Epithelial junctions cell cycle. Medical search. Frequent questions

In this epithelium, as well as in the more fragile single cell layer epithelium of endocervix, the cells are held together by proteins that form desmosomes, tight junctions, and adherens junctions, which decrease its permeability [ 19 ]. (hindawi.com)
This is mainly achieved by its dual role as structural component of cadherin-based adherens junctions, and as a key nuclear effector of the Wnt pathway. (unich.it)

Microarray analysis reveals that inhibition of Notch signalling causes downregulation of stem cell-associated genes in parallel with decreased proliferation and increased numbers of ciliated cells and that organoids also respond to oestradiol and progesterone treatment in a physiological manner. (nature.com)
2010 recognized broad classes of TTK69-regulated genes: protein folding mRNA splicing cell proliferation phagocytosis tracheal development and axon guidance. (ecologicalsgardens.com)
These results point out hCG and Ang-(1 - 7) as effective compounds to inhibit cell proliferation, since they decrease cell viability and increase apoptosis in both normal and in tumoral breast cells, being the effect more pronounced in the tumoral cell line. (scirp.org)
Collectively, these studies demonstrate that the rate of endothelial cell proliferation is highest during corpus luteum formation, then decreases and remains low during the mid-luteal phase and structural regression of the corpus luteum. (biomedcentral.com)
The regulation of endothelial cell proliferation in the corpus luteum of pregnancy is less clear. (biomedcentral.com)
Embryonic stem cell-specific microRNAs regulate the G1-S transition and promote rapid proliferation. (ca.gov)
Even though its sequence along with its expressional pattern in cancer cell lines are evident, the functional aspects concerning cell proliferation, viability, differentiation and cell cycle regulation of NDRG1 remains vague. (scirp.org)
Unpredictably, cell cycle progression, cell proliferation and DNA synthesis were unaffected fol lowing NDRG1 expression. (scirp.org)
T. Napso, N. Azzam, A. Lerner and F. Fares, " N-myc Downstream Regulated Gene 1 Increases Differentiation Factors Level in Human Prostate Cancer Cells without Affecting Cell Proliferation and Cell Cycle Profiles," Journal of Cancer Therapy , Vol. 4 No. 2, 2013, pp. 568-574. (scirp.org)
The remaining follicular cells develop into a corpus luteum that produces E and progesterone (P). In turn, P promotes more proliferation within the uterus and vagina, and cornification in the vagina. (biomedcentral.com)
JAM3 knockdown additionally inhibited trophoblast proliferation and increased the number of trophoblasts in the sub-G1 and G2/M phases, indicating cell-cycle disturbance and apoptosis. (bioone.org)
Recently, signaling by GCC and its downstream effector, cyclic GMP (cGMP) has emerged as a principal regulator of proliferation in human colon cancer cells. (jefferson.edu)
In close agreement, induction of GCC signaling in mucosal sheets ex vivo and intestinal cells in vitro inhibited proliferation by activating cGMP-dependent protein kinase and delaying the cell cycle at the G1/S transition. (jefferson.edu)
Separately, deletion of GCC increased tumor growth by releasing a restriction on the cell cycle normally constraining epithelial cell proliferation. (jefferson.edu)

Intercellular Junctions in Animal Cells are. (freezingblue.com)
Electron microscopy reveals loss of desmosomes (epithelial intercellular junctions formed by membrane and submembrane protein complexes), breakdown of desmosome-keratin intermediate filament attachment, and perinuclear aggregates of keratin intermediate filaments. (medscape.com)

Evidence of temporary airway epithelial repopulation and rare clonal formation by BM-derived cells following naphthalene injury in mice. (ca.gov)

