Epithelial cells different phases cell cycle. Medical search. Frequent questions

Methotrexate may inhibit rapid proliferation of epithelial cells in skin. (medscape.com)
Here, we have investigated the role of ChoK in the development of breast cancer and found that ChoK is both necessary and sufficient for growth factor-induced proliferation in primary human mammary epithelial cells and an absolute requirement for the specific mitogenic response to heregulin in breast tumor-derived cells. (aacrjournals.org)
These results demonstrate that ChoK plays an essential role in both normal human mammary epithelial cell proliferation and breast tumor progression. (aacrjournals.org)
An aberrant miRNA expression could contribute to cancer development and progression [ 6 , 7 ] and could affect their target genes that are involved in many biological processes, such as cell differentiation, proliferation, apoptosis, metabolism, and development [ 8 ]. (hindawi.com)
Comparing HESC controls with HESCs deficient in SRC-3, gene enrichment analysis of the differentially expressed gene set revealed an overrepresentation of genes involved in chromatin remodeling, cell proliferation/motility, and programmed cell death. (frontiersin.org)
miRNA-149 was underexpressed in gastric cancer tissues and cells, while overexpression of miRNA-149 promoted cell apoptosis, retarded cell cycle, and inhibited proliferation and migration in AGS and MKN28 cells. (hindawi.com)
It possesses a unique forkhead domain combined with a fragment of the target gene to initiate transcription [ 10 ] and regulates various biological processes such as tumor cell differentiation, cell proliferation, and migration [ 11 ]. (hindawi.com)
Proliferation, survival, and epithelial-mesenchymal transition (EMT) are three fundamental events that are deeply linked to carcinogenesis. (edu.iq)
We hypothesized that FXR and FMD may inhibit proliferation and the metastatic phenotype in PC-3 prostate cancer cells. (edu.iq)
Results showed that the ADSC-CM increased the proliferation of the dermal papilla cells (DPCs) and the HaCaT cells. (dermatologytimes.com)
By modulating the cell cycle and activating the anagen phase in the hair cycle, the application of the ADSCs appear to promote hair growth by increasing the proliferation of the dermal papilla cells and possibly the HaCaT epithelial cells. (dermatologytimes.com)
We noticed less of an influence of the ADSCs on the proliferation of HaCaT cells and organ culture, with relatively narrow therapeutic concentrations of ADSC-CM,' Dr. Kim says. (dermatologytimes.com)
Negative growth regulation generally occurs during the G0/G1 phase of the cell cycle, yet the redundancy and complexity among components of this regulatory network have made it difficult to discern how negative growth cues protect cells from aberrant proliferation. (uwo.ca)
To investigate the effects of silibinin on the growth of oral cancer cells, cell proliferation and anchorage-independent colony formation tests were conducted on YD10B and Ca9-22 oral cancer cells. (jcancer.org)
Silibinin effectively suppressed YD10B and Ca9-22 cell proliferation and colony formation in a dose-dependent manner. (jcancer.org)
The ovarian-derived sex steroids estrogen and progesterone have been found to influence cell proliferation, differentiation and functionality of the oviduct. (refine.bio)
Overexpression of Notch1 can also supress proliferation in breast epithelial cells depending on dosage and cell type. (iyte.edu.tr)
It was recently identified that IRF6 is a mediator of Notch in proliferation and transformation of breast epithelial cells. (iyte.edu.tr)
In conclusion, our previous observation was supported that IRF6 is a mediator of Notch in cell proliferation. (iyte.edu.tr)
JNK/SAPKs are stress activated MAPK kinases that play an essential role in several processes known to be important for successful completion of the initiation phase such as cellular proliferation, mesenchymal to epithelial transition and cell cycle regulation. (ncl.ac.uk)
Inhibition of JNK/SAPK signalling results in reduced cell proliferation, disruption of mesenchymal to epithelial transition and loss of the pluripotent phenotype, which either singly or in combination prevent establishment of pluripotent colonies. (ncl.ac.uk)
Downregulation of CDCA5 Can Inhibit Cell Proliferation, Migration, and Invasion, and Induce Apoptosis of Prostate Cancer Cells. (nih.gov)
This study showed ginseng protects folliculogenesis via alteration of hypothalamic- pituitary-gonadal (HPG) axis, induction of proliferation in ovarian somatic cells, reduction of lipid peroxidation, and downregulation of apoptotic markers in the mouse ovary, treated with nicotine. (biomedcentral.com)

