• Primary peritoneal cancer or carcinoma is also known as serous surface papillary carcinoma, primary peritoneal carcinoma, extra-ovarian serous carcinoma, primary serous papillary carcinoma, and psammomacarcinoma. (wikipedia.org)
  • Histomorphological and molecular biological characteristics suggest that serous carcinomas, which include ovarian serous carcinoma, uterine serous carcinoma, Fallopian tube serous carcinoma, cervical serous carcinoma, and primary peritoneal serous carcinoma really represent one entity. (wikipedia.org)
  • Primary peritoneal carcinoma shows similar rates of tumor suppressor gene dysfunction (p53, BRCA, WT1) as ovarian cancer and can also show an increased expression of HER-2/neu. (wikipedia.org)
  • Despite the advances in modern medical treatment and surgery, ovarian carcinoma remains the most lethal gynaecological cancer. (4science.ge)
  • Epithelial ovarian carcinoma-infiltrating lymphocytes (TIL) have attracted much interest in the last five years. (4science.ge)
  • The germ cell carcinoma tumours segment is much smaller by comparison and is only poised to be a US$ 50 million market by the end of the five year study. (clickpress.com)
  • Even the stromal carcinoma tumours segment is marginal at best when contrasted with epithelial tumours in the ovarian cancer diagnostics market. (clickpress.com)
  • The stromal carcinoma tumours segment is likely to be valued at only US$ 28 million in 2017. (clickpress.com)
  • The lack of proven screening tools for early detection and the high mortality of ovarian serous carcinoma (OSC), particularly high grade, have focused attention on identifying putative precursor lesions with distinct morphological and molecular characteristics. (hindawi.com)
  • Up to 80% of women with ovarian carcinoma of epithelial origin have elevated serum CA 125 levels, with the frequency of elevation correlating with the clinically detected stage. (medscape.com)
  • Similar findings for an unspecified CMTM5 isoform are reported in ovarian cancer, hepatocellular carcinoma, pancreatic cancer, non-small-cell lung carcinoma, renal cell carcinoma, and breast cancer. (wikipedia.org)
  • From January, 1988, to December, 1993, 113 patients with FIGO stage IA-IIC epithelial ovarian carcinoma were treated with postoperative radiotherapy. (avhandlingar.se)
  • Introduction/Background Primary debulking/cytoreductive surgery (PDS) is considered the optimal approach in the management of tubo-ovarian carcinoma (TOC). (bmj.com)
  • The larger expectation for improved prognosis in ovarian carcinoma is related to the use of the new biological agents. (biomedcentral.com)
  • 1. PM from histologically confirmed primary epithelial ovarian, tubal, or primary peritoneal platinum-resistant carcinoma (including clinical recurrence, refractory disease, or persistent disease within 6 months of last chemotherapy). (who.int)
  • By definition, pseudomesotheliomatous carcinoma refers to an epithelial neoplasm that secondarily involves the pleura and encases the lung, thereby simulating the radiologic and macroscopic appearance of malignant mesothelioma. (medscape.com)
  • If a diagnosis of ovarian cancer is confirmed, the ovaries, fallopian tubes, uterus, cervix, omentum (thin tissue covering the stomach and intestines), lymph nodes, and all visible tumours will be removed. (singaporecancersociety.org.sg)
  • EOC can include cells of origin from both the ovarian surface epithelium and the fallopian tube ( 2 ). (spandidos-publications.com)
  • Mercier AM, Shahzad MM. Discussing maintenance therapy for ovarian, peritoneal, and fallopian tube cancers. (moffitt.org)
  • It appears that the vast majority of what seem to be primary epithelial ovarian and primary peritoneal carcinomas is, in fact, secondary from the fimbria, the most distal part of the fallopian tube. (biomedcentral.com)
  • Events underlying malignant transformation are poorly characterised in ovarian cancer, but accumulating evidence suggests that a majority of ovarian cancers arise in the Fallopian tube epithelium. (lu.se)
  • The median survival of primary peritoneal carcinomas is usually shorter by 2-6 months time when compared with serous ovarian cancer. (wikipedia.org)
  • The microenvironment of ovarian carcinomas is mainly represented by macrophages, dendritic cells, neutrophils and lymphocytes. (4science.ge)
