• SFTs of the pleura are localized mesenchymal neoplasms composed of fibroblastlike cells believed to arise from the subpleural connective tissue. (medscape.com)
  • The World Health Organization (2019) classified papillary neoplasms (i.e. benign or cancerous tumors) of the breast into 5 types: intraductal papilloma, papillary ductal carcinoma in situ (PDCIS), encapsulated papillary carcinoma (EPC), solid-papillary carcinoma (SPC), and invasive papillary carcinoma (IPC). (wikipedia.org)
  • CONTEXT: Gastric neuroendocrine tumors are rare neoplasms that originate from gastric enterochromaffin-like (ECL) cells in the oxyntic mucosa. (tum.de)
  • While most tumors metastatic to the serous membranes are of epithelial origin, cytologists should be aware that non-epithelial neoplasms can also cause malignant effusions including sarcomas, melanomas, germ cell tumors, and, more rarely, brain tumors. (cytojournal.com)
  • Diagnosing non-epithelial malignancies in effusion specimens based entirely upon their cytomorphologic features is difficult because these neoplasms often exhibit considerable morphological overlap and their cytomorphology can differ from the original tumor. (cytojournal.com)
  • Common non-epithelial neoplasms that may cause malignant effusions include malignant melanoma, sarcomas, and other neoplasms including germ cell tumors [ Figure 1 ]. (cytojournal.com)
  • 4 Malignant effusions caused by non-epithelial neoplasms are more frequently encountered in children than in adults. (cytojournal.com)
  • Most of the cervical epithelial neoplasms and their precursors occur at the squamocolumnar junction or within the transformation zone. (cytojournal.com)
  • Meningiomas , as defined by the 2016 World Health Organization (WHO), are "a group of mostly benign, slow-growing neoplasms that most likely derive from the meningothelial cells of the arachnoid layer. (medscape.com)
  • Aberrant (upregulated) expression of the MUC1 mucin has been seen in breast carcinomas and other neoplasms, such as colon and pancreatic cancers. (bmj.com)
  • Renal Cell Carcinoma. (iiarjournals.org)
  • All 8 EBV-GCLSs occurred in male patients and invaded deep submucosa (SM2) without lymph node metastasis (LNM), four (50%) of which had synchronous non-gastric malignant tumors (3 gastric gastrointestinal stromal tumors and 1 primary clear cell renal cell carcinoma), and four (50%) arose in the proximal stomach. (biomedcentral.com)
  • Immune response in colorectal carcinoma: a review of its significance as a predictive and prognostic biomarker. (nih.gov)
  • Interval colorectal carcinoma: An unsolved debate. (nih.gov)
  • Metastasis of colorectal carcinoma to the testes: clinical presentation and possible pathways. (nih.gov)
  • Metachronous colorectal carcinoma. (nih.gov)
  • Molecular Approach to Colorectal Carcinoma: Current Evidence and Clinical Application. (nih.gov)
  • Colorectal carcinoma screening: Established methods and emerging technology. (nih.gov)
  • The microscopic histopathology of typical PDCIS lesions (refer to adjacent high-power photomicrograph) prepared with a hematoxylin and eosin stain consists of mammary ducts that have papillary fronds (i.e. thin, finger-like or leaf-like structures) lined with one or several layers of neoplastic, columnar-shaped epithelial cells (i.e. tall, narrow cells with their nuclei close to the site of their ductal attachment). (wikipedia.org)
  • Calcifications are not usually an intrinsic feature of mammary lymphoma, but they may occur coincidentally in epithelial lesions or in fat necrosis. (basicmedicalkey.com)
  • In addition of the categories of squamous dysplasia and carcinoma in situ , two additional lesions were added to the group of pre-invasive lesions: atypical adenomatous hyperplasia (AAH) and diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH). (ersjournals.com)
  • Carcinoma of cervix is classified as per the WHO classification into primary tumors which are predominantly epithelial tumors, mesenchymal tumors and tumor like lesions, mixed epithelial stromal tumors, melanocytic, germ cell, and lymphoid tumors. (cytojournal.com)
