The latter encompass human skin regenerated on immune deficient mice as well as organotypic constructs with epithelial and stromal cells embedded within architecturally faithful mesenchyma in vitro. (stanford.edu)
Proliferation2
This process is mediated by 2 mutually exclusive programs of gene expression: 1) an undifferentiated program supporting proliferation by stem cells within the basal layer and 2) a differentiation program instructing growth arrest and differentiation-associated programmed cell death in suprabasal layers. (stanford.edu)
Primary endometrial epithelial cells for cell therapy are largely hampered with the extremely limited proliferation capacity of uterine epithelial cells. (biomedcentral.com)
Stem4
The control of this transition from epithelial stem cell to differentiated corneocyte, which is abnormal in epidermal cancers, is not well understood. (stanford.edu)
We are currently pursuing studies of the dominant signaling and gene regulatory networks that control this process, including the Ras/MAPK cascade, which is required for stem cell-mediated self-renewal and the p53 transcription factor family member, p63, which is required for epidermal differentiation. (stanford.edu)
The function of histone modifying epigenetic regulators and noncoding RNA as central mediators of epithelial stem cell renewal and differentiation represent major emerging areas of study in the lab. (stanford.edu)
Stem cell-based therapy has emerged as a therapeutic option with unsolved issues for IUA patients in the past few years. (biomedcentral.com)
Biology1
Conditionally reprogrammed physiological endometrial epithelial cells provide a novel strategy in IUA clinics in a personalized or generalized manner and also serve as a physiological model to explore biology of endometrial epithelial cells and mechanisms of IUA. (biomedcentral.com)
Primary1
Epigenetic control of gene expression lasts through multiple cell divisions without alterations in primary DNA sequence and can occur via mechanisms that include histone modification and DNA methylation. (stanford.edu)
Mice2
To address this and to also study the oncogenic potential of unregulated function of dominant regulators of epithelial homeostasis noted above, we developed Multi-Functional Human Tissue Genetics noted above which, when combined with skin tissue regeneration on immune deficient mice, has permitted the molecular reconstruction of events sufficient to trigger human cancer. (stanford.edu)
Mouse endometrial epithelial cells (MEECs) were isolated from C57BL female mice, and long-term cultures of MEECs were established and maintained with conditional reprogramming (CR) method. (biomedcentral.com)
Study1
This study was to evaluate whether IUA is curable with conditionally reprogrammed (CR) endometrial epithelial cells. (biomedcentral.com)
Past1
Progress in understanding epithelial carcinogenesis has been hindered in the past by a lack of models that faithfully recapitulate the 3-dimensional architecture of tumor-stroma co-evolution. (stanford.edu)
Layers1
The uppermost one is the epidermis, which is divided into five layers of cells made mostly out of keratinocytes, along with melanocytes, Merkel cells, and Langerhans cells. (hindawi.com)
Skin2
Skin malignancies, including epidermal squamous cell carcinoma (SCC), alone account for nearly as many cancers as all other tissues combined. (stanford.edu)
However, the precise localization of the H 2 S-generating enzymes in the different cell types of the skin has not yet been completely determined. (hindawi.com)
Fetal5
Here, they differentiate into compact, acidophilic epithelial masses which lose contact with the coelomic epithelium and form the primitive or fetal cortex of the suprarenal glands. (myendoconsult.com)
These cells, which are smaller than those of the first wave, surround the fetal cortex to form the definitive cortex of the adrenal gland. (myendoconsult.com)
In the newborn, the atrophy of the fetal cortex proceeds rapidly, except for its outermost cell layers, which are taken up into the zona reticularis of the definitive cortex. (myendoconsult.com)
Ar and Esr1 mRNA levels were quantified in primary cultures of fetal mouse prostate mesenchyme cells treated with E 2 and BPA. (nih.gov)
Therefore, fetal mouse UGS mesenchyme cells provide an informative model of endocrine control of prostate development. (nih.gov)