Epithelial cells cell line tumor. Medical search. Frequent questions

An aberrant miRNA expression could contribute to cancer development and progression [ 6 , 7 ] and could affect their target genes that are involved in many biological processes, such as cell differentiation, proliferation, apoptosis, metabolism, and development [ 8 ]. (hindawi.com)
To test this hypothesis we examined the dose-dependent cytotoxicity effects of single-walled (SWCNT) and multi-walled (MWCNT) carbon nanotube s on NHBE and A549 cells using lactate dehydrogenase (LDH) release and the cell proliferation/viability WST-1 assays. (cdc.gov)
We used VES and FBZ, at low concentrations, singly and in combination, to test their inhibitory effects on proliferation of human and mouse prostate cancer cells in vitro. (researchgate.net)
Administered alone, FBZ inhibited proliferation faster than VES in both mouse and human prostate cancer cell lines and a synergistic effect between both was also observed. (researchgate.net)
Our results indicated that insulin induces cell proliferation in a dose-dependent fashion in the LNCaP, C4-2, and P69 cell lines. (scienceopen.com)
LncRNAs involved in tumor cell proliferation, apoptosis, invasion and metastasis [ 4 ] . (jcancer.org)
Previous studies have reported that LINC00673 can promote epithelial-mesenchymal transition (EMT), proliferation and metastasis in thyroid carcinoma [ 5 ] . (jcancer.org)
Our previous study showed that downregulation of LINC00673 promotes PDAC cell proliferation by inhibiting HNF1A. (jcancer.org)
The researchers started to genetically reprogram adult Club cells isolated from mice, transiently expressing the four iPS reprogramming factors, but interrupted the process early, prior to reaching the pluripotent state, to generate progenitor-like cells, which are more committed to a specific lineage and show more controlled proliferation than pluripotent cells. (eurekalert.org)
We demonstrated that while intestinal epithelial cell (IEC) proliferation and death are unaltered in mice with ubiquitous suppression of NF-κB activity, goblet cell numbers increase at the expense of Paneth cells. (hu-berlin.de)
and promoted the proliferation and invasiveness of breast cancer cells both in vivo and in vitro. (cancerindex.org)
Additionally, DBC1 knockdown eliminated the up-regulation of MMP7, EMT-related proteins, and cell cycle-related proteins as well as the enhanced proliferation and invasiveness induced by ZNF326. (cancerindex.org)
Finally, we studied the effects of arsenide trioxide and 5-azacitidine on the proliferation of leukemia cells and the TGF- β signaling pathway. (hindawi.com)
At the same time, arsenide trioxide and 5-azacitidine are associated with the inhibition of cellular proliferation of acute leukemia cells and also promote the elevated expression of TGF- β signaling pathway-linked proteins, including TGF- β , Smad2, Smad3, and Smad4. (hindawi.com)
We demonstrate that CD117+ cells display increased proliferation and migration. (biorxiv.org)
Further, in cell lines, CD117 activation by SCF promotes faster proliferation and invasiveness, while blocking CD117 activation with tyrosine kinase inhibitors (TKIs) decreased progression in a context-dependent manner. (biorxiv.org)
High expression of RAD18 facilitated a highly stem-cell phenotype through the Hippo/YAP pathway, which supports the proliferation of TNBC. (nature.com)
Inhibition of YAP or TGF-β breaks this loop and suppresses cancer stemness and proliferation In nude mice, RAD18 promoted subcutaneous transplanted tumor growth and M2-type TAM recruitment. (nature.com)
Unlike the invasive carcinomas, borderline ovarian tumors are characterized by cytoplasmic and nuclear atypia, (element of differential diagnosis with benign tumors), absence of stromal invasion, (element of differential diagnosis with malignant tumors), unusual degree of proliferation of the epithelial cells with cellular stratification including remarkable architectural atypia and the formation of papillary protuberances. (intechopen.com)

E1A transfection results in the transformation of peripheral lung epithelial cells and normal lung fibroblasts to a phenotype intermediate between that of the two primary cells. (ersjournals.com)
The changes that occur during adenoviral E1A transformation of primary guinea pig PLECs were also compared with those occurring during the transformation of the fibroblasts that frequently contaminate primary epithelial cultures, and evidence is presented that both cell types are transformed to an intermediate phenotype. (ersjournals.com)
E1a thus appeared to partially convert diverse human tumor cells into an epithelial phenotype. (rupress.org)
2 EndMT is a process by which endothelial cells lose a portion of their cellular features and obtain the mesenchymal phenotype, including the loss of tight junctions and increased production of extracellular matrix. (dovepress.com)
In addition, we show that MDA-MB-231 cells and MDA-MB-436 cells which are both epithelial breast cancer cell lines with a mesenchymal-like phenotype derived from metastatic cancers are mechanically more different from each other than from non-malignant epithelial MCF-10A cells. (umd.edu)
Therefore, we concluded that ZNF326 is highly expressed in breast cancer, is associated with poor prognosis, and plays a vital role in promoting the malignant phenotype of breast cancer cells by interacting with DBC1. (cancerindex.org)
Abnormal methylation of Grainyhead-like 2 (GRHL2) is associated with a substantial role in the malignant phenotype of tumor patients. (hindawi.com)
In addition, the cytokine byproduct TGF-β activates macrophages to have an M2-like tumor-associated macrophage (TAM) phenotype. (nature.com)
These tumour-associated macrophages (TAMs) were of the M2 phenotype (CD206+). (lu.se)

