Epithelial tissue without invasion carcinoma in situ. Medical search. Frequent questions

A variant from this approach, defined on the basis of physical exam findings, is that inflammatory breast cancer (IBC), a form of ductal carcinoma or malignant cancer in the ducts, is distinguished from other carcinomas by the inflamed appearance of the affected breast, which correlates with increased cancer aggressivity. (wikipedia.org)
Although breast cancer has many different histologies, the considerable majority of breast cancers are derived from the epithelium lining the ducts or lobules, and are classified as mammary ductal carcinoma. (wikipedia.org)
Stage 0 is a pre-cancerous or marker condition, either ductal carcinoma in situ (DCIS) or lobular carcinoma in situ (LCIS). (wikipedia.org)
Ductal carcinoma in situ isn't cancer, some say, because " in situ " means "in place," and invading healthy tissue is one of the nine characteristics of cancer I've listed for years in my textbooks . (plos.org)
Once through, it's invasive ductal carcinoma (IDC). (plos.org)
An invasive (infiltrating) CARCINOMA of the mammary ductal system (MAMMARY GLANDS) in the human BREAST. (lookformedical.com)
Ductal Carcinoma In Situ (DCIS) is a non-obligate precursor for invasive cancer. (mcgill.ca)
We envision that epithelial phenotypic diversity and plasticity contribute to progression of DCIS to invasive cancer by endowing cells the ability to adapt from a ductal environment to a stromal environment. (mcgill.ca)
Ductal carcinoma in situ (DCIS) is characterized by a suppressive epithelial and and immune microenvironment that restricts cell invasion. (mcgill.ca)
To study the differences of ALDH1 expression in Invasive Ductal Carcinoma (IDC), Atypical Ductal Hyperplasia (ADH), Usual Ductal Hyperplasia (UDH) and normal ducts and their clinical significance. (omicsonline.org)
Papillary lesions of the breast represent a heterogeneous group of lesions including benign papillomas, papillomas with focal epithelial atypia, fully fledged ductal carcinoma in situ (DCIS) or lobular neoplasia, papillary DCIS, encapsulated papillary carcinomas without or with invasion, solid papillary carcinomas, and invasive papillary carcinomas. (nih.gov)
Patient developed infiltrating ductal carcinoma of underlying breast tissue with axillary lymph metastasis. (medscape.com)
An underlying Ductal Carcinoma In Situ (DCIS) or invasive ductal carcinoma of the breast is present in >90% of the cases. (jcimcr.org)
Breast carcinoma is the common- noma not otherwise specified, 17 cases sues (according to the specification of est malignancy among women in of lobular carcinoma, 5 cases of mixed the second differential kit which gave developed and developing countries ductal and lobular carcinoma and 7 the blue colour). (who.int)

Breast cancers are most often epithelial tumors involving the ducts or lobules. (msdmanuals.com)
General references Breast cancers are most often epithelial tumors involving the ducts or lobules. (msdmanuals.com)
Gastric carcinoma comprises more than 90% of all gastric malignant tumors. (poznayka.org)
Research has shown that some solid tumors are stiffer than their surrounding tissues, and tumor stiffness is related to solid tumor progression and aggression [ 7 , 8 ]. (ijbs.com)
All 8 EBV-GCLSs occurred in male patients and invaded deep submucosa (SM2) without lymph node metastasis (LNM), four (50%) of which had synchronous non-gastric malignant tumors (3 gastric gastrointestinal stromal tumors and 1 primary clear cell renal cell carcinoma), and four (50%) arose in the proximal stomach. (biomedcentral.com)
As little is known about epithelial-stromal interactions in vivo, it is necessary to visualize the stroma surrounding normal epithelium and mammary tumors in intact tissues to better understand how matrix organization, density, and composition affect tumor formation and progression. (biomedcentral.com)
Epithelial-stromal interactions in normal mammary glands, mammary tumors, and tumor explants in three-dimensional culture were studied with histology, electron microscopy, and nonlinear optical imaging methodologies. (biomedcentral.com)
In particular, local cell invasion was found predominantly to be oriented along certain aligned collagen fibers, suggesting that radial alignment of collagen fibers relative to tumors facilitates invasion. (biomedcentral.com)
As such, TACS should provide indications that a tumor is, or could become, invasive, and may serve as part of a strategy to help identify and characterize breast tumors in animal and human tissues. (biomedcentral.com)
One important step to elucidating these signaling interactions is to determine the organization of the collagenous stroma surrounding both normal mammary glands and tumors within intact tissue so as to better understand the cell-matrix interaction and how matrix organization, density, and composition affect tumor formation and progression. (biomedcentral.com)
Modified HPV particles may be used for the treatment of diseases or conditions of mucosal tissue, including HPV (human papilloma virus) infection and HPV-related tumors. (justia.com)
Squamous cell carcinoma of varying degrees of differentiation is observed in 90% of patients with malignant tumors of the vulva. (med-blog.com)
The primary source of metastatic tumors is more oftentotal is squamous cell carcinoma of the cervix, then - cancer of the endometrium, bladder and urethra. (med-blog.com)
The etiological classification of squamous cell carcinoma of the vulva includes at least two groups: the smaller - basaloid and warty tumors induced by human papillomaviruses (HPV), and the larger - squamous cell carcinoma, the etiology of which is unknown. (med-blog.com)