  • Developmental lesions such as heterotopia of meningothelial cells in the scalp are believed to be the origin of meningiomas under the scalp and skin of the head. (medscape.com)
  • Macroscopically, the lesions of early gastric carcinoma may have 3 patterns-superficial, polypoid and ulcer-associated. (poznayka.org)
  • Primary lesions include epithelial ovarian carcinoma (70% of all ovarian malignancies). (medscape.com)
  • The World Health Organization regarded solid papillary carcinoma as having two subtypes: in situ and invasive SPC. (wikipedia.org)
  • It is the most common type of ductal carcinoma in situ diagnosed in men. (wikipedia.org)
  • PDCIS tumors may occur alongside of (non-papillary) ductal carcinoma in situ or EPC tumors. (wikipedia.org)
  • Extension of lymphoma cells into the glandular epithelium of ducts and lobules may mimic in situ carcinoma or pagetoid spread of carcinoma. (basicmedicalkey.com)
  • carcinoma in situ in the stomach (a state of severe cellular atypia or dysplasia, without invasion across the basement membrane of the glands). (poznayka.org)
  • Papillary carcinomas of the breast (PCB), also termed malignant papillary carcinomas of the breast, are rare forms of the breast cancers. (wikipedia.org)
  • Information on the frequency and clinical features of PDCIS is limited since it and EPC were regarded as the same lesion termed intracystic papillary carcinoma until 2012. (wikipedia.org)
  • Epithelial cells lining the fronds' inner surfaces commonly form solid, cribriform (i.e. large nests of cells perforated by many rounded, variably sized spaces), or micro-papillary patterns. (wikipedia.org)
  • Although some of the observed variants, such as chondroid meningiomas, clear-cell meningiomas, papillary meningiomas, and rhabdoid meningiomas, are associated with unfavorable prognoses, the other histologic patterns are not indicators of unfavorable biologic behavior. (medscape.com)
  • Microscopically, fungating or polypoid carcinomas are well-differentiated adenocarcinomas, commonly papillary type. (poznayka.org)
  • An enlarged ovary with a papillary serous carcinoma on the surface. (medscape.com)
  • The pattern of metastasis is different for gastric signet cell carcinoma than for intestinal-type gastric carcinoma. (wikipedia.org)
  • Our results demonstrate that tumor growth, peritoneal dissemination and peritoneum or organ metastasis implanted MKN45 cells were significantly decreased in shAhR and Biseugenol-treated mice and that endoplasmic reticulum (ER) stress was caused. (oncotarget.com)
  • In general, mucins have the unique function of protecting and lubricating epithelial surfaces, but in recent years they have also been implicated in additional diverse roles, such as growth, fetal development, epithelial renewal and differentiation, epithelial integrity, carcinogenesis, and metastasis. (bmj.com)
  • Rat Muc4, a homologue of human MUC4, has been extensively studied in mammary gland tumours and has been shown to play an important role in epithelial growth, cell differentiation, cell-cell adhesion, metastasis, and tumour apoptosis. (bmj.com)
  • Gastrin and its derivates have been reported to regulate epithelial cell proliferation, migration, and differentiation. (tum.de)
  • Large cell neuroendocrine carcinoma (LCNEC) is now recognized as a histologically high grade non small cell carcinoma showing histopathological features of neuroendocrine differentiation as well as immunohistochemical neuroendocrine markers. (ersjournals.com)
  • Finally, a new class was defined called carcinoma with pleomorphic, sarcomatoid, or sarcomatous elements, which brings together a number of proliferations characterized by a spectrum of epithelial to mesenchymal differentiation. (ersjournals.com)
  • Extracellular matrix plays a major role in cell communication, function, and differentiation, and therefore may play a role in disease development and pathophysiology. (mugen-noe.org)
  • The occurrence of synchronous and metachronous lymphoma and breast carcinoma has been described ( 3 ). (basicmedicalkey.com)
