Epithelial cells embryonic stem adult mammalian cells. Medical search. Frequent questions

Derivation of autologous induced pluripotent stem cells (iPSCs) through direct reprogramming of easily accessible somatic cells holds the potential to transform the field of regenerative medicine. (biomedcentral.com)
Here, we summarize current reprogramming methodologies with a focus on the production of transgene-free or genetically unmanipulated iPSCs and highlight important technical details that ultimately may influence the biological properties of pluripotent stem cells. (biomedcentral.com)
Although exciting results have been achieved by means of somatic cell nuclear transfer, cell fusion, and culture-induced reprogramming [ 1 ], these procedures are technically demanding and inefficient and therefore unlikely to become a common approach for producing patient-specific pluripotent cells. (biomedcentral.com)
In 2006, a major breakthrough was reported in Japan by Takahashi and Yamanaka, who described the generation of induced pluripotent stem cells (iPSCs) from mouse fibroblasts via over expression of defined transcription factors [ 2 ]. (biomedcentral.com)
A dedifferentiation program was suggested for inducing differentiated somatic cells to become pluripotent embryonic-like stem cells (Halley-Stott et al. (forgetmenotinitiative.org)
In vitro generation of human pluripotent stem cell derived lung organoids. (nature.com)
In addition, the authors also review future strategies in DN treatment such as transcriptional reprogramming of mature adult kidney cells into uncommitted induced pluripotent stem cells for renal repair and therapeutics. (emjreviews.com)
Growing evidence supports the contention that epithelial cancers including colorectal cancer, the incidence of which increases with aging, are diseases driven by the pluripotent, self-renewing cancer stem cells (CSCs). (biomedcentral.com)
Mouse somatic cells can be reprogrammed into induced pluripotent stem cells (iPSCs) by defined factors known to regulate pluripotency, including Oct4, Sox2, Klf4, and c-Myc. (biomedcentral.com)
RNA sequencing was measured to identify the differential expressed genes due to loss of Sirt6 in somatic and pluripotent cells. (biomedcentral.com)
Particularly, by performing transcriptome analysis, we observed that several pluripotent transcriptional factors increase in knockout cell line, which explains the underlying loss of pluripotency in Sirt6-null iPS-like cell line. (biomedcentral.com)
Differentiated somatic cells can be reprogrammed into a pluripotent-like state through four defined factors known to regulate pluripotency, including Oct4, Sox2, Klf4, and c-Myc (OSKM) [ 1 , 2 ]. (biomedcentral.com)
Since the discovery of induced pluripotent stem (iPS) cells, the molecular mechanism underlying the reprogramming process has been an active area of research. (biomedcentral.com)
We found that Sirt6 is highly expressed in pluripotent stem cells and also it regulates the efficiency of somatic reprogramming. (biomedcentral.com)
Human pluripotent stem cells, with their ability to proliferate indefinitely and to differentiate into virtually all cell types of the human body, provide a novel resource to study human development and to implement relevant disease models. (mdpi.com)
Here, we employed a human pancreatic differentiation platform complemented with an shRNA screen in human pluripotent stem cells (PSCs) to identify potential drivers of early endoderm and pancreatic development. (mdpi.com)
Later on, she developed a novel method to maintain self-renewal in 3D epithelial cultures of pluripotent stem cells. (cam.ac.uk)
Embryonic stem (ES) cells are derived from the embryo and are pluripotent, thus possessing the capability of developing into any organ, cell type or tissue type. (justia.com)
Whilst differentiation of some lineage specific stem cells can be induced with a degree of certainty, a differentiation outcome of a population of pluripotent stem cells is less predictable. (justia.com)
On the cover: Human induced pluripotent stem cell-derived neuroepithelial-like stem cells stained for actin (green) and DNA (blue). (5dok.org)

In addition, as the genetic identity of the donor egg from which the ESCs are derived most likely will differ from that of potential recipients, patients who receive ESC-derived cells or tissues may face the same complications that result from organ transplantation (for example, immunorejection, graft-versus-host disease, and need for immunosuppression). (biomedcentral.com)
Adult stem cell-based organoid technology is a versatile tool for the generation and long-term maintenance of near-native 3D epithelial tissues in vitro. (nature.com)
Here, we provide an overview of the protocols used by different groups to establish organoids from various epithelial tissues and cancers, plus the different protocols subsequently used to test the in vitro therapy sensitivity of these patient-derived organoids. (nature.com)
While many studies have demonstrated the importance of cTEC and mTEC during T-cell development, thymic stromal microenvironments also contain heterogenous non-epithelial stromal (NES) populations in a similar manner to that seen in peripheral lymphoid tissues. (frontiersin.org)
Mechanochemical Principles of Spatial and Temporal Patterns in Cells and Tissues. (mpi-cbg.de)
Patterns are ubiquitous in living systems and underlie the dynamic organization of cells, tissues, and embryos. (mpi-cbg.de)
He predicted that cancers occur upon activation of dormant embryonic-like cancerous cells present in mature tissues but not spontaneously [ 8 ]. (biomedcentral.com)
Single-cell RNA sequencing has been widely adopted to estimate the cellular composition of heterogeneous tissues and obtain transcriptional profiles of individual cells. (biomedcentral.com)
Solid tissues need to be dissociated to release individual cells suitable for 10x Genomics Chromium scRNA-seq. (biomedcentral.com)
Marta will combine studies in embryonic and adult tissues to identify common principles and key differences, with the aim of determining how epithelial features regulate stem cell identity, differentiation and plasticity. (cam.ac.uk)
Comparison of human mesenchymal stromal cells from four neonatal tissues: Amniotic membrane, chorionic membrane, placental decidua and umbilical cord. (sciendo.com)
Key areas of investigation are the identification and functional characterization of stem cell niches in developing tissues and adult organs. (ki.se)
Mammalian adult stem cells resemble the blastomeres of planktonic and benthic organisms with small eggs and may have evolved in mature organisms as an adaptation to the growth and maintenance of tissues via proliferation and the regulation of organ size via cell loss (e.g., terminal differentiation). (iospress.com)
Strategies for regenerative therapies in adult mammals, therefore, might be based on stimulating growth of adult stem cells or their surrogates in specific tissues rather than on introducing embryonic stem cells into adults. (iospress.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
The planarian ortholog Smed-Akt is molecularly conserved providing unique opportunities to analyze the function of Akt during cellular turnover and repair of adult tissues. (biomedcentral.com)
The reduced neoblast numbers largely affected the maintenance of adult tissues including the nervous and excretory systems and ciliated structures in the ventral epithelia, which impaired planarian locomotion. (biomedcentral.com)
The neoblasts are the only dividing cells in planarians and constantly proliferate to repair tissues and support systemic cellular turnover [ 21 ]. (biomedcentral.com)
Notch-1, Jagged-1, Jagged-2, and stem cell marker Nanog are expressed in SHED cultured in KGM which may be involved in the differentiation into epithelial-like cells in human dental pulp tissues. (bvsalud.org)
Stem cells from human exfoliated deciduous teeth (SHED) are multipotent stem cells derived from the pulp tissues of extracted deciduous teeth 1 . (bvsalud.org)
Notch signaling pathway is also involved in the regulation of epithelial cell differentiation in various tissues 5-6 . (bvsalud.org)

