Epithelial or stromal. Medical search. Frequent questions

Taken together, our results show that modulation of stromal paracrine signaling and ECM remodeling by SPRY1 regulates mammary epithelial morphogenesis during postnatal development. (muni.cz)
A ZEB1/p53 signaling axis in stromal fibroblasts promotes mammary epithelial tumours. (atsbio.com)
Ectopic expression of AUF1 also promoted stemness in mammary epithelial cells, and thereby increased the proportion of cancer stem cells. (nature.com)
These data prompted us to ask whether AUF1 upregulation could promote EMT as well as stemness in mammary epithelial cells. (nature.com)
Park, B.H. Interleukin-1 alpha mediates the growth proliferative effects of transforming growth factor-beta in p21 null MCF-10A human mammary epithelial cells. (hopkinsmedicine.org)

While adult lymphoid progenitor cells are produced by the bone marrow, their lineage commitment and development into mature T-cells is dependent on their migration into the thymus, where essential interactions with heterogeneous thymic stromal cells take place ( 1 ). (frontiersin.org)
The hedgehog pathway regulates epithelial-mesenchymal interactions, differentiation, proliferation and survival during development. (rti.org)
Development of the prostate gland as well as development of prostatic cancer is closely associated with stromal-epithelial interactions and in the centre of these interactions stands the Androgen Receptor in both stromal and epithelial cells. (journalcra.com)
The Wnt pathway, epithelial-stromal interactions, and malignant progression in phyllodes tumours. (ox.ac.uk)
In view of this finding, it was decided to study stromal-epithelial interactions in these tumours by examining the Wnt-APC-beta-catenin pathway. (ox.ac.uk)
Stromal-epithelial interactions are likely of major importance for the biological, clinical, and pathological distinctions between high- and low-risk DCIS cases. (lu.se)
2) Stromal and immune interactions in colorectal cancer. (qub.ac.uk)

Using real-time, quantitative PCR, laser capture microdissection, and immunohistochemistry, distinctive patterns of expression of the hedgehog pathway members patched 1 (PTCH1), smoothened, GLI1, GLI2 and the 3 hedgehog ligands were identified for epithelial cells and stromal fibroblasts in benign breast and breast cancer. (rti.org)
However, cyclopamine reduced viability of cancer epithelial cell lines, including MDA-MB-435, but did not specifically affect fibroblasts or epithelial cells from benign breast, including MCF10AT. (rti.org)
MiR-132 was upregulated in the stroma surrounding CCH compared to stoma surrounding normal terminal duct lobular units (TDLUs), and overexpression of miR-132 in immortalized fibroblasts and in fibroblasts co-cultured with epithelial CCH cells caused substantial expression changes of genes involved in metabolism, DNA damage and cell motility. (manchester.ac.uk)
The molecular mechanisms regulating stromal PDGFR expression were investigated in experimental in vitro co-culture systems of DCIS cells and fibroblasts and analyzed using immunoblot and quantitative real-time PCR. (lu.se)

Microscopic pathological features determine whether a surface epithelial-stromal tumor is benign, a borderline tumor, or malignant (evidence of malignancy and stromal invasion). (wikipedia.org)

Black women with epithelial ovarian cancer are diagnosed most often with high-grade serous tumors, the most aggressive kind. (webmd.com)

Patterns of metastasis in sex cord-stromal tumors of the ovary: can routine staging lymphadenectomy be omitted? (cancercentrum.se)
Patterns of spread and recurrence of sex cord-stromal tumors of the ovary. (cancercentrum.se)

Epithelial-stromal tumors are classified on the basis of the epithelial cell type, the relative amounts of epithelium and stroma, the presence of papillary processes, and the location of the epithelial elements. (wikipedia.org)
Glands bearing a strong resemblance to endometrial-type glands Benign tumors have mature-appearing glands in a fibrous stroma Borderline tumors have a complex branching pattern without stromal invasion Carcinomas (malignant tumors) have invasive glands with crowded, atypical cells, frequent mitoses. (wikipedia.org)
Broadly separated into mesenchymal and endothelial cells, NES have been implicated in thymus organogenesis, thymocyte development, tolerance induction and development/maintenance of epithelial stroma. (frontiersin.org)
In this review, we cover how the non-epithelial compartment of thymic stroma represent essential cell populations in regulating thymus function. (frontiersin.org)
In early experiments, physical separation of mesenchymal and epithelial stroma from embryonic murine thymus resulted in defective thymus development when epithelium was cultured in vitro in the absence of mesenchyme ( 7 ). (frontiersin.org)
By contrast, down-regulation of EGFR-ERK signaling due to gain of Sprouty function in the stroma led to stunted epithelial branching. (muni.cz)
Light microscopy shows irregular thickening and thinning of the epithelial layer, which offset the ridges and furrows in the underlying stroma and the focal absences of the epithelial basement membrane. (aao.org)
The Jagged-1/Notch2/PDGFR stroma-epithelial pathway was described as a novel signaling mechanism regulating this poor prognosis-associated fibroblast subset. (lu.se)

