• Collagen receptors are cell surface receptors that modulate signal transduction between cells and the EXTRACELLULAR MATRIX. (lookformedical.com)
  • Cytokines bind to their receptors, activating signal transduction pathways such as adenylate cyclase/cAMP, phospholipase C/inositol trisphosphate, and Ca 2+ and tyrosine kinases. (biomedcentral.com)
  • Agrin-like glycoproteins and proteins with sugar-binding domains are also predominant. (biomedcentral.com)
  • The predominant form of the protein is comprised of two alpha1(IV) subunits and one alpha2(IV) subunit, however, at least six different alpha subunits can be incorporated into the heterotrimer. (lookformedical.com)
  • Comparison of the mechanisms that govern the production of calcium carbonate (CaCO 3 ) biominerals in hexacorallians (scleractinians) and octocorallians is thus expected to shed light on the conservation of the protein toolkit used by these organisms for making their biocalcification. (biomedcentral.com)
  • A polypeptide substance comprising about one third of the total protein in mammalian organisms. (lookformedical.com)
  • We identified a total of 102 OM proteins, 52 are found in the two red coral biominerals with scleritin being the most abundant protein in each fraction. (biomedcentral.com)
  • A hallmark of events observed during segmentation was the induction of multiple transcription factors, including a large group of homeobox proteins in pace with decay of a large fraction of maternal transcripts. (biomedcentral.com)
  • Transcripts found in unfertilized oocytes also encoded a large number of proteins implicated in cell adherence, tight junction and focal adhesion, suggesting high complexity in terms of structure and cellular interactions in embryos prior to midblastula transition (MBT). (biomedcentral.com)
  • The oocyte is loaded with maternal mRNAs and proteins that control the cell maintenance and fate and the formation of the body plan prior to the onset of zygotic genome expression [ 3 , 4 ]. (biomedcentral.com)
  • Contrary to reef building corals, the red coral organic matrix possesses a large number of collagen-like proteins. (biomedcentral.com)
  • 4. Matrix metalloproteinases (MMP), EMMPRIN (extracellular matrix metalloproteinase inducer) and mitogen-activated protein kinases (MAPK): co-expression in metastatic serous ovarian carcinoma. (nih.gov)
  • The 37/67-kDa laminin receptor (LAMR/RPSA) was originally identified as a 67-kDa binding protein for laminin, an extracellular matrix glycoprotein that provides cellular adhesion to the basement membrane. (nih.gov)
  • Mesenchymal stromal cells and macrophages release tolerogenic cytokines and favor anti-apoptotic signaling pathway activation, while the urokinase plasminogen activator receptor (uPAR) system contributes to migration through an extracellular matrix. (bvsalud.org)
  • MMPs in turn increase proteolysis of different protein substrates in the extracellular matrix particularly collagen and elastin, leading to weakening of the vein wall. (oaepublish.com)
  • MMPs are Zn 2+ -dependent endopeptidases that cause degradation of different protein substrates in the extracellular matrix (ECM). (oaepublish.com)
  • LAMR has evolutionary origins, however, as a 37-kDa RPS2 family ribosomal component. (nih.gov)
  • UN induced dramatic alterations in expression levels of more than 200 genes, mainly up-regulated, including oxidative-response-related genes, genes encoding for cellular metabolism, ribosomal proteins, signal transduction, and solute transporters. (nih.gov)
  • Platelet GPVI is a 60-65 kDa type I transmembrane glycoprotein belonging to the immunoglobulin superfamily and is considered to be the major signaling collagen-binding platelet receptor. (medscape.com)
  • 15. Granulin-epithelin precursor is a novel prognostic marker in epithelial ovarian carcinoma. (nih.gov)
  • In particular, experimental and clinical trials performed in emergency departments highlight the validity of soluble urokinase plasminogen activator receptor (suPAR) as a predictive and prognostic biomarker in patients with sepsis. (bvsalud.org)
  • AB - Using computer-aided molecular modeling techniques to analyze models recently proposed for the receptor binding sites of dopaminergic agonists, we superimposed the chemical structures of various compounds that mimic the pharmacological behavior of dopamine, as well as inactive enantiomers, on a postulated three dimensional frame of reference. (nih.gov)
  • AB - A series of apomorphine congeners has been studied with respect to their ability to mimic the structural requirements of the dopamine pharmacophore in the potent and stereoselective dopamine receptor agonist (R)-apomorphine. (nih.gov)
  • Neurotransmission through dopamine D1 receptors is required for aversive memory formation and Arc activation in the cerebral cortex. (niigata-u.ac.jp)
  • Here, we investigated the role of dopaminergic neurotransmission via dopamine D1 receptors (D1Rs) in aversive memory formation in a passive avoidance test using D1R knockdown (KD) mice, in which the expression of D1Rs can conditionally and reversibly be controlled by doxycycline (Dox) treatment. (niigata-u.ac.jp)
  • Differential behavioral phenotypes of dopamine D1 receptor knockdown mice at the embryonic, postnatal, and adult stages. (niigata-u.ac.jp)