Mouse utricle sensory epithelial cellCderived progenitor cells (MUCs), which possess locks cell progenitor and mesenchymal features via epithelial-to-mesenchymal changeover (EMT) seeing that previously described, provide a potential strategy for locks cell regeneration via cell transplantation. (forgetmenotinitiative.org)
In the auditory system, we have generated mouse utricle sensory epithelial cellCderived progenitor cells (MUCs) via EMT (Zhang and Hu, 2012). (forgetmenotinitiative.org)
The retina has greater proliferative potential than the other two compartments by virtue of the presence of retinal progenitor cells (RPCs), which are capable of dividing repeatedly and generating retinal neurons and Müller glia on distinct developmental schedules. (molcells.org)
Despite significant advances in understanding nephron segment patterning, many questions remain about the underlying genes and signaling pathways that orchestrate renal progenitor cell fate choices and regulate differentiation. (mdpi.com)
Identification of multipotent luminal progenitor cells in human prostate organoid cultures. (nature.com)
Interestingly, Lin28B inhibits the processing of mature let7 miRNA, which functions to induce cell cycle exit in progenitor cells [ 2 ] . (encyclopedia.pub)
Studies using a zebrafish model further illustrate an important role of Lin28A in the recovery of progenitor cells. (encyclopedia.pub)
While adult lymphoid progenitor cells are produced by the bone marrow, their lineage commitment and development into mature T-cells is dependent on their migration into the thymus, where essential interactions with heterogeneous thymic stromal cells take place ( 1 ). (frontiersin.org)
Cortical epithelial cells (cTEC) support the earliest thymocyte progenitor populations, guiding them through the cortex, directing them to a T-cell lineage fate and ensuring their functional qualities as self-MHC restricted cells through the process of positive selection ( 2 ). (frontiersin.org)
The Notch signaling pathway provides important intercellular signaling mechanisms essential for cell fate specification and it regulates differentiation and proliferation of stem or progenitor cells by para-inducing effects 3-4 . (bvsalud.org)
1983) and the multipotent progenitor cells from fetal disease (Bjorklund and Lindvall, 2000). (lu.se)

Expression of AND-34 regulates epithelial cell growth pattern, motility, and growth factor dependence. (molvis.org)
The LMB looks forward to Marta's pursuit to understand how tissue architecture regulates stem cell identity at the molecular level - a fundamental question that involves multiple levels of biological organization. (cam.ac.uk)
My research is interested in how cell signalling regulates cell function in normal tissue, stem cells and tumours to gain insight into how cancer is initiated, grows and metastasises. (cardiff.ac.uk)
However, the mechanisms by which Akt signaling regulates stem cell behavior in the complexity of the whole body are poorly understood. (biomedcentral.com)
Thus, Akt signaling regulates neoblast biology and mediates in the distribution of injury-mediated cell death during tissue repair in planarians. (biomedcentral.com)
The protein kinase Akt also known as PKB, regulates multiple cellular functions including proliferation, survival, and growth during embryonic development and adult tissue homeostasis [ 1 - 5 ]. (biomedcentral.com)
This signaling pathway is a highly conserved cell-to-cell communication system that regulates cell fate in development and disease. (5dok.org)
Eph/ephrin signaling is a cell-to-cell communication pathway, which regulates cell migration and proliferation. (5dok.org)
In the process of tooth development, complex orchestration between genetic and epigenetic programs regulates the spatiotemporal expression of cell proliferation-, differentiation-, and migration-related genes, and finally tooth formation. (gjkqyxzz.cn)
2] Li Z, Yu M, Tian W. An inductive signalling network regulates mammalian tooth morphogenesis with implications for tooth regeneration[J]. Cell Prolif, 2013, 46(5):501-508. (gjkqyxzz.cn)