Exposure to hormonal growth promoters or endocrine disruptors elevates the probability of histological alterations in human mammary epithelial cells, which may lead to the growth of pre-neoplastic cells ( 16 ). (spandidos-publications.com)
Ex vivo fibroblasts from mice fed dietary-AGEs retain an activated phenotype and promoted epithelial migration and invasion of non-transformed immortalized and tumor-derived mammary epithelial cells. (biomedcentral.com)
Although the mechanisms mediating the effects of the extracellular matrix (ECM) on breast carcinoma development in vivo are largely unknown, contributing factors may be adhesion mediated signaling and mechanical signals imparted on mammary epithelial cells from surrounding type-I collagen-rich stroma, either directly or across basement membrane proteins. (biomedcentral.com)

This is the first study describing the production and distribution of ETS-1 and ETS-2 mRNAs and proteins using in situ hybridization and immunohistochemistry in murine ocular tissue sections of normal control eyes and tumoral eyes from mice of the same age. (molvis.org)
Expression of a subset of candidates was verified by qRT-PCR and in situ hybridization (ISH) analyses. (biomedcentral.com)
This study in Iraq used in situ hybridization to detect the frequency and genotyping of HPV in tissue specimens from 129 patients diagnosed with malignant breast cancer, 24 with benign breast tumours and 20 healthy controls. (who.int)
In situ hybridization (ISH) was used to investigate the presence of HPV-16, while immunohistochemistry (IHC) was used to estimate the expression level of TIMP-2. (bvsalud.org)
In formalin-fixed paraffin-embedded (FFPE) upper respiratory tract (URT) specimens, conventional reverse transcription-polymerase chain reaction (cRT-PCR) was more sensitive than in situ hybridization (ISH) or immunohistochemistry (IHC) for detection of SARS-CoV-2. (cdc.gov)

Top-to-bottom epithelial dysplasia, like other dysplastic lesions, has no characteristic clinical appearance, although erythroplasia often proves to be carcinoma in situ or early invasive carcinoma. (medscape.com)
Oral Cavity CA1) Lip CAa- which lesions are most aggressiveb- when do you need flaps2) T/F- In tongue CA you can still operate with jaw invasion? (brainscape.com)
Macroscopically, the lesions of early gastric carcinoma may have 3 patterns-superficial, polypoid and ulcer-associated. (poznayka.org)
In addition, a variety of other rare breast lesions reveals a papillary architecture such as tall cell carcinoma with reversed polarity (TCCRP) and mucinous cystadenocarcinoma, adenomyoepithelioma, and secretory carcinoma. (nih.gov)
The lesions are composed of lobules of epithelial cells extending down into the stroma. (medscape.com)
HPV is now known to be a small deoxyribonucleic acid (DNA) virus that infects epithelial cells and causes a variety of skin lesions. (medscape.com)
Invasive squamous and glandular where the excision is performed at the including radiological examination to lesions first diagnostic colposcopy visit, assess the extent of invasion within the The World Health Organization classi- depends on expert assessment of the cervix and its surroundings. (who.int)

A micropapillary pattern characterized by lack of fibrous stalks within the papillae is observed in micropapillary DCIS and invasive micropapillary carcinoma. (nih.gov)

Some leukoplakias culminate in oral squamous cell carcinoma (OSCC). (medscape.com)
CEACAM6 promoted oral squamous cell carcinoma cell invasion, migration, cytoskeletal rearrangement, and metastasis via interaction with EGFR and enhancing it activation. (cusabio.cn)
To determine the expression of tissue inhibitors of metalloproteinases (TIMP-2) in oral squamous cell carcinoma (OSCC) and the difference in its expression level between positive and negative HPV-16 (human papilloma virus- 16) OSCC patients. (bvsalud.org)
The recurrence is a serious prognostic influence in patients with oral squamous cell carcinoma (OSCC) 1-3 . (bvsalud.org)