Androgen deprivation therapy induces apoptosis or cell cycle arrest in prostate cancer (PCa) cells. (oncotarget.com)
Using constructs downregulating or overexpressing MCL1 we demonstrate that expression of MCL1 prevents induction of apoptosis when PCa cells are grown under steroid-deprived conditions. (oncotarget.com)
The BH3-mimetic Obatoclax induces apoptosis and decreases MCL1 expression in androgen-sensitive PCa cells, while castration-resistant PCa cells are less sensitive and react with an upregulation of MCL1 expression. (oncotarget.com)
Flow cytometry was used to examine apoptosis, cell cycle distribution, and accumulation of reactive oxygen species (ROS). (jcancer.org)
Moreover, it induced cell cycle arrest in the G0/G1 phase, apoptosis, and ROS generation in these cells. (jcancer.org)
Silibinin considerably reduced the development of oral cancer cells by inducing apoptosis, G 0 /G 1 arrest, ROS generation, and activation of the JNK/c-Jun pathway. (jcancer.org)
Beginning after completion of hair morphogenesis (postnatal day 14 in the mouse), hair growth cycles commence with catagen, an involution process of the hair follicle during which the majority of its epithelial compartments undergo apoptosis [ 1 ]. (aging-us.com)
In this study, it was aimed to identify whether IRF6 has any effect on cell cycle regulation, apoptosis and breast cancer stem cell population (BCSCs) under Notch and whether IRF6 has a role in expression of luminal and basal markers in breast cell lines. (iyte.edu.tr)
Furthermore, these data showed that IRF6 has a novel role on early apoptosis and stem cell population independent of Notch signaling. (iyte.edu.tr)
During the catagen phase, which is a transitional phase, the hair follicles shrink, and the HFSCs begin to undergo apoptosis or programmed cell death. (stemaidinstitute.com)
Resveratrol could play a toxic role through inducing apoptosis of the cancer cell in a time- and concentration-dependent manner. (mdpi.com)
Loss of cell division cycle‑associated 5 promotes cell apoptosis by activating DNA damage response in clear cell renal cell carcinoma. (nih.gov)
Silencing oncogene cell division cycle associated 5 induces apoptosis and G1 phase arrest of non-small cell lung cancer cells via p53-p21 signaling pathway. (nih.gov)

mmc9.pdf (66K) GUID:?55F9BD4F-0F85-40B3-99F0-75E20D3D96BC Supplemental Physique?S10 Silencing p21 reversed cell cycle G2/M arrest of TGF-1Ctreated proximal tubular epithelial cells. (holyexperiment.org)
In addition, Plk1 also prevented partial epithelial-mesenchymal transition (pEMT) of tubular epithelial cells via autophagy pathway. (nature.com)
In this study, we explored the role of Plk1 in the classical kidney fibrosis model, UUO, and cultured fibroblast and renal tubular epithelial cells by using specific Plk1 inhibitors, genetic silencing, and heterozygous global knockout mice. (nature.com)

Regulation of attachment of equine spermatozoa to homologous oviduct epithelium was investigated by co-culture of spermatozoa with oviductal epithelial cell explants. (tamu.edu)
The objective of this study was to investigate steroidal regulation of oviductal epithelial cell function by using the Bovine Gene 1.0 ST array (Affymetrix Inc., CA) for transcriptional profiling. (refine.bio)

Here, we show that epithelial cells sense local cell density through mechanosensitive E-cadherin adhesions to control G2/M cell-cycle progression. (ibecbarcelona.eu)
A novel UCS cell line (PF338) was established from the malignant pleural effusion of a 59-year-old patient at time of disease progression. (por-journal.com)
Importantly, UCS is the prototype tumor for epithelial-mesenchymal transition (EMT), a reversible biological process that associates with tumor progression and metastasis and in which epithelial cells transform into more invasive mesenchymal cells by losing their epithelial properties [ 10 - 12 ]. (por-journal.com)
Transforming growth factor (3(TGF-P) is a crucial mediator of mammary epithelial morphogenesis and can negatively regulate cell cycle progression. (uwo.ca)
In different systems, cyclic adenosine monophosphate (cAMP) either blocks or promotes cell cycle progression in mid to late G1 phase. (ac.be)
Dog thyroid epithelial cells in primary culture constitute a model of positive control of DNA synthesis initiation and G0-S prereplicative phase progression by cAMP as a second messenger for thyrotropin (TSH). (ac.be)
This study examined the involvement of D-type G1 cyclins and their associated cyclin-dependent kinase (cdk4) in the cAMP-dependent G1 phase progression of dog thyroid cells. (ac.be)
This effect correlated with G1 and S phase progression. (ac.be)
Interestingly, a large fraction of the genome, more than six thousand genes, exhibits changes in expression that correlates with the progression of the hair growth cycle, thus underscoring the complexity of this process [ 4 , 5 ]. (aging-us.com)
A checkpoint is one of several points in the eukaryotic cell cycle at which the progression of a cell to the next stage in the cycle can be halted until conditions are favorable. (openstax.org)
Some studies showed that blocking cell cycle progression ameliorated fibrosis. (nature.com)
Using gene manifestation profiling, practical siRNA library testing and reverse-phase protein arrays (RPPA), we buy Dihydrotanshinone I found that J2 cells and Y produced a cooperative effect on human being foreskin keratinocytes (HFKs), which resulted in suppression of TGF- signaling juxtaposed with up-regulation of changes in cell cycle progression, cell adhesion and motility. (cell-metabolism.com)