Here, we reconstructed Par-dependent polarity using non-polarized Drosophila S2 cells expressing all three components endogenously in the cytoplasm. (elifesciences.org)
Thus, this reconstruction system provides an experimental paradigm to study features of the assembly process and structure of Par-dependent cell-autonomous polarity. (elifesciences.org)
We used Drosophila Schneider cells (S2 cells) of mesodermal origin, as host cells for cell-autonomous reconstruction of cell polarity ( Schneider, 1972 ). (elifesciences.org)
2011 indicated that TTK69 interacts with known pathways (chitin rate of metabolism septate junction polarity proteins) corroborating earlier observations. (ecologicalsgardens.com)
Gene ontology annotation revealed a number of critical signalling pathways that were differentially expressed in cells treated with LA, including biological processes involved in establishment of cell polarity, molecular functions that regulate junctional structures, and cellular components associated with epithelial repair (cell leading edge, ruffle and apical junctional complex). (ecco-ibd.eu)
Junctional adhesion molecule 3 (JAM3) is involved in epithelial cell junction, cell polarity, and motility. (bioone.org)
Photoreceptor cells of the vertebrate neural retina originate in the neuroepithelium, and like other neurons, must undergo cell body translocation and polarity transitions to acquire their final functional morphology, which includes features of neuronal and epithelial cells. (ehu.eus)
The ectopic photoreceptor progenitors initially migrated in an apparent random manner, profusely extending cell processes, until they encountered other cells to establish cell rosettes in which they stayed, acquiring photoreceptor-like polarity. (ehu.eus)
LKB1, also known as STK11 , is a master kinase that serves as an energy metabolic sensor and is involved in cell polarity regulation. (biomedcentral.com)
However, little work has been done on the roles of LKB1 in cell polarity and epithelial-mesenchymal transition in breast cancer. (biomedcentral.com)
In this study, we tried to prove that loss of LKB1 disrupts breast epithelial cell polarity and causes tumor metastasis and invasion. (biomedcentral.com)
The roles of LKB1 in cell polarity and epithelial-mesenchymal transition in breast cancer were determined by using immunofluorescence, western blot assay, and cell migration and invasive assays. (biomedcentral.com)
Finally, the non-transformed human breast cell line MCF-10A was cultured in three dimensions to further reveal the role of LKB1 in breast epithelial cell polarity maintenance. (biomedcentral.com)
Finally, it was found for the first time that endogenous LKB1 knockdown resulted in abnormal cell polarity in acini formed by non-transformed breast epithelial cells grown in 3D culture. (biomedcentral.com)
Knockdown of endogenous LKB1 gave rise to dysregulation of cell polarity and invasive phenotype of breast cancer cells. (biomedcentral.com)
LKB1 also plays crucial roles in establishment and maintenance of cell polarity. (biomedcentral.com)
Furthermore, LKB1 helps establish and maintain cell polarity in mammals. (biomedcentral.com)

This study explores the use of a simple human neurosphere-based in vitro model to characterise the pharmacological and toxicological effects of LiCl and VPA using gene expression changes linked to phenotypic alterations in cells. (plos.org)
Human embryonic stem cells (hESc) can also be used to analyze the in vitro development from undifferentiated pluripotent cells leading to terminally differentiated cell types, recapitulating the process of early embryonic development [5] . (plos.org)
Three SH-SY5Y cell models induced by okadaic acid (OA), Na2S2O4, and H2O2 were established for in vitro validation. (bvsalud.org)
We show that single epithelial stem cells in vitro can give rise to differentiated organoids containing ciliated and secretory cells. (nature.com)
The presence of 'stem cell-like' cells has previously been postulated based on sphere-forming capacity and differentiation in vitro 1 and evidence for the presence of label-retaining cells in the distal fallopian tube 2 . (nature.com)
Here we demonstrate the existence of adult stem cells in the human fallopian tube epithelium, which gives rise to a monolayer of differentiated epithelial cells in a complex 3D organoid in vitro . (nature.com)
Skeletal muscle and myogenic C2C12 cells were used to study the effects of MSY3 phosphorylation in vivo and in vitro on its sub-cellular localization and activity, by blocking the IGF1/PI3K/Akt pathway, by Akt depletion and over-expression, and by mutating potential MSY3 phosphorylation sites. (biomedcentral.com)
Important insights on the morphology and function of luteal endothelial cells have been gained from a combination of in vitro and in vivo studies on endothelial cells. (biomedcentral.com)
In vitro analysis revealed that loss of LKB1 expression enhanced migration, invasion and the acquisition of mesenchymal phenotype, while LKB1 overexpression in MDA-MB-435 s cells, which have a low basal level of LKB1 expression, promoted the acquisition of epithelial phenotype. (biomedcentral.com)
Recently, the first in vitro norovirus cell culture model was reported for a virus that infects mice ( 18 , 19 ). (cdc.gov)