Some lncRNAs affect the growth and development of breast cancer by regulating cell proliferation and apoptosis, and others are involved in invasion and metastasis and drug resistance of breast cancer [ 6 ]. (jcancer.org)
Invasion and metastasis of malignant epithelial cells into normal tissues is accompanied by adaptive changes in the mesenchyme-derived supporting stroma of the target organs. (aacrjournals.org)
Matrix metalloproteinases (MMPs) are involved in the degradation of protein components of the extracellular matrix and thus play an important role in tumor invasion and metastasis. (biomedcentral.com)
Tumor invasion and metastasis define malignancy and are the principal causes of cancer associated death. (biomedcentral.com)
Previous studies showed that MMPs facilitate tumor invasion and metastasis in general. (biomedcentral.com)
CTCs are recognized as playing important roles in the metastasis of carcinomas ( 11 , 12 ) and their analysis enables the prediction of metastatic relapse and progression ( 11 ). (iiarjournals.org)
Studies provide evidence that dysregulated overexpression of CEACAM6 plays a role in several of the hallmarks of cancer, including uncontrolled proliferation, anoikis resistance, immune evasion, invasion and metastasis. (cusabio.cn)
Compared with squamous cell carcinoma and large cell carcinoma, adenocarcinoma is the most common type of NSCLC due to its high incidence and rapid metastasis. (molcells.org)

The sensitivity of Papanicolaou smears for detecting endocervical adenocarcinoma in situ (AIS) is very low. (cytojournal.com)
Microscopically, early gastric carcinoma is a typical glandular adenocarcinoma, usually well-differentiated. (poznayka.org)
Microscopically, it may be an adenocarcinoma or signet-ring cell carcinoma, extensively infiltrating the stomach wall, but due to marked desmoplasia cancer cells may be difficult to find. (poznayka.org)
Salivary duct carcinoma and high-grade adenocarcinoma are the histologic types that most commonly arise in the background of Pleomorphic adenoma. (org.pk)
3 Low-grade carcinoma ex pleomorphic adenoma can be of the following types: myoepithelial Carcinoma, epithelial-myoepithelial Carcinoma, basal cell adenocarcinoma, etc. (org.pk)
Also involved in the metastatic cascade process by inducing gain resistance to anoikis of pancreatic adenocarcinoma and colorectal carcinoma cells. (cusabio.cn)
[ 3 , 4 ] The term "pseudomesotheliomatous carcinoma" was first applied by Harwood and colleagues in 1976 to 6 cases of peripheral lung adenocarcinoma that closely mimicked mesothelioma. (medscape.com)
Cystoscopy revealed a pedunculated mass in the right posterior-lateral wall, inferior to the transplant urethral orifice, and biopsy of this mass showed invasive small cell carcinoma with a prominent adenocarcinoma component. (cdc.gov)
Adenocarcinoma in situ (AIS) is the mortality rates in a population is the tion, no improvement in survival is only well characterized intraepithelial hysterectomy rate, since this affects seen. (who.int)

Unfortunately, exclusion of dysplasia in a biopsy sample does not guarantee that elsewhere in the lesion there is not dysplasia or even carcinoma. (medscape.com)
A lesion with cytological characteristics associated with invasive carcinoma but the tumor cells are confined to the epithelium of origin, without invasion of the basement membrane. (lookformedical.com)
The biopsy showed a neoplastic lesion predominantly seen in the subcutaneous tissue exhibiting nodular appearance separated by thick fibrous bands. (org.pk)
Gastric intestinal metaplasia (GIM) is a precancerous gastric carcinoma (GC) lesion with pivotal roles in carcinogenesis. (oncotarget.com)
Patient was treated by conservative excision of lesion and lumpectomy for in situ carcinoma. (medscape.com)

Myoepithelial Carcinoma is associated with a benign tumour in approximately 50-70% of cases. (org.pk)
Only 3 benign breast tumour tissues (12.5%) and none of the healthy breast tissue specimens were HPV-DNA-positive. (who.int)
Proper recognition of this disorder is required to initiate an appropriate workup (eg, skin biopsy) for differentiating it from other benign inflammatory dermatoses and for detecting an underlying breast carcinoma. (medscape.com)
Iraq have demonstrated that most patients with benign epithelial mam- 100 lens for counting the positive cells. (who.int)

Loss of tissue organization and apical-basal polarity (i.e. the segregation of apical and basolateral membrane domains) are characteristics of epithelial cancers. (mcgill.ca)
The control of this transition from epithelial stem cell to differentiated corneocyte, which is abnormal in epidermal cancers, is not well understood. (stanford.edu)
Skin malignancies, including epidermal squamous cell carcinoma (SCC), alone account for nearly as many cancers as all other tissues combined. (stanford.edu)
In tumor tissues, lncRNAs are markedly deregulated and pervasively involved in development and progression of cancers [ 6 - 8 ]. (jcancer.org)
We have used stroma-rich models in immunodeficient mice, which recapitulate the histotypic arrangement found in human epithelial cancers. (aacrjournals.org)
Malignant epithelial cancers, the major cause of cancer morbidity and mortality, arise in organs composed of both epithelial and mesenchyme-derived stromal cells, such as fibroblasts, myofibroblasts, endothelial cells, pericytes, smooth muscle, and hematopoietic cells. (aacrjournals.org)
Their expression is related to the progression of gynecological cancers (e.g. endometrial, cervical or ovarian carcinoma). (biomedcentral.com)
More than 90% of invasive vulvar cancers are squamous cell carcinomas. (cancer.gov)
prise about 4% of cancers in women, invasive squamous-cell carcinoma. (who.int)