The differentiation of these cells is necessary for this virus to complete its life cycle. (wikipedia.org)
and cell differentiation ( SOX2 and TGFB3 ) as well as immunohistochemical assay for VEGFA, TP53, Bcl2, TGFB1, and Ki67 protein expression have been performed in 85 FFPE RCC tumor specimens. (hindawi.com)
It is involved in p53 pathways and is implicated in cell death/survival signaling, the cell cycle, and differentiation, thereby playing a regulatory role in carcinogenesis [ 12 ]. (hindawi.com)
Our data suggest that HDAC inhibition is effective in a novel UCS cell line by interfering with both viability and differentiation. (por-journal.com)
The anagen phase is the growth phase where hair follicles actively grow and is fueled by the division and differentiation of HFSCs into various cell types, including epithelial cells and dermal papilla cells. (stemaidinstitute.com)
We are analyzing the physiological role of several genes implicated in different aspects of stem cell activation, self-renewal, and differentiation. (ad-astra.ro)

These data support the existence of a spermatozoal reservoir in the oviductal isthmus of the mare and suggest that there may be cycle stage-specific regulation of both motility and the number of spermatozoa attached to oviductal epithelium. (tamu.edu)
At the cellular level, FXR activation resulted in down-regulation of procaspase -3, vimentin, and MMP9, which triggers apoptotic cell death, cell cycle arrest, and switch from mesenchymal to an epithelial phenotype. (edu.iq)
Regulation of MCL1 through the AR signaling axis is indirectly mediated via a cell cycle-dependent mechanism. (oncotarget.com)
In our recent study we found that circadian clock genes play a role in regulation of the hair growth cycle during synchronized hair follicle cycling, uncovering an unexpected connection between these two timing systems within skin. (aging-us.com)
Our general focus is on stem cell fate choice by epigenetic regulation, transcription regulation via specific developmental transcription factors, and chromatin modifying factors. (ad-astra.ro)
and regulation of cell cycle process. (nih.gov)

We investigated the role of CAL-101 (GS-1101, Idelalisib) TGF-1 in inducing profibrotic signaling from epithelial cells to activate pericyte-myofibroblast transition. (holyexperiment.org)
Lamouille S, Xu J, Derynck R. Molecular mechanisms of epithelial-mesenchymal transition. (edu.iq)
This morphology can be attributed to epithelial-mesenchymal transition (EMT) that often associates with tumor invasion and metastasis. (por-journal.com)
Strikingly, histone deacetylase (HDAC) inhibition markedly reduced cell viability by inducing a dose-dependent G0/1 arrest and led to mesenchymal-epithelial transition as evidenced by morphological change and increased E-cadherin and β-catenin expression. (por-journal.com)
Furthermore, silibinin inhibited the migration and invasion abilities of YD10B and Ca9-22 cells by regulating the expression of proteins involved in the epithelial-mesenchymal transition. (jcancer.org)
One of the surprises that came from this study was the finding that genes regulated by the core circadian clock mechanism showed expression changes that correlated with the hair growth cycle, with highest expression during the telogen-anagen transition. (aging-us.com)
Myofibroblast activation and partial epithelial-mesenchymal transition (pEMT) are the key steps of fibrosis that synthesize and deposit extracellular matrix and progressively destroy kidney structure [ 3 , 4 ]. (nature.com)

B: Silencing p21 reversed cell cycle G2/M arrest of TGF-1Ctreated PTECs. (holyexperiment.org)
In addition, epithelial cell cycle G2/M arrest and production of profibrotic cytokines were both attenuated. (holyexperiment.org)
Moreover, our study showed that INT 747 either alone or combined with FMD robustly induced cell cycle arrest at the S phase. (edu.iq)
In a cell cycle analysis, ADSC-CM shortened G1 arrest and prolonged the synthesis and mitosis phases in the dermal papilla cells. (dermatologytimes.com)
IRF6 overexpression induces cell cycle arrest in breast cancer cells showing a tumor suppressor role. (iyte.edu.tr)

Both estrophilic ligand and estrophilic platinum complex produced strong estrogenic effects as well as features characteristic of the uterine epithelial cell in the luteal phase of the cycle, corresponding to a massive stimulation of the surface and glandular epithelial cells. (uni-regensburg.de)
It not only disrupts the luteal phase by inhibiting progesterone secretion [ 8 ], but also causes morphological changes in the endometrium and epithelium of the fallopian tubules, and reduces the number of glands and mucosal folds [ 5 ]. (biomedcentral.com)
Progesterone is produced in the luteal phase of the cycle. (medscape.com)
Due to the effect of progesterone, a peak (transient) of mitotic activity occurs in the luteal phase but falls to its nadir in the follicular phase. (medscape.com)

