Epithelial early follicle morphogenesis. Medical search. Frequent questions

The development of teeth is initiated by epithelial-mesenchymal interactions, which form dental papilla cells and dental sac cells, subsequently forming pulp, dentin, cementum, periodontal ligament and proper alveolar bone, except enamel 1 - 4 . (researchsquare.com)
In an anagen human hair follicle PPARγ expression is detected in the mesenchymal DP cells, epithelial cells of the outer root sheath (ORS), inner root sheath and matrix 16 . (nature.com)
[ 7 ] Similarly, in 2001, Priolo and Laganà reclassified the ectodermal dysplasias into 2 main functional groups: (1) defects in developmental regulation/epithelial-mesenchymal interaction and (2) defects in cytoskeleton maintenance and cell stability. (medscape.com)
Epithelial wnt7b and mesenchymal eda are expressed in the inter-germ and inter-row regions, and likely regulate the spacing of these shh -positive units. (biomedcentral.com)
Repeated injuries can stimulate airway epithelial cells to produce inflammatory mediators that activate epithelial cells, immune cells, or the epithelial?mesenchymal trophic unit. (molcells.org)
Structural alterations in the nasal epithelium include goblet cell hyperplasia, squamous metaplasia, epithelial-mesenchymal transition (EMT), epithelial barrier disruption, epithelial exfoliation, and basement membrane thickening. (molcells.org)
The conversion of an epithelial cell to a mesenchymal cell is critical to metazoan embryogenesis and a defining structural feature of organ development. (rupress.org)
Current interest in this process, which is described as an epithelial-mesenchymal transition (EMT), stems from its developmental importance and its involvement in several adult pathologies. (rupress.org)
The EMT International Association was formed in 2002 to provide an international body for those interested in EMT and the reverse process, mesenchymal-epithelial transition, and, most importantly, to bring together those working on EMT in development, cancer, fibrosis, and pathology. (rupress.org)

Interestingly, the elongation of the ovarian follicle, which progressively matures from a spherical to an elongated form, is generated by the follicular epithelium. (igred.fr)
For this, we analyze the modes of communication between the germ cells and the follicular cells, allowing the synchronization of their growth during the development of the ovarian follicles and thus ensuring the homeostasis of the reproductive organ. (igred.fr)
We study on the one hand F-actin cytoskeleton function and dynamics at the apical domain and cell junctions of follicular epithelial cells, in contact with the germ cells during the early elongation of the follicles. (igred.fr)
Although earlier studies show that Mirror patterns the follicular epithelium prior to DA tubulogenesis we display that Mirror has an self-employed novel part in tube development involving positive rules of ovary. (ecologicalsgardens.com)

Anatomically, this epithelium surrounds the germ cells within the reproductive organ, forming 'ovarian follicles' or 'egg chambers', precursors of the future egg. (igred.fr)
On the other hand, we analyze the involvement of the Dystrophin-Dystroglycan protein complex and the basal domain of the epithelium in the later follicle elongation phase and especially its implication in planar cell polarity and extracellular matrix organization. (igred.fr)
For example, purely physical mechanisms can account for branching morphogenesis of the embryonic mouse airway epithelium, when cultured ex vivo in the absence of biochemical patterning 14 . (nature.com)
The Drosophila follicle-cell epithelium provides an appropriate model system for studying the potential role of electrochemical signals, like intracellular pH (pH i ) and membrane potential (V mem ), during development. (biomedcentral.com)
Our data show that in the Drosophila follicle-cell epithelium stage-specific pH i - and V mem -gradients develop which result from the activity of several ion-transport mechanisms. (biomedcentral.com)

Adherens junctions (AJs) are thought to be key landmarks for establishing epithelial cell polarity, but the origin of epithelial polarity in Drosophila remains unclear. (rupress.org)
Thus, we examined epithelial polarity establishment during early Drosophila development. (rupress.org)
During Drosophila gastrulation, actomyosin contraction in ventral cells generates a long, narrow epithelial furrow, termed the ventral furrow, in which actomyosin fibres and tension are directed along the length of the furrow. (nature.com)
In the Drosophila embryo, apical constriction in a strip of epithelial cells along the ventral midline results in the folding of the tissue and the internalization of ventral cells, forming a ventral furrow (VF). (nature.com)