3. Endo K., Terada T. Protein expression of CD44 (standard and variant isoforms) in hepatocellular carcinoma: relationships with tumor grade, clinicopathologic parameters, p53 expression, and patient survival. (roche.com)
Immunotherapy with dendritic cells and/or cytokine-induced killer cells for the treatment of hepatocellular carcinoma. (aetna.com)

Estrogen production in adipose tissue has previously been demonstrated to provide excessive estrogen for the stimulation and progression of postmenopausal breast cancer cells, and elevated enzymatic activity of aromatase has been detected in the adjacent adipose stroma of breast carcinoma ( 8 , 9 ). (spandidos-publications.com)
A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (lookformedical.com)
Progress in understanding epithelial carcinogenesis has been hindered in the past by a lack of models that faithfully recapitulate the 3-dimensional architecture of tumor-stroma co-evolution. (stanford.edu)
The score of ALDH1 in luminal epithelial cytoplasm expression is 3, 2, and 1 while myoepithelial cells and stroma expression are 3, 2, and 2 in ADHÃ¯Â¼ÂŒUDH and normal ducts respectively. (omicsonline.org)
Epstein-Barr virus-associated early gastric carcinoma with lymphoid stroma (EBV-GCLS) is a rare variant of early gastric carcinomas. (biomedcentral.com)
In the present study, we aimed to analyze the clinicopathology and prognosis of EBV-GCLS and to compare them with those of invasion-depth stratified conventional early gastric carcinomas without lymphoid stroma or micropapillary components. (biomedcentral.com)

However, studies have revealed carcinoma or severe dysplasia in the excision specimens of approximately 5% of leukoplakias excised when the diagnostic biopsy specimens had revealed no dysplasia. (medscape.com)
Carcinoma in situ is a controversial term used for severe dysplasia in which the abnormalities extend throughout the thickness of the epithelium. (medscape.com)
carcinoma in situ in the stomach (a state of severe cellular atypia or dysplasia, without invasion across the basement membrane of the glands). (poznayka.org)
So far, it is well recognized that a multistep process is involved in the progression from normal gastric mucosa to intestinal-type GC, including chronic gastritis, chronic atrophic gastritis, intestinal metaplasia, dysplasia and invasive carcinoma, which was originally proposed by Correa [ 2 , 3 ]. (oncotarget.com)
and CIN III refers to cellular dysplasia encompassing greater than two-thirds of the epithelial thickness. (justia.com)

Degradation of the extracellular matrix allows tumor cells to detach from the primary tumor mass, invade local tissue, intravasate, extravasate and build new metastatic formations [ 1 ]. (biomedcentral.com)

Gastric carcinoma is most commonly located in the region of gastric canal (prepyloric region), less common localization are the body, cardia and fundus. (poznayka.org)
1. Early gastric carcinoma, when carcinoma confined only mucosal layers. (poznayka.org)
2. Advanced gastric carcinoma, when it penetrates the muscular layer or beyond. (poznayka.org)
1. Pyloric (50%) gastric carcinoma. (poznayka.org)
Early gastric carcinoma is the term used to describe cancer limited to the mucosa and submucosa. (poznayka.org)
When the carcinoma crosses the basement membrane into the muscular propria or beyond, it is referred to as advanced gastric carcinoma. (poznayka.org)
However, the relationships of AQP3 with GIM classification and with other proteins, and their roles in the transition from GIM to gastric carcinoma (GC) remain unknown. (oncotarget.com)
Gastric carcinoma (GC) remains one of the most common malignances and the third leading cause of cancer-related mortality worldwide [ 1 ]. (oncotarget.com)
By a retrospective review of 595 consecutive radical gastrectomies for early gastric carcinoma from 2006 to 2018, we identified 8 (1.3%, 8/595) EBV-GCLS cases. (biomedcentral.com)
With the improvement in endoscopic technology and accumulating operative experience among endoscopists, endoscopic therapy, such as endoscopic submucosal dissection, has become the treatment of choice for early gastric carcinoma in many countries, including China [ 3 ]. (biomedcentral.com)

The function of histone modifying epigenetic regulators and noncoding RNA as central mediators of epithelial stem cell renewal and differentiation represent major emerging areas of study in the lab. (stanford.edu)
The formation of the mammalian respiratory unit is initiated during the transition between the pseudoglandular and canalicular/saccular stages and is characterized by coordinated proliferation and differentiation of epithelial and mesenchymal cells. (biomedcentral.com)
Even with poor differentiation and SM2 invasion, EBV-GCLS showed very low risk of LNM and may be a candidate for endoscopic therapy such as endoscopic submucosal dissection. (biomedcentral.com)
The abnormalities observed on a cytologic smear or tissue biopsy of the cervix represent alterations in the degree of differentiation of cervical epithelial cells. (justia.com)