Primary endometrial stromal cells (ESCs), decidual stromal cells (DSCs), decidual immune cells (DICs) and peripheral blood mononuclear cells (PBMCs) were isolated. (bvsalud.org)

SPDEF expression promoted DC recruitment and activation in association with induction of Il33, Csf2, thymic stromal lymphopoietin (Tslp), and Ccl20 transcripts. (nih.gov)

There are three types of ovarian cancers: epithelial ovarian carcinomas, germ cell tumors, and stromal cell tumors. (medlineplus.gov)

Significantly, there are additional non-epithelial stromal cells (NES) that exist alongside TEC within thymic microenvironments, including multiple subsets of mesenchymal and endothelial cells. (frontiersin.org)
Since epithelial-to-mesenchymal transition (EMT) and the acquisition of cancer stem cell traits are important for cancer onset and progression, we sought to determine the role of AUF1 in these two important processes. (nature.com)
Sukumar, S. HOXB7, a Homeodomain Protein, Is Overexpressed in Breast Cancer and Confers Epithelial-Mesenchymal Transition. (hopkinsmedicine.org)
Therapeutic Candidate or Device Novel testing of a cell based therapy (Mesenchymal Stromal Cells) for respiratory failure from ARDS. (ca.gov)
Müllerian adenosarcoma (MA) is a rare mixed and low malignant tumor of female genital system, and is a biphasic differential tumor that is composed of admixed benign epithelial and sarcomatoid mesenchymal components. (scirp.org)

These data suggest that stromal proliferation in benign phyllodes tumours relies on abnormalities in the Wnt pathway which result not from mutation, but from Wnt5a expression in the epithelium. (ox.ac.uk)
In the progression to malignancy, the stromal proliferation appears to become independent of the Wnt pathway and, presumably, of the epithelial component of these tumours. (ox.ac.uk)

Separately, deletion of GCC increased tumor growth by releasing a restriction on the cell cycle normally constraining epithelial cell proliferation. (jefferson.edu)
Unlike the invasive carcinomas, borderline ovarian tumors are characterized by cytoplasmic and nuclear atypia, (element of differential diagnosis with benign tumors), absence of stromal invasion, (element of differential diagnosis with malignant tumors), unusual degree of proliferation of the epithelial cells with cellular stratification including remarkable architectural atypia and the formation of papillary protuberances. (intechopen.com)
We are now aware that lung cancer tissues are rich in nontumor cells, of which stromal cells significantly regulate tumor proliferation, invasion, and angiogenesis [ 6 ]. (hindawi.com)

Epithelial defects are common in a conjunctivalized corneal surface and may lead to corneal ulceration, melting, and loss of vision. (medscape.com)
Large epithelial defects are common after PK, but they should heal within 7-14 days. (aao.org)

The miRNA signatures identified in CCH indicate early changes in the epithelial and stromal compartment of CCH and could represent early key alterations in breast cancer progression that potentially could be targeted in novel prevention or treatment schedules. (manchester.ac.uk)

Hedgehog ligands were expressed at higher levels in some cancer epithelial cell lines compared to noncancerous epithelial cells. (rti.org)
Hedgehog-mediated transcription, as indicated by a reporter of GLI-dependent promoter activity and by expression of GLI1 transcripts, was reduced by the hedgehog pathway inhibitor cyclopamine in both MDA-MB-435 cancer epithelial cells and MCF10AT epithelial cells, a cell line derived from benign breast. (rti.org)
These results demonstrate modulation of GLI-mediated transcription in both cancer and benign-derived epithelial cells by cyclopamine and sonic hedgehog, and further suggest that hedgehog signaling contributes to the survival of only the cancer epithelial cells. (rti.org)
Let-7c were among the identified downregulated epithelial miRNAs and its functions were delineated in unique CCH derived cells and breast cancer cell line MCF-7 suggesting anti-proliferative traits potentially due to effects on Myb and ERα. (manchester.ac.uk)
Studies have been conducted to evaluate androgen receptor expression in cancer cells and most of the studies have concentrated on cancer epithelial cells and not cancer stromal cells. (journalcra.com)
Ovarian stromal tumors are a rare form of ovarian cancer. (medicalnewstoday.com)
The American Cancer Society states that around 5% of ovarian stromal tumors occur in young females. (medicalnewstoday.com)
With the development of bioinformatics in recent years and the acquisition of open lung cancer cohorts, it becomes possible to evaluate tumor purity content in the samples according to the estimated infiltration of stromal and immune cells ESTIMATE algorithm [ 7 ]. (hindawi.com)
Non-epithelial ovarian cancer: ESMO clinical recommendations for diagnosis, treatment and follow-up. (cancercentrum.se)