  • subsequently, this group of tumors of the ovary were classified in 1973 by the World Health Organization as "low malignant potential ovarian tumor" [ 2 ] and, finally, in 2003 WHO separates them from carcinomas and call them borderline tumors. (intechopen.com)
  • Unlike the invasive carcinomas, borderline ovarian tumors are characterized by cytoplasmic and nuclear atypia, (element of differential diagnosis with benign tumors), absence of stromal invasion, (element of differential diagnosis with malignant tumors), unusual degree of proliferation of the epithelial cells with cellular stratification including remarkable architectural atypia and the formation of papillary protuberances. (intechopen.com)
  • It is estimated that 60% of sporadic ovarian carcinomas and the majority of those diagnosed in BRCA1 mutation carriers are of the high-grade serous type [ 4 , 5 ]. (hindawi.com)
  • Malignant Brenner tumors are uncommon ovarian carcinomas and represent less than 5% of all Brenner tumors. (cap.org)
  • Most tumors are confined to the ovary at diagnosis, and malignant Brenner tumors have a better prognosis than other epithelial ovarian carcinomas. (cap.org)
  • Malignant mixed mesodermal tumors (carcinosarcomas) are included in the type II category because their epithelial components are identical to the pure type II carcinomas. (biomedcentral.com)
  • Background: International Federation of Gynecology and Obstetrics stage I epithelial ovarian cancer (EOC) has a significantly better prognosis than stage III/IV EOC, with about 80% of patients surviving at 5 years (compared with about 20% of those with stage III/IV EOC). (omicsonline.org)
  • Treatment regimen, surgical outcome, and t-cell differentiation influence prognostic benefit of tumor-infiltrating lymphocytes in high-grade serous ovarian cancer," Clinical Cancer Research, vol. 22, no. 3, pp. 714-724, Feb. 2016, doi: 10.1158/1078-0432.CCR-15-1617. (4science.ge)
  • One third of all ovarian tumors are serous, and two thirds of these serous tumors are benign. (medscape.com)
  • A tubal origin for high-grade serous ovarian cancer is supported by gene expression profiles of OSC that reveal that they are more similar to normal müllerian epithelium than the ovarian surface epithelium [ 7 ]. (hindawi.com)
  • The aim of this study was to isolate three members of miR-200 family from tumor tissue, plasma and urine of high-grade serous ovarian cancer patients in comparison with samples from patients with benign ovarian tumors. (biomedcentral.com)
  • This study is a pilot part of the ongoing registered prospective CHEMOVA study, which aims at analyzing the role of miRNAs in prediction of primary treatment response and in the development of chemoresistance in high-grade serous ovarian cancer (HGSOC). (biomedcentral.com)
  • Gene expression profiling (Affymetrix, U133) was carried out on 14 matched sets of primary (ovary) and metastatic (omentum) ovarian cancer (serous adenocarcinoma) patient samples. (biomedcentral.com)
  • A type of tumour that occurs in the cells on the surface of the ovary. (gynecancer.org)
  • Ovarian cancer that does not start in the lining of the ovary. (cancerqld.org.au)
  • A current perspective on the pathological assessment of FOXL2 in adult-type granulosa cell tumours of the ovary. (cancercentrum.se)
  • Prognostic impact of lymphadenectomy in clinically early stage malignant germ cell tumour of the ovary. (cancercentrum.se)
  • Ovarian cancer is heterogeneous, like other cancers, comprising a collection of subtypes with different histologic and molecular characteristics that in turn inform prognosis [ 1 ]. (hindawi.com)
  • The histopathology of ovarian cancer is heterogeneous, and each subtype harbors specific genetic mutations that can be used for diagnostics and targeted treatment. (spandidos-publications.com)
  • Epithelial ovarian cancer is heterogeneous and associated with poor survival relative to breast cancer. (lu.se)
  • Prognosis and treatment is the same as for the most common type of ovarian cancer, which is epithelial ovarian cancer. (wikipedia.org)
  • Due to the lack of early screening methods and asymptomatic clinical courses, most ovarian cancer is diagnosed at an advanced stage, when the prognosis of the disease is already poor. (4science.ge)
  • Borderline ovarian tumors represent 10-20% of epithelial ovarian neoplasm's [ 5 ] with an incidence of 1.8-4.8 out of 100.000 women per year [ 6 ] and typically have an excellent prognosis. (intechopen.com)