In latest years, regeneration of locks cells offers produced guaranteeing outcomes (Groves et al. (forgetmenotinitiative.org)
Consistent with this activity, functional analyses in mice suggest that Lin28B plays an important role in hair cell development and regeneration. (encyclopedia.pub)
In neonatal murine cochlear organoids and explants, Lin28B antagonizes the activity of let7 miRNA and increases Akt-mTORC1 signaling to promote hair cell regeneration from immature supporting cells by inducing their de-differentiation and proliferation as well as by directly converting them into hair cells [ 3 ] . (encyclopedia.pub)
Thus, Lin28B functions in hair cell regeneration through mitotic and non-mitotic mechanisms, which are dependent on mitotic division or trans-differentiation of supporting cells into hair cells, respectively. (encyclopedia.pub)
This suggests that coactivation of Lin28B and Follistatin may represent an endogenous mechanism mediating reprogramming of supporting cells for hair cell regeneration. (encyclopedia.pub)
Lin28A is required for hair cell regeneration in the mammalian cochlea, and may function in redundant processes with Lin28B [ 3 ] [ 5 ] . (encyclopedia.pub)
This review considers the genetic and epigenetic control of nephrogenesis, together with the epigenetic mechanisms that accompany kidney development and recent advances in induced reprogramming and kidney cell regeneration in the context of DN. (emjreviews.com)
The regeneration is maintained by adult stem cells. (biomedcentral.com)
To further understand the epigenetic regulators for specific lineage differentiation from iPS cell would have great significance for potential regeneration therapy and human disease modeling [ 8 ]. (biomedcentral.com)
My expertise is in the areas of regeneration, evolution, the nervous system and cell biology. (stanford.edu)
I use a marine colonial tunicate, Botryllus schlosseri, characterized by having robust regenerative capabilities and an assayable and frequent (weekly) CNS (Central nervous system) tissue regeneration and loss throughout adult life. (stanford.edu)
It is well-established that early embryonic signaling pathways are critical for growth and patterning of new tissue during regeneration. (frontiersin.org)
The regeneration of a tissue intuitively recapitulates aspects of its embryonic development. (frontiersin.org)
Methods of inducing differentiation in stem cells and muscle cells produced therefrom may be used for the study of cellular and molecular biology of tissue development, for the discovery of genes and proteins such as differentiation factors that play a role in tissue development and regeneration. (justia.com)
2020. Mesenchymal niche-derived neuregulin-1 drives intestinal stem cell proliferation and regeneration of damaged epithelium . (cardiff.ac.uk)
However, the growing interest in the development of innovative treatments that are aimed at the regeneration damaged tissue CNS is based on the latest research in the field of stem cells and neurology. (kiev.ua)
Thus, the introduction or mobilization of NSCs could be expected to lead to CNS regeneration by recapitulating normal CNS development, in terms of the activation of the endogenous regenerative capacity and cell transplantation therapy. (kiev.ua)
The stem cell and developmental biology program at CMB is engaged in a broad range of basic research aimed at understanding the molecular mechanisms underlying diverse aspects of embryonic development and tissue regeneration. (ki.se)
Planarians are flatworms with large populations of stem cells capable of dividing to support adult tissue renewal and regeneration. (biomedcentral.com)
Our results also reveal novel roles for Akt signaling during regeneration, specifically for the timely localization of cell death near the injury site. (biomedcentral.com)
This paucity is likely due to the ubiquitous nature of this signaling pathway and the difficulty of analyzing stem cells in their natural environment during physiological cell turnover and regeneration in conventional animal models [ 15 - 17 ]. (biomedcentral.com)
From embryonic development to tissue regeneration and disease progression, the human body is continuously subject to mechanical stresses. (5dok.org)
3] Jussila M, Thesleff I. Signaling networks regulating tooth organogenesis and regeneration, and the specification of dental mesenchymal and epithelial cell lineages[J]. Cold Spring Harb Perspect Biol, 2012, 4(4):a008425. (gjkqyxzz.cn)

Ideally, iPSC-based therapies in the future will rely on the isolation of skin fibroblasts or keratinocytes, their reprogramming into iPSCs, and the correction of the genetic defect followed by differentiation into the desired cell type and transplantation. (biomedcentral.com)
Mouse embryonic fibroblasts isolated from transgenic Oct4-GFP reporter mice with or without Sirt6 were used for reprogramming by Yamanaka factors. (biomedcentral.com)
2018). Development of bovine embryos in vitro in coculture with murine mesenchymal stem clls and embryonic fibroblasts. (sciendo.com)
Mutant embryonic fibroblasts fail to respond to insulin-like growth factor I (IGF) by the IGF-I-induced increase in cell number observed in wild-type cells. (aacrjournals.org)

OP9 feeder cell co-culture system was used to measure the hematopoietic differentiation from mouse ES and iPS cells. (biomedcentral.com)

In this study, we maintained mesenchymal-like MUCs in adherent cultures to test new methods that were able to guide MUCs to buy SB-649868 become a number of epithelial cells expressing epithelial genes such as in MUCs. (forgetmenotinitiative.org)
These results were confirmed by transcriptomic analyses that highlighted the specific genes involved in these cell death pathways. (stanford.edu)
Moreover, the presence of tubulovesicular structures in the brain medulla alongside the over-expression of prion disease genes in late cycle suggested a cell-to-cell, prion-like propagation recalling the conformational disorders typical of some human neurodegenerative diseases. (stanford.edu)
We found that neurons in the brain and cells of the vascular network both express multiple genes for voltage gated Na+ and Ca2+ ion channels homologous (based on sequence) to mammalian ion channel genes. (stanford.edu)
During differentiation the expression of stem cell specific genes and markers are often lost and cells acquire gene expression profiles of somatic cells or their precursors. (justia.com)
Generally, when a stem cell culture is induced to differentiate, the differentiated population is analysed for particular cell types by expression of genes, markers or phenotypic analysis. (justia.com)
Immunofluorescence, RT-PCR, and western blotting were used to measure expression changes of stem-related genes and activation of related signaling pathways. (biomedcentral.com)
BCLC9-miR122 cells down-regulate expression of MYC, KLF4, FOXM1, AKT2 and AKT3 genes and up-regulate FOXO1 and FOXO3A gene expression. (oncotarget.com)

His main research areas are developmental biology, cell morphogenesis, adult stem cells and cardiac function analysis. (amrita.edu)
Dr. Rajaguru Aradhya and Jagla, K., "Insulin-dependent Non-canonical Activation of Notch in Drosophila: A Story of Notch-Induced Muscle Stem Cell Proliferation", in Notch Signaling in Embryology and Cancer: Molecular Biology of Notch Signaling, vol. 1227, J. Reichrath and Reichrath, S., Eds. (amrita.edu)
Also covered in detail was the basic cell biology of EMT and its role in cancer and fibrosis, as well as the identification of new markers to facilitate the observation of EMT in vivo. (rupress.org)
Arguably, the most recognized and well-studied stromal populations in thymus biology are thymic epithelial cells (TEC) within the cortical and medullary areas, which are defined by their anatomical separation and function. (frontiersin.org)
The LMB is delighted to announce the appointment of two new group leaders to the LMB's Cell Biology Division: Kate McDole and Marta Shahbazi. (cam.ac.uk)
I also anticipate potential interactions with scientists working on stem cell biology, proteomics, polarity and membrane traffic," she added. (cam.ac.uk)
In this review we summarized the recent progress in study of basic stem cell biology, on the prospective identification of NSCs, the elucidation of the mechanisms of ontogenic changes, potential differentiation, and their therapeutic applications. (kiev.ua)
4 ] in 1951 cell culturing has become one of the most widely used methods with exceptional contribution to the advances in almost all fields of contemporary biology - cell biology, genetics, cell biochemistry, physiology etc. (intechopen.com)
CMB is comprised of more than 30 independent research groups organized in three themes: Cell Biology, Developmental and Stem Cell Biology and Infection and Cancer. (ki.se)
The central aim of the research within the Cell Biology theme is to gain a deeper understanding of the biology of the eukaryotic cell. (ki.se)
Thus the theme encloses expertise within bioinformatics, biophysics, biochemistry, molecular cell biology and genetics. (ki.se)
Basic genetic and molecular biology methodologies are combined with complementary bioinformatic and genome-wide approaches, allowing investigation global molecular changes in cells in various differentiation processes. (ki.se)