Cell viability was estimated by cell counting kit-8 and cell apoptosis by flow cytometry. (karger.com)
In LPS-induced ARDS cell model, astragaloside IV up-regulated cell viability, SOD activity and ZO-1 and LC3B I expressions but down-regulated cell apoptosis, TNF-α, IL-6, LC3B II, Beclin-1 and atg5 expressions and LDH and MDA levels. (karger.com)
Astragaloside IV might suppress autophagy initiation directly or indirectly through suppressing the oxidative stress and inflammatory response, which further enhances the cell viability and tight junction and reduces apoptosis in LPS-stimulated pulmonary endothelial ARDS cell model, thus exerting its therapeutic function in ARDS. (karger.com)
Wu X, Song M, Qiu P, Li F, Wang M, Zheng J, Wang Q, Xu F, Xiao H. A metabolite of nobiletin, 4'-demethylnobiletin and atorvastatin synergistically inhibits human colon cancer cell growth by inducing G0/G1 cell cycle arrest and apoptosis. (umassmed.edu)
Induction of cell cycle arrest and apoptosis with downregulation of Hsp90 client proteins and histone modification by 4? (umassmed.edu)
In UV models of ALCs and human lens epithelial cell lines, the expression levels of histone H3, cell apoptosis factors (Bax/Bcl-2, cleaved caspase-3), and inflammation factors (interleukin-6, tumor necrosis factor-α) were all up-regulated. (techscience.com)
LINC00673 Overexpression is associated with good survival in pancreatic cancer patients, Effects of LINC00673 on pancreatic cancer cell apoptosis, viability, migration. (jcancer.org)
Initially, the group did not observe such dire consequences: Gibson says that delaminating cells generally "fall out of the epithelium" and are killed off by apoptosis, a mechanism healthy tissues use to eradicate damaged cells. (stowers.org)
The effects of single or daily application of 0.1-100 µM curcumin on cell apoptosis in ultraviolet B (UVB)-induced mice were tested using an experimental double-blind posttest design with a control group and two research models: a single application of curcumin before a single UVB exposure and daily application of curcumin for 7 days before a single UVB exposure on the seventh day. (bvsalud.org)

Here we show that the T-box transcription factor Brachyury induces in tumor cells epithelial-mesenchymal transition (EMT), an important step in the progression of primary tumors toward metastasis. (jci.org)
Then, can it repress the cancer cells' metastasis potential? (scielo.br)
Thus, we conclude that As2O3 can reduce metastasis potential of NPC cells, involving inhibition of MMP-9 expression. (scielo.br)
Co-senior author Sendurai Mani, Ph.D ., assistant professor in MD Anderson's Department of Molecular Pathology and Co-Director of the Metastasis Research Center, is an expert on epithelial-to-mesenchymal transition (EMT). (weeksmd.com)
This change from stationary epithelial cells to the mobile mesenchymal stem cells is an important step in metastasis," Mani said. (weeksmd.com)
The formation of CSCs is highly associated with cancer cell epithelial-mesenchymal transition (EMT), which contributes to the plasticity of cancer cells and comprises an initial step for metastasis. (ku.edu)
In an orthotopic pancreatic cancer mouse model, KH-3 significantly inhibited tumor growth and metastasis. (ku.edu)
Overexpression of LINC00673 promotes invasion and metastasis which associated with a poor prognosis in tongue squamous cell carcinoma [ 6 ] . (jcancer.org)
In the TNM system, the overall stage is determined after the cancer is assigned a letter or number to describe the tumor (T), node (N), and metastasis (M) categories . (knowbreastcancer.org)
Cancer stem-like cells (CSCs) are associated with cancer progression, metastasis, and recurrence, and may also represent a subset of circulating tumor cells (CTCs). (biorxiv.org)
Combined, these data indicate that CD117 expression potentially promotes tumor initiation and metastasis. (biorxiv.org)
Bone metastasis occurs through a complex cascade of events that ultimately results in circulating tumor cells (CTCs) from the blood extravasating and invading the bone marrow - these cells within the bone marrow are referred to as disseminated tumor cells (DTCs) [ 4 ]. (oncotarget.com)

The biological role and underlying mechanism of action of zinc-finger protein 326 (ZNF326) in malignant tumors, including breast cancer, are still not clear. (cancerindex.org)
research shows that about 90% of the blood system of malignant tumors with at least the height of single gene methylation is closely related since this is a reversible process of genetic modification can be through to handle to restore the normal expression of gene methylation, to achieve the purpose of prevention and treatment of tumor [ 10 ]. (hindawi.com)

Using RNA-Seq, we identified a total of 163 and 568 differentially expressed genes in primary normal human bronchial epithelial (NHBE) cells that were exposed to diacetyl and 2,3-pentanedione, respectively. (nature.com)
In this study, we utilized primary normal human bronchial epithelial (NHBE) cells that are cultured at an air-liquid interface (ALI) to mimic the in vivo airway characteristics 30 . (nature.com)
Comparison of carbon nanotube -induced cytotoxicity in A549 and normal human bronchial epithelial (NHBE) cells. (cdc.gov)

The effects of the two macrolides on tumor necrosis factor-α (TNF-α) release were also examined. (karger.com)
Cigana C, Assael BM, Melotti P: Azithromycin selectively reduces tumor necrosis factor alpha levels in cystic fibrosis airway epithelial cells. (karger.com)
The expression of tumour necrosis factor (TNF)-α, interleukin (IL)-6, zonula occludens (ZO)-1, Beclin-1 and autophagy-related (atg) 5 mRNA was evaluated by quantitative PCR, and the expression of ZO-1, microtubule-associated proteins 1A/1B light chain 3B (LC3B) I and, LC3B II protein by Western blot. (karger.com)
Tumor necrosis factor- mRNA was seen not been clearly established by immunohistochemical in lung tissue. (cdc.gov)

Germ cell tumors- start in the ovarian cells that form eggs. (mountsinai.org)
Germ cell tumors tend to occur in young women or are in their reproductive years. (mountsinai.org)
Diagnosed at an early stage, germ cell tumors are curable. (mountsinai.org)
Yolk sac tumors are germ cell tumors that resembles the yolk sac, allantois, and extraembryonic mesenchyme. (medscape.com)
Pure yolk sac tumor (YST) is the most common testicular neoplasm in prepubertal children, accounting for 30% of testicular germ cell tumors in this age group, with a median age of 1.5 years. (medscape.com)
In adults, yolk sac tumor (YST) presents as a component of mixed nonseminomatous germ cell tumor, with an age averaging 25-30 years. (medscape.com)
Yolk sac tumor (YST) components are present in 40-50% of nonseminomatous germ cell tumors in the adult testis. (medscape.com)
[ 1 ] In adults, yolk sac tumors (YSTs) are associated with other germ cell components such as embryonal carcinoma, choriocarcinoma, teratoma, and seminoma as a part of a mixed germ cell tumor. (medscape.com)
The radiographic findings are specific for malignant mixed germ cell tumors but are not specific for yolk sac tumors (YSTs). (medscape.com)
[ 1 ] which are relatively small and less pleomorphic relative to those in embryonal carcinoma, another common subtype of malignant germ cell tumor of the testis. (medscape.com)
Germ cell tumors are considered rarer and usually show up in younger women. (uhc.com)
They contain eggs, also called germ cells. (cancer.net)
There are three types of ovarian cancers: epithelial ovarian carcinomas, germ cell tumors, and stromal cell tumors. (medlineplus.gov)
Ninety percent of patients with germ cell tumors survive five years after diagnosis. (medlineplus.gov)