Stimulates proliferation and differentiation of early progenitor cells within hair follicles. (plurisomes.com)

because epithelial cells have a relatively simple and very stereotyped shape. (igred.fr)
The growth of cervical loop cells into the deeper tissues forms Hertwig Epithelial Root Sheath, which determines the root shape of the tooth. (wikipedia.org)
Keratin is also present in epithelial cells of tooth germ and a thin film of keratin is present on a recently erupted tooth (Nasmyth's membrane or enamel cuticle). (wikipedia.org)
NGF-R is present in the condensing ectomesenchymal cells of the dental papilla in the early cap stage tooth germ and plays multiple roles during morphogenetic and cytodifferentiation events in the tooth. (wikipedia.org)
The stage technically begins once epithelial cells proliferate into the ectomesenchyme of the jaw. (wikipedia.org)
Loss of tissue is then repaired in a complex process that involves tissue-resident immune, stromal, and epithelial cells, as well as infiltrating immune cells [ 2 ]. (biomedcentral.com)
Total and conditional knock out of PPARγ in hair follicle bulge stem cells showed similar result where scarring alopecia was observed in mice with the loss of pilosebaceous units and inflammatory cells infiltration 18 , 19 . (nature.com)
A surprising recent discovery has been that mammary epithelial cells commit to differentiated lineages using the same signalling pathways that regulate lineage determination in T helper cells. (biologists.com)
Launch Hair follicle advancement requires reciprocal conversation between surface area epithelial cells as well as the root mesenchyme that's mediated by secreted signaling substances (Schmidt-Ullrich and Paus, 2005). (bio-cavagnou.info)
How epithelial cells actively respond to mechanical constraints by adjusting how they generate force is important to understand tissue morphogenesis. (nature.com)
These cells, surrounding the hair follicles, secrete signaling molecules that control the progression of the hair cycle. (jcadonline.com)
Constant using a earlier research, this lack of correlation can be the result of de novo methylation at already transcription ally silent CGI promoters in undifferentiated stem cells. (pkainhibitors.com)
We also show that during coordinated cell death of hair follicle cells in mice, TNF-α is expressed in apoptotic cells and is required for normal cell death. (elifesciences.org)
found that TNF is produced by apoptotic cells in hair follicles, and that blocking TNF inhibits the death of other cells in the same cohort: this suggests that a common mechanism could regulate the communal death of cells in flies and mammals. (elifesciences.org)
A role for the complex in mammalian synapse formation and neurite outgrowth has been suggested by the early presence of Sec6/Sec8 immunoreactivity at sites of synaptogenesis in culture (Hazuka, 1999) and the impairment of neurite outgrowth with dominant-negative forms of sec10 and sec8 in PC12 cells (Vega, 2001). (sdbonline.org)
Epithelial tissue is one of the four major types of tissue found in animals, and is the only type of tissue that is able to form and maintain layers of cells that are just one cell thick. (elifesciences.org)
This mechanism preserves the single-cell layer pattern throughout the body and prevents epithelial cells from growing in inappropriate locations. (elifesciences.org)
It is estimated that up to 90% of cancers in humans originate in epithelial tissue, and the cells within such tumors are known to survive and divide even when they are no longer attached to the extracellular matrix. (elifesciences.org)
explored which genes enable epithelial cells from the human mammary gland to grow without being attached to the extracellular matrix. (elifesciences.org)
Normally, the PVRL4 gene is not active in breast epithelial cells, but its activity is detected in many breast, lung, and ovarian tumors. (elifesciences.org)

Induces anagen phase in resting hair follicles. (plurisomes.com)
The histological morphology of hair follicles demonstrated an active anagen phase with the induction of stem cell factor. (biomedcentral.com)
22 The underlying mechanism is believed to be a higher concentration of dihydrotestosterone (DHT) to androgen-sensitive hair follicles, causing thinning of the dermal papillae and shortening of the anagen phase. (jcadonline.com)

After birth, mammary development is arrested until puberty, when extensive elongation of the ducts, accompanied by secondary branching, takes place, thus providing a readily accessible system in which to study branching morphogenesis. (biologists.com)
Studies have shown how gene networks are employed to pattern butterfly eyespots, fly bristles and vertebrate epithelial appendages such as teeth, feathers, hair and mammary glands. (biomedcentral.com)

2008). Conversely, ectopic manifestation from the secreted Wnt inhibitor Dkk1 in embryonic mouse epidermis prevents the initiation of locks follicle advancement and blocks patterned manifestation of most molecular placode markers, including Wnt ligands, recommending the need for an earlier performing, broadly indicated Wnt sign (Andl et al. (bio-cavagnou.info)