The biopsy showed spindle cell component with mild atypia, invasion into surrounding tissue, and increased mitotic activity on the basis of which a diagnosis of Low-grade carcinoma ex pleomorphic adenoma developing in a background of pleomorphic adenoma was made. (org.pk)
After obtaining the biopsy, place the tissue flat on a piece of firm paper/cardboard before placing in fixation medium. (medscape.com)

Leukoplakias that are speckled, or erythroleukoplakic, are usually dysplastic or frank carcinomas. (medscape.com)

Breast ducts are organized as a bilayer of luminal epithelial cells surrounded by a contractile myoepithelial layer. (mcgill.ca)

Worldwide, the human papillomavirus (HPV) has been detected in more than 90% of cervical carcinomas and in as many as 99.7% of cervical neoplasias. (medscape.com)

Low-grade carcinoma ex pleomorphic adenoma can be difficult to differentiate from cellular pleomorphic adenoma as it does not show obvious cytologic atypia. (org.pk)
Epithelial cells do not demonstrate atypia, and dysplastic changes are uncommon for conjunctival inverted papillomas. (medscape.com)

Classification of breast cancer is usually, but not always, primarily based on the histological appearance of tissue in the tumor. (wikipedia.org)
Carcinoma in situ is proliferation of cancer cells within the epithelial tissue without invasion of the surrounding tissue. (wikipedia.org)
Perineural and/or lymphovascular space invasion is usually considered as part of the histological description of a breast cancer, and when present may be associated with more aggressive disease. (wikipedia.org)
Grading focuses on the appearance of the breast cancer cells compared to the appearance of normal breast tissue. (wikipedia.org)
But the "c" stands for carcinoma , a cancer of epithelial tissue. (plos.org)
The findings of the present study suggest that zeranol promotes breast cancer cell growth by stimulating aromatase activation and increasing estrogen biosynthesis in adipose tissue. (spandidos-publications.com)
Cancer-associated adipocytes exhibit an activated phenotype and contribute to breast cancer invasion ( 11 ). (spandidos-publications.com)
It represents a large group of epithelial lung malignancies which can be divided into two clinical groups: SMALL CELL LUNG CANCER and NON-SMALL-CELL LUNG CARCINOMA . (lookformedical.com)
Key regulators of apical-basal polarity control a wide range of cellular activities, including proliferation, survival, motility, and invasion that are important for breast cancer progression. (mcgill.ca)
This theme investigates novel mechanisms by which tissue organization and polarity are regulated during cancer progression. (mcgill.ca)
Control of epithelial architecture during cancer progression. (mcgill.ca)
Landscape of epithelial phenotypes in breast cancer progression. (mcgill.ca)
Epithelial-Immune interactions in cancer initiation. (mcgill.ca)
To address this and to also study the oncogenic potential of unregulated function of dominant regulators of epithelial homeostasis noted above, we developed Multi-Functional Human Tissue Genetics noted above which, when combined with skin tissue regeneration on immune deficient mice, has permitted the molecular reconstruction of events sufficient to trigger human cancer. (stanford.edu)
The expression of the identified long noncoding RNAs was downregulated in cancer tissue samples compared with normal tissue samples, and these long noncoding RNAs correlated with a favorable prognosis in breast cancer patients and the patients in the pancancer cohort. (cancerindex.org)
Finally, EPB41L4A-AS2 inhibited breast cancer cell proliferation, migration and invasion and induced cell apoptosis in vitro. (cancerindex.org)
In breast cancer tissues, UASR1 was upregulated. (jcancer.org)
I served as a member of Breast Cancer Campaign Scientific Advisory Board and I am a member of the Breast Cancer Now Tissue Access Committee. (nottingham.ac.uk)
Notch signaling has been implicated in many microenvironmental processes associated with cancer progression such as vascular remodeling, immunosuppression, epithelial to mesenchymal transition (EMT), as well as maintenance of the CSC pool 21 . (nature.com)
tissue stiffness, LOX, colorectal cancer. (ijbs.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
Another suggestion is to have intensive postoperative follow-up which includes consultations every 4-6 months, physical examination and evaluation of serum carcinoembryonic antigen (CEA), tissue polypeptide antigen (TPA) and breast cancer-associated antigen 115 D8/DF3 (CA15.3), at each visit. (iiarjournals.org)
This method uses either epithelial cell-specific markers which are generally expressed in all tumor cells, or tumor markers expressed by specific types of cancer ( 13 ). (iiarjournals.org)
Colorectal cancer develops through a process involving genetic change in the epithelial cells of the colon lining. (bioresonancetherapy.com.sg)
In the breast cancer group, cocktail HPV genotypes were detected in 60 (46.5%) archived tissue blocks. (who.int)
L'étude menée en Iraq a utilisé la méthode d'hybridation in situ pour déterminer la fréquence du papillomavirus humain et pour son génotypage dans les échantillons de tissus prélevés auprès de 129 patientes ayant reçu un diagnostic de cancer du sein malin, de 24 patientes porteuses d'une tumeur du sein bénigne et de 20 femmes témoins en bonne santé. (who.int)
Human papillomavirus in clinically and histologically normal tissue of patients with genital cancer. (cancer.gov)
These proteins play a master role in diverse physiological processes and diseases such as the homeostatic tissue remodeling and cancer 17 . (bvsalud.org)