  • In one instance, occult low grade non-Hodgkin lymphoma was found in a mastectomy specimen after the operation was performed for intraductal carcinoma ( 4 ). (basicmedicalkey.com)
  • The majority of mammary lymphomas are of the B-cell type, with infrequent examples of T-cell and histiocytic lymphoma described ( 10 , 13 , 14 , 15 , 16 , 17 , 18 ). (basicmedicalkey.com)
  • Lymphoma in the breast typically consists of a dense population of tumor cells that diffusely infiltrate the mammary parenchyma. (basicmedicalkey.com)
  • The needle core biopsy specimen shown here revealed diffuse large cell B-cell lymphoma. (basicmedicalkey.com)
  • Signet ring cell lymphoma bears a striking resemblance to signet ring cell lobular carcinoma, and it may require immunostains for lymphoid and epithelial markers to distinguish between these entities. (basicmedicalkey.com)
  • The appearance of lymphoma involving mammary stroma that is altered by pseudoangiomatous stromal hyperplasia may also be mistaken for invasive carcinoma ( 13 , 14 ). (basicmedicalkey.com)
  • It represents a large group of epithelial lung malignancies which can be divided into two clinical groups: SMALL CELL LUNG CANCER and NON-SMALL-CELL LUNG CARCINOMA . (lookformedical.com)
  • It is an epithelial malignancy characterized by the histologic appearance of signet ring cells. (wikipedia.org)
  • Although some published studies have analyzed and discussed adenosquamous carcinomas, hybrid malignancy of the ampulla of Vater has rarely been discussed thus far in the literature. (biomedcentral.com)
  • The term "Krukenberg tumor" is used in practice to include all metastatic ovarian tumors although only 40% of ovarian metastases are due to Krukenberg tumor which is a signet cell gastrointestinal malignancy [1]. (symptoma.com)
  • Twaalhoven 1999,Houck 2000, Tempfer 2007, Brun 2008 Accuracy for malignancy of epithelial OvTu 90-94% Accuracy for borderline tumors approx. (symptoma.com)
  • A malignant epithelial neoplasm that arises from the colon or rectum and invades through the muscularis mucosa into the submucosa. (nih.gov)
  • A malignant epithelial tumor with a glandular organization. (lookformedical.com)
  • By definition, pseudomesotheliomatous carcinoma refers to an epithelial neoplasm that secondarily involves the pleura and encases the lung, thereby simulating the radiologic and macroscopic appearance of malignant mesothelioma. (medscape.com)
  • A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. (lookformedical.com)
  • A primary malignant neoplasm of epithelial liver cells. (lookformedical.com)
  • It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. (lookformedical.com)
  • A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (lookformedical.com)
  • An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. (lookformedical.com)
  • PCB are carcinomas derived from the epithelial cells of mammary gland ducts. (wikipedia.org)
  • The largest subgroup of primary mammary lymphomas has been described as diffuse histiocytic when classified by the Rappaport system ( 1 , 5 , 6 , 8 ) or as diffuse large cell ( 13 ) ( Fig. 24.1 ). (basicmedicalkey.com)
  • An invasive (infiltrating) CARCINOMA of the mammary ductal system (MAMMARY GLANDS) in the human BREAST. (lookformedical.com)
  • Intraventricular meningiomas probably arise from the meningothelial cells of the tela choroidea, where there is an arachnoidal invagination into the stromal base of the choroid plexus. (medscape.com)
  • MFP induced tissue remodeling in PRA-overexpressing tumors, increasing the stromal/tumor cell ratio and the number of functional vessels. (oncotarget.com)
  • Accordingly, an increase in nanoparticles and drug accumulation was observed in stromal and tumor cells in MFP-treated tumors. (oncotarget.com)
  • Stromal tumors of the ovary include germ-cell tumors, sex-cord stromal tumors, and other more rare types. (medscape.com)
  • An Immunohistochemical study conducted in 2009 of 54 individuals diagnosed with PDCIS found that the tumor cells in 34, 31, and 35 cases, respectively, expressed the estrogen receptor, progesterone receptor, and HER2/neu protein. (wikipedia.org)