Based on the findings of single-cell RNA sequencing (scRNA-seq), viral RNA has been detected within macrophages in lung tissue and bronchoalveolar lavage (BAL) fluid from COVID-19 patients. (news-medical.net)
In UCS, several studies identified characteristic EMT-related expression signatures including active TGF-β signaling in tissue and cell lines [ 7 , 11 , 13 , 14 ]. (por-journal.com)
Adipose tissue-derived stem cells display multi-lineage developmental plasticity, very much like bone marrow-derived mesenchymal stromal cells (BM-MSCs), and can differentiate into several cell lines, including adipocytes, chondrocytes and osteoblasts, as well as endothelial and neural lineages. (dermatologytimes.com)
Analysis of MCL1 protein and mRNA expression in PCa tissue and primary cell culture specimens of luminal and basal origin, respectively, reveals higher expression in cancerous tissue compared to benign origin. (oncotarget.com)
The lower extreme is penetrated by the Dermal Papilla an upward protrusion of connective tissue which produces microscopic cells of several kinds from which the hair is formed and developed by cellular elongation and keratinisation. (hairscientists.org)
The epidermis is a simple, unstratified epithelial tissue. (collembola.org)
Hair follicle stem cells reside in their niche in a quiescent state, but become rapidly activated in response to homeostatic and injury signals to regenerate the tissue. (ad-astra.ro)
These conditionally reprogrammed epithelial cells indicated markers of adult stem cells, but not of embryonic and induced pluripotent stem cells, and appeared to consist of cell populations resembling their main tissue of source, making them ideal to study tissue regeneration, as well as normal physiologic and pathologic processes [8]. (cell-metabolism.com)
Recent news of an impending clinical cell transplantation trial in Parkinson's disease using parthenogenetic stem cells as a source of donor tissue have raised hopes in the patient community and sparked discussion in the research community. (lu.se)

The papillomavirus life cycle begins with cells actively multiplying in epithelial cells of basal and parabasal layers. (wikipedia.org)
Moreover, clonogenicity of primary basal PCa cells is efficiently inhibited by Obatoclax. (oncotarget.com)

Some SARS-CoV-2 variants, such as Omicron, also infect the host cell through the endocytic pathway. (news-medical.net)
In UCS, TP53 has been identified as the most frequently mutated gene, followed by mutations in the PI3K pathway, KRAS , cell cycle regulators including FBXW7 and chromatin remodeling and histone genes including ARID1A [ 7 - 9 ]. (por-journal.com)
Western blotting revealed that silibinin downregulated SOD1 and SOD2 and triggered the JNK/c-Jun pathway in oral cancer cells. (jcancer.org)
In the current study we show that stably transfected cells adapted to chronic ER stress imposed by constitutive expression of SP-Cdeltaexon4 via an NF-kB-dependent pathway. (refine.bio)
In view of this we postulated that manipulation of this pathway would have significant impacts on reprogramming of human fibroblasts to induced pluripotent stem cells. (ncl.ac.uk)
Accordingly, we found that key components of the JNK/SAPK signalling pathway increase expression as early as day 3 of the reprogramming process and continue to rise in reprogrammed cells throughout the initiation and maturation stages. (ncl.ac.uk)
Our major project is to investige a pathway that controls the polarity of epithelial cells within the plane of the epithelium. (stanford.edu)

qRT-PCR was used to detect the expression of miRNA-149 and FOXC1 in gastric cancer tissues and cells. (hindawi.com)
The LMU team analyzed the motions of two types of hair-like cell protrusions made up of proteinaceous filaments-the so-called flagella found on the unicellular green alga Chlamydomonas reinhardtii and the primary cilium found on many epithelial tissues in multicellular organisms. (genengnews.com)
Furthermore, ADSCs are known to have various cytokine-secreting properties and beneficial paracrine effects on surrounding cells or tissues through secretion of multiple angiogenic and antiapoptotic growth factors, including vascular endothelial growth factor (VEGF), hepatocyte growth factor (HGF), basic fibroblast growth factor (bFGF) and platelet-derived growth factor (PDGF). (dermatologytimes.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
In each case, PCP is critical to the function of these cells and tissues, and errors in the signaling system controlling PCP lead to human diseases and developmental defects, including congenital deafness, neural tube closure defects and cardiac outflow tract anomalies. (stanford.edu)
The focus of my laboratory is the understanding of basic mechanisms that regulate the fate of stem cells within tissues. (ad-astra.ro)

although it is derived from cells of the renal tubular epithelium, it has several histological subtypes which differ in their clinical outcome and biological features. (hindawi.com)
In entomology the cell layer of the body wall is commonly called the "hypodermis", but the term epidermis is preferable inasmuch as the integumental epithelium is the homologue of the ectodermal layer of the skin so designated in vertebrate anatomy, though either term is illogical when applied to invertebrates having no accompanying "dermis" (Snodgrass, 1935). (collembola.org)

Beta-hCG and alpha-fetoprotein have proved to be useful markers for ovarian germ cell tumors. (medscape.com)
Young HA, Mills PK, Riordan DG, Cress RD. Triazine herbicides and epithelial ovarian cancer risk in Central California. (who.int)

During the anagen phase, anagen hair follicles stem cells divide and differentiate into various cell types, including epithelial cells and dermal papilla cells. (stemaidinstitute.com)
The dermal papilla cells secrete various signaling molecules, such as growth factors and hormones, which stimulate the hair matrix cells to proliferate and produce hair fibers. (stemaidinstitute.com)