In early experiments, physical separation of mesenchymal and epithelial stroma from embryonic murine thymus resulted in defective thymus development when epithelium was cultured in vitro in the absence of mesenchyme ( 7 ). (frontiersin.org)
These findings were confirmed in later studies in which removal of mesenchyme from embryonic day 12 murine thymic lobes impaired thymus growth in vitro ( 8 ). (frontiersin.org)
Among these is the isolation of the first line of murine stem cells [ 5 , 6 ] in 1981, followed by establishment of the first human embryonic stem cell lines by Thompson [ 7 ]. (intechopen.com)

Embryonic origin of gustatory cranial sensory neurons. (shengsci.com)
Gustatory neurons innervate taste buds and project centrally to the rostral nucleus of the solitary tract (NTS), whereas neurons providing general epithelial innervati. (shengsci.com)

These studies have served to highlight the role of AND-34/BCAR3 and p130Cas in cell adhesion and migration signaling pathways. (molvis.org)
It is relatively well documented that transcription factors and signaling pathways are critically involved in the formation of inner ear structures and in the development of hair cells. (encyclopedia.pub)
However, the molecular pathways that lead to specification and terminal differentiation of specific cell types, such as myocytes, from embryonic stem cells during development are not entirely clear. (justia.com)
Likewise, strategies for the containment of cancer might be based on promoting normal pathways of cell loss, the basal mode for handling excess cells. (iospress.com)

Three main epithelial cell lineages comprise a crypt: the columnar cells or colonocytes, the mucin-secreting cells or goblet cells, and the enteroendocrine cells. (biomedcentral.com)
Under normal circumstances, turnover of epithelial cell lineages occurs constantly in every 2-7 days but this process become faster during tissue repair and wound healing [ 5 ]. (biomedcentral.com)
According to unitarian theory, proposed in 70s, all four cell lineages within the gastrointestinal epithelium are clonal populations derived from a slowly cycling clonogenic stem cells (SC) [ 6 ]. (biomedcentral.com)
The process of differentiation in stem cells involves selective development of immature cells to committed and fully mature cells of various lineages. (justia.com)
SHED has the ability to be differentiated to specific cell lineages such as odontoblasts and osteoblasts as well as epithelial like cells. (bvsalud.org)
This preferential B cell tropism for the meninges and the formation of meningeal ectopic lymphoid tissue was partially dependent on the expression of the transcription factor Bcl6 in Th17 cells that is required in other T cell lineages to induce isotype class switching in B cells. (bvsalud.org)

It is expressed in ESCs, embryonic germ (EG) cells and embryonic carcinoma (EC) cells and essential for early embryonic development [ 14 , 15 ]. (biomedcentral.com)

To circumvent these obstacles, considerable effort has been invested in attempting to derive ESC-like cells by reprogramming somatic cells to an embryonic state. (biomedcentral.com)
Several experimental strategies have been developed to derive iPSCs from differentiated somatic cells (summarized in Figure 1 ). (biomedcentral.com)

Remarkably, these mesenchymal-like MUCs expressed prosensory cell markers, which indicated that MUCs were prosensory-like hair cell progenitors that may be able to differentiate into new hair cells. (forgetmenotinitiative.org)
Prosensory cells are hair cell progenitors because they differentiate into hair and supporting cells during development (Kelley, 2006). (forgetmenotinitiative.org)
In particular, the induction of stem cells to differentiate into muscle cells (myocytes) is useful for muscle transplantation and therapeutic purposes, as well as providing potential human disease models in culture (e.g. for testing pharmaceuticals). (justia.com)
However, one of the bottlenecks in the stem cell therapy is that stem cells tend to differentiate into other types of cells during culture in vitro. (biomedcentral.com)
SHED was able to differentiate into epithelial like cells when cultured in keratinocyte growth medium (KGM) 2 . (bvsalud.org)

BMP-7 is also important in homeostasis of the adult kidney by inhibiting ephithelial-mesenchymal transition (EMT). (wikipedia.org)
Besides the well-known role of miR122 in favoring hepatitis C virus replication in hepatocytes [ 4 ], its function in the normal adult liver is related to cholesterol and lipid homeostasis [ 5 ]. (oncotarget.com)

Functional vascular smooth muscle-like cells derived from adult mouse uterine mesothelial cells. (ox.ac.uk)
In mammalian visceral organs, vascular smooth muscle cells (VSMCs) originate from an epithelial-to-mesenchymal transition (EMT) of embryonic mesothelial cells (MCs). (ox.ac.uk)
check the tag ADOLESCENCE HN - 2008 BX - Nutrition in Adolescence FX - Adolescent Nutrition Physiology MH - Peritoneal Stomata UI - D054048 MN - A01.047.025.600.700 MN - A10.810 MS - Natural openings in the subdiaphragmatic lymphatic plexus in the PERITONEUM, delimited by adjacent mesothelial cells. (bvsalud.org)

The embryos of larger arthropods and deuterostomes with well-provisioned eggs or viviparity, on the other hand, exhibit regulative development, while their larval "set-aside" or adult stem cells function in the growth, maintenance, and regulation of organ size coupled to constrained proliferation and cell turnover. (iospress.com)
Functional disruption of Smed-Akt alters the balance between cell proliferation and cell death leading to systemic impairment of adult tissue renewal. (biomedcentral.com)