  • More resent reports find that these tumor cells strongly express the estrogen receptor in most cases and that PDCIS with tumor cells that do not express the estrogen receptor generally have a more malignant microscopic histopathology. (wikipedia.org)
  • carcinoma contains abundant pools of mucin in which are seen a small number of tumor cells, sometimes having signet-ring appearance. (poznayka.org)
  • A lesion with cytological characteristics associated with invasive carcinoma but the tumor cells are confined to the epithelium of origin, without invasion of the basement membrane. (lookformedical.com)
  • A cell line derived from cultured tumor cells. (lookformedical.com)
  • Tumor cells are small to medium size, discohesive with eccentrically placed oval to round, and hyperchromatic nuclei. (biomedcentral.com)
  • Other rare non-epithelial malignancies that may be encountered in effusion cytology include neuroblastoma, Wilms tumor, and metastatic brain tumors. (cytojournal.com)
  • 1. Early gastric carcinoma, when carcinoma confined only mucosal layers. (poznayka.org)
  • Early gastric carcinoma is the term used to describe cancer limited to the mucosa and submucosa. (poznayka.org)
  • Epstein-Barr virus-associated early gastric carcinoma with lymphoid stroma (EBV-GCLS) is a rare variant of early gastric carcinomas. (biomedcentral.com)
  • By a retrospective review of 595 consecutive radical gastrectomies for early gastric carcinoma from 2006 to 2018, we identified 8 (1.3%, 8/595) EBV-GCLS cases. (biomedcentral.com)
  • With the improvement in endoscopic technology and accumulating operative experience among endoscopists, endoscopic therapy, such as endoscopic submucosal dissection, has become the treatment of choice for early gastric carcinoma in many countries, including China [ 3 ]. (biomedcentral.com)
  • A reactive lymphoid infiltrate composed of small lymphocytes is very commonly present at the periphery of the tumor, often localized around epithelial elements and blood vessels. (basicmedicalkey.com)
  • In the present study, we aimed to analyze the clinicopathology and prognosis of EBV-GCLS and to compare them with those of invasion-depth stratified conventional early gastric carcinomas without lymphoid stroma or micropapillary components. (biomedcentral.com)
  • Primary SRCC tumors are most often found in the glandular cells of the stomach (SRCC originates in the stomach in 56 percent of patients), and less frequently in the breast, gallbladder, urinary bladder, and pancreas. (wikipedia.org)
  • OBJECTIVE: In this study we investigated the histopathological and molecular findings in the gastrointestinal wall of a patient with multiple endocrine neoplasia type 1 with malignant duodenal gastrinoma and multiple gastric ECL cell tumors, who additionally developed a signet-ring cell carcinoma of the stomach. (tum.de)
  • HDGC seems to occur when the normal CDH1 gene is not present in the cells that line the inside of the stomach. (nostomachforcancer.org)
  • However, what happens to stomach cells after they have lost CDH1 and begin to form cancer is unknown. (nostomachforcancer.org)
  • To find better stomach cancer treatments, we must understand why and how these early cancer cells form. (nostomachforcancer.org)
  • Macroscopically, ulcerative carcinomas are poorly-differentiated adenocarcinomas, which invade deeply into the stomach wall. (poznayka.org)
  • Establishment of cultured cell lines of human stomach cancer origin and their morphological characteristics. (cellosaurus.org)
  • There may be a second population of epithelial cells lining the papillae that have abundant clear cytoplasm in addition to the usual neoplastic epithelial cells which line the papillae. (wikipedia.org)
  • Both non-neoplastic meningothelial cells and meningiomas possess mixed features of epithelial and mesenchymal cells. (medscape.com)
  • Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. (lookformedical.com)