However, the mechanism through which RAD18 influences triple-negative breast cancer (TNBC), especially the interaction between tumor cells and the tumor microenvironment, remains elusive. (nature.com)
Tumor microenvironment (TME) remodeling is a critical process in primary tumor progression. (nature.com)
The development of CRC is highly influenced by the tumour microenvironment. (lu.se)

Tumor suppressor candidate 3 is a protein that in humans is encoded by the TUSC3 gene. (wikipedia.org)
This gene is a candidate tumor suppressor gene. (wikipedia.org)
This may include oncomir (oncogenic miRNA) inhibition, or tumor suppressor-miRNA replacement therapies [ 6 , 9 ]. (hindawi.com)
E-cadherin has many other functions including acting as a tumor suppressor protein, which means it prevents cells from growing and dividing too rapidly or in an uncontrolled way. (medlineplus.gov)
The loss of this protein prevents it from acting as a tumor suppressor, contributing to the uncontrollable growth and division of cells . (medlineplus.gov)
I have previously reported (Frisch, 1991) that adenovirus E1a is a tumor suppressor gene in certain human cell lines. (rupress.org)
It is believed that the occurrence of leukemia is the result of genetic and epigenetic changes in protooncogene and tumor suppressor genes [ 8 ]. (hindawi.com)
The tumor suppressor genes are inactivated, and the oncogenes are dominant during the formation of the tumor [ 9 ]. (hindawi.com)
Furthermore, methylation-dependent silencing of SOX11 has been reported for B cell lymphomas and indicates that epigenetic drugs may be used to re-express this tumour suppressor, but information on SOX11 promoter methylation in EOC is still lacking. (lu.se)

Genetic and phenotypic cell-to-cell variability have been observed in numerous studies both within the same type of cancer cells and across different types of cancers. (umd.edu)
It also hints at a surprising way that cells initiate a gene expression program seen in invasive cancers when that process goes awry. (stowers.org)
The term "ovarian cancer" is often used to describe cancers that begin in the cells in the ovary, fallopian tube, or peritoneum. (cancer.net)
Epithelial carcinoma makes up 85% to 90% of ovarian/fallopian tube cancers. (cancer.net)
Breast cancers are most often epithelial tumors involving the ducts or lobules. (msdmanuals.com)
General references Breast cancers are most often epithelial tumors involving the ducts or lobules. (msdmanuals.com)
This a locally aggressive tumor that accounts for about 10% of odontogenic tumors 3 and 1% of all oral cancers 4 . (bvsalud.org)
Background: The neural transcription factor SOX11 has been described as a prognostic marker in epithelial ovarian cancers (EOC), however its role in individual histological subtypes and tumour grade requires further clarification. (lu.se)
About 85% to 90% of these cancers start in the cells that cover the outer surface of the ovary. (medlineplus.gov)

Andreeff and Mani in 2010 discovered that human mammary epithelial cells that undergo epithelial-to-mesenchymal transition act similarly to human bone-marrow-derived mesenchymal stem cells. (weeksmd.com)
Cardiac fibroblasts are generally the primary effector cells of fibrosis and have been reported to be partly derived from cardiac endothelial cells through the endothelial to mesenchymal transition (EndMT) process. (dovepress.com)

The current results indicated that B[a]P seems to induce EMT in lung cancer cells, and it also may drive disease progression in patients with lung cancer. (nih.gov)
We also determined that the percentage of human lung tumor tissues positive for Brachyury expression increased with the stage of the tumor, indicating a potential association between Brachyury and tumor progression. (jci.org)
The selective expression of Brachyury in tumor cells and its role in EMT and cancer progression suggest that Brachyury may be an attractive target for antitumor therapies. (jci.org)
Most tumors originate in the epithelial tissue and loss of polarity is a common occurrence in tumor progression. (pasteur.fr)
They also discovered that the location of the apical domain is dependent on a direct link between Rab35 and another apical protein, Podocalyxin, which is already known to control polarity and is involved in tumor progression. (pasteur.fr)
Andreeff and colleagues are refining the drug as a potential targeted therapy for breast cancer stem cells, which are thought to be crucial to therapy resistance, disease progression and spread to other organs. (weeksmd.com)
These compounds contribute to the suppression of tumor progression and aggressiveness in various degrees. (ku.edu)
HNF1A inhibited cell progression in pancreatic cancer cells. (jcancer.org)
Therefore, we hypothesized that CRC cancer stem cell markers (CRCSC) will identify a group of patients at high risk for progression. (jcancer.org)
Our previous study showed that it plays an essential role in the progression of multiple tumors. (nature.com)

Human T cell infiltration was observed in both carcinomas with the majority of live T cells responsive post infiltration. (genengnews.com)
But if epithelial cells fail to hold together, they die, or worse, produce jumbled masses resembling tumors known collectively as carcinomas. (stowers.org)
subsequently, this group of tumors of the ovary were classified in 1973 by the World Health Organization as "low malignant potential ovarian tumor" [ 2 ] and, finally, in 2003 WHO separates them from carcinomas and call them borderline tumors. (intechopen.com)

Although no apparent morphologic changes were observed, the B[a]P-exposed A549 cells exhibited enhanced proliferative activity in 1% bovine serum that contained medium, and dramatic changes in expression levels were observed in a large number of genes. (nih.gov)
Kim YD, Cho JS, Kim HS, Song SH: Effect of macrolide on the interleukin-1 β-mediated MUC2/5AC genes expression and mucin secretion in human airway epithelial cells. (karger.com)
We used whole-transcriptome shotgun sequencing (RNA-seq) to compare the S. pneumoniae transcriptome in biofilms, bacteria dispersed from biofilms after exposure to IAV, febrile-range temperature, or ATP, and planktonic cells grown at 37°C. Compared with biofilm bacteria, actively dispersed S. pneumoniae, which were more virulent in invasive disease, upregulated genes involved in carbohydrate metabolism. (lu.se)
Consistent with this, qRT-PCR confirmed that the expression of multiple genes involved in cilia biogenesis was significantly downregulated by diacetyl and 2,3-pentanedione in NHBE cells. (nature.com)
and (d) down-regulation of non-epithelial genes. (rupress.org)
Comparing gene expression between GD2+ cells and CD44 high/CD24 low cells revealed 100 percent correlation in the expression of 231 genes. (weeksmd.com)
To create specialized cell types for use in cell therapy requires only that we insert the genes (or use non-transgenic approaches) and then test the drug dose and timing required for each cell type and each patient, so it should be relatively scalable at low cost compared to other approaches using each patient's own cells," Waddell says. (eurekalert.org)
Total RNA from tumors the expression of thousands of genes (3) to address complex questions was isolated using two successive rounds of Trizol. (lu.se)