Dr. Aradhya aims to understand molecular aspects regulating the development of mesodermal derivatives both in Drosophila and mammalian counterparts. (amrita.edu)
The role of BMP7 in mammalian kidney development is through induction of MET of the metanephrogenic blastema. (wikipedia.org)
Moreover, BMP7 is eventually partially "turned off" in embryonic development in order to create the dorsal parts of the organism. (wikipedia.org)
The conversion of an epithelial cell to a mesenchymal cell is critical to metazoan embryogenesis and a defining structural feature of organ development. (rupress.org)
The EMT International Association was formed in 2002 to provide an international body for those interested in EMT and the reverse process, mesenchymal-epithelial transition, and, most importantly, to bring together those working on EMT in development, cancer, fibrosis, and pathology. (rupress.org)
Kretzschmar, K. & Clevers, H. Organoids: modeling development and the stem cell niche in a dish. (nature.com)
Accumulating evidence highlights emerging functions of RBPs in the post-transcriptional regulation of inner ear development and hair cell function. (encyclopedia.pub)
The thymus supports T-cell development via specialized microenvironments that ensure a diverse, functional and self-tolerant T-cell population. (frontiersin.org)
Extensive research on thymic epithelial cells (TEC) within the cortex and medulla has defined their essential roles during T-cell development. (frontiersin.org)
However, experimental evidence suggests these cells are important for thymus function by either directly influencing T-cell development, or by indirectly regulating TEC development and/or function. (frontiersin.org)
Broadly separated into mesenchymal and endothelial cells, NES have been implicated in thymus organogenesis, thymocyte development, tolerance induction and development/maintenance of epithelial stroma. (frontiersin.org)
Morphogenesis in the embryo requires coordinated cell behaviour, which is stimulated by cues from the cells' environment that are generated as a result of patterning processes in early development. (silverchair.com)
We are studying function, development, and aging of the adult nervous system in the colonial tunicate Botryllus schlosseri. (stanford.edu)
The LMB looks forwards to the next phase of Kate's research to advance the field of mammalian development by using new approaches to address long standing questions. (cam.ac.uk)
Marta's overarching aim is to understand the molecular mechanisms that govern cell identity - the development of specialised cells during embryogenesis, and plasticity - the ability of adult tissue-specific stem cells to switch to new identities, both in the physiological three-dimensional context of the tissue. (cam.ac.uk)
Normal CNS development is initiated by the induction of stem cells in the CNS, i.e., neural stem cells (NSCs). (kiev.ua)
A defined synthetic mixture of amino acids, salts, carbohydrates, vitamins and serum was shown to support cells in vitro[ 3 ], thus unifying a major variable in cell culturing experiments and providing a possibility for rapid development of this novel method. (intechopen.com)
Neuronal determination during embryonic development of the grasshopper nervous system. (shengsci.com)
Mystification may have been introduced historically with the concepts of determinate and regulative development, but, hopefully, the muddle can be resolved by tracing the evolution of stem cells in Metazoa. (iospress.com)
To assess the role of an individual HDAC isoenzyme in physiology and tumor development, HDAC2-mutant mice were generated from a gene trap embryonic stem cell clone. (aacrjournals.org)
We propose an opportunity to target the cancer cell/microenvironment interface instead of the Notch pathway itself in the development of cancer therapies. (5dok.org)
2005). Finally, negative revealed that SSEA4 is detectable in the early neuroepi- selection strategies have been also developed as an alter- thelium, and its expression decreases as development native method to enrich for NSCs from both adult proceeds. (lu.se)

Thus, we show for the first time that UtMCs could recapitulate in vitro differentiative events of early cardiovascular differentiation and transdifferentiate in cells exhibiting molecular and functional characteristics of VSMCs. (ox.ac.uk)
Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis. (nature.com)
The induction of a specific differentiated cell type can be useful for transplantation or drug screening and drug discovery in vitro. (justia.com)
However, the limited amount of stem cells and their tendency to undergo spontaneous differentiation upon extended propagation in vitro restrict their practical application. (biomedcentral.com)
In addition, we found that in the presence of LIF, MDLS could replace feeder cells to maintain the undifferentiated state of OG2-mES cells (Oct4-GFP reporter gene mouse embryonic stem cell line), and the MDLS-expanded OG2-mES cells showed an elevated expression levels of pluripotency markers in vitro. (biomedcentral.com)
Therefore, finding a way to effectively maintain the pluripotency of stem cells cultured in vitro is important for the application of stem cells. (biomedcentral.com)
Using biologically relevant elastic substrates to study cell function in vitro has proven beneficial, as the in vivo microenvironment usually is much softer than rigid plastic dishes. (5dok.org)
Although other irritants in the smoke may have contributed to the incident, there is supporting evidence that stable strontium can stimulate the release of histamine from mast cells in vitro (ATSDR 2001e). (cdc.gov)

J Cell Biol (2006) 172 (7): 973-981. (rupress.org)
Nat Rev Mol Cell Biol , Art. (mpi-cbg.de)
A summarization of DNA methyaltion modification research [J]. Chin J Cell Biol, 2010, 32(2):189-192. (gjkqyxzz.cn)

Current interest in this process, which is described as an epithelial-mesenchymal transition (EMT), stems from its developmental importance and its involvement in several adult pathologies. (rupress.org)
This article provides an overview of the general structures and signalling mechanisms, and of typical developmental functions along with cell biological principles. (silverchair.com)
Knowledge on the expression analysis of Notch signaling pathway molecules in SHED cultured in KGM could highlight its involvement in controlling the biological activity of these stem cells, particularly during odontogenesis and other developmental process. (bvsalud.org)

In addition, Lin28B functions to enhance the regenerative competence of maturing supporting cells in the cochlea through cooperation with Follistatin, which inhibits Lin28B-induced TGF-ß signaling that can trigger proliferative quiescence [ 5 ] . (encyclopedia.pub)
Stem cells have been extensively explored for a variety of regenerative medical applications and they play an important role in clinical treatment of many diseases. (biomedcentral.com)
This organism is well known for its stem cell-based regenerative capability. (biomedcentral.com)

The key interests lie within the field of genome integrity and variation, cell division, regulation of gene expression, protein turnover and signal transduction. (ki.se)
Nonetheless, there is limited understanding of how Akt signaling controls the response of stem cells during cellular turnover and tissue injury in the complexity of the whole organism. (biomedcentral.com)

LIN28 (LIN28A and LIN28B) proteins are highly conserved small cytoplasmic RNA-binding proteins (RBPs) that function as pluripotency factors, regulating the transition from self-renewal to a differentiated cell fate [ 1 ] . (encyclopedia.pub)
Furthermore, we showed that Sirt6-null iPS-like cell line has intrinsically a differentiation defect even though the establishment of normal self-renewal. (biomedcentral.com)
This research aims at characterizing molecules and signals involved in controlling the undifferentiated state and self-renewal capacity of stem cells, and to develop methods to direct the differentiation of stem cells into clinically relevant cell types. (ki.se)
Octamer-binding transcription factor-4 (Oct4), a transcription factor belongs to the POU transcription factor family Class V, is fundamental for maintaining self-renewal ability and pluripotency of stem cells. (biomedcentral.com)
Colony formation assay, sphere-forming ability assay, alkaline phosphatase (AP) activity assay and teratoma-formation assay were used to assess the role of modaline sulfate (MDLS) in promoting self-renewal and reinforcing pluripotency of P19 cells. (biomedcentral.com)
Moreover, MDLS significantly promoted the self-renewal capacity of P19 cells. (biomedcentral.com)
These findings demonstrated, for the first time, that MDLS could maintain self-renewal and pluripotency of stem cells. (biomedcentral.com)
We used conjugated polymers to develop a novel neural stem cell culture substrate with anchored growth factors to promote cell self-renewal. (5dok.org)