  • neoplastic cells are frequently palisaded at the periphery of the small groups, and the latter have a tendency to infiltrate surrounding tissue . (en-academic.com)
  • SRCC cancers are usually diagnosed during the late stages of the disease, so the tumors generally spread more aggressively than non-signet cancers, making treatment challenging. (wikipedia.org)
  • A) . Clear cell tumour. (mrcoggoal.com)
  • 1, 2 Most studies of MUC1 expression in breast carcinomas have shown that increased membrane MUC1 mucin expression on the apical cell surface is associated with a better prognosis (reviewed in Rahn and colleagues 2 ), whereas circumferential staining in tumour cell cytoplasm is associated with a worse prognosis. (bmj.com)
  • Most tumors metastatic to the serous membranes are of epithelial origin. (cytojournal.com)
  • Pathologic differential diagnosis of metastatic carcinoma in the liver. (nih.gov)
  • ASC has also been identified in the esophagus, anus, and vagina, where squamous cell carcinomas predominate. (biomedcentral.com)
  • Squamous cell carcinoma (SCC) in various morphological forms needs to be separated from other epithelial tumors for treatment modality selection. (cytojournal.com)
  • 3. Squamous-cell carcinoma. (poznayka.org)
  • Notably, early-stage HDGC in E-cadherin mutant carriers is characterized by multiple foci of invasive carcinoma cells invading the superficial lamina propria. (nostomachforcancer.org)
  • Those invasive cells' phenotypic singularity is their abnormal nuclear position and morphology, known as signet ring cell features. (nostomachforcancer.org)
  • a painless, slowly growing, mixed radiolucent-radiopaque lesion characterized histologically by cords of polyhedral epithelial cells, deposits of amyloid , and spherical calcifications. (en-academic.com)
  • CONCLUSION: Our immunohistochemical studies might suggest that the gastrinoma-associated excessive progastrin tissue concentrations led to diminished expression of E-cadherin within the gastric mucosa and promoted tumor development of a signet-ring cell carcinoma. (tum.de)
  • [ 2 ] The arachnoid cells have several proposed functions, including acting as a structural barrier with cellular wrapping/ensheathing, acting as a conduit for cerebrospinal fluid (CSF) drainage/absorption into dural sinuses/veins (arachnoid villi), epithelial-like/secretory functions, monocytelike functions, trophic support and byproduct detoxification for glial and neuronal cells, and participation in reactive/reparative processes. (medscape.com)
  • Epithelial mucins can be classified into two distinct families: secretory (gel forming) and membrane bound. (bmj.com)
  • SRCCs are named due to their resemblance to signet rings, which result from the formation of large vacuoles full of mucin that displaces the nucleus to the cell's periphery. (wikipedia.org)
  • With the close resemblance between meningiomas and meningothelial cells, these cells are believed to be the cell of origin of meningiomas. (medscape.com)
  • Mutations in the epithelial cadherin (E-cadherin) gene have been shown to be associated with the occurrence of diffuse gastric carcinomas in affected families. (tum.de)
  • and diffuse or follicular mixed cell lymphomas are the three most common cell types, according to the Working Formulation ( 6 ). (basicmedicalkey.com)
  • atypical adenomatous hyperplasia and diffuse idiopathic pulmonary neuroendocrine cell hyperplasia. (ersjournals.com)
  • This rare and very aggressive form is called plasmacytoid urothelial carcinoma (PUC), also known as poorly cohesive or diffuse carcinoma. (biomedcentral.com)
  • Interestingly, a recent study suggests that invasion is highly dependent on cell plasticity that involves nuclear remodeling. (nostomachforcancer.org)
  • Since E-cadherin is a causative event in HDGC and the major epithelial cell adhesion molecule, our goal is to determine the impact of E-cadherin dysfunction in nuclei of HDGC cells during cancer invasion. (nostomachforcancer.org)