One of the potential factors that contributes to breast carcinogenesis is the increased exposure of epithelial cells to estrogens produced locally by the tissue microenvironment ( 2 ). (spandidos-publications.com)
A previous report demonstrated that zeranol is comparable to natural 17β-estradiol (E2) and the synthetic estrogen diethylstilbestrol in its ability to transform MCF-10A normal human breast epithelial cells to a pre-cancerous phenotype in vitro ( 17 ). (spandidos-publications.com)
A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. (lookformedical.com)
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. (lookformedical.com)
A primary malignant neoplasm of epithelial liver cells. (lookformedical.com)
It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. (lookformedical.com)
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. (lookformedical.com)
An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. (lookformedical.com)
Myoepithelial cells are hypothesized to be natural repressors of tumour progression by acting as a physical barrier to prevent luminal cells from invading into surrounding tissue. (mcgill.ca)
The latter encompass human skin regenerated on immune deficient mice as well as organotypic constructs with epithelial and stromal cells embedded within architecturally faithful mesenchyma in vitro. (stanford.edu)
The consecutive steps of tumor growth, local invasion, intravasation, extravasation, and invasion of anatomically distant sites are obligatorily perpetrated through specific interactions of the tumor cells with their microenvironment. (hindawi.com)
Using mouse models, we discovered that mutations in murine Col4a1 and Col4a2 genes affected the balance between lung epithelial progenitors and differentiated cells. (biomedcentral.com)
In the developing lung, the specific temporal-spatial interactions between mesenchymal and epithelial cells are carefully orchestrated to permit the gradual establishment of an effective blood-gas barrier (BGB) [ 1 , 2 ]. (biomedcentral.com)
CD44 is expressed in many normal human hematopoietic, epithelial,and mesenchymal cells. (roche.com)
In mammary gland development, Notch-dependent heterotypic signaling between resident tissue macrophages and mammary stem cells supports survival and function of the normal mammary stem cell 20 . (nature.com)
carcinoma contains abundant pools of mucin in which are seen a small number of tumor cells, sometimes having signet-ring appearance. (poznayka.org)
Analysis of chemically distinct conjugates, resistance models, and biomarkers implicates a unique mode of action, with mitotic arrest and apoptosis of malignant epithelial cells coupled to disruption of fibroblastic and vascular structures. (aacrjournals.org)
in turn, the malignant epithelial cells can undergo reversible epithelial-mesenchymal transitions ( 1 - 5 ). (aacrjournals.org)
A total of 36,424 single-cell data sets were obtained, which were annotated by 20 cell type markers The main cell populations such as epithelial cells, fibroblasts, monocyte-macrophage cell lines, endothelial cells, mast cells, and T cells are included. (medicaltrend.org)
16 subgroups can be obtained by further grouping epithelial cells. (medicaltrend.org)
Another subgroup of epithelial cells (Cluster 12) was found to be in the G2/M phase of mitosis, which was named CellCycle cells. (medicaltrend.org)
Morphological-based isolation separates CTCs according to size discrepancies, using isolation by size of epithelial tumor cells (ISET) or according to density, using density-gradient separation ( 4 ). (iiarjournals.org)
Furthermore, the migration and invasion ability of GBM cells were significantly decreased after CASP5 down-regulation, while increased migration and invasion can be observed after CASP5 up-regulation. (cancerindex.org)
In some embodiments, compositions and methods of the invention are useful for treating mucosal conditions (e.g., diseases and/or infections of mucosal tissue, for example of mucosal epithelial cells). (justia.com)
A colorectal carcinoma is a malignant (cancerous) new growth that arises from cells in the bowel lining. (bioresonancetherapy.com.sg)
positively regulates cell migration, cell adhesion to endothelial cells and cell invasion. (cusabio.cn)
This study aimed to elucidate the role of miR-153-3p-EVs in the invasion and migration capabilities of LUAD cells and explore its mechanism through in vivo and in vitro experiments. (molcells.org)
Besides, we found that miR-153-3p-EVs could damage the respiratory ability of mice and produce a mass of inflammatory cells around the lung tissue of mice. (molcells.org)
SFTs of the pleura are localized mesenchymal neoplasms composed of fibroblastlike cells believed to arise from the subpleural connective tissue. (medscape.com)
A further 20 blocks from The ISH results were given percentage vanced stages with a likely prevalence samples from normal breast tissues scores based on positive signals and of more aggressive tumour forms were labelled as a control group (i.e. number of cells that gave these signals. (who.int)
Of greatest interest is the~300 amino acid receptor binding domain (RBD) within the S1 subunit of the spike protein because of its key interaction with the human angiotensin converting enzyme 2 (hACE2) receptor present on many cell types, especially lung epithelial cells. (cdc.gov)