  • Lymphocytic infiltration is associated with better prognosis in several epithelial malignancies including breast cancer. (escholarship.org)
  • ABSTRACT The value of serum tumour markers in the prognosis of patients with breast cancer is controversial. (who.int)
  • It has conventionally been assumed that ovarian cancers arise from the ovarian surface epithelium (OSE), which is viewed as a modified type of mesothelium similar to that which lines the peritoneal cavity, by a process of invagination leading to the development of cortical inclusion cysts (CICs). (hindawi.com)
  • However, others believe it is unlikely that CICs are precursors and have instead proposed that ovarian epithelial tumors develop from müllerian-type epithelium lining paraovarian and paratubal cysts (the so-called secondary müllerian system) [ 6 ]. (hindawi.com)
  • In terms of origin of ovarian cancer, many of researchers and gynecologic oncologists have traditionally understood that the various different ovarian tumors are all derived from the ovarian surface epithelium (mesothelium) and that subsequent metaplastic changes lead to the development of the different cell types (Table 2 ). (biomedcentral.com)
  • Inhibin B also appears to be a suitable serum marker for epithelial tumours of the mucinous type with about 55% to 60% having elevated inhibin B levels. (southtees.nhs.uk)
  • Onsrud M, Shabana A, Austgulen R, Nustad K. Comparison between soluble tumor necrosis factor receptors and CA125 in peritoneal fluids as a marker for epithelial ovarian cancer. (aaem.pl)
  • GSK is also studying dostarlimab for endometrial cancer in earlier treatment lines and in combination with other therapeutic agents for patients with advanced solid tumours or metastatic cancer as we work to expand our oncology pipeline and reinforce our portfolio of cancer treatments. (gsk.com)
  • Solid tumours are abnormal masses of cells which may be non-cancerous (benign) or cancerous (malignant). (nihr.ac.uk)
  • Some solid tumours may be caused by specific genetic changes, for example, mutation in the NTRK genes, which can affect signalling inside the cell which drives cell growth. (nihr.ac.uk)
  • Hence, entrectinib offers the potential to treat many different types of solid tumours that are positive to the NTRK gene mutation. (nihr.ac.uk)
  • Inhibiting DNA methylation and RNA editing upregulates immunogenic RNA to transform the tumor microenvironment and prolong survival in ovarian cancer," J Immunother Cancer, vol. 10, no. 11, p. e004974, Nov. 2022, doi: 10.1136/jitc-2022-004974. (4science.ge)
  • Oncolytic adenovirus shapes the ovarian tumor microenvironment for potent tumor-infiltrating lymphocyte tumor reactivity," J Immunother Cancer, vol. 8, no. 1, Jan. 2020, doi: 10.1136/jitc-2019-000188. (4science.ge)
  • A 2-year interim analysis from the International Ovarian Tumor Analysis Phase 5 (IOTA5) study showed that 80% of ovarian cysts considered benign on ultrasonography either disappeared or required no intervention. (medscape.com)
  • Cancer antigen 125 (CA 125) is the only tumor marker recommended for clinical use in the diagnosis and management of ovarian cancer . (medscape.com)
  • The aim of the present study was to determine the significance of this tumor suppressor gene for ovarian tumorigenesis, investigating both numerical aberrations of chromosome 9 and p16 gene alterations in 28 cases of ovarian tumors, by the fluorescence in situ hybridization (FISH) technique. (iiarjournals.org)
  • Nests are large and crowded and may show fusion, as a result of epithelial proliferation that exceeds what is seen in benign Brenner tumor. (cap.org)
  • MiR-200a, miR-200b and miR-200c were isolated from samples of nine ovarian cancer patients and seven patients with benign ovarian tumor. (biomedcentral.com)
  • Taking into account the important regulatory roles that miRNAs have in cancer development, by acting either as oncogenes or as tumor-suppressor genes, they represent potential biomarkers in ovarian cancer [ 5 ]. (biomedcentral.com)
  • Thus, we selected from the CHEMOVA cohort nine HGSOC patients with large tumor mass as malignant group and seven patients with benign ovarian tumor as benign group. (biomedcentral.com)
  • Ovarian cancer metastasis is primarily due to the exfoliation of malignant cells or cell aggregates from the primary tumor into the abdominal cavity and their subsequent spread and attachment to visceral and parietal peritoneal surfaces of abdominal organs such as the omentum. (biomedcentral.com)