  • Cell co-culture and gastric CAF conditioned medium transfer models were established to investigate the paracrine effects of activated CAFs on the migration and invasion of gastric cell lines. (biomedcentral.com)
  • The migration and invasion abilities of gastric cells were significantly enhanced in both the co-culture group and the conditioned medium group. (biomedcentral.com)
  • These two genes are responsible for the proliferation, scattering, and invasion of cancer cells. (pronursingtutors.com)
  • Some cases are inherited, and these cases are often caused by mutations in the CDH1 gene, which encodes the important cell-cell adhesion glycoprotein E-cadherin. (wikipedia.org)
  • Cell adhesion and gap junction proteins, such as integrins and connexins, are also important for mobile communication and behavior, and can interact directly (integrins) or indirectly (connexins) with the extracellular matrix. (mugen-noe.org)
  • These findings may be linked to reports that MUC1 plays an important role in the impairment of cell-cell adhesion, the immune response, and/or altered intracellular signalling. (bmj.com)
  • RESULTS: Immunohistochemical studies of gastric ECL cell tumors showed a largely diminished E-cadherin expression in comparison to gastric surface mucosa cells and a loss of E-cadherin expression in the cells of the signet-ring carcinoma. (tum.de)
  • Biseugenol-exposure tumors showed acquired epithelial features such as phosphorylation of E-cadherin, cytokeratin-18 and loss mesenchymal signature Snail, but not vimentin regulation. (oncotarget.com)
  • and 5) the presence of signet ring-shaped cells bearing mucin-containing granules. (wikipedia.org)
  • Several studies have reported conflicting and inconclusive results concerning the clinical relevance of mucin expression in gastric carcinoma. (bmj.com)
  • namely, MUC3, MUC4, MUC12, MUC13, and the recently described mucin MUC17, which share a C-terminal structural domain that consists of two or three epithelial growth factor (EGF)-like regions, a transmembrane segment, and a short cytoplasmic tail. (bmj.com)
  • Primary cutaneous signet-ring cell melanoma: a clinico-pathologic and immunohistochemical research of two circumstances Am J Dermatopathol. (ehd.org)
  • The differential diagnosis of a malignant effusion is accordingly broad, especially for the small round blue cell tumors that includes not only mesenchymal tumors, but also non-mesenchymal tumors, such as neuroblastoma and Wilms tumor. (cytojournal.com)
  • Synovial sarcomas encompass both biphasic (epithelial and spindle cell components) and monophasic (purely spindle cell) variants. (medscape.com)
  • PDCIS tumors with these cells have been termed dimorphic variants of PDCIS. (wikipedia.org)
  • The WHO publication of 2016 recognizes 10 variants of urothelial carcinoma (UC), significant from the diagnostic, prognostic, and/or therapeutic perspective (Table 1 ). (biomedcentral.com)
  • [ 4 , 5 ] are small perivascular nodules that are histologically and ultrastructurally identical to meningothelial cells of the CNS. (medscape.com)
  • characterized histologically by columnar cells organized in a ductlike configuration interspersed with spindle-shaped cells and amyloidlike deposition that gradually undergoes dystrophic calcification . (en-academic.com)
  • These carcinomas are typically unresponsive to adjuvant therapy and are associated with high relapse rates, resulting in a very poor prognosis. (nostomachforcancer.org)
  • however, it has been found that a colon carcinoma cell known as HCC2998 causes an increase in differentiated tumor production. (wikipedia.org)
  • In recent years, there has been a major paradigm shift in the management of non-small cell lung cancer (NSCLC). (amegroups.org)
  • Over the last decade, molecular translational research advances have heralded major breakthroughs in the understanding, diagnosis and management of lung cancer, particularly for the more common (~80%) non-small cell lung cancer (NSCLC). (amegroups.org)
  • Conversely, treatment for small cell lung cancer remains chemotherapy-based and whilst there are promising results with novel cytotoxics, its platinum-etoposide backbone holds strong ( 2 ). (amegroups.org)