Thus, macrophages not only inhibit viral dissemination but can sense infected cells and infectious viral particles to subsequently elicit antiviral and proinflammatory programs. (news-medical.net)
A lack of HGH can inhibit cell division, resulting in dwarfism, whereas too much HGH can result in gigantism. (openstax.org)
Crowding of cells can also inhibit cell division. (openstax.org)

In bronchial biopsies from 21 normal subjects, 11 subjects with chronic bronchitis, 9 subjects with mild asthma, and 31 subjects with severe asthma, we evaluated epithelial cell morphology: epithelial thickness, lamina reticularis (LR) thickness, and epithelial desquamation. (atsjournals.org)

In order to systematically discover transcriptional activity associated with the hair growth cycle, we profiled mRNA expression at a genome-wide level over multiple time points corresponding to morphogenesis and two synchronized hair growth cycles. (aging-us.com)

Thus, targeting fibroblast cell activation and pEMT are critical strategies for attenuating fibrosis. (nature.com)
Co-culture of human being main epithelial cells with irradiated 3T3 fibroblast feeder cells (J2 cells) and the Rho kinase inhibitor Y-27632 (Y) allows for the unrestricted growth of cells of epithelial source by the process termed conditional reprogramming. (cell-metabolism.com)
When keratinocytes Rabbit Polyclonal to CSTL1 are co-cultured with irradiated 3T3 fibroblast feeder cells (J2 cells) and growth factors [1, 4, 5], they undergo continuous replication over many decades resulting in their immortalization. (cell-metabolism.com)

We show here that, like SRC-2, SRC-3 is expressed in the epithelial and stromal cellular compartments of the human endometrium during the proliferative and secretory phase of the menstrual cycle as well as in cultured HESCs. (frontiersin.org)

We previously demonstrated the critical involvement of SRC-2 in murine embryo implantation as well as in human endometrial stromal cell (HESC) decidualization, a cellular transformation process required for trophoblast invasion and ultimately placentation. (frontiersin.org)
These molecular findings are supported at the cellular level by the inability of HESCs to morphologically transform from a stromal fibroblastoid cell to an epithelioid decidual cell when endogenous SRC-3 levels are markedly reduced. (frontiersin.org)
Using PCa cellular models in vitro and in vivo we show that MCL1 expression is upregulated in androgen-deprived PCa cells. (oncotarget.com)
Polarization is a fundamental cellular property that plays a vital role in various biological processes in multi-cellular as well as single-cell organisms. (elifesciences.org)

Although the endometrium has an overall low risk of COVID-19 infection, due to the low expression of ACE 2 and transmembrane protease serine protease-2 (TMPRSS2), but the expression of these host receptors increase at specific stages of the menstrual cycle and varies based on the woman's age and endometrial susceptibility to the infection [ 19 ]. (biomedcentral.com)

Other results showed that the ADSC-CM induced the anagen phase and promoted hair growth in the experimental mice. (dermatologytimes.com)
this growth phase is referred to as anagen [ 2 ]. (aging-us.com)
While these genes show a clear circadian pattern of expression in skin, as was previously demonstrated [ 9 - 11 ], their amplitude was higher during telogen and early anagen (Figure 1 ), indicating that in skin, the expression of clock controlled genes is dependent both on circadian mechanism and the hair growth cycle. (aging-us.com)
Hairs in the anagen phase may grow faster during the early years. (hairscientists.org)
The follicle remains quiescent in its shortened state and awakens to regenerate with the onset of the new Anagen phase. (hairscientists.org)
Whereas hairs may be shed at any stage of the cycle, the majority of shedding occurs during the 'new' Anagen phase. (hairscientists.org)
anagen stage (growth phase), catagen (transitional phase), and telogen (resting phase). (stemaidinstitute.com)
Once the hair reaches the end of the anagen phase, it enters the catagen phase, during which the hair stops growing and the hair follicle shrinks. (stemaidinstitute.com)
They are responsible for the continuous renewal and regeneration of hair follicles during the hair growth cycle, which consists of three stages: anagen (growth phase), catagen (transitional phase), and telogen (resting phase). (stemaidinstitute.com)

Airway epithelial and LR thickness was greater in subjects with severe asthma compared with those with mild asthma, normal subjects, and diseased control subjects (p = 0.009 and 0.033, respectively). (atsjournals.org)
There was a greater level of apoptotic activity in the airway biopsy in subjects with severe asthma as compared with the normal subjects using the TUNEL assay (p = 0.002), suggesting increased cell death. (atsjournals.org)
During the process of airway inflammation, complex interactions of innate and adaptive immune cells as well as structural cells and their cytokines have many important roles. (cdc.gov)
Interleukin (IL)-9-producing subset called Th9 cell, Th22 cells which primarily secrete IL-22, IL-13 and tumor necrosis factor- and Th25 cells via producing IL-25 are believed to be important for initiating allergic reactions and developing airway inflammation. (cdc.gov)

They have developed a method that can differentiate between the active motions characteristic of living cells and those driven by the random molecular movements that give rise to passive diffusion. (genengnews.com)
Development requires that cells differentiate to acquire the necessary complement of cell fates, and that they adopt the structure required to carry out their functions. (stanford.edu)