A malignant epithelial tumor with a glandular organization. (lookformedical.com)
Physical examination and imaging showed no relation to the nipple-areola complex or breast glandular tissue. (jcimcr.org)
We present a case of Paget's disease located in the inframammary fold without any relation to the nipple or mammary glandular tissue. (jcimcr.org)

Cet anticorps est conçu pour être utilisé en diagnostic in vitro (DIV)", "Language": "fr", "Country": "XG", "Code": "Intended Use" }, { "Name": "Background Information", "Value": "Anti-CD44 (SP37) is a rabbit monoclonal antibody produced against a conserved region of the CD44 protein. (roche.com)
4. Southgate J., Trejdosiewicz L. et al.Patterns of splice variant CD44 expression by normal human urothelium in situ and in vitro and by bladder-carcinoma cell lines. (roche.com)

Lastly, we revealed that addition of type IV collagen protein induced myofibroblast proliferation and migration in monolayer culture and increased the formation of mesenchymal-epithelial septal-like structures in co-culture. (biomedcentral.com)

Microscopically, fungating or polypoid carcinomas are well-differentiated adenocarcinomas, commonly papillary type. (poznayka.org)

Carcinoma squamous cell. (lookformedical.com)
3. Squamous-cell carcinoma. (poznayka.org)
2014) 16 reported and compared the histologic, immunohistochemical and clinical features as well as the survival rates of carcinoma arising in patients with PVL (p-scca) and conventional squamous cell carcinoma (c-scca). (bvsalud.org)

only invasion of the underlying connective tissue is absent. (medscape.com)
Individual fronds are surrounded by connective tissue, each having a central vascularized core. (medscape.com)

2. Signet-ring cell carcinoma, scirrhous carcinoma, solid carcinoma (poorly-differentiated). (poznayka.org)
Macroscopically, ulcerative carcinomas are poorly-differentiated adenocarcinomas, which invade deeply into the stomach wall. (poznayka.org)

We aimed to study whole genomic lncRNA expression patterns in colorectal adenoma-carcinoma transition and to analyze the underlying functional interactions of aberrantly expressed lncRNAs. (biomedcentral.com)
Two candidates with the greatest increase in expression in the adenoma-carcinoma transition were further confirmed by qRT-PCR (UCA1, CCAT1) and by ISH (UCA1). (biomedcentral.com)
The defined lncRNA sets may have a regulatory role in the colorectal adenoma-carcinoma transition. (biomedcentral.com)
Dysregulated lncRNAs are known to contribute to CRC formation through the disruption of various signaling cascades including Wnt/β-catenin, EGFR/IGF-IR (KRAS and PI3K pathways), TGF-β, p53 and Akt signaling pathways, and also via influencing the epithelial-mesenchymal transition program [ 12 ]. (biomedcentral.com)
Using lncRNA array, we identified a novel lncRNA (named lnc408) in epithelial-mesenchymal transition-related breast CSCs (BCSCs). (nature.com)
Through further investigation, we found that the downregulation of BANCR activates the PI3K/AKT pathway and accelerates the process of epithelial-mesenchymal transition (EMT), which ultimately leads to the aggravation of LUAD. (molcells.org)

The directed expression of SV40 T antigen has led to the development of several important transgenic models with spontaneous epithelial tumor formation. (molvis.org)

It is a myoepithelial or epithelial neoplasm that arises from pleomorphic adenoma, whether primary or recurrent. (org.pk)
The morphological and immunohistochemical features confirmed the carcinoma component to be myoepithelial. (org.pk)
The case of a low-grade carcinoma, ex-pleomorphic adenoma arising in a background of pleomorphic adenoma in submandibular gland with morphological and immunohistochemical features compatible with myoepithelial carcinoma is reported here. (org.pk)
4 Myoepithelial carcinoma developing in a background of pleomorphic adenoma accounts for 35% of the cases and is reported infrequently in the literature. (org.pk)

The lung is a complex, precisely structured organ in which the vascular network is intimately associated with epithelial-lined tubes and sacs for the prime purpose of gas exchange. (biomedcentral.com)

A concept that we have championed is that loss of apical-basal polarity deregulates signaling pathways involved in epithelial homeostasis, which is a permissive step in the progression to a malignant state. (mcgill.ca)
The results demonstrate that the expression of ECM components in CRC tissues is closely correlated with CRC progression and poor prognosis, which indicates that ECM stiffness may be associated with CRC development. (ijbs.com)
We further studied lysyl oxidase (LOX) expression in CRC tissue and demonstrated that LOX expression is closely correlated with CRC progression. (ijbs.com)