  • Over the past three decades, surgical tumor debulking, followed by platinum-based chemotherapy is the standard treatment for advanced ovarian cancer. (biomedcentral.com)
  • Ovarian granulosa cell tumor and increased risk of breast cancer. (cancercentrum.se)
  • While the tumours found in her ovaries were benign, cancerous cells had spread to her stomach muscles, with chemotherapy recommended rather than surgery. (dailymail.co.uk)
  • Instead tumours were found in both ovaries and she was diagnosed with ovarian cancer in November 2021. (dailymail.co.uk)
  • After the pap smear, she had an ultrasound and then a CT scan which detected the tumours on both ovaries. (dailymail.co.uk)
  • While the surgery went well and the tumours in her ovaries were benign, three weeks later she was told the devastating news that cancerous cells were found in her abdomen. (dailymail.co.uk)
  • While the tumours in her ovaries were benign, cancerous cells were found in her abdomen and chemotherapy was needed (pictured: Jo, right, with her partner Nick Goetting, left). (dailymail.co.uk)
  • Ovarian cancer is a malignant tumour in one or both ovaries. (dailymail.co.uk)
  • The ovaries are made up of three main kinds of cells - epithelial cells, stromal cells and germ cells. (dailymail.co.uk)
  • The nurses were so surprised because I was young, healthy and the tumours in my ovaries were benign but it had already spread (to my abdomen) and turned cancerous,' she said. (dailymail.co.uk)
  • Ovarian cancer is developed by uncontrollable growth of cells in ovaries. (clickpress.com)
  • Hundreds of dysregulated miRNAs have been found in studies comparing the expression profiles of miRNAs in malignant ovarian tumors and normal ovaries. (biomedcentral.com)
  • Conservative surgery to preserve ovarian function in patients with malignant ovarian germ cell tumors. (cancercentrum.se)
  • Note: If the type of ovarian cancer is not known consider referral. (eviq.org.au)
  • The family cancer clinic will attempt to verify the histological type of ovarian cancer and determine whether testing is appropriate. (eviq.org.au)
  • Rockville, US, 2018-Nov-16 - /EPR Network/ - As scientists in cancer research organizations continue to develop more advanced diagnosis tests for ovarian cancer, medical device manufacturers are expected to face challenges in adapting to such changes. (express-press-release.net)
  • The Fact.MR report on global ovarian cancer diagnostics market projects that by the end of 2017, around US$ 638 Mn worth of revenues will be procured globally through diagnosis of ovarian cancer. (express-press-release.net)
  • Emergence of multi-purpose diagnosis tests on ovarian cancer is expected to boost the market's expansion in the future. (express-press-release.net)
  • According to the report, diagnosis of epithelial tumors will procure largest share in the global ovarian cancer diagnostics market. (express-press-release.net)
  • With more than 90% share, over US$ 875 Mn revenues are anticipated to be procured by diagnosis of epithelial tumors in the global market. (express-press-release.net)
  • However, owing to the lack of sensitivity and specificity, elevations in single or sequential CA 125 levels alone are not recommended for ovarian cancer screening or in the initial diagnosis of ovarian cancer. (medscape.com)
  • Testing for inhibin can be used as an aid in the diagnosis of granulosa cell tumours and mucinous epithelial ovarian tumours. (southtees.nhs.uk)
  • For aid in diagnosis, follow-up, re-occurrence indicator of ovarian granulosa and mucinous tumours. (southtees.nhs.uk)
  • Although new tumour markers models are promising, they do not contribute significantly to the diagnosis of ovarian cancer. (nih.gov)
  • Non-epithelial ovarian cancer: ESMO clinical recommendations for diagnosis, treatment and follow-up. (cancercentrum.se)
  • WHO Classification of Tumours fifth edition: evolving issues in the classification, diagnosis, and prognostication of prostate cancer. (who.int)
  • The global ovarian cancer diagnostics market is predicted to grow with a CAGR of 8.7% and be worth nearly US$ 1 billion in 2022, from less than US$ 640 million in 2017. (clickpress.com)