Cell adhesion The 96-well plates were coated with 2 mg/ml HA (50 μL/well). (pdesignal.com)

These stem cells are an integral part of the epithelial stem cell niche. (stemaidinstitute.com)
Are Stem Cell-Based Therapies for Parkinson's Disease Ready for the Clinic in 2016? (lu.se)
Based on discussions held by a global collaborative initiative on translation of stem cell therapy in Parkinson's disease, we have identified a set of key questions that we believe should be addressed ahead of every clinical stem cell-based transplantation trial in this disorder. (lu.se)
In this article, we first provide a short history of cell therapy in Parkinson's disease and briefly describe the current state-of-art regarding human stem cell-derived dopamine neurons for use in any patient trial. (lu.se)
With this background information as a foundation, we then discuss each of the key questions in relation to the upcoming therapeutic trial and critically assess if the time is ripe for clinical translation of parthenogenetic stem cell technology in Parkinson's disease. (lu.se)
Stem cell-based therapies for Parkinson's dis- ogy company International Stem Cell Corporation ease (PD) are rapidly moving towards clinical trials. (lu.se)
A second press release [2] has indicated stem cell source, resulting in widespread excitement that the program is planning to move forward very rapidly, with all of the patients being enrolled in the Correspondence to: Roger A. Barker, John van Geest Centre first quarter of 2016 and interim results being shared for Brain Repair, Department of Clinical Neurosciences, Univer- in October 2016. (lu.se)

Whatever the source of the message, the cell receives the signal, and a series of events within the cell allows it to proceed into interphase. (openstax.org)

Co-immunoprecipitation The protein was extracted from cells before and after transfection with the method described in Western Blot section. (pdesignal.com)

Nature Reviews Molecular Cell Biology. (edu.iq)
hence a better understanding of this phase and how this is regulated may provide the molecular cues for improving the reprogramming process. (ncl.ac.uk)
Together these data provide new evidence for an indispensable role for JNK/SAPK signalling to overcome the well-established molecular barriers in human somatic cell induced reprogramming. (ncl.ac.uk)
The primary goal of my work on PCP has been to elucidate, at molecular and cell biological levels, the nature of the signals that induce subcellular asymmetry, and how cells then respond to this molecular asymmetry to orient their cytoskeletons. (stanford.edu)
Because of the availability of remarkably powerful genetic, molecular and cell biological tools, we use the fruitfly, Drosophila melanogaster, as our primary model for investigating the fundamental mechanisms of PCP signaling. (stanford.edu)
American Journal of Respiratory Cell and Molecular Biology. (lu.se)

Due to its key role in the eukaryotic cell cycles, Plk1 has been one of the most validated drug targets for cancer treatment. (nature.com)

Telogen: the resting phase of the follicle which lasts for approximately four months. (hairscientists.org)
Finally, the hair enters the telogen phase, during which it rests for a few months before falling out and the hair growth cycle starts again. (stemaidinstitute.com)
In the telogen phase, which is a resting phase, the club hair remains in the follicle while a new hair begins to form. (stemaidinstitute.com)

For the change from the luteal back to the follicular phase, progesterone decreases gonadotrophin-releasing hormone (GnRH) pulse frequency to suppress gonadotropin release and reset the hypothalamic-pituitary-gonadal axis. (medscape.com)

The common pathological feature of CKD is the loss of tubular cells and progressive interstitial fibrosis. (nature.com)

Analyses of the cell viability, cell cycle, migration, and matrigel invasion assays were performed to elucidate how INT 747 and /or FMD functions in prostate cancer. (edu.iq)
Viability assays and cell cycle analyses were used to test in vitro sensitivity to different standard and novel treatments. (por-journal.com)
The effects of silibinin on the migration and invasion of oral cancer cells were evaluated using transwell assays. (jcancer.org)
Furthermore, because of the antigenic and genetic diversity of "Norwalk-like viruses"* (NLVs) and the inability to cultivate these viruses in cell lines, developing assays to detect the full spectrum of NLVs associated with outbreaks of gastroenteritis was not possible. (cdc.gov)

The hair follicle stem cells (HFSCs) present in the hair follicle play a vital role in hair growth and regeneration. (stemaidinstitute.com)
We are currently studying skin and hair follicle stem cells using cell culture and the mouse as model systems. (ad-astra.ro)

Yu J, Yang K, Zheng J, Zhao W, Sun X. Synergistic tumor inhibition of colon cancer cells by nitazoxanide and obeticholic acid, a farnesoid X receptor ligand. (edu.iq)
PF338 tumor cells were resistant to MEK- and TGF-β signaling-inhibition but sensitive to PIK3CA- and PARP-inhibition and first-line chemotherapeutics. (por-journal.com)
Both the initiation and inhibition of cell division are triggered by events external to the cell when it is about to begin the replication process. (openstax.org)