Epithelial tubes are the infrastructure for organs and tissues and tube morphogenesis requires exact orchestration of cell signaling shape migration and adhesion. (ecologicalsgardens.com)
and platelet/endothelial cell adhesion molecule-1, PECAM-1). (biomedcentral.com)
Gap junction adhesion is necessary for radial migration in the neocortex. (ca.gov)
To assess the role of cell adhesion in the organization of photoreceptor progenitors, we knocked-down cdh2 /N-cadherin and observed the cell behavior by time-lapse microscopy. (ehu.eus)
beta-catenin plays an important role as regulatory hub in several cellular processes including cell adhesion, metabolism, and epithelial mesenchymal transition. (unich.it)

Here, we applied a liquid chromatography-mass spectrometry (LC-MS/MS) approach to identify proteins modulated after beta-catenin knockdown in the breast cancer cell line MCF-7. (unich.it)
We used a label free analysis to compare trypsin-digested proteins from CTR (shCTR) and beta-catenin knockout cells (sh beta cat). (unich.it)
In detail, proteins involved in carbohydrate metabolism and tricarboxylic acid cycle were found to be down-regulated, whereas proteins associated to lipid metabolism were found up-regulated in sh beta cat compared to shCTR. (unich.it)
We assessed changes in the gut microbiota, intestinal permeability, gut peptides, intestinal epithelial tight-junction proteins ZO-1 and occludin (qPCR and immunohistochemistry), hepatic and systemic inflammation. (bmj.com)
We have recently shown that the replication of rhinovirus, poliovirus and foot-and-mouth disease virus requires the co-translational N-myristoylation of viral proteins by human host cell N-myristoyltransferases (NMTs), and is inhibited by treatment with IMP-1088, an ultrapotent small molecule NMT inhibitor. (cdc.gov)

also called myosin heavy chain 95F (Mhc95F), or 95F MHC), which is a motor protein necessary for the morphogenesis of epithelial tissues during Drosophila development. (nih.gov)

Describe the structure, function, and location of epithelial tissues. (montcalm.edu)
Relate the structure of cell junctions to their function in epithelial tissues. (montcalm.edu)
Relate the functions of the integumentary system to the layers, tissues, cells, and other structures. (montcalm.edu)
We develop new technologies to map and perturb the main physical properties that determine how cells and tissues grow, move, invade and remodel. (ibecbarcelona.eu)
Where researchers once struggled to connect events at static timepoints, imaging tools now offer the ability to visualize the dynamic form and function of molecules, cells, tissues, and whole embryos throughout the entire developmental process. (cshlpress.com)
Further techniques are organized by the level of visualization they provide, from cells to tissues and organs to whole embryos. (cshlpress.com)
Cells grown on porous collage-coated beads under fluid shear conditions in rotating wall vessel bioreactors differentiate into 3-D architectures resembling both the morphologic and physiologic function of in vivo tissues. (cdc.gov)

Trends in Cell Biology. (wikipedia.org)
Molecular Cell Biology. (wikipedia.org)
The Journal of Cell Biology. (wikipedia.org)
Directed cell migration is one of the earliest observations in cell biology, dating back to the late XIX century. (ibecbarcelona.eu)
Drosophila neuroblast asymmetric cell division: recent advances and implications for stem cell biology. (ca.gov)
Dr. Mukhopadhyay did his doctoral studies in Biochemistry at the Department of Biochemistry from Calcutta University and received the postdoctoral training in the Department of Cell Biology, Cleveland Clinic Foundation, USA. (jnu.ac.in)
Current opinion in cell biology. (manchester.ac.uk)