  • Presence of prominent cancer research societies in the US and Canada is anticipated to boost the contribution of North America towards growth of the global ovarian cancer diagnostics market. (express-press-release.net)
  • Prevalence of malignancy was 29% (49 primary invasive epithelial ovarian cancers, 18 borderline ovarian tumours, and 7 metastatic tumours). (nature.com)
  • One model that has gained credibility in recent years is that metastasizing cells at least partially recapitulate the developmental process of epithelial-to-mesenchymal transition (EMT) in their transit from primary to metastatic sites. (biomedcentral.com)
  • Our results are consistent with a role of EMT in most if not all ovarian cancer metastases and demonstrate that identical morphologies between primary and metastatic cancer samples is insufficient evidence to negate a role of EMT in the metastatic process. (biomedcentral.com)
  • This mechanism of intra-abdominal metastatic spread allows for the capture and molecular comparison of primary and metastatic cancer cells isolated from the same patient, providing a favorable opportunity to evaluate the potential role of epithelial-to-mesenchymal transition (EMT) in the metastatic process. (biomedcentral.com)
  • It has been argued that changes in the microenvironment of the ovarian stroma surrounding the CICs leads to müllerian-type differentiation. (hindawi.com)
  • Elevations of serum inhibin A and/or B are detected in some patients with granulosa cell tumours. (southtees.nhs.uk)
  • Inhibin B elevations have been reported in 89% to 100% of patients with granulosa cell tumours. (southtees.nhs.uk)
  • Kaplan-Meier analysis and the log rank test were applied to evaluate ovarian cancer-specific survival (OCSS) and overall survival (OS) in strata, according to SOX11 expression. (lu.se)
  • We profiled miRNA expression in stage I EOC tumours to assess whether there is a miRNA signature associated with overall and progression-free survival (PFS) in stage I EOC. (omicsonline.org)
  • A few recent studies demonstrated positive results of bevacizumab on progression-free survival in ovarian cancer patients, however, investigation of molecular targeting drugs in patients with ovarian cancer are still underway. (biomedcentral.com)
  • Ovarian cancer is a heterogeneous disease concerning tumour-infiltrating lymphocytes and TILs. (4science.ge)
  • By stratifying diploid and tetraploid tumours according to a cytometric proliferation index (PI), we suggest a new DNA-classification that is prognostic of death from prostate cancer in multivariate analysis including conventional prognostic factors. (avhandlingar.se)
  • CT radiomics-based machine learning classification of atypical cartilaginous tumours and appendicular chondrosarcomas. (cdc.gov)
  • World Health Organization classification of Tumours. (cancercentrum.se)
  • An introduction to the WHO 5th edition 2022 classification of testicular tumours. (who.int)
  • The WHO Classification of Haematolymphoid Tumours. (who.int)
  • The WHO classification of haematolymphoid tumours: response to Swerdlow et al. (who.int)
  • Understanding the use of evidence in the WHO Classification of Tumours: a protocol for an evidence gap map of the classification of tumours of the lung. (who.int)
  • Evidence-levels in pathology for informing the WHO classification of tumours. (who.int)
  • D. L. Longo and R. C. Young, "The natural history and treatment of ovarian cancer," Annu Rev Med, vol. 32, pp. 475-490, 1981, doi: 10.1146/annurev.me.32.020181.002355. (4science.ge)
  • In most cases, modern treatment of ovarian cancer includes radical cytoreductive surgery, followed by platinum- and paclitaxel-based systemic chemotherapy ( 5 - 7 ). (spandidos-publications.com)
  • The average age of women when they are diagnosed with ovarian cancer is age 64. (dailymail.co.uk)
  • 20,000 women will be diagnosed with ovarian cancer in the U.S. and more than 14,000 will lose their lives because of it in 2017 alone. (clickpress.com)
  • Even though the rate at which women have been diagnosed with ovarian cancer has been falling, it is still a public health menace that needs to be tackled effectively. (clickpress.com)
  • Background Epithelial ovarian tumours exhibit a range of malignant potential, presenting distinct clinical phenotypes. (gatech.edu)
  • The tumour indications for the expansion phase were selected based on pre-clinical and published data of the activity and expression of CD200R1 and its ligand, CD200, together with immune cell and tumour characteristics that have the potential to increase the likelihood of a response to CD200R1 inhibition. (pharmaphorum.com)