The study of mechanisms controlling growth and morphogenesis is based on dynamic multi-scale biological processes (molecular, cellular and tissular) and requires approaches involving developmental biology, genetics, cell biology and biophysics. (igred.fr)
This variation in gene expression among species occurs early in the developmental programme for dental patterning. (biomedcentral.com)
Increased IGFBP-4 and -5 protease along with lower amounts of IGFBP-4 binding activity and greater amounts of free IGF-I are some of the earliest developmental changes documented in bovine growing antral follicles. (bioone.org)

Current opinion views androgens as the pathogenic driver in the miniaturization of hair follicles of androgenetic alopecia by interfering with the dermal papilla. (nature.com)
We demonstrate the concurrent up-regulation of PPARGC1a in the epithelial compartment and androgen receptor in the dermal papilla of miniaturized hair. (nature.com)
This is supported by reduced proliferation of human dermal papilla and predominantly epithelial keratinocytes after incubation with AICAR, the agonist for AMPK signaling which activates PPARGC1a and serves as co-activator of PPARγ. (nature.com)
Signaling in the placodes promotes clustering of root dermal fibroblasts, developing dermal condensates that will be the precursors of locks follicle dermal papillae (Schmidt-Ullrich and Paus, 2005). (bio-cavagnou.info)
Further signaling relationships between the locks placode as well as the nascent dermal papilla result in placode down-growth and locks follicle morphogenesis. (bio-cavagnou.info)

Our model for epithelial tubulogenesis resembles vertebrate neural tube formation and entails the synthesis of the dorsal appendages [DAs] respiratory constructions of the eggshell (Dorman et al. (ecologicalsgardens.com)

The tissues primarily involved are the skin and its appendages (hair follicles, eccrine glands, sebaceous glands, and, nails) and teeth. (medscape.com)

All stages (bud, cap, bell, crown), growth and morphogenesis of the teeth are regulated by a protein called sonic hedgehog. (wikipedia.org)
3 ] found that downregulation of osteoprotegerin (OPG) which is needed for tooth eruption is mediated by colony-stimulating factor-1 (CSF-1) expressed in the dental follicle of erupting teeth [ 3 ]. (hindawi.com)

Accordingly, several experimental studies have been performed that show how the follicle functions in the resorption process that is invoked in the bone tissue during eruption. (hindawi.com)
To define TTK69's regulatory part during epithelial tubulogenesis and to determine novel effectors we exploited the unique allele expression profiles via microarrays to identify direct and indirect focuses on of TTK69 evaluated the energy of TTK69-binding motifs as predictive tools and ascertained which TTK69-controlled genes are required for DA-tube development through hybridization (ISH) and tissue-specific RNAi. (ecologicalsgardens.com)
We illustrate where such mechanisms of pattern formation arise in biological systems from cellular to tissue scales, with an emphasis on morphogenesis. (mpi-cbg.de)

These protease-induced decreases in IGFBP-4 and -5 likely cause increased levels of bioavailable (or free) IGFs that stimulate steroidogenesis and mitogenesis in developing dominant follicles, which ultimately prepare the follicle(s) and oocyte(s) for successful ovulation and fertilization. (bioone.org)

Epithelial tubes are the infrastructure for organs and tissues and tube morphogenesis requires exact orchestration of cell signaling shape migration and adhesion. (ecologicalsgardens.com)

We show the up-regulation of PGC1a in the inner and outer root sheath (IRS/ORS) of hair follicles from AGA patients and the dynamic expression in the mouse hair cycle. (nature.com)
In our recent study we found that circadian clock genes play a role in regulation of the hair growth cycle during synchronized hair follicle cycling, uncovering an unexpected connection between these two timing systems within skin. (aging-us.com)

Furthermore since ovaries from well-nourished females contain all phases of egg chamber development and since egg chambers can be dissected and cultured outside of the ovary this system is ideal for investigating epithelial tube patterning formation and development (Berg 2005 Fig. 1 twin peaks (ttktwk) a female sterile mutation affects gene manifestation during late oogenesis. (ecologicalsgardens.com)