Our data reveal a significant overlap between Notch-dependent genes in the fallopian epithelium and the defined 'stem cell signature' of the mouse intestine, suggesting the existence of a conserved pathway that regulates tissue renewal and directly controls cell fate specification and differentiation in the organoid by inhibiting cilliogenesis. (nature.com)
These results revealed that NDRG1 is functional in prostate cancer cells and able to induce expression of differentiation factors through p53 independent pathway. (scirp.org)
A Novel Gene Which Is Up-Regulated during Colon Epithelial Cell Differentiation and Down-Regulated in Colorectal Neoplasms," Laboratory Investigation: A Journal of Technical Methods and Pathology, Vol. 77, No. 1, 1997, pp. 85-92. (scirp.org)
The models use isolated primary support cells cultured onto a biological scaffold and within a microfluidic system to create a niche and support the desired differentiation of epithelia, germ and somatic cells from patient-derived induced pluripotent stem cells. (biomedcentral.com)

In Eukaryotes, made of a cell membrane that is filled with microtubules and is not connected. (freezingblue.com)
A loss of mitochondrial mass and membrane potential was also assessed by fluorescent probes in sh beta cat cells with respect to the controls. (unich.it)
Importantly, we observed that loss of N-myristoylation resulted in greatly reduced infectivity of assembled mature virus particles, characterized by significantly reduced host cell entry and a decline in membrane fusion activity of progeny virus. (cdc.gov)

Gene expression patterns of human colon tops and basal crypts and BMP antagonists as intestinal stem cell niche factors. (ca.gov)
Indian hedgehog regulates intestinal stem cell fate through epithelial-mesenchymal interactions during development. (ca.gov)
Tight junctions (TJs) located at the apical lateral region of adjacent intestinal epithelial cells are largely responsible for regulating the intestinal mucosal barrier. (ecco-ibd.eu)
This decreased inflammatory tone was associated with a lower intestinal permeability and improved tight-junction integrity compared to controls. (bmj.com)
Representative models of differentiated human intestinal epithelium can be established by growing cells in 3 dimensions (3-D) on collagen-I-coated porous microcarrier beads in rotating-wall vessel (RWV) bioreactors that model the physiologic fluid-shear environment in their respective organs ( 21 - 24 ). (cdc.gov)

Both cell lines received an hCG and angiotensin peptides 24-hour treatment, in combina tion or alone followed by cell viability, apoptosis and cell cycle assays performed by flow cytometer (GUAVA). (scirp.org)
After hCG, Ang-(1 - 7), hCG + Ang-(1 - 7) and hCG + Ang-(1 - 7)-Fmoc treatments, MCF7 displayed cell viability decrease and mid-apoptosis increase. (scirp.org)
These cells had an increase in late apoptosis and necrosis after AngII Toac, hCG + Ang-(1 - 7) and hCG + Ang-(1 - 7)-Fmoc treatments. (scirp.org)
In summary, cell viability was decreased and apoptosis (initial, mid and late) was in creased after hCG and/or Ang-(1 - 7) peptides treatments. (scirp.org)
On the other end of the spectrum, the microvascular endothelial cells are the first cells to undergo apoptosis at the onset of corpus luteum regression. (biomedcentral.com)
In a different study, in which researchers systematically analyzed mutations identical to those found in patients with Darier disease, mutant SERCA2 protein aggregates were found to cause stress to the endoplasmic reticulum, subsequently inducing cell apoptosis. (medscape.com)
Crypt hyperplasia in GCC-/- mice was associated with compensatory increases in cell migration and apoptosis. (jefferson.edu)
The tumor suppressor gene LKB1, also known as serine/threonine protein kinase 11 (STK11 ), encodes a serine/threonine protein kinase that has multiple cellular functions, including tumor suppression, cell cycle regulation, and promotion of apoptosis. (biomedcentral.com)

Our model for epithelial tubulogenesis resembles vertebrate neural tube formation and entails the synthesis of the dorsal appendages [DAs] respiratory constructions of the eggshell (Dorman et al. (ecologicalsgardens.com)