I use a multidisciplinary methodology that integrates advanced single cell RNAseq, imaging, multi-parameter flow cytometric isolation of cellular populations and transplantation assays to elucidate the cellular and genetic changes associated with neuronal degeneration process in young and old colonies. (stanford.edu)
Here, we characterized neuronal death in B. schlosseri, a marine colonial tunicate that shares substantial genomic homology with mammals and has a life history in which controlled neurodegeneration happens simultaneously in the brains of adult zooids during a cyclical phase named takeover. (stanford.edu)
Using an ultrastructural and transcriptomic approach, we described neuronal death forms in adult zooids before and during the takeover phase while comparing adult zooids in takeover with their buds where brains are refining their structure. (stanford.edu)

Morrison, S. J. & Spradling, A. C. Stem cells and niches: mechanisms that promote stem cell maintenance throughout life. (nature.com)
This simplified approach towards understanding the essence of the mechanisms, underlying the processes determining life and death of a cell has undoubtedly provided scientists with enormous amount of knowledge. (intechopen.com)
Through detailed characterization of fundamental molecular mechanisms of normal and perturbed cells, the theme strives to unravel information that increases the understanding of various diseases such as cancer and neurodegenerative, cardiovascular and inflammatory disorders. (ki.se)
Cancer stem cells, instrumental in metastasis, would seem to ignore mechanisms normally functioning in the removal of excess cells. (iospress.com)
While much is known about biochemical signaling, many of the mechanisms that drive cell outcome in response to biophysical influences remain to be uncovered. (5dok.org)
B cell differentiation and the subsequent release of class-switched immunoglobulins have been speculated to occur in the meninges, but the exact cellular composition and underlying mechanisms of meningeal-dominated inflammation remain unknown. (bvsalud.org)

The epithelial-menenchymal transition is also problematic in cancer metastasis, so the diminution of EMT with recombinant DNA could have great implications in future cancer treatment options. (wikipedia.org)
2007). Such a dedifferentiation program occurs in mammalian pancreatic epithelial cell cultures, in which pancreatic cells dedifferentiate into mesenchymal-like cells that are able to re-enter the cell cycle, probably via epithelial-to-mesenchymal transition (EMT) (Gallo et al. (forgetmenotinitiative.org)

Here, we compare gene expression and cellular composition of single-cell suspensions prepared from adult mouse kidney using two tissue dissociation protocols. (biomedcentral.com)
Single-cell RNA sequencing (scRNA-seq) is an increasingly powerful technology that enables analysis of gene expression in individual cells. (biomedcentral.com)
H. Kwon, T. Enomoto, M. Shimogawara, K. Yasuda, Y. Nakajima and Y. Ohmiya, Bioluminescence imaging of dual gene expression at the single-cell level. (atto.co.jp)
Epigenetic modifications play pivotal roles in organogenesis by controlling gene expression during cell fate determination and reprogramming. (gjkqyxzz.cn)
7] Orphanides G, Reinberg D. A unified theory of gene expression[J]. Cell, 2002, 108(4):439-451. (gjkqyxzz.cn)
SOD3 represses the laminin α5 gene (LAMA5), but LAMA5 expression is not changed in SOD1-overexpressing cells. (bvsalud.org)
SOD3 inhibited the phosphorylation and degradation of IκBα (nuclear factor of the kappa light polypeptide gene enhancer in B-cells inhibitor alpha), an NF-κB inhibitor. (bvsalud.org)

Eventually this restores the healthy epithelial cell population, and normal function of the kidneys in mice. (wikipedia.org)
It was discovered that mice injected with BMP7 increased their production of "good" brown fat cells, while keeping their levels of the normal white fat cells constant. (wikipedia.org)
Tudor-related proteins TDRD1/MTR-1, TDRD6 and TDRD7/TRAP: domain composition, intracellular localization, and function in male germ cells in mice. (shengsci.com)
In mice, nuage that is prominent in postnatal male germ cells is also called intermitochondrial cement or chromatoid bodies. (shengsci.com)
The stage-specific embryonic antigen 4 (SSEA4) is com- isolate the NSCs from neonatal mice and rats (Campos monly used as a cell surface marker to identify the pluri- et al. (lu.se)
Immunohisto- have been used for positive selection of NSCs from em- chemistry on human embryonic central nervous system bryonic mice (Nagato et al. (lu.se)

As ErbB-family ligands and receptors are highly expressed within the stem-cell niche 7 , we hypothesize that strong endogenous regulators must control the pathway in the stem-cell compartment. (nature.com)
In addition, the entire vascular network undergoes slow rhythmic contractions that appear to arise from processes endogenous to vascular epithelial cells. (stanford.edu)

In this review, we cover how the non-epithelial compartment of thymic stroma represent essential cell populations in regulating thymus function. (frontiersin.org)
It also reveals cell types more abundant either in the cold or warm dissociations that may represent populations that require gentler or harsher conditions to be released intact. (biomedcentral.com)
Using a combination of cutting-edge live-imaging, biochemical techniques, computational methods, genetics and biophysics, Kate's group will study how forces shape such complex three-dimensional structures out of simple cell populations. (cam.ac.uk)
Current knowledge of cellular behavior is mainly acquired by studies concerning homogenous populations of cells cultured as monolayers. (intechopen.com)
Whole-amount staining is a powerful technique for macrophage characterization within the 3D environment of the adipose tissue, enabling the visualization of different macrophage populations and their interaction with other cells within their in vivo niche. (bvsalud.org)

A potential alternative treatment, adoptive transfer of mature T cells (ATMTC) through bone marrow transplantation has emerged as a successful therapy for 22q11.2DS. (medscape.com)

Prior to the PhD he also worked in the laboratory of Dr. Maneesha Inamdar, JNCASR, India, where he worked on the characterization of pericardial cells in Drosophila Melanogaster. (amrita.edu)
Equine mesenchymal stem cells from bonemarrow, adipose tissue and umbilical cord:immunophenotypic characterization anddifferentiation potential. (sciendo.com)