Here, we reconstructed Par-dependent polarity using non-polarized Drosophila S2 cells expressing all three components endogenously in the cytoplasm. (elifesciences.org)
Thus, this reconstruction system provides an experimental paradigm to study features of the assembly process and structure of Par-dependent cell-autonomous polarity. (elifesciences.org)
We used Drosophila Schneider cells (S2 cells) of mesodermal origin, as host cells for cell-autonomous reconstruction of cell polarity ( Schneider, 1972 ). (elifesciences.org)

Renal cell carcinoma (RCC) accounts for approximately 3% of human malignancies, and its incidence appears to be increasing globally [ 1 ]. (hindawi.com)
In contrast to epithelial cells, human macrophages manifest an abortive replication cycle for many viruses, such as rhinovirus and seasonal influenza A viruses. (news-medical.net)
Since human monocyte-derived macrophages (HMDMs) do not express ACE2, these cells were used as in vitro models for ACE2-negative macrophages. (news-medical.net)
Human gastric cancer cell lines AGS and MKN28 were cultured and transfected with miR-149 overexpression plasmid and its control or FOXC1 siRNA and its control. (hindawi.com)
The human gastric epithelial permanent cell line (GES-1), human gastric cancer cell lines (AGS, BGC-823, MKN45, and SGC-7901), and HEK293 cells were provided by the Biomedical Experiment Center of Xi'an Jiaotong University. (hindawi.com)
To investigate genotoxicity of NDMW and HTMW compared to PMW we used two human lung epithelial cell types, an immortalized BEAS-2B and primary SAEC. (cdc.gov)
In humans, the frequency of cell turnover ranges from a few hours in early embryonic development, to an average of two to five days for epithelial cells, and to an entire human lifetime spent in G 0 by specialized cells, such as cortical neurons or cardiac muscle cells. (openstax.org)
In rapidly dividing human cells with a 24-hour cell cycle, the G 1 phase lasts approximately nine hours, the S phase lasts 10 hours, the G 2 phase lasts about four and one-half hours, and the M phase lasts approximately one-half hour. (openstax.org)
An event may be as simple as the death of a nearby cell or as sweeping as the release of growth-promoting hormones, such as human growth hormone (HGH). (openstax.org)
Materials and Methods Cells Human being keratinocytes were cultured from discarded and de-identified neonatal foreskin cells. (cell-metabolism.com)
Without this, the patient cells lost in PD could be replaced by grafted community is left trying to interpret complex scien- immature human dopaminergic neurons [3, 5]. (lu.se)

These cells are readily triggered to divide following epithelial wounding due to the consequent increase in intercellular forces and resulting degradation of Wee1. (ibecbarcelona.eu)

Hair follicles undergo continuous cycles of growth, involution and rest. (aging-us.com)
The hair shaft is currently believed to be a dead structure composed of cells which undergo keratinisation after leaving the dermal papilla. (hairscientists.org)
We propose a phase IIb, randomized, double-blind placebo-controlled trial of MAG-EPA supplementation for 130 men who will undergo radical prostatectomy as treatment for a prostate cancer of Gleason score ≥ 7 in an academic cancer center in Quebec City. (biomedcentral.com)

Cell spreading The 2 mg/mL HA-coated 35-mm culture dishes were placed at 37°C for 1 h, and then blocked by 1% bovine serum albumin (BSA) for 1 h. (pdesignal.com)

Its biology and transmission cycle have been reviewed elsewhere ( 1 , 2 ) and are therefore only briefly introduced. (cdc.gov)

Catagen: the preliminary stage of the retrogressive catagen phase. (hairscientists.org)

Our overall goals were to increase our understanding of known epithelial cell processes critical for fertility, and to identify novel genes and biochemical processes for future analysis. (refine.bio)
Cell polarization involving the Par-complex in situ is linked to various other processes. (elifesciences.org)
Because of such association between Par-dependent polarization and other processes, the Par-complex exhibits different behavioral characteristics in an individual context, making it difficult to determine general features of the dynamic process taking place during cell polarization by the Par-complex. (elifesciences.org)

Renal cell carcinoma (RCC) incidence has increased over the past two decades. (hindawi.com)

In this study, INT 747 treatment caused apoptotic morphological changes and significantly reduced the survival of PC-3 cells incubated in normal mediums. (edu.iq)

We also found that SRC-3 depletion in cultured HESCs results in a significant attenuation in the induction of a wide-range of established biomarkers of decidualization, despite exposure of these cells to a deciduogenic stimulus and normal progesterone receptor expression. (frontiersin.org)
The abrupt decline in progesterone toward the end of the cycle causes the onset of menstruation. (medscape.com)
However, continued exposure to progesterone causes decrease in the growth of the epithelial cells. (medscape.com)
Progesterone serum levels increase from approximately 25 ng/mL during the midluteal phase to 150 ng/mL at the end of pregnancy. (medscape.com)

Generally, after SARS-CoV-2 infects the epithelial cells of the respiratory tract, antiviral and proinflammatory cytokines are released. (news-medical.net)
T helper (Th) 2 cells, which recruit and accumulate in the lungs and produce a range of different effector cytokines. (cdc.gov)
However, more recent studies have revealed the potential collaboration of other helper T cells and their cytokines in this process. (cdc.gov)
The aim of this review is to summarize the current knowledge about the possible roles of newly identified helper T cells derived cytokines (IL-9, 17, 22, 25 and IL-33) in asthma. (cdc.gov)