  • A cyst is sent for histologic investigation and the report shows an insular pattern of round uniform cells with 80% neurosecretory granules. (mrcoggoal.com)
  • One study suggests that when signet-ring cells are found in a breast tumor, the presence of gastric cancer should also be considered. (wikipedia.org)
  • In the future, case studies indicate that bone marrow metastases will likely play a larger role in the diagnosis and management of signet ring cell gastric cancer. (wikipedia.org)
  • Cancer of the Appendix (also known as appendiceal cancer) occurs when cells in the appendix become abnormal and multiply without control. (cancerindex.org)
  • Stem Cells and Cancer. (iiarjournals.org)
  • This project involves a team of researchers with expertise in cancer genetics (Raquel Seruca), cell biology (Joana Figueiredo), pathology (Fatima Carneiro), and image analysis (João Sanches) from i3S and ISR/IST, in collaboration with members from the International Gastric Cancer Linkage Consortium. (nostomachforcancer.org)
  • Our research aims to fully characterize the signet ring cancer cells found in the stomachs of patients with CDH1 mutation who have had total prophylactic gastrectomy. (nostomachforcancer.org)
  • Carcinoma cervix is not the only cancer caused by HPV. (cytojournal.com)
  • The modern cancer model has developed into a cancer-niche complex that includes cancer cells, cancer-associated fibroblasts (CAFs), endothelial cells, immune inflammatory cells, pericytes, and cancer stem cells [ 2 ]. (biomedcentral.com)
  • Among these components, CAFs, as the major mesenchymal cell component surrounding cancer cells, have various interactions within the featured characteristics of cancer related microenvironment and play a vital role in tumor progression. (biomedcentral.com)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). (cellosaurus.org)
  • Evaluation of the regrowth assay method as an in vitro drug sensitivity test and its application to cultured human gastric cancer cell lines. (cellosaurus.org)
  • Thromboplastic and fibrinolytic activities of cultured human gastric cancer cell lines. (cellosaurus.org)
  • Aberrant elevation of tyrosine-specific phosphorylation in human gastric cancer cells. (cellosaurus.org)
  • Even though these genes are crucial for stem cell renewal, they can also lead to cancer when expresses inappropriately at high levels. (pronursingtutors.com)
  • This study investigated the correlations between aberrant expression of mucins in gastric carcinoma and patient clinicopathological features. (bmj.com)
  • The expression of MUC1, MUC2, MUC3, MUC5AC, and MUC6 was investigated immunohistochemically in gastric carcinoma (n = 46) in relation to patient clinicopathological features. (bmj.com)
  • PDCIS tissues may also contain areas of "Comedo-type necrosis", i.e. areas where dead cells have accumulated. (wikipedia.org)
  • About two thirds of appendix tumours are carcinoid tumours which develop in hormone-producing cells that are present in many parts of the body, including the appendix. (cancerindex.org)
  • adenomatoid t. a small benign t. of the male epididymis and female genital tract , consisting of fibrous tissue or smooth muscle enclosing anastomosing glandlike spaces containing acid mucopolysaccharide lined by flattened cells that have ultra-structural characteristics of mesothelial cells. (en-academic.com)
  • The cells are arranged in cords, single files, small nests, solid sheetlike and occasionally assume a deceptive benign appearance, mimicking an inflammatory process (Fig. 2 ). (biomedcentral.com)
  • Additionally, an obvious elevation of epithelial-mesenchymal transition level was observed in the conditioned medium group. (biomedcentral.com)
  • Snail expression, through AhR activation, is an epithelial-to-mesenchymal transition (EMT) determinant. (oncotarget.com)
  • Around half of them are pure, but conventional UC, sarcomatoid, micropapillary, nested and small cell carcinoma can also be identified. (biomedcentral.com)