A malignant skin neoplasm that seldom metastasizes but has potentialities for local invasion and destruction. (lookformedical.com)
Carcinoma ex pleomorphic adenoma is a neoplasm of the salivary gland that causes 3.6% of salivary gland tumours and 12% of salivary gland malignancies. (org.pk)
By definition, pseudomesotheliomatous carcinoma refers to an epithelial neoplasm that secondarily involves the pleura and encases the lung, thereby simulating the radiologic and macroscopic appearance of malignant mesothelioma. (medscape.com)
Synovial sarcoma is a malignant soft-tissue neoplasm that most commonly affects the extremities near to, but not in continuity with, large joints. (medscape.com)

LncRNA CASP5 have been found to be up-regulated in GBM tissues compared with normal tissues in a microarray-based lncRNA profiling study. (cancerindex.org)

Historically carcinoma ex pleomorphic adenoma is considered a high-grade malignancy. (org.pk)
Historically, Carcinoma ex pleomorphic adenoma is considered a high-grade malignancy with malignant features like increased mitosis, marked nuclear pleomorphism, necrosis and infiltrative growth. (org.pk)

Preadipocytes and adipocytes are major cell types present in the breast adipose tissue microenvironment ( 10 ). (spandidos-publications.com)
Characterization of cell-generated forces in tissue dynamics. (mcgill.ca)
Epithelial cell dynamics in therapeutic resistance. (mcgill.ca)
Our experimental focus is on the mammalian setting using multiomics, informatics, mouse genetics, human genetics, single cell studies, and new human tissue platforms. (stanford.edu)
Cell type and tissue specific alterations in fine GAG structure, which are strictly predetermined [ 8 - 10 ], allow these molecules to modulate with high specificity different cellular processes [ 7 ]. (hindawi.com)
Hh proteins are secreted morphogens that play essential roles in regulation of embryogenesis, development, tissue homeostasis, regeneration and stem cell maintenance in a concentration-dependent manner [ 6 ]. (biomedcentral.com)
Functionally, CD44 is involved in lymphocyte recirculation, adhesion, activation, lymph node homing, and to a larger extent in other tissue types, cell- cell and cell-matrix interactions. (roche.com)
Mammary epithelial cell migration and invasion in response to AGE-mediated fibroblast activation was determined in two-compartment co-culture models. (biomedcentral.com)
Mechanistically, we found that the receptor for AGE (RAGE) is required for AGE-mediated increases in epithelial cell migration and invasion. (biomedcentral.com)
Further, both epithelial and stromal cell populations were impacted by the high AGE diet in the mammary gland. (biomedcentral.com)
We examined the expression level of lncRNA CASP5 in GBM tissues as well as GBM cell lines. (cancerindex.org)
We observed that lncRNA CASP5 was highly expressed in GBM tissues and cell lines. (cancerindex.org)
Synovial sarcomas encompass both biphasic (epithelial and spindle cell components) and monophasic (purely spindle cell) variants. (medscape.com)
Histopathology and localization of SARS-CoV-2 and its host cell entry receptor ACE2 in tissues from naturally infected US-farmed mink (Neovison vison). (cdc.gov)

Differing functions, including binding of diverse protein epitopes, viral neutralization, impact on RBD-hACE2 binding, and immunohistochemical staining of infected lung tissue, were correlated with variable gene usage and sequence. (cdc.gov)

Perineural invasion. (cancer.gov)

Nipple changes were associated with intraductal carcinoma of breast. (medscape.com)

Clinicopathologic characteristics were compared between EBV-GCLSs and 109 conventional early gastric carcinomas, which were divided into intramucosal, SM1, and SM2 subgroups. (biomedcentral.com)

We characterized the pathological findings in 72 mink from US farms with SARS-CoV-2 outbreaks, localized SARS-CoV-2 and its host cellular receptor angiotensin-converting enzyme 2 (ACE2) in mink respiratory tissues, and evaluated the utility of various test methods and specimens for SARS-CoV-2 detection in necropsy tissues. (cdc.gov)

Anatomy44

Organisms10

Diseases73

Chemicals and Drugs44

Analytical, Diagnostic and Therapeutic Techniques and Equipment44

Phenomena and Processes40

Disciplines and Occupations2

Information Science5

Health Care9

Ductal14

Tumors14

Mammary epithelial cells3

Hybridization5

Lesions7

DCIS1

Oral squamous cell carc4

Metastasis8

Adenocarcinoma9

Lesion5

Benign4

Cancers9

Hepatocellular2

Stroma6

Dysplasia5

Metastatic1

Gastric carcinoma10

Differentiation4

Biopsy2

Frank carcinomas1

Luminal epithelial1

Cervical carcinomas1

Atypia2

Cancer28

Cells31

Glandular3

Vitro2

Proliferation1

Papillary1

Squamous Cell3

Connective tissue2

Poorly differentiated2

Transition6

Tumor formation1

Myoepithelial4

Vascular1

Progression3

Neoplasm4

Normal tissues1

Malignancy2

Cell14

Lung1

Perineural1

Intraductal1

Characteristics1

Receptor1