Medullary epithelial cells (mTEC), in conjunction with dendritic cells, then take over control of developing thymocytes. (frontiersin.org)
The lymphocytes' selection process and developmental progression are influenced by direct contact between the TCR-CD3 complex on the thymocyte and the major histocompatibility complex (MHC)-antigen complex on thymic epithelial cells, dendritic cells, and B lymphocytes. (medscape.com)
and T-LYMPHOCYTES, and is produced by various cell types, including epithelial and dendritic cells. (bvsalud.org)

In the stromal cells a decline in Androgen Receptor expression was also noted but this decline was more pronounced and statistically significant correlation of Androgen Receptor expression was noted between well differentiated carcinomas and moderately and poorly differentiated prostatic carcinomas. (journalcra.com)

It has also been postulated that stromal induction of phyllodes tumors can occur as a result of growth factors produced by the breast epithelium. (hindawi.com)

The basal epithelial cell layer shows high reflectivity associated with small granular deposits without any shadows (Fig 7-6A), which would be typical of TBCD. (aao.org)
The deposits in the basal epithelial cell layer show reflectivity, with round edges and dark shadows not seen in RBCD (Fig 7-7A). (aao.org)
For example, damage to the deep limbal crypts and their normal reserves of basal epithelial cells may destroy important sources for reepithelialization of the cornea. (medscape.com)
The cell size can vary from small (basal cells) to very large (squamous epithelial cells). (vin.com)
In squamous epithelia, this is defined as continuous strong nuclear, or nuclear plus cytoplasmic, staining of the basal cell layer with extension upward involving at least one-third of the epithelial thickness. (cancer.org.au)

While many studies have demonstrated the importance of cTEC and mTEC during T-cell development, thymic stromal microenvironments also contain heterogenous non-epithelial stromal (NES) populations in a similar manner to that seen in peripheral lymphoid tissues. (frontiersin.org)
The epithelial cells and these other stromal tissues of the thymus influence the selection and maturation of the T lymphocytes. (medscape.com)

In 1981 [ 6 ] the World Health Organization adopted the term phyllodes tumor and as described by Rosen [ 7 ] subclassified them histologically as benign, borderline, or malignant according to the features such as tumor margins, stromal overgrowth, tumor necrosis, cellular atypia, and number of mitosis per high power field. (hindawi.com)
The term phyllodes tumor represents a broad range of fibroepithelial diseases and presence of an epithelial component with stromal components differentiates the phyllodes tumor from other stromal sarcomas. (hindawi.com)

Clear stromal invasion is used to differentiate borderline tumors from malignant tumors. (wikipedia.org)

Research from 2017 found that in women aged 40 and below, 72% of ovarian cancers were epithelial tumors. (medicalnewstoday.com)
Breast cancers are most often epithelial tumors involving the ducts or lobules. (msdmanuals.com)
General references Breast cancers are most often epithelial tumors involving the ducts or lobules. (msdmanuals.com)

Thymoma is a neoplasm of thymic epithelial cells. (medscape.com)

The 2015 International Committee for Classification of Corneal Dystrophies (IC3D) classification system has divided corneal dystrophies into 4 categories: epithelial and subepithelial dystrophies, epithelial-stromal dystrophies, stromal dystrophies, and endothelial dystrophies. (uiowa.edu)
4 , 5 HSK can be further divided anatomically into epithelial, stromal, or endothelial involvement. (dovepress.com)
Epithelial involvement typically causes pain and redness, while stromal and endothelial HSK can cause vision loss. (dovepress.com)

Histopathology reveals anterior stromal and subepithelial deposits of hyaline-like material which disrupt and often replace Bowman's layer (See Figure 1A and 1B). (uiowa.edu)