  • Dr. Shahzad's clinical interests are in the surgical management of advanced gynecologic malignancies, including cytoreductive surgery for ovarian cancer, complex minimally invasive laparoscopic and robotic surgery for endometrial and cervical cancers as well as fertility sparing surgical techniques. (moffitt.org)
  • Loss of expression of IGF binding proteins as well as specific cell adhesion molecules may be a significant mechanism of disease progression in ovarian cancer. (gatech.edu)
  • This review describes recent advances in the role of human HMGB proteins and other proteins interacting with them, in cancerous processes related to oxidative stress, with special reference to ovarian and prostate cancer. (hindawi.com)
  • Olsson I, Gatanaga T, Gullberg U, Lantz M, Granger GA. Tumour necrosis factor (TNF) binding proteins (soluble TNF receptor forms) with possible roles in inflammation and malignancy. (aaem.pl)
  • Pathology and Genetics of Tumours of the Breast and Female Genital Organs. (cancercentrum.se)
  • Chemotherapy patients whose tumours exhibited benign-like expression patterns remained disease free for the duration of this study as indicated by continued normal serum CA-125 levels. (gatech.edu)
  • patients often present with ovarian torsion. (medscape.com)
  • Methods: We analysed tumour samples from 144 patients (29 of whom relapsed) with stage I EOC gathered from two independent tumour tissue collections (A and B), both with a median follow-up of 9 years. (omicsonline.org)
  • 89 samples from tumour tissue collection A were stratified into a training set (51 samples, 15 of which were from patients who relapsed) for miRNA signature generation, and into a validation set (38 samples, seven of which were from patients who relapsed) for signature validation. (omicsonline.org)
  • Tumour tissue collection B (55 samples, seven of which were from patients who relapsed) was used as an independent test set. (omicsonline.org)
  • A study by Potenza et al indicated that in patients with epithelial ovarian cancer, combined analysis of CA 125 and human epididymis protein 4 (HE4) is an effective indicator of success in chemotherapy. (medscape.com)
  • Twenty-eight cases of patients who had undergone surgical resection of ovarian cancer between the years 2005 to 2009 were included in the present study. (iiarjournals.org)
  • Methods: Identification of tumour-associated endothelial markers (TEM) by comparing antigen expression on normal vs t-CEC and assess the presence of t-CEC in peripheral blood of cancer patients by incorporating TEM in our novel flow cytometry-based CEC detection assay. (researchgate.net)
  • The combination of two tumour markers, CA125 and HE4, in the risk of ovarian malignancy assay (ROMA) has been shown to be successful in classifying patients into those who have a high or low risk of epithelial ovarian cancer. (nih.gov)
  • Opala T, Rzymski P, Wilczak M, Woźniak J. Evaluation of soluble tumour necrosis factor alpha receptors p55 and p75 in ovarian cancer patients. (aaem.pl)
  • This prospective study in Yazd, Islamic Republic of Iran, assessed the value of the tumour markers carcinoembryonic antigen (CEA) and cancer antigen (CA) 15-3 in 159 patients with primary breast cancer. (who.int)
  • sis in primary breast cancer patients, toms of metastasis or recurrence and Tumour markers assays with elevated levels reflecting adverse with no other malignant disorders. (who.int)
  • Microscopically, the tumors are composed of solid to cystic nests of epithelial cells embedded in a fibrous stroma. (cap.org)
  • Treatment of epithelial ovarian cancer is based on the combination of cytoreductive surgery and combination chemotherapy using taxane and platinum. (biomedcentral.com)
  • Ultrasound, especially subjective assessment by ultrasound, remains superior in discriminating malignant from benign ovarian masses. (nih.gov)
  • These are as follows: sustained proliferative signalling, cell death resistance, replicative immortality, genome instability and increased mutations, tumour-promoted inflammation, insensibility to growth repressors, deregulation of cellular energetics, evasion of immune destruction, induction of metastasis, and promotion of angiogenesis. (hindawi.com)