Koontongkaew S, Monthanapisut P, Saensuk T: Inhibition of arachidonic acid metabolism decreases tumor cell invasion and matrix metalloproteinase expression. (karger.com)
Conversely, inhibition of Brachyury resulted in downregulation of mesenchymal markers and loss of cell migration and invasion and diminished the ability of human tumor cells to form lung metastases in a xenograft model. (jci.org)
The data demonstrated that inhibition of HuR destabilized SNAI1 mRNA, and subsequently reduced Snail protein levels, resulting in the EMT and CSCs inhibition in pancreatic cancer cells. (ku.edu)
The membrane permeability and inhibition of cellular HDAC activity of selected compounds were confirmed by whole-cell HDAC inhibition assays and immunoblot experiments. (bvsalud.org)

and cell differentiation ( SOX2 and TGFB3 ) as well as immunohistochemical assay for VEGFA, TP53, Bcl2, TGFB1, and Ki67 protein expression have been performed in 85 FFPE RCC tumor specimens. (hindawi.com)
It is involved in p53 pathways and is implicated in cell death/survival signaling, the cell cycle, and differentiation, thereby playing a regulatory role in carcinogenesis [ 12 ]. (hindawi.com)
It is speculated that hypermethylation of the RUNX3 gene promoter and overexpression of GATA-4, a transcription factor that regulates differentiation and function of yolk sac endoderm, may play important roles in the pathogenesis of yolk sac tumors (YSTs). (medscape.com)
Many other cell types emerge via epithelial-mesenchymal differentiation. (rupress.org)
Human colonic ADENOCARCINOMA cells that are able to express differentiation features characteristic of mature intestinal cells such as the GOBLET CELLS. (umassmed.edu)
Establishing 3D organoid culture from the small intestine and using different mouse lines, we prove in the second part of the thesis that NF-kB plays an important function in cell differentiation and stem cell maintenance in vivo and in ex-vivo. (hu-berlin.de)
In summary, our results revealed a novel IEC-intrinsic role of NF-κB in cell fate decisions and differentiation which occur via regulation of Wnt signaling and Sox9 expression downstream of NF-κB. (hu-berlin.de)
It is involved in cell differentiation, maintenance of cell differentiation state, tumorigenesis, and cell senescence, mainly through DNA methylation, histone acetylation, and RNA-related silencing [ 6 ]. (hindawi.com)
Additionally, RAD18 functions beyond DNA repair and may regulate many other key biological processes, such as chromatin strengthening, cell survival/death, stemness, and differentiation. (nature.com)
Coexisting foamy and nonfoamy adenocarcinoma with glandular differentiation devoid of basal cell lining is helpful in clarifying their malignant nature. (medscape.com)

This exposure results in a regulated, dose-dependent loss of epithelial barrier function in the lung epithelial monolayers. (nih.gov)
Our results demonstrate that the smoke-induced loss of epithelial barrier function in human bronchial epithelium is a regulated process rather than a cytotoxic response. (nih.gov)
I did not expect that spindle orientation defects could be sufficient to cause loss of epithelial identity," explains Yu-ichiro Nakajima, Ph.D., a postdoctoral fellow in the Gibson lab and the study's first author. (stowers.org)

AZM and MDM attenuated PMA-induced MUC5AC and MUC2 gene and protein expression in NCI-H292 cells. (karger.com)
The CDH1 gene provides instructions for making a protein called epithelial cadherin or E-cadherin. (medlineplus.gov)
This protein is found within the membrane that surrounds epithelial cells, which are the cells that line the surfaces and cavities of the body. (medlineplus.gov)
Furthermore, E1A DNA and protein persisted in epithelial cells in the lungs of these animals 9 . (ersjournals.com)
We aim to study the coupling between LTCC and β adrenergic receptors in different cardiomyocyte microdomains, the distinct involvement of PKA and CAMKII (Ca2+/calmodulin-dependent protein kinase II) and explore how this functional complex is disrupted in heart failure.Methods:Global signaling between LTCCs and β adrenergic receptors was assessed with whole-cell current recordings and western blot analysis. (imperial.ac.uk)
Breast cancer stem cells wear a cell surface protein that is part nametag and part bull's eye, identifying them as potent tumor-generating cells and flagging their vulnerability to a drug, researchers at The University of Texas MD Anderson Cancer Center report online in Journal of Clinical Investigation . (weeksmd.com)
The marker is the cell surface protein ganglioside GD2. (weeksmd.com)
Moreover, I contributed in the characterization of the potential oncogenic role of the common gamma chain (γc) in primary human hematopoietic malignant cell lines, by evaluating the molecular mechanisms by which this protein promotes tumor growth. (unina.it)
The researchers showed that the resulting Club-iPL cells could give rise to not only Club cells, but also to other respiratory tract cells such as mucus-secreting goblet cells and ciliated epithelial cells that produce the CFTR protein, which is mutated in patients with cystic fibrosis. (eurekalert.org)
Secondly, we employed qRT-PCR and Western blotting to detect the mRNA and protein levels of GRHL2 in leukemia cell lines. (hindawi.com)
Then we investigated the demethylating effect of arsenic trioxide and 5-azacitidine on the mRNA and protein expression levels of GRHL2 in cell lines of acute leukemia. (hindawi.com)
The methylation level of the GRHL2 promoter region in acute leukemia patients and cell lines was significantly higher than the normal control group, and we found the elevated mRNA and protein levels of GRHL2 in acute leukemia cell lines after the use of the demethylation drug arsenic trioxide and 5-azacitidine. (hindawi.com)
CD47 is involved in crosstalk between colon cancer cells and macrophages by interacting with its ligand signal-regulatory protein α on macrophages. (lu.se)
Further analyses of EOC cell lines showed that SOX11 mRNA and protein were expressed in two of five cell lines, correlating with promoter methylation status. (lu.se)
Demethylation was successfully performed using 5'-Aza-2'deoxycytidine (5-Aza-dC) resulting in SOX11 mRNA and protein expression in a previously negative EOC cell line. (lu.se)