The tooth germ is organized into three parts: the enamel organ, the dental papilla and the dental sac or follicle. (wikipedia.org)
One of the earliest signs in the formation of a tooth that can be seen microscopically is the distinction between the vestibular lamina and the dental lamina. (wikipedia.org)
The dental lamina connects the developing tooth bud to the epithelial layer of the mouth for a significant time. (wikipedia.org)
Animal experimental studies have generally demonstrated that the tooth follicle plays a major role as the structure that forms the path for the crown through the overlying bone during the eruption process [ 1 - 3 ]. (hindawi.com)
They concluded in their study [ 1 ] that resorption and alveolar bone formation occurring around an erupting tooth are regulated by adjacent parts after the dental follicle. (hindawi.com)
Combinatorial epithelial expression of pitx2 and shh appears to govern the competence both of initial tooth sites and future tooth rows. (biomedcentral.com)

They also saw that the eruption pathway created by bone resorption did not develop after removal of the follicle. (hindawi.com)
Comparative full transcriptome profile analysis of the hair bulb region of normal and miniaturized hair follicles from vertex and occipital region in males with and without androgenetic alopecia revealed that next to the androgen receptor as well the retinoid receptor and particularly the PPAR pathway is involved in progressive hair miniaturization. (nature.com)
Binding from the A1 isoform from the Tumor Necrosis Element relative Ectodysplasin to its receptor EDAR induces nuclear translocation from the transcription element NF-B, and NF-B pathway activation in developing locks follicle placodes (Kumar et al. (bio-cavagnou.info)

In some species (e.g., bovine), evidence indicates that decreases in IGFBP-4 and -5 levels in estrogen-dominant preovulatory follicles are likely due, in part, to increased protease activity, whereas lower levels of IGFBP-2 are not due to increased proteolysis. (bioone.org)

Beginning after completion of hair morphogenesis (postnatal day 14 in the mouse), hair growth cycles commence with catagen, an involution process of the hair follicle during which the majority of its epithelial compartments undergo apoptosis [ 1 ]. (aging-us.com)
2001), and pressured activation of -catenin signaling promotes locks follicle destiny in both embryonic and postnatal pores and skin (Gat et al. (bio-cavagnou.info)

In addition to these basic aspects, our work is also medically relevant since 80% of cancers have an epithelial origin and deregulation of the mechanisms controlling their growth or their morphogenesis are involved in tumor development. (igred.fr)
Indeed, loss of epithelial cell polarity is associated with tumor development and metastasis. (rupress.org)

Eiger is related to a protein called TNF that has been implicated in cycles of destruction and renewal of hair follicles in mice. (elifesciences.org)
ESP is the earliest known protein to be recognized as a marker for the specification of the equatorial segment, and it allows this region to be traced through all phases of acrosomal biogenesis. (bioone.org)

In particular, epithelial cell polarity is critical for the development, remodeling, and maintenance of epithelial structure. (rupress.org)
Early-life inflammation primes a T helper 2 cell-fibroblast niche in skin. (ucsf.edu)

2011 indicated that TTK69 interacts with known pathways (chitin rate of metabolism septate junction polarity proteins) corroborating earlier observations. (ecologicalsgardens.com)
Thus, Baz acts upstream of AJs during epithelial polarity establishment. (rupress.org)
Thus, although epithelial polarity develops in the absence of AJs, AJs play specific roles in maintaining epithelial architecture and segregating basolateral cues. (rupress.org)
AJs localize to the boundary between the apical and basolateral domains, and are thought to be critical landmarks for establishing epithelial polarity ( Nelson, 2003 ). (rupress.org)

It is therefore important to understand how our genes sculpt these organs into a specific form (morphogenesis) and with an appropriate size (growth). (igred.fr)
The clock genes that we identified as upregulated in telogen/early anagen were all CLOCK/BMAL1 target genes, including Pers, Dbp and Rev-Erbα. (aging-us.com)
While these genes show a clear circadian pattern of expression in skin, as was previously demonstrated [ 9 - 11 ], their amplitude was higher during telogen and early anagen (Figure 1 ), indicating that in skin, the expression of clock controlled genes is dependent both on circadian mechanism and the hair growth cycle. (aging-us.com)

At the same time, skin and hair follicles harbor a functional circadian clock that regulates gene expression with a periodicity of approximately twenty four hours. (aging-us.com)

Sensory circuits are typically established during early development, yet how circuit specificity and function are maintained during organismal growth has not been elucidated. (sdbonline.org)
The development of new tools and culture techniques has also enabled the factors that influence branching morphogenesis in the embryonic and pubertal gland to be identified. (biologists.com)
Mouse locks follicle development happens in a number of waves, with major (safeguard) locks follicle placodes showing up at around E14.5, and secondary (awl and zigzag locks) placodes forming between E16.5 and birth (Schmidt-Ullrich and Paus, 2005). (bio-cavagnou.info)
2006). Development of a normal, patterned selection of major hair follicles can be thought to take place with a reaction-diffusion system predicated on competition between placode marketing and placode-inhibitory morphogens (Jiang et al. (bio-cavagnou.info)