  • Breast and ovarian cancers share many features, including genetic predisposition caused by mutations in BRCA1/2. (lu.se)
  • The purpose of this study is to evaluate the diagnostic performance of the International Ovarian Tumour Analysis (IOTA) logistic regression model (LR2), ultrasound Simple Rules (SR), the Risk of Malignancy Index (RMI) and subjective assessment (SA) for preoperative characterisation of adnexal masses, when ultrasonography is performed by examiners with different background training and experience. (nature.com)
  • A systematic review and meta-analysis by Liu et al found that the malignancy rate, including borderline tumors, for simple ovarian cysts in postmenopausal women was approximately 1 in 10,000. (medscape.com)
  • Results: The highest incidence of ovarian tumours was within the age range of 20-45 years. (bvsalud.org)
  • Epidemiologic evidence indicates that lower circulating vitamin D levels are associated with a higher risk of ovarian cancer and that vitamin D supplementation is associated with decreased cancer mortality. (mdpi.com)
  • Annual pelvic examination and vaginal ultrasound, with or without blood test for tumour marker (CA 125), is recommended for women who are at high risk of ovarian cancer. (singaporecancersociety.org.sg)
  • Plasma, but also urine sample could represent a simple liquid biopsy for ovarian cancer biomarker detection. (biomedcentral.com)
  • According to the latest epidemiological data, there will be 21,421 new cases of ovarian cancer and 13,770 deaths from ovarian cancer in the United States in 2021. (4science.ge)
  • Newer markers for ovarian cancer are on the horizon. (medscape.com)
  • Patient demographics, staging, histology and pre-treatment biochemistry and tumour markers were reviewed. (bmj.com)
  • Background: The neural transcription factor SOX11 has been described as a prognostic marker in epithelial ovarian cancers (EOC), however its role in individual histological subtypes and tumour grade requires further clarification. (lu.se)
  • Accumulating evidence suggests that there are two general pathways in the molecular pathogenesis of what is known as ovarian cancer [ 2 , 3 ]. (hindawi.com)
  • De-regulation of cell-cycle control, in particular G 1 - to S-phase transition, is implicated in the pathogenesis of most types of human cancer, including ovarian cancer ( 1 ). (iiarjournals.org)
  • The origin and pathogenesis of epithelial ovarian cancer (EOC) have long been investigated but still poorly understood. (biomedcentral.com)
  • Ovarian cancer is one of the leading causes of death from gynaecological malignancies worldwide. (iiarjournals.org)
  • PDF) Kraan J, van den Broek P, Verhoef C, Grunhagen DJ, Taal W, Gratama JW, Sleijfer SEndothelial CD276 (B7-H3) expression is increased in human malignancies and distinguishes between normal and tumour-derived circulating endothelial cells. (researchgate.net)
  • Ovarian cancer is the leading cause of death from gynaecological cancers worldwide. (4science.ge)
  • Results Gene expression profiling (Affymetrix, U95Av2) was carried out on 18 ovarian tumours including benign adenomas, borderline adenocarcinomas of low malignant potential and malignant adenocarcinomas. (gatech.edu)
  • Conclusion Our findings indicate that gene expression profiling can reliably distinguish between benign and malignant ovarian tumours. (gatech.edu)
  • Materials and Methods: To investigate both the presence of numerical abnormalities of chromosome 9 and p16 gene alterations in ovarian cancer, we studied 28 cases by the fluorescence in situ hybridization (FISH) technique using a DNA p16 probe and an a-satellite probe specific for chromosome 9. (iiarjournals.org)
  • Conclusion: Numerical aberrations of chromosome 9 and p16 gene deletion are common findings in ovarian cancer. (iiarjournals.org)
  • Data suggest that the p16 gene, located in the short arms of chromosome 9, may play a role in ovarian carcinogenesis. (iiarjournals.org)
  • There are few studies focusing on the molecular analysis of p16 gene in ovarian cancer ( 13 - 16 ). (iiarjournals.org)
  • New Insights into Ferroptosis Initiating Therapies (FIT) by Targeting the Rewired Lipid Metabolism in Ovarian Cancer Peritoneal Metastases. (4science.ge)
  • Utilizing comprehensive biobanks, genomics methods and in vitro model systems we aim to improve our understanding of tumour evolution, heterogeneity and therapy response. (lu.se)