Despite significant progress, these protocols remain limited by low yield and purity of the desired mature cell types, as well as the potential of immature cells to form tumors. (eurekalert.org)
Home to three different kinds of cells, it may breed potential for cancer to start in any one of those cells and form tumors. (uhc.com)

Overexpression of Brachyury in human carcinoma cells induced changes characteristic of EMT, including upregulation of mesenchymal markers, downregulation of epithelial markers, and an increase in cell migration and invasion. (jci.org)
3) Tumour invasion and dissemination. (qub.ac.uk)
Then the survival cells were collected to investigate their potential of colony formation, attachment, invasion, and migration. (scielo.br)
Our data showed that knockdown of HuR in pancreatic cancer cells significantly inhibited cell migration, invasion, and stem-like features. (ku.edu)
As an HuR/mRNA disruptor, KH-3 treatment successfully mimicked the effects of HuR knockdown in pancreatic cancer cell lines: KH-3 significantly inhibited pancreatic cancer cell migration, invasion, tumor sphere formation and EMT. (ku.edu)
The enhanced levels of MMP-7 and -9 mRNA expressions and increased cell invasion into matrigel were observed in colon cancer cells upon stimulation with TAM-conditioned medium. (lu.se)

although it is derived from cells of the renal tubular epithelium, it has several histological subtypes which differ in their clinical outcome and biological features. (hindawi.com)
Tight junctions between adjacent epithelial cells constitute the physiological barrier to fluid and macromolecules in epithelium. (nih.gov)
About 85 percent of all solid tumors start in the lining of an organ, called the epithelium. (weeksmd.com)
The starting point for this work was the lab's 2011 Current Biology paper showing that when columnar cells packed in an epithelium divided, their upper (apical) end briefly ballooned out to allow the cell's nucleus to move into that region. (stowers.org)
As division began, the mitotic spindle (which faithfully distributes chromosomes into each daughter cell) invariably oriented itself parallel to the apical surface of the epithelium. (stowers.org)
Next, by directly perturbing the spindle, the researchers video-captured the process by which cells with misoriented spindles began to peel away, or delaminate, from the epithelium. (stowers.org)
Ameloblastoma is a rare odontogenic tumor of the jaws that originates from the epithelium involved in teeth formation: enamel organ, odontogenic rests of Malassez, reduced enamel epithelium and odontogenic cyst lining 1,2 . (bvsalud.org)
Clara cells lining the respiratory epithelium metabolize ST to styrene 7,8- oxide (SO), which is cytotoxic and weakly genotoxic. (cdc.gov)
Cells which lack ER expression at diagnosis arise from an ER compart- were harvested at 60 - 80% confluency and used as a reference in all hybrid- ment within the mammary epithelium or represent evolution from an izations. (lu.se)

Furthermore, we found Brachyury to be overexpressed in various human tumor tissues and tumor cell lines compared with normal tissues. (jci.org)
Brachyury expression in human lung tumor tissues. (jci.org)
E-cadherin helps neighboring cells stick to one another (cell adhesion) to form organized tissues. (medlineplus.gov)
A lack of E-cadherin also impairs cell adhesion, increasing the likelihood that cancer cells will not come together to form a tumor but will invade the stomach wall and metastasize as small clusters of cancer cells into nearby tissues. (medlineplus.gov)
It is unclear why CDH1 gene mutations primarily occur in the stomach lining and these other tissues. (medlineplus.gov)
Cancer stem cells are similar to normal stem cells that renew specialized tissues. (weeksmd.com)
CRL's CD34 + humanized NCG model, HuCD34-NCG, injected with umbilical cord blood-derived CD34 + cells shows robust engraftment of major human immune cells and demonstrates infiltration of T cells into tissues and xenograft tumors. (genengnews.com)
Our work is addressing how epithelial tissues maintain structural integrity, even during the extreme events of cell division. (stowers.org)
Stage 2 usually means that the tumour is larger than in stage 1 but the cancer hasn't started to spread into the surrounding tissues . (knowbreastcancer.org)
These cells can harm healthy tissues in your body and begin to spread to other parts of your body. (knowbreastcancer.org)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
Tissues and Cells. (lu.se)

Furthermore, we demonstrate a large variation between the particle-induced cytotoxic responses in A549 cells and normal primary epithelial cells. (cdc.gov)

Real-time PCR was performed for Brachyury on lung tumor tissue cDNA from 80 lung cancer patients of the indicated stages of disease. (jci.org)
They may also develop in the tissue that lines the abdominal wall (peritoneum). (mountsinai.org)
Epithelial-mesenchymal transformation is now recognised as an important feature of tissue remodelling. (ersjournals.com)
Reports from several laboratories suggest that a phenomenon termed epithelial-mesenchymal transformation, in which epithelial cells transform into fibroblasts capable of producing connective tissue matrix, is an important feature of tissue remodelling 10 , 11 . (ersjournals.com)
This disease is caused by uncontrolled cell growth and division that damages tissue. (nih.gov)
Compared to normal colon tissue, primary tumors were associated with increased expression of ALDH1B1 (p=0.008). (jcancer.org)
When the Club-iPL cells were administered to CFTR-deficient mice, the cells incorporated into tissue lining the respiratory tract and partially restored levels of CFTR in the lungs without inducing tumor formation. (eurekalert.org)
As long as epithelial cells pack tightly and adhere to their neighbors, the cellular business of building tissue barriers and constructing ducts goes smoothly. (stowers.org)
Solicited models include patient-derived cell lines, patient-derived xenograft (PDX) mouse models, and 3D human tissue model culture systems established from racially/ethnically diverse patient populations. (sbir.gov)
3D human tissue model culture systems: While immortalized cell lines have been standard practice in cancer research for decades, adequate modeling of the heterogeneity of human cancer is an unmet need. (sbir.gov)
The peritoneum is a tissue that lines the abdomen and most of the organs in the abdomen. (cancer.net)

Histologically, most of them are serous or mucinous, but endometrioid, clear cell, Brenner (transitional cell) or mixed histotypes can be also seen. (intechopen.com)
Micrograph of a mucinous ovarian tumor. (medlineplus.gov)