At the LMB, Kate will focus on defining the sequence of events and physical forces required for one of the earliest symmetry-breaking events in mammalian organogenesis, the formation of the foregut. (cam.ac.uk)

Like other members of the bone morphogenetic protein family of proteins, it plays a key role in the transformation of mesenchymal cells into bone and cartilage. (wikipedia.org)
At the crypt base, in the vicinity of basal lamina, stem cells are surrounded by mesenchymal cells that are of myofibroblast lineage. (biomedcentral.com)
Intra-articular injection of expanded autologous bone marrow mesenchymal cells in moderate and severe knee osteoarthritis is safe: a phase I/II study. (sciendo.com)

The present invention also provides methods of using the differentiated cells of the present invention for therapeutic purposes. (justia.com)
The induction of cardiomyocyte differentiation in stem cells is especially useful in developing therapeutic methods and products for heart disease and abnormal heart conditions. (justia.com)

Western blot analysis and in situ hybridization confirmed the presence of AND-34 RNA and protein in lens epithelial cells, particularly at the lens equator. (molvis.org)
These pericryptal myofibroblasts produce the Wnt signalling ligands which bind to Frizzled receptors as well as morphogenetic protein (BMP) antagonists gremlin 1(GREM1), gremlin 2 (GREM2) on basal epithelial stem cells and also can modulate notch signaling. (biomedcentral.com)
It has been reported that Sirtuin 6 (Sirt6), a member of the sirtuin family of NAD + -dependent protein deacetylases, is involved in embryonic stem cell differentiation. (biomedcentral.com)
In addition, miR122 transfected cells decreased AKT2 kinase activation while decreased FOXO1 and FOXO3A protein inactivation. (oncotarget.com)

Multiple approaches for optimal sample dissociation and storage of single cells have been proposed as have single-nuclei profiling methods. (biomedcentral.com)
The present invention relates to methods of inducing differentiation of stem cells. (justia.com)
In particular, the invention relates to methods of inducing differentiation of embryonic stem cells into muscle cells or vascular endothelial cells. (justia.com)
The invention also includes cells, cell lines, testing models and culture systems used in the methods of the present invention and differentiated cells produced therefrom. (justia.com)
Therefore there remains a need for providing effective methods of inducing differentiation of stem cells into specific cell types, such as myocytes or endothelial cells. (justia.com)

Making a tooth: growth factors, transcription factors, and stem cells [J]. Cell Res, 2005, 15(5):301-316. (gjkqyxzz.cn)

In both processes, rapid proliferation gives rise to new tissue, cell fate has to be specified within that tissue, and distinct positional identities have to be established to generate a properly patterned structure. (frontiersin.org)
Mammalian embryonic stem cells would seem adapted to rapid proliferation, functioning in part to enclose yolk or to acquire access to maternal resources. (iospress.com)

Keratin 5-Cre-driven excision of nonmuscle myosin IIA in early embryo trophectoderm leads to placenta defects and embryonic lethality. (shengsci.com)
The smaller AB-cell of the 2-cell embryo of Tubifex divides 40 min later than the larger CD-cell. (shengsci.com)

However, it remains unknown whether adult MCs-derived SM-like cells may acquire specific vascular SM lineage markers and the functionality of differentiated contractile VSMCs. (ox.ac.uk)
miR122 is the prevalent miRNA in adult healthy liver and it is responsible for liver stem cell differentiation towards hepatocyte lineage. (oncotarget.com)

While Akt Ser 473 phosphorylation was readily detectable in AND-34 +/+ lens epithelial cells, it was markedly reduced in the AND-34 −/− lens epithelium. (molvis.org)
The adult mammalian intestinal epithelium is unique for its rapidly self renewing property. (biomedcentral.com)

culturing a stem cell in the presence of an embryonic cell and/or extracellular medium of an embryonic cell, under conditions that induce differentiation of the stem cell. (justia.com)
Cells sense and respond to the mechanics of their substrate - be it the extracellular matrix, neighboring cells or artificial matrix in cell culture. (5dok.org)
Extracellular superoxide dismutase (SOD3) induces laminin α4 expression in tumor blood vessels, which is associated with enhanced intratumor T cell infiltration in primary human cancers. (bvsalud.org)

Trans interactions of Eph receptors with ephrins at cell-cell interfaces promote a variety of cellular responses, including repulsion, attraction and migration. (silverchair.com)
The cellular products of embryonic stem cells routinely come under global influences and give rise to the cells of germ layers and organ rudiments. (iospress.com)
In mammals, Akt is ubiquitously expressed and is associated with regulation of cellular proliferation, metabolism, cell growth and cell death. (biomedcentral.com)
The most pronounced cellular and transcriptional differences between these compartments was the localization of B cells exhibiting a follicular phenotype exclusively to the meninges. (bvsalud.org)

The growth of individual tissue compartments is mainly related to the proliferation of the cells that comprise that compartment, whereas intercellular communication mediated by various morphogens and growth factors is responsible for coordination of growth between neighboring tissue compartments. (molcells.org)
We thus identify the induction of a B cell-supporting meningeal microenvironment by Bcl6 in Th17 cells as a mechanism controlling compartment specificity in neuroinflammation. (bvsalud.org)

The ability of adult MCs to recapitulate EMT and to acquire smooth muscle (SM) markers upon provasculogenic culture suggested they might retain embryonic vasculogenic differentiation potential. (ox.ac.uk)
Furthermore, MDLS could promote teratoma formation and enhanced differentiation potential of P19 cells in vivo. (biomedcentral.com)

Replacing dying or diseased kidney cells with new nephrons is an attractive strategy. (emjreviews.com)

Immunoselected STRO-3+ mesenchymal precursor cells reduce inflammation and improve clinical outcomes in a large animal model of monoarthritis. (sciendo.com)

They can regulate stem cell functions by modulating effects of Wnt signalling on ephrin B1 (EFNB1) and its receptors EPHB2, EPHB3 in the stem cells [ 4 ]. (biomedcentral.com)

The production of a diverse αβ-T-cell pool is vital to establishing and maintaining a functional adaptive immune system. (frontiersin.org)
Stem cells are undifferentiated cells which can give rise to a succession of mature functional cells. (justia.com)

A function of Bcl6 in Th17 cells was only detected in vivo and was reflected by the induction of B cell-supporting cytokines, the appearance of follicular B cells in the meninges, and of immunoglobulin class switching in the cerebrospinal fluid. (bvsalud.org)