Angiotensin II Activates Extracellular Signal Regulated Kinases via Protein Kinase C and Epidermal Growth Factor Receptor in Breast Cancer Cells," Journal of Cellular Physiology, Vol. 196, No. 2, 2003, pp. 370-377. (scirp.org)
We aim to study the coupling between LTCC and β adrenergic receptors in different cardiomyocyte microdomains, the distinct involvement of PKA and CAMKII (Ca2+/calmodulin-dependent protein kinase II) and explore how this functional complex is disrupted in heart failure.Methods:Global signaling between LTCCs and β adrenergic receptors was assessed with whole-cell current recordings and western blot analysis. (imperial.ac.uk)
Ai XL, Chi Q, Qiu Y, Li HY, Li DJ, Wang JX, Wang ZY (2017) Gap junction protein connexin43 deregulation contributes to bladder carcinogenesis via targeting MAPK pathway. (edu.pl)
Banerjee D, Gakhar G, Madgwick D, Hurt A, Takemoto D, Nguyen TA (2010) A novel role of gap junction connexin46 protein to protect breast tumors from hypoxia. (edu.pl)
The investigators found that the resultant transfected cells showed defects in ATP2A2 protein expression (15 mutants), ATP hydrolysis (29 mutants), calcium transport (4 mutants), and calcium binding and kinetics (3 mutants). (medscape.com)

To define TTK69's regulatory part during epithelial tubulogenesis and to determine novel effectors we exploited the unique allele expression profiles via microarrays to identify direct and indirect focuses on of TTK69 evaluated the energy of TTK69-binding motifs as predictive tools and ascertained which TTK69-controlled genes are required for DA-tube development through hybridization (ISH) and tissue-specific RNAi. (ecologicalsgardens.com)
To study cell and tissue dynamics we develop new technologies to measure physical forces at the cell-cell and cell-matrix interface. (ibecbarcelona.eu)
By combining these technologies with computational analysis of cell shape and velocity we obtain a full experimental characterization of epithelial dynamics during tissue growth, wound healing and cancer cell invasion. (ibecbarcelona.eu)
Surprisingly, some cells in the tissue barely stretch, while others become 'superstretched', increasing their area more than ten times. (ibecbarcelona.eu)
Moreover, these receptors are functional, as treatment of FRT tissue cells with ligands for TLR and NOD induces production of proinflammatory CXCL8 [ 13 ], and those receptors actively participate in immune response to pathogens, as Neisseria gonorrhea and HIV-1 [ 14 ]. (hindawi.com)
Cell Tissue Res 360: 685-699. (edu.pl)
The relationships of LKB1 expression to clinic-pathological parameters and epithelial markers E-cadherin and high-molecular-weight -cytokeratin (HMW-CK) were investigated in 80 clinical breast cancer tissue samples and their paired normal control breast tissue samples by using immunohistochemistry. (biomedcentral.com)

Furthermore, Notch is responsible for the regulation of known stem cell factor genes. (nature.com)
Cell cycle regulation by MicroRNAs in embryonic stem cells. (ca.gov)
Das D, Tapryal N, Goswami S.K., Fox P.L, and Mukhopadhyay C.K. Regulation of Ceruloplasmin in human hepatic cells by redox active copper: Identification of a novel AP-1 site in ceruloplasmin gene. (jnu.ac.in)
Our data highlight a role of beta-catenin in the regulation of metabolism and energy homeostasis in breast cancer cells. (unich.it)

1995 TTK69 also regulates varied processes during take flight development from cell-cycle rules to tracheal tubulogenesis (Baonza Isoacteoside et al. (ecologicalsgardens.com)
Thus, LKB1 regulates multiple biological pathways involved in cell growth and metabolism. (biomedcentral.com)

We also use organoids grown from primary tumors to understand how epithelial structure and function are lost with disease progression. (ibecbarcelona.eu)
However, the pathway downstream NDRG1, involving p21 and c8/18, regulating cell cycle progression and DNA synthesis is unfunctional. (scirp.org)
Here, we show that epithelial cells sense local cell density through mechanosensitive E-cadherin adhesions to control G2/M cell-cycle progression. (ibecbarcelona.eu)