Overall, the results presented here indicate that SWCNT or MWCNT induce cytotoxicity in human lung epithelial cells in a time and dose-dependent manner. (cdc.gov)
Guinea pig primary peripheral lung epithelial cells (PLECs) transfected with adenovirus E1A (E1A-PLECs) were compared to guinea pig normal lung fibroblasts (NLFs) transfected with E1A (E1A-NLFs). (ersjournals.com)
Adenoviral DNA is retained by peripheral epithelial cells of the lung (PLECs) in humans in whom the viral E1A gene is expressed 4 without replication of a complete virus 5 . (ersjournals.com)
Case-control studies have shown that the E1A DNA from group C adenoviruses is present in greater amounts in the lungs of patients with COPD than in controls with normal lung function matched for age, sex and smoking history 5 , and that the excess inflammation in the lungs of smokers with severe emphysema is associated with increased numbers of alveolar epithelial cells expressing E1A 6 . (ersjournals.com)
Levels of total CD3 + T cells and CD4 + and CD8 + subsets in addition to other cell populations, such as CD19 + and CD16/56 + , were evaluated as well as cells from spleen, liver, bone marrow, lung, and lysed whole blood. (genengnews.com)
In pilot studies, CRL evaluated the antitumor effects of immune checkpoint inhibitors (CPIs) on colon epithelial carcinoma (RKO) and basal lung cell adenocarcinoma (A549) cell lines in the HuCD34-NCG model and showed significant immunomodulatory antitumor response. (genengnews.com)
Another study assessed the sensitivity of six NSCLC (non-small cell lung cancer) PDX models toward the same two CPIs and the combinations thereof. (genengnews.com)
We have pursued cell therapy for lung diseases for many years," Waddell says. (eurekalert.org)
For these short fibers, which can be fully engulfed by lung cells and do not dissolve in airway fluids in less than a few weeks, their clearance will be similar to other mineral and vitreous particles. (cdc.gov)
The model-based analysis suggests that humans would be expected to be 100- fold less sensitive to ST-inducted lung tumors than mice, based on pharmacokinetic differ- ences. (cdc.gov)
The absence of detectable viral mented in other mammals and birds, H5N1 viral replication antigen-positive cells in previous reports may relate to the in humans may be restricted to the lung and intestine, and fact that the patients died during the late phase of the dis- the major site of H5N1 viral replication in the lung is the pneumocyte. (cdc.gov)

E1a induces the expression of epithelial characteristics. (rupress.org)

The cultured cells show anchorage-independent growth in both monolayers and in soft agar suspension and produce subcutaneous tumors in nude mice. (scienceopen.com)

Cells from the bronchioloalveolar carcinoma cell line A549 were exposed to benzo(a)pyrene (B[a]P) for 24 weeks, and morphology, proliferative activity, and gene expression profiles were analyzed. (nih.gov)
Renal cell carcinoma (RCC) incidence has increased over the past two decades. (hindawi.com)
Renal cell carcinoma (RCC) accounts for approximately 3% of human malignancies, and its incidence appears to be increasing globally [ 1 ]. (hindawi.com)
Nasopharyngeal carcinoma (NPC) is a tumor arising from the epithelial cells that cover the surface and line the nasopharynx. (nih.gov)
Establishment and characterization of a human prostatic carcinoma cell line (PC-3). (scienceopen.com)
Epithelial carcinoma. (cancer.net)
Foamy gland carcinoma of the prostate features cells with abundant finely vacuolated cytoplasm and pyknotic hyperchromatic nuclei. (medscape.com)

We do this by examining you, understanding your symptoms, and analyzing the cells of your tumor through a biopsy to determine if it is cancerous (malignant) or noncancerous (benign). (mountsinai.org)
Adenocarcinoma is the malignant counterpart to adenoma, which is the benign form of such tumors. (knowbreastcancer.org)
A tumor can be cancerous or benign. (cancer.net)
A benign tumor means the tumor can grow but will not spread. (cancer.net)
Other patterns include arrangement of the histiocytes in cords or single cells that percolate between benign prostatic glands. (medscape.com)

Using xenograft limiting dilution assays and serial tumor initiation assays, we show that CD117+ cells represent a CSC population. (biorxiv.org)

M2 macrophages derived from human monocyte cell line THP-1 secreted high levels of IL-8 and leukotriene D4 (LTD4), which induced colon cancer cell migration, and Th2 cytokines (IL-4, IL-10) to maintain a tumoral immunosuppressive environment. (lu.se)
CD47, as a key regulator of crosstalk between colon cancer cells and TAMs, could thus be a therapeutic target for CRC. (lu.se)

16-membered) on MUC5AC and MUC2 gene expression and secretion from human airway epithelial cells. (karger.com)
Confluent NCI-H292 human mucoepidermoid airways epithelial cells were pretreated with AZM or MDM for 2 h and then stimulated with 200 nmol/l phorbol 12-myristate 13-acetate (PMA) for 8 h. (karger.com)
The present study demonstrates that AZM and MDM suppress the synthesis of mucin and TNF-α from human airway epithelial cells. (karger.com)
The tumor cell line A549, a pulmonary human type-II like epithelial cells, is widely used for evaluation of particle toxicity. (cdc.gov)
Using a physiologically relevant air-liquid interface exposure system, electrically tight monolayers of the human bronchial epithelial cell-line Calu-3 were exposed to fresh, whole mainstream cigarette smoke. (nih.gov)
The establishment, characterization, and tumorigenicity of a new epithelial cell line (PC-3) from a human prostatic adenocarcinoma metastatic to bone is reported. (scienceopen.com)
Culture of the transplanted tumor yielded a human cell line with characteristics identical to those used initially to produce the tumor. (scienceopen.com)
An analysis of 12 human breast cancer tumors found an even higher correlation of 95.5 percent between GD2+ cells and CD44 high/CD24 low status. (weeksmd.com)
An in vitro model of EndMT was developed using human umbilical vein endothelial cells (HUVECs) via treatment with transforming growth factor-β (TGF-β) at 10 ng/mL for 24 h. (dovepress.com)
A total of 99 anterior lens capsules (ALCs) of patients with ARC of various nuclear grades, ultraviolet models of ALCs, and two human lens epithelial cell lines (FHL-124 and SRA01/04) were used, and the expression of histone H3, CRYAA, GLB1, and p53 were detected by immunoblotting and reverse transcription and real time-quantitative polymerase chain reaction. (techscience.com)
In vivo models of human immunity in human tumor-bearing mice are frequently used to study mechanisms of targeted immunotherapies, safety, and efficacy. (genengnews.com)
These severely immunodeficient animals are required to support human cell engraftment to generate multiple differentiated lineages from human hematopoietic stem cells (HSCs). (genengnews.com)
They robustly support the engraftment of human cells, and develop functional human immune, systems making them ideal for studying immune-related therapies in a vast array of applications. (genengnews.com)
A QC screening flow cytometry panel and a more extensive T cell and myeloid panel identify the presence of human cell populations and evaluate the model's functionality. (genengnews.com)
Flow cytometry analysis of peripheral blood at 12 and 16 weeks post injection verified engraftment of human cell subpopulations. (genengnews.com)
Viable human CD45 + cells were detected in all samples. (genengnews.com)
Intracellular cytokine staining showed release of human IFN-γ, IL-2, and TNF-α by the activated tumor-infiltrating lymphocytes (TILs). (genengnews.com)
A human Pancreatic duct epithelial cells line (HPDE), HEK-293T and three human pancreatic cancer cell lines (CanPan-1, Hs-766T, CFPAC-1) were obtained from Chinese typical culture preservation center. (jcancer.org)
According to the authors, the approach could be used for a variety of regenerative medicine practices, including cell replacement therapy, disease modelling, and drug screening for human diseases. (eurekalert.org)
For their own part, the researchers plan to test this approach with other cell types, including human cells. (eurekalert.org)
To determine how CD117 expression and activation by its ligand stem cell factor (SCF, kit ligand, steel factor) alter prostate cancer aggressiveness, we used LNCaP-C4-2 and PC3-mm human prostate cancer cells, which contain a CD117+ subpopulation. (biorxiv.org)