Along with the formation of the dental lamina, 10 round epithelial structures, each referred to as a bud, develop at the distal aspect of the dental lamina of each arch. (wikipedia.org)
A sign in the dermis is considered to start formation of a normal selection of epithelial thickenings, referred to as locks follicle placodes (Hardy, 1992). (bio-cavagnou.info)

The dental sac or follicle gives rise to three important entities: cementoblasts, osteoblasts, and fibroblasts. (wikipedia.org)

Recent studies showed that treatment of hair follicles by agonistic modulators induced entry into catagen with an anti-inflammatory mechanism 20 . (nature.com)

24,25 Current well-established treatment modalities focus on reducing the androgenic effects on hair follicles (5a-reductase inhibitors), stimulating hair growth (minoxidil), or transferring androgen-independent hair to the affected scalp (hair transplantation). (jcadonline.com)

Light microscopic immunofluorescent observations revealed that during acrosome biogenesis ESP first appears in the nascent acrosomal vesicle in early round spermatids and subsequently segregates to the periphery of the expanding acrosomal vesicle, thereby defining a peripheral equatorial segment compartment within flattened acrosomal vesicles and in the acrosomes of early and late cap phase, elongating, and mature spermatids. (bioone.org)
Based on these observations, we propose a new model of acrosome biogenesis in which the equatorial segment is defined as a discrete domain within the acrosomal vesicle as early as the Golgi phase of acrosome biogenesis. (bioone.org)

They found that removal of either the basal or coronal halves of the follicle prevented eruption. (hindawi.com)

hypothesized that NP pathogenesis involves epithelial rupture and necrosis, leading to protrusions from the lamina propria and epithelial repair. (molcells.org)

Some epithelial structures are retained, however. (rupress.org)

Accordingly, the mechanism of eruption depends on the correlation between space in the eruption course, created by the crown follicle, eruption pressure triggered by innervation in the apical root membrane, and the ability of the periodontal ligament to adapt to eruptive movements. (hindawi.com)

2002). TUBB3 Inefficient depletion of -catenin from embryonic epidermis also blocks first stages of locks follicle advancement 848591-90-2 (Huelsken et al. (bio-cavagnou.info)

Hair follicles undergo continuous cycles of growth, involution and rest. (aging-us.com)
In mice, the two initial hair growth cycles are synchronized such that the majority of hair follicles are in a similar stage of the hair growth cycle at a given time. (aging-us.com)
In order to systematically discover transcriptional activity associated with the hair growth cycle, we profiled mRNA expression at a genome-wide level over multiple time points corresponding to morphogenesis and two synchronized hair growth cycles. (aging-us.com)
The growing body of evidence now supports that a wide range of neuropeptides, neurotransmitters, and neurohormones modulating systemic stress responses can indeed alter hair growth, indicating that hair follicles represent an important target for stressors [ 8 ]. (biomedcentral.com)

2. Understand the morphogenetic mechanisms leading to elongation of ovarian follicles. (igred.fr)

Adherens junctions (AJs) play key roles in establishing and maintaining epithelial structure ( Nelson, 2003 ). (rupress.org)

Since our mRNA expression studies were performed using whole skin, we asked which compartments of the skin and hair follicles contribute to the robust rhythmic circadian gene expression in telogen. (aging-us.com)

Anatomy32

Organisms11

Diseases2

Chemicals and Drugs34

Analytical, Diagnostic and Therapeutic Techniques and Equipment13

Phenomena and Processes28

Disciplines and Occupations1

Information Science3

Mesenchymal9

Follicular4

Epithelium5

Drosophila4

Progenitor cells1

Cells20

Anagen phase3

Mammary2

Embryonic mouse1

Developmental3

Dermal5

Vertebrate1

Appendages1

Teeth2

Tissue3

Oocyte1

Tissues1

Regulation2

Ovary1

Tooth6

Pathway3

Bovine1

Postnatal2

Tumor development2

Protein2

Cell2

Polarity4

Genes3

Regulates1

Development4

Formation2

Dental sac1

Catagen1

Minoxidil1

Vesicle2

Basal1

Involves1

Structures1

Membrane1

Stages1

Growth4

Mechanisms1

Roles1

Gene expression1