We sought to establish the effects of the loss of AND-34 expression in a mammalian organism. (molvis.org)

Significantly, there are additional non-epithelial stromal cells (NES) that exist alongside TEC within thymic microenvironments, including multiple subsets of mesenchymal and endothelial cells. (frontiersin.org)
2017). MMP-2 and MMP-14 Silencing Inhibits VEGFR2 Cleavage and Induces the Differentiation of Porcine Adipose-Derived Mesenchymal Stem Cells to Endothelial Cells. (sciendo.com)
We show now that SOD3 overexpression in neoplastic and endothelial cells (ECs) reduces laminin α5 in tumor blood vessels. (bvsalud.org)

HYPOTHESIS: Do LRIG Proteins Regulate Stem Cell Quiescence by Promoting BMP Signaling? (nature.com)
The precise mechanism by which Lin28B and let7 miRNA regulate mTORC1 activity in cochlear epithelial cells awaits further investigation. (encyclopedia.pub)
Placing the cells under conditions which induce specific cell types has been one form of an attempt to regulate the differentiation outcome. (justia.com)

Central nervous system (CNS) of adult mammalian and, in particular of people, is a typical example of organs that are not restored. (kiev.ua)
Although the prognosis for 22q11.2DS varies widely, depending largely on the nature and degree of involvement of different organs, many adults live long and productive lives. (medscape.com)

These microenvironments are classically defined as distinct cortex and medulla regions that each contain specialized subsets of stromal cells. (frontiersin.org)
Use of a chronic model of articular cartilage and meniscal injury for the assessment of long-term effects after autologous mesenchymal stromal cell treatment in Steep. (sciendo.com)
Osteogenic proliferation and differentiation of canine bone marrow and adipose tissue derived mesenchymal stromal cells and the influence of hypoxia. (sciendo.com)

The mammalian telencephalon, which comprises the cerebral cortex, olfactory bulb, hippocampus, basal ganglia (striatum and globus pallidum), and amygdala, is a highly complex and evolutionarily advanced brain structure. (intechopen.com)

It has been demonstrated that BMP7 treatment is sufficient to induce all of the genetic markers of osteoblast differentiation in many cell types. (wikipedia.org)
We found that adult mouse utricle sensory epithelial cells underwent EMT to become MUCs that were able to propagate in adherent cultures, express mesenchymal markers, and lose the expression of epithelial markers. (forgetmenotinitiative.org)
In suspension cultures, we found that MUCs formed spherical structures buy SB-649868 and started to express epithelial markers and bundle-like structures, which indicates that MUCs may possess the potential to become epithelial hair-like cells. (forgetmenotinitiative.org)
CD133+), but are rarely codetected with the neural stem dents, very few human-specific NSC markers have been cell (NSC) marker CD15. (lu.se)
2000). In *Correspondence to: Perrine Barraud, Department of Veterinary Medi- contrast, several cell surface markers have been used to cine, Neurosciences, Madingley Road, Cambridge CB3 OES, United enrich for NSCs in the rodent CNS. (lu.se)

Cell 173 , 515-528 (2018). (nature.com)

Their larval and adult cells have narrow potencies, sometimes coupled to virtually unlimited … proliferation, and function in the growth, maintenance and regulation of body size. (iospress.com)
Up to 70% of hepatocellular carcinomas (HCC) show miR122 down-regulation [ 6 ] and the same applies for HCC-derived cell lines [ 7 ]. (oncotarget.com)
Here we have investigated biophysical regulation of cell function. (5dok.org)

Shi and Advantage 2013), and locks cell progenitors possess been determined in the adult mammalian utricle and cochlea (Li et al. (forgetmenotinitiative.org)
In the cochlea of mouse embryos, it is highly expressed in prosensory cells and down-regulated at the onset of hair cell differentiation. (encyclopedia.pub)

Relevantly, UtMCs-derived VSM-like cells could generate "mechanical force" to compact collagen lattices and displayed in diverse degree voltage (K(+)) and receptor (endothelin-1, oxytocin, norepinephrine, carbachol and vasopressin)-induced [Ca(2+)](i) rises and contraction. (ox.ac.uk)
Eph and ephrin proteins interact with a number of other ligand/receptor systems to influence how cells translate environmental signals to orchestrate morphogenetic events. (silverchair.com)

This study defined the role of Smed-Akt in abnormal cell proliferation triggered by the abrogation of the phosphatase PTEN, an upstream component of the Akt signaling pathway, which is highly mutated in human cancers. (biomedcentral.com)
Aim: To detect the expression of molecules associated with Notch signaling pathway in stem cells from human exfoliated deciduous teeth (SHED) cultured in specific differentiation medium, namely, keratinocyte growth medium (KGM). (bvsalud.org)
RNA was reverse-transcribed to obtain the cDNA and then proceeded with PCR using specific primers for the Notch signaling pathway molecules (Notch1, Jagged-1, Jagged-2 and, Hes1) as well as stem cell marker (Nanog). (bvsalud.org)
Since the Notch signaling pathway molecules play an important role in differentiation of epithelial cells, it is important to identify the presence of notch signaling molecules in SHED during the process of cell differentiation. (bvsalud.org)

Anatomy74

Organisms18

Diseases4

Chemicals and Drugs59

Analytical, Diagnostic and Therapeutic Techniques and Equipment37

Phenomena and Processes65

Disciplines and Occupations4

Information Science3

Pluripotent20

Tissues21

Progenitor11

Regulates10

Regeneration23

Fibroblasts4

Hematopoietic1

Genes8

Biology12

Murine3

Neurons2

Pathways4

Lineages6

Early embryonic1

Somatic cells2

Differentiate5

Homeostasis2

Mesothelial cells3

Proliferation and cell2

Development22

Vitro8

Biol3

Developmental3

Regenerative3

Turnover2

Self-renewal8

Neuronal3

Mechanisms6

Transition2

Gene7

Mice6

Endogenous2

Populations5

Transplantation1

Characterization2

Organogenesis1

Mesenchymal cells3

Therapeutic2

Protein4

Methods5

Transcription factors1

Rapid proliferation2

Embryo2

Lineage2

Epithelium2

Extracellular3

Cellular4

Compartment2

Differentiation potential2

Kidney1

Precursor cells1

Receptors1

Functional2

Induction1

Organism1

Endothelial3

Regulate3

Organs2

Stromal3

Basal1

Markers5

20181

Regulation3

Cochlea2

Receptor2

Pathway4