Some tumors found in glandular cells are not cancerous. (knowbreastcancer.org)
A cancerous tumor is malignant, meaning it can grow, invade, and spread to other parts of the body. (cancer.net)

DTCs occupy the hematopoietic stem cell niche within the bone marrow [ 5 ], often remaining dormant for years before becoming reactivated, leading to cancer recurrence [ 6 ]. (oncotarget.com)

What are adenocarcinoma cells? (knowbreastcancer.org)
Adenocarcinoma develops in cells located in the glands that line your organs ( glandular epithelial cells ). (knowbreastcancer.org)
Adenocarcinoma happens when the cells in the glands that line your organs begin to grow out of control . (knowbreastcancer.org)
If prostate biopsies are performed following hormonal therapy for prostatic adenocarcinoma, the appearance of residual tumor cells can mimic xanthoma cells. (medscape.com)

When an ovarian tumor is present, your gynecologic oncologist will need to find out the type of tumor you have. (mountsinai.org)
Recently the Styrene Information and Re- search Center (SIRC) conducted subchronic and chronic inhalation studies exposing both rats and mice to various concentrations of ST. No evidence of treatment-related increases in any type of tumor was observed in rats, com- pared to controls, at the end of the 2-yr inhalation study (Cruzan et al. (cdc.gov)

Yolk sac tumors (YSTs) can be seen in males and females, involving the testis, ovary, and other sites, such as the mediastinum. (medscape.com)

Shimizu T, Shimizu S: Azithromycin inhibits mucus hypersecretion from airway epithelial cells. (karger.com)

The findings described here improve our understanding of NF-κB functions in stem cell biology which, when deregulated, also have an impact on intestinal inflammation and tumorigenesis. (hu-berlin.de)
CD47 binding to α2β1 integrin could regulate cyclooxygenase-2 expression and cell migration on collagen I surface in intestinal epithelial cells. (lu.se)

Sex cord-stromal cell tumors- begin in the connective cells that hold the ovaries in place and produce female hormones. (mountsinai.org)
Sex cord-stromal cell tumors tend to occur in women past menopause. (mountsinai.org)

The factors and cellular processes required for the induction of dormancy and subsequent tumor cell reactivation remain largely undefined [ 6 ]. (oncotarget.com)

Cellular heterogeneity in tumor cells is a well-established phenomenon. (umd.edu)
A proper immune response relies on the innate immunity, that is responsible for a first line of defense against aggression and the aspecific recognition of a limited repertoire of antigens, and, later, on the adaptative immunity which includes chemical and cellular mediators responsible for a more powerful and specific defensive response from any form of antigen. (unina.it)
Nowhere is that clearer on a cellular level than in the case of epithelial sheets, single layers of cells that line every body cavity from the gut to mammary glands. (stowers.org)
For example, RAD18 plays a vital role in regulating the DNA stability of embryonic stem cells and cellular homeostasis in highly prolific cells [ 6 ]. (nature.com)
It changes the permeability of the fungal cell membrane after binding to cell membrane sterols, causing cellular contents to leak. (medscape.com)

We hypothesized that A549 cells are more resistant to toxicity compared to the normal epithelial cells. (cdc.gov)
In comparison, exposure of A549 cells to similar concentration of CNT resulted in only a milder response. (cdc.gov)
Anti-PD1 (Pembrolizumab [Keytruda] or CD279, BioXCell) monotherapy significantly inhibited RKO and A549 tumor growth whereas anti-CTLA-4 (CD152, BioXCell) dosing, but not combined blockade of CTLA-4 and PD-1, increased intratumoral CD8 + T lymphocytes in A549 tumor-bearing mice. (genengnews.com)

The Membrane Traffic and Cell Division Laboratory, directed at the Institut Pasteur by Arnaud Echard (Institut Pasteur/CNRS UMR 3691), is looking into apical-basal polarity acquisition mechanisms during cell division when organs are being formed. (pasteur.fr)
Epithelia are layers of cells that cover the surface of our bodies and internal organs. (pasteur.fr)
This technology can theoretically be applied to almost any cell type that can be isolated and purified, and isolation of highly purified populations of adult cells from most organs is already possible with existing techniques. (eurekalert.org)
They commonly spread first to the lining and organs of the pelvis and abdomen and then to other parts of the body. (medlineplus.gov)

Pulmonary bronchial epithelial cells are a potential target for toxicity during respiratory exposure. (cdc.gov)
Increased incidences of pulmonary bronchioloalveolar tumors have been observed in mice, but not in rats. (cdc.gov)

Clotrimazole is a broad-spectrum antifungal agent that inhibits yeast growth by altering cell membrane permeability, causing death of fungal cells. (medscape.com)

Clinical characteristics of patients with COVID-19 harboring detectable intracellular SARS-CoV-2 RNA in peripheral blood cells. (google.com)
Finally, IR isoforms form heterodimers, IR-A/IR-B, and hybrid IR/IGF-IR receptors (HR-A and HR-B). The functional characteristics of such hybrid receptors and their role in physiology, in diabetes, and in malignant cells are not yet fully understood. (scienceopen.com)
Our approach starts with purifying the cell type we want and then manipulating it to give those cell types characteristics of progenitor cells, which can grow rapidly but produce only a few cell types. (eurekalert.org)