Lattice corneal dystrophy (LCD) is the most common of the corneal epithelial-stromal dystrophies. (uiowa.edu)

May form very large cystic masses, with recorded weights exceeding 25 kg Mucinous tumors are characterized by a lining of tall columnar epithelial cells with apical mucin and the absence of cilia, similar in appearance with benign cervical or intestinal epithelia. (wikipedia.org)
Here we have defined novel epithelial as well as stromal miRNA signatures from columnar cell hyperplasia lesions compared to normal terminal duct lobular units by using microdissection and miRNA microarrays. (manchester.ac.uk)

We show here that, like SRC-2, SRC-3 is expressed in the epithelial and stromal cellular compartments of the human endometrium during the proliferative and secretory phase of the menstrual cycle as well as in cultured HESCs. (frontiersin.org)

HPV-related squamous disease reflects a unified epithelial biology. (cancer.org.au)

Extensive research on thymic epithelial cells (TEC) within the cortex and medulla has defined their essential roles during T-cell development. (frontiersin.org)
Cortical epithelial cells (cTEC) support the earliest thymocyte progenitor populations, guiding them through the cortex, directing them to a T-cell lineage fate and ensuring their functional qualities as self-MHC restricted cells through the process of positive selection ( 2 ). (frontiersin.org)
We previously demonstrated the critical involvement of SRC-2 in murine embryo implantation as well as in human endometrial stromal cell (HESC) decidualization, a cellular transformation process required for trophoblast invasion and ultimately placentation. (frontiersin.org)
These molecular findings are supported at the cellular level by the inability of HESCs to morphologically transform from a stromal fibroblastoid cell to an epithelioid decidual cell when endogenous SRC-3 levels are markedly reduced. (frontiersin.org)
The transcription factors SPDEF and FOXA3 are both selectively expressed in epithelial cells lining the conducting airways, where they regulate goblet cell differentiation and mucus production. (nih.gov)
Here, we show that expression of SPDEF or FOXA3 in airway epithelial cells in neonatal mice caused goblet cell differentiation, spontaneous eosinophilic inflammation, and airway hyperresponsiveness to methacholine. (nih.gov)
There's some evidence that Black women are a little more likely to have germ-cell and stromal tumors, compared to other groups. (webmd.com)

Arguably, the most recognized and well-studied stromal populations in thymus biology are thymic epithelial cells (TEC) within the cortical and medullary areas, which are defined by their anatomical separation and function. (frontiersin.org)

There are different forms of ocular vaccinia: blepharitis (inflammation of the eyelid), conjunctivitis, keratitis (inflammation of the cornea, including epithelial and stromal forms), iritis, or combinations thereof. (cdc.gov)

They appear similar to other surface epithelial-stromal tumors, with solid and cystic areas. (wikipedia.org)

The absence of obvious stromal invasion is a principal diagnostic criterion for BOTs. (intechopen.com)

In addition to tumor cells, there are also other components such as stromal cells, inflammatory cells, vasculature, and the extracellular matrix [ 1 ]. (hindawi.com)

We have shown that AUF1 induces EMT and stemness in breast epithelial cells via stabilization of the SNAIL1 and TWIST1 mRNAs, and their consequent upregulation. (nature.com)

See the discussions of neurotrophic keratopathy and persistent epithelial defects in Chapter 4 and of tarsorrhaphy in Chapter 13. (aao.org)

The old classification for corneal stromal dystrophies is listed in Table 3. (uiowa.edu)

Anatomy44

Organisms8

Diseases33

Chemicals and Drugs70

Analytical, Diagnostic and Therapeutic Techniques and Equipment39

Phenomena and Processes35

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science2

Mammary epithelial5

Interactions7

Fibroblasts4

Surface epith1

Women with epithelial ovarian cancer1

Tumors of the Ovary2

Stroma8

Endometrial stromal cells1

Thymic Stromal Lymphopoietin1

Germ cell t1

Mesenchymal5

Tumours2

Proliferation3

Defects are common2

Alterations in breast1

Cancer9

Dendritic3

Carcinomas1

Epithelium1

Basal5

Tissues2

Phyllodes Tumor2

Malignant tumors1

Cancers3

Neoplasm1

Endothelial3

Histopathology1

Corneal dystrophy1

Columnar2

Endometrium1

Squamous1

Cell7

Biology1

Inflammation1

Cystic1

Invasion1

Inflammatory1

Breast1

Chapter1

Classification1