Using RNA-Seq, we identified a total of 163 and 568 differentially expressed genes in primary normal human bronchial epithelial (NHBE) cells that were exposed to diacetyl and 2,3-pentanedione, respectively. (nature.com)
Consistent with this, qRT-PCR confirmed that the expression of multiple genes involved in cilia biogenesis was significantly downregulated by diacetyl and 2,3-pentanedione in NHBE cells. (nature.com)
These genes displayed enriched manifestation in DA-tube cells except mutants and exhibited RNAi phenotypes that were enhanced inside a genetic interactions. (ecologicalsgardens.com)
K. Kokame, H. Kato and T. Miyata, "Homocysteine-Respondent Genes in Vascular Endothelial Cells Identified by Differential Display Analysis. (scirp.org)

The granulosa cells and theca cells of the developing antral follicle and the steroidogenic cells of the corpus luteum produce and respond to angiogenic factors and vasoactive peptides. (biomedcentral.com)

Dlx1 and Dlx2 control neuronal versus oligodendroglial cell fate acquisition in the developing forebrain. (ca.gov)

The RPE is a monolayer of cells between the neural retina and choroidal blood supply, and is critically important for photoreceptor function. (arvojournals.org)
Our results demonstrate that the highly differentiated 3-D cell culture model can support the natural growth of human noroviruses, whereas previous attempts that used differentiated monolayer cultures failed. (cdc.gov)

The contributions of vasoactive peptides generated by the luteal endothelin-1 and the renin-angiotensin systems are discussed in context with the function of endothelial cells during corpus luteum formation and regression. (biomedcentral.com)

In particular, the disturbance of connexin function during the multi-stage process of tumor development leads to abnormal reactions of tumor cells to stress stimuli. (edu.pl)

The epithelial lining of the fallopian tube is of critical importance for human reproduction and has been implicated as a site of origin of high-grade serous ovarian cancer. (nature.com)
The review highlights areas for future investigation of ovarian microvascular endothelial cells. (biomedcentral.com)
The potential clinical applications of research directed on corpus luteum endothelial cells are intriguing considering reproductive processes in which vascular dysfunctions may play a role such as ovarian failure, polycystic ovary syndrome (PCOS), and ovarian hyperstimulation syndrome (OHSS). (biomedcentral.com)
1. PM from histologically confirmed primary epithelial ovarian, tubal, or primary peritoneal platinum-resistant carcinoma (including clinical recurrence, refractory disease, or persistent disease within 6 months of last chemotherapy). (who.int)

In that context, differentiated enterocytes in villi exhibit higher guanylin expression and ligand-dependent cGMP accumulation compared to proliferating progenitor cells in crypts. (jefferson.edu)
Crypt expansion reflected hyperplasia of the proliferating compartment with reciprocal increases in rapidly cycling progenitor cells and reductions in differentiated cells of the secretory lineage, including Paneth and goblet, but not enteroendocrine, cells. (jefferson.edu)

The ability of two cytokines, tumor necrosis factor alpha and interferon gamma, are evaluated as paracrine mediators of endothelial cell function during angioregression. (biomedcentral.com)
Both processes are the result of a complex interaction between tumor cells and their microenvironment. (ibecbarcelona.eu)
Benassi MS, Picci P, Krenacs T (2015) Prognostic impact of reduced connexin43 expression and gap junction coupling of neoplastic stromal cells in giant cell tumor of bone. (edu.pl)

For some, this is an impenetrable barrier for agents such as HIV, but Langerhans cells within the squamous layer have been shown to transmit the virus for target cells [ 20 ]. (hindawi.com)

Figure 1: Single fallopian epithelial cells give rise to organoids that can be maintained long term. (nature.com)
Organoids from many organs have now been obtained from embryonic stem cells, induced pluripotent stem cells and organ progenitors. (ibecbarcelona.eu)

Photoreceptor progenitors detached from the basal retina at pre-mitotic stages, rapidly retracting a short basal process as the cell body translocated apically. (ehu.eus)

Intrapulmonary delivery of bone marrow-derived mesenchymal stem cells improves survival and attenuates endotoxin-induced acute lung injury in mice. (ca.gov)

In addition, in order to phenotypically anchor the gene expression data, changes in the heterogeneity of cell subtype populations and cell cycle phase were monitored using flow cytometry. (plos.org)

DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal. (ca.gov)
Hematopoietic stem cell quiescence promotes error-prone DNA repair and mutagenesis. (ca.gov)