Cancer stem cells are thought to be responsible for tumor initiation, dissemination and treatment failure. (jcancer.org)

Mechanistically, co-immunoprecipitation and immunofluorescence assays both demonstrated that ZNF326 interacted with deleted in breast cancer-1 (DBC1) in breast cancer cells. (cancerindex.org)

LMP1-negative cell line HNE1 and LMP1-positive cell line HNE1-LMP1 were used as in vitro model. (scielo.br)
MLE-12 cells were induced by LPS to construct an ARDS model in vitro. (karger.com)
Using a 3D in vitro polarity model, scientists have demonstrated full polarity inversion in renal cells deprived of Rab35, whereby the apical domain switches places with the basolateral domain. (pasteur.fr)
Photo : spheroid of renal cells cultivated in vitro. (pasteur.fr)
CRCs have marked benefits over traditional immortalized cell lines as they are generated using special in vitro conditions that permit cells to pharmacologically bypass replicative senescence without any detectable cell crisis. (sbir.gov)

If the ovaries develop abnormal cells that grow uncontrollably, it may be a type of gynecologic cancer. (mountsinai.org)
These tumors grow in the cells that line or cover the ovaries. (mountsinai.org)
Epithelial cell tumors may also develop in the fallopian tubes that carry the eggs produced in the ovaries to the uterus. (mountsinai.org)
these tumors tend to grow very rapidly and metastasize, particularly to structures around the ovaries as well as via the lymph nodes. (medscape.com)
These are cells that cover the outer lining of the ovaries. (uhc.com)
Because the surfaces of the ovaries, the lining of the fallopian tubes, and the covering cells of the peritoneum are made up of the same types of cells, most of these diseases look alike under a microscope. (cancer.net)

Tumor cells usually retain prostatic epithelial antigenicity, and immunohistochemical stains can be used for their identification. (medscape.com)

It is the result of the dissemination of cancer cells to the bone marrow. (oncotarget.com)

Moreover, these cells showed potential as a cell replacement therapy in mice with cystic fibrosis. (eurekalert.org)

Since stiffness of tumor cells can be an indicator of metastatic potential, this result suggests that metastatic abilities could vary within the same monoclonal tumor cell line. (umd.edu)

In addition, TMZ effectively inhibited EndMT in ISO-treated rat hearts and TGF-β-treated HUVECs, as manifested by increased CD31 expression, decreased α-SMA expression, and suppressed cell migration. (dovepress.com)
Restoration of HuR in HuR deleted (KO) pancreatic cancer cells enhanced migration and enriched CSC population. (ku.edu)
This interaction enhanced cell migration of CRC cells and TAMs. (lu.se)

Enhancement by Nano-Diamino-Tetrac of Antiproliferative Action of Gefitinib on Colorectal Cancer Cells: Mediation by EGFR Sialylation and PI3K Activation. (umassmed.edu)
In the present study, the anti-cancer activity of two different NSAIDs, sulindac- (Pc-1) or diclofenac-substituted (Pc-2) asymmetric silicon phthalocyanine derivatives, was evaluated in four different colorectal cancer cell lines bearing various carcinogenic mutations. (bvsalud.org)

Grossly, yolk sac tumors (YSTs) are solid gray-white with a gelatinous, myxoid, or mucoid appearance. (medscape.com)

however, because this type of cancer is hidden underneath the stomach lining, it is usually not diagnosed until the cancer has become widely invasive. (medlineplus.gov)
Pancreatic cancer is a highly invasive malignant tumor of the digestive system. (jcancer.org)
Pancreatic cancer is a highly invasive type of malignant tumor with a very poor prognosis [ 1 ] . (jcancer.org)

Triptolide stymied cancer growth in cell line experiments and resulted in smaller tumors and prolonged survival in mouse experiments. (weeksmd.com)
The E3 ubiquitin ligase RAD18 is well known for the maintenance of genome stability and cell survival through many DNA damage response (DDR) pathways such as translesion DNA synthesis (TLS) and homologous recombination repair (HRR) [ 4 , 5 ]. (nature.com)

Almost all the patients with a yolk sac tumor (YST), either in pure form or mixed form have a significantly elevated serum alpha fetoprotein (AFP). (medscape.com)
The number of apoptotic cells under a single or daily application of curcumin for 7 days was significantly lower than that of the UVB controls (p ≤ 0.05). (bvsalud.org)
No other tumor type was increased significantly in either species. (cdc.gov)
1998). However, the chronic inhalation study with mice resulted in statisti- cally significantly increased incidences of bronchioloalveolar tumors in both male and female mice at the end of 2 yr, but not after 12 or 18 mo (Cruzan et al. (cdc.gov)

A known combination marker of cancer stem cells is high expression of CD44 and low expression of CD24 surface proteins. (weeksmd.com)
Your doctor can check for tumor markers (like certain proteins) in your blood that may help indicate a sign or risk of ovarian cancer. (uhc.com)
Gibson reasoned that the reported tumor-suppressive activity of these proteins might be linked to a role in keeping the mitotic spindle in line. (stowers.org)

Anatomy41

Organisms13

Diseases43

Chemicals and Drugs64

Analytical, Diagnostic and Therapeutic Techniques and Equipment42

Phenomena and Processes57

Disciplines and Occupations1

Information Science3

Health Care1

Proliferation19

Phenotype9

Apoptosis9

Metastasis12

Malignant tumors2

Normal human bronchial epithelial3

Necrosis factor4

Germ14

Microenvironment3

Suppressor9

Cancers9

Transition2

Progression10

Carcinomas3

Genes8

Inhibition4

Differentiation10

Loss of epithelial3

Protein15

Form tumors2

Invasion6

Epithelium9

Tissues12

Primary epithelial1

Tissue11

Mucinous2

Lung11

Induces1

Nude mice1

Carcinoma7

Benign5

Xenograft1

Colon2

Human21

Cancerous2

Hematopoietic stem1

Adenocarcinoma4

Type of tumor2

Ovary1

Airway1

Intestinal2

Stromal cell2

Induction1

Cellular5

A5493

Organs4

Pulmonary2

Inhibits1

Characteristics3

Initiation1

Assays1

Vitro5

Ovaries6

Prostatic1

Dissemination1

Cystic fibrosis1

Monoclonal1

Migration3

Colorectal2

Grossly1

Invasive3

Survival2

Significantly4

Proteins3