life. (jci.org)
  • In some cases, detachment of viable cells from the epithelial surface and nuclear condensation (pyknosis) and cellular shrinkage of scattered cells within the epithelium, suggestive of imminent death of individual cells, may be interpreted as epithelial degeneration because it may be consistent with reversible damage to an epithelial surface, and evidence of outright necrosis may be lacking. (nih.gov)
  • Here, however, we show that purely physical mechanisms can drive spatial patterning within embryonic epithelia. (pnas.org)
  • Histological analyses in Hif2a-uKO mice revealed persistence of the intact luminal epithelium, which blocked direct contact between stroma and embryo, inactivation of PI3K-AKT pathway (embryonic survival signal), and failed embryo invasion. (jci.org)
  • These findings provide new insight that stromal HIF2α allows trophoblast invasion through detachment of the luminal epithelium and activation of an embryonic survival signal. (jci.org)
  • The cells in the epithelium are connected via tight junctions. (wikipedia.org)
  • Important for the barrier function of intenstinal epithelium, its cells are joined securely together by four types of junctions (cell junctions), which can be identified at the ultrastructural level: Gap junctions Desmosomes Adherens junctions Tight junctions Gap junctions bring the adjacent cells within 2 nanometers of each other. (wikipedia.org)