The cyclic nature of the capillary bed in the corpus luteum offers a unique experimental model to examine the life cycle of endothelial cells, involving discrete physiologically regulated steps of angiogenesis, blood vessel maturation and blood vessel regression. (biomedcentral.com)
Endothelial cells communicate with cells comprising the functional unit of the corpus luteum, i.e ., other vascular cells, steroidogenic cells, and immune cells. (biomedcentral.com)
This review is designed to provide an overview of the types of endothelial cells present in the corpus luteum and their involvement in corpus luteum development and regression. (biomedcentral.com)
Available evidence indicates that microvascular endothelial cells of the corpus luteum are not alike, and may differ during the process of angiogenesis and angioregression. (biomedcentral.com)
Finally, chemokines are discussed as a vital endothelial cell secretory products that contribute to the recruitment of eosinophils and macrophages. (biomedcentral.com)
Evidence of proliferating endothelial cells was determined by the presence of Ki-67 antigen-positive cells, bromodeoxyuridine-positive cells, or [ 3 H] thymidine-positive cells. (biomedcentral.com)

Tyrosine kinase inhibitors (TKIs) against the human epidermal growth factor receptor (EGFR) are now standard treatment in the clinic for patients with advanced EGFR mutant non-small-cell lung cancer (NSCLC). (researchgate.net)

Also known as taxis, directed cell migration has been commonly associated with chemotaxis, i.e. the ability of a broad variety of cell types to migrate following gradients of chemical factors. (ibecbarcelona.eu)
This new migration mode emerges only in cell collectives and, strikingly, does not require isolated cells to exhibit gradient sensing. (ibecbarcelona.eu)

Explain the relationship between DNA, cell cycle, and cancer. (montcalm.edu)
Cancer cell invasion and metastasis remain the leading cause of death in patients with cancer. (ibecbarcelona.eu)
One of our main lines of research is to study how tumours exploit the functions of non-cancer cells in their microenvironment to invade and metastasize. (ibecbarcelona.eu)
We focus on the interaction between epithelial cancer cells and Cancer Associated Fibroblasts (CAFs), the most abundant cell type in the tumour stroma. (ibecbarcelona.eu)
Breast cancer cells attached to a surface rich in collagen. (ibecbarcelona.eu)
Furthermore, human cDNA of NDRG1 from normal placenta was cloned into a eukaryotic expression vector and transfected into the three cancer cell lines. (scirp.org)
Loss of sensitivity to p21 cell cycle control may be associated with prostatic cancer behavior. (scirp.org)
β-Catenin Knockdown Affects Mitochondrial Biogenesis and Lipid Metabolism in Breast Cancer Cells. (unich.it)
Then, the LKB1 expressions in metastatic and non-metastatic breast cancer cell lines were compared. (biomedcentral.com)
There are two main subcategories of lung cancer: nonsmall cell lung cancer (NSCLC) and small cell lung cancer (SCLC). (hindawi.com)
Cancer Cell. (manchester.ac.uk)
5. Fit enough to receive full dose of systemic anti-cancer therapy (SACT) in cycle 1 as defined in the protocol. (who.int)

Ki-67-positive cells were distributed along the epithelial folds, without restriction to a particular region with occasional clustering ( Fig. 1a , asterisk). (nature.com)

Gap junctions: multifaceted regulators of embryonic cortical development. (ca.gov)

Cellular stress responses are also regulated through the activity of unpaired connexons (hemichannels) and via the intracellular interference of connexins with the cell cycle and pro-apoptotic machinery. (edu.pl)

We have developed optogenetic tools based on controlling the activity of endogenous RhoA to upregulate or downregulate cell contractility and to control cell shape and mechanotransduction. (ibecbarcelona.eu)
Mouse ES cells express endogenous shRNAs, siRNAs, and other Microprocessor-independent, Dicer-dependent small RNAs. (ca.gov)

Furthermore, H 2 O 2 -induced oxidative stress reduced JAM3 expression in trophoblasts and cell culture supernatants. (bioone.org)
Berthoud VM and Beyer EC (2009) Oxidative stress, lens gap junctions, and cataracts. (edu.pl)