Plk1 protein and activity are low in G1, accumulate during S and G2/M phases, and are rapidly reduced in the late stages of mitosis [ 7 ]. (nature.com)

The underlying mechanisms of the SARS-CoV-2 replication cycle have been elucidated using various epithelial cell lines. (news-medical.net)
Susceptibility of specific organs to COVID-19 has provoked research towards the disease mechanisms [ 5 ], which resulted in identification of spike glycoprotein (S protein), one of the main structural components of SARS-CoV-2, which facilitates binding of the envelope viruses to host cells by forming homotrimers protruding on the viral surface, which attracts angiotensin-converting enzyme 2 (ACE 2 ) [ 6 ]. (biomedcentral.com)
The timing of events in the cell cycle is controlled by mechanisms that are both internal and external to the cell. (openstax.org)
If the checkpoint mechanisms detect problems with the DNA, the cell cycle is halted, and the cell attempts to either complete DNA replication or repair the damaged DNA. (openstax.org)

As local cell density increases, tensile forces on E-cadherin adhesions are reduced, which prompts the accumulation of the G2 checkpoint kinase Wee1 and downstream inhibitory phosphorylation of Cdk1. (ibecbarcelona.eu)
The G 1 checkpoint determines whether all conditions are favorable for cell division to proceed. (openstax.org)
The G 1 checkpoint, also called the restriction point (in yeast), is a point at which the cell irreversibly commits to the cell division process. (openstax.org)
External influences, such as growth factors, play a large role in carrying the cell past the G 1 checkpoint. (openstax.org)
In addition to adequate reserves and cell size, there is a check for genomic DNA damage at the G 1 checkpoint. (openstax.org)
The G 2 checkpoint bars entry into the mitotic phase if certain conditions are not met. (openstax.org)
As at the G 1 checkpoint, cell size and protein reserves are assessed. (openstax.org)

However, macrophages support the early phase of viral infection, particularly the entry and synthesis of new viral RNA and protein. (news-medical.net)
Even though HMDMs phagocytosed the virus, they did not allow early-phase viral replication or protein synthesis to induce inflammatory responses due to the absence of ACE2. (news-medical.net)

the silencing of FOXC1 inhibited the biological function of AGS and MKN28 cells. (hindawi.com)

Collectively, FXR activation alone markedly decreases, and when combined with FMD abrogates the survival and carcinogenic potential of metastatic prostate cancer cells. (edu.iq)
The primary endpoint is the proliferative index (Ki-67) measured in prostate cancer cells at radical prostatectomy. (biomedcentral.com)

Transforming proteins E6 and E7 induce the S-phase in the lower epithelial layers. (wikipedia.org)

With the help of our imaging data," said LMU physicist Professor Chase Broedersz, "we were able to demonstrate that, instead of simply waving back and forth, both flagella and cilia on average carry out cycles of actively driven and distinct movements-and in so doing they violate the principle of detailed balance. (genengnews.com)

E4 proteins are expressed, and viral DNA amplification starts in the differentiated cells. (wikipedia.org)
HLA- em DRB1 /em genotypes, high disease activity, high disability scores, and high levels of acute phase proteins [2]. (exposed-skin-care.net)

Interestingly, the combination treatment on PC-3 cells not only showed several lines of evidence of apoptotic cells death but also inhibited carcinogenic potential as evaluated by impairment of spheroid formation capacity and delayed wound healing and matrigel invasion. (edu.iq)

Anatomy44

Organisms12

Diseases7

Chemicals and Drugs88

Analytical, Diagnostic and Therapeutic Techniques and Equipment27

Psychiatry and Psychology2

Phenomena and Processes75

Disciplines and Occupations1

Information Science5

Health Care5

Proliferation23

Apoptosis13

Tubular epithelial cells3

Oviductal epithelial cell2

Progression12

Differentiation6

Regulation6

Transition7

Arrest5

Luteal phase4

Tissue9

Basal2

Pathway7

Tissues6

Epithelium2

Ovarian2

Dermal papilla cells2

Inhibit3

Morphology1

Morphogenesis1

Fibroblast3

Compartments1

Cellular4

Menstrual cycle1

Anagen9

Airway4

Differentiate2

Adhesion1

Stem Cell7

Interphase1

Transfection1

Molecular6

Eukaryotic cell1

Telogen3

Follicular Phase1

Fibrosis1

Assays4

Hair follicle stem cells2

Inhibition3

Polarity3

Human11

Triggered to divide1

Undergo3

Bovine1

Biology1

Catagen1

Processes3

Renal Cell Carc1

Morphological1

Progesterone4

Cytokines4

Mitosis1

Mechanisms4

Checkpoint7

Synthesis2

Silencing1

Prostate cancer cells2

Induce1

Actively1

Proteins2

Interestingly1