  • Dopamine signal is transduced through the dopamine receptor gene family. (niigata-u.ac.jp)
  • The dopamine D1 receptor (D1R) is highly expressed in the striatum, and is responsible for regulating the motor function. (niigata-u.ac.jp)
  • Functioning in a receptor capacity, this protein also confers susceptibility to bacterial and viral infection. (nih.gov)
  • Protein glycosylation is an important posttranslational modification that confers both structural and functional properties to the molecules [ 1 ]. (intechopen.com)
  • The type I transmembrane protein G6f ( Table 1 ) was found to be specifically phosphorylated on Tyr-281 in response to collagen but not thrombin or ADP. (medscape.com)
  • used a GPVI-activating monoclonal antibody to stimulate the collagen receptor prior to 2-D DIGE, MALDI-MS/MS and LC-MS/MS analysis. (medscape.com)
  • [ 31 ] Eight proteins were identified as differentially up- or downregulated following antibody addition, including the Src substrate cortactin and aldose reductase (AR). (medscape.com)
  • 5. Interleukin-8 and vascular endothelial growth factor mRNA and protein levels are down-regulated in ovarian carcinoma cells in serous effusions. (nih.gov)
  • Alterations in the mRNA expression, protein levels and proteolytic activity of matrix metalloproteinases (MMPs) have been detected in VVs and VLU. (oaepublish.com)
  • MMP mRNA expression, protein levels and proteolytic activity can be modulated by numerous factors including venous hydrostatic pressure, hypoxia, tissue metabolites and the inflammatory response. (oaepublish.com)
  • Thorough studies have shown that to undertake these processes epithelial cells can employ two alternative approaches: first, leading edge cells facing a free cellular space become specified and promote the migration of epithelial sheets acting as the main driving force for migration (in most cases in the absence of cell proliferation), e.g. (biologists.com)
  • This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. (nih.gov)
  • Human GPVI complexes with the Fc receptor γ-chain at the platelet membrane. (medscape.com)
  • initiating downstream signaling through Syk kinases, LAT, SLP-76 and phospholipase C [ 31 ] and allowing recruitment of proteins to receptor-proximal signaling complexes on the inner surface of the plasma membrane. (medscape.com)
  • [ 36 ] Van Goch-like protein 1, a protein with four transmembrane domains, is serine/threonine phosphorylated in response to intestinal trefoil factor (ITF) in epithelial cells. (medscape.com)
  • The movement and fusion of epithelial cells during development is an essential and general morphogenetic event. (biologists.com)
  • As a pivotal signaling receptor, it is no surprise that proteomic-based approaches have focused on the identification of GPVI signaling pathways, however as these proteins are often present at low concentrations, signaling module characterization using mass spectrometry is limited due to high sample complexity. (medscape.com)
  • 18. Death domain-associated protein (DAXX) expression is associated with poor survival in metastatic high-grade serous carcinoma. (nih.gov)
  • [ 37 ] Additionally, the previously uncharacterized protein-coupled receptor kinase-interactor 2 (GIT2) was upregulated in the platelet cytosol in concurrence with Src, which has previously been reported to associate with the GIT protein family. (medscape.com)
  • 9. Expression levels of the nerve growth factor receptors TrkA and p75 in effusions and solid tumors of serous ovarian carcinoma patients. (nih.gov)
  • The regression analysis of log KD with respect to the distances of the vectors of the acidic hydrogen support the hypothesis that these compounds bind to the receptor as donors in hydrogen bond formation. (nih.gov)
  • We also performed whole-brain imaging after aversive footshock stimulation in activity-regulated cytoskeleton protein (Arc)-dVenus D1RKD mice, which were crossbred from Arc-dVenus transgenic mice and D1RKD mice, to examine the distribution of Arc-controlled dVenus expression in the hippocampus and cerebral cortex during aversive memory formation. (niigata-u.ac.jp)
  • Probe Set ID Ref Seq Protein ID Signal Strength Name Gene Symbol Species Function Swiss-Prot ID Amino Acid Sequence 1367452_at NP_598278 16.8 small ubiquitin-related modifier 2 precursor Sumo2 Rattus norvegicus " Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. (nih.gov)
  • Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (By similarity). (nih.gov)
  • Expressed in all domains of life, RPS2 proteins have been shown to have remarkably diverse physiological roles that vary across species. (nih.gov)
  • 12. Expression of the 67 kDa laminin receptor and the alpha6 integrin subunit in serous ovarian carcinoma. (nih.gov)
  • 17. HMGA2 protein expression in ovarian serous carcinoma effusions, primary tumors, and solid metastases. (nih.gov)
  • Nitrodi's water induces alpha-SMA expression in dermal fibroblasts, thus promoting their transition to myofibroblast-protein ECM deposition. (bvsalud.org)
  • the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). (nih.gov)
  • Regulates E3 ubiquitin-protein ligase activity of RNF19A (By similarity). (nih.gov)