Cell-cycle arrest was associated with the engagement of checkpoint kinase 2-cell division cycle 25C-cyclin-dependent kinase 1/cyclin B1 signaling. (bioone.org)
As local cell density increases, tensile forces on E-cadherin adhesions are reduced, which prompts the accumulation of the G2 checkpoint kinase Wee1 and downstream inhibitory phosphorylation of Cdk1. (ibecbarcelona.eu)

Here we report on the establishment of long-term, stable 3D organoid cultures from human fallopian tubes, indicative of the presence of adult stem cells. (nature.com)
The upper portion of the female reproductive tract consists of the fallopian tubes, uterus body, and endocervix, which has columnar epithelial cells and is distincted from ectocervix which is part of the lower tract characterized by squamous epithelial cells [ 4 , 6 ]. (hindawi.com)

Epithelial cell divisions are coordinated with cell loss to preserve epithelial integrity. (ibecbarcelona.eu)

Studies of viral attachment to cultured gastrointestinal epithelial cells (Caco-2) using recombinant virus-like particles or infectious noroviruses indicate that specific histo-blood group antigens play a key role in the attachment of the virus to the host cells ( 13 - 17 ). (cdc.gov)

The complete blood cell (CBC) count frequently reveals profound normocytic normochromic anemia . (medscape.com)

Whilst LiCl exposure did not significantly alter the proportion of cells expressing markers for stem cells/undifferentiated cells (Oct4, SSEA4), neurons (Neurofilament M), astrocytes (GFAP) or cell cycle phase, the drug caused a 1.4-fold increase in total cell number. (plos.org)

Indeed, both the hESc and human neuroprogenitor cell (hNPC) models provide valid and useful tools for studying DNT. (plos.org)
In this study, we utilized primary normal human bronchial epithelial (NHBE) cells that are cultured at an air-liquid interface (ALI) to mimic the in vivo airway characteristics 30 . (nature.com)
Students will explain the overall structure and organization of the human body from cell to system. (montcalm.edu)
Myelin Restoration: Progress and Prospects for Human Cell Replacement Therapies. (ca.gov)
However, these models do not answer the fundamental questions of human norovirus attachment and entry into cells of the human gastrointestinal tract. (cdc.gov)

Intra-endodermal interactions are required for pancreatic beta cell induction. (ca.gov)

It is lined by simple columnar epithelium containing secretory and ciliated cells, which produce tubular fluid and facilitate transport of gametes, respectively. (nature.com)

It contributes to synaptic transmission and development at the Drosophila neuromuscular junction. (nih.gov)

Polarization is a fundamental cellular property that plays a vital role in various biological processes in multi-cellular as well as single-cell organisms. (elifesciences.org)
Cell polarization involving the Par-complex in situ is linked to various other processes. (elifesciences.org)
Because of such association between Par-dependent polarization and other processes, the Par-complex exhibits different behavioral characteristics in an individual context, making it difficult to determine general features of the dynamic process taking place during cell polarization by the Par-complex. (elifesciences.org)

Anatomy23

Organisms7

Chemicals and Drugs80

Analytical, Diagnostic and Therapeutic Techniques and Equipment15

Phenomena and Processes57

Disciplines and Occupations1

Information Science3

Adherens2

Proliferation14

Intercellular Junctions2

Airway epithelial1

Polarity17

Vitro10

Adhesion5

Proteins5

Morphogenesis1

Tissues7

Biology7

Differentiation4

Membrane3

Intestinal5

Apoptosis8

Vertebrate neural1

Protein5

Tissue7

Regulation4

Regulates2

Progression3

Genes4

Follicle1

Neuronal1

Monolayer2

Peptides1

Connexin1

Ovarian4

Progenitor cells2

Tumor3

Barrier1

Organoids2

Basal1

Mesenchymal stem1

Subtype1

Stem cell2

Endothelial6

Epidermal Growth F1

Migration2

Cancer12

Restriction1

Cortical1

Cellular stress1

Endogenous2

Oxidative2

Checkpoint2

Fallopian tubes2

Integrity1

Viral1

Reveals1

Markers1

Human5

Interactions1

Secretory1

Drosophila1

Processes3