CD98 (4F2) is a type II transmembrane glycoprotein which serves as the heavy chain of the heterodimeric amino acid transporters (HATs). (exbio.cz)
Carcinoembryonic antigen (CEA) is a glycoprotein involved in cell adhesion . (wikidoc.org)
Colonic1
Demonstration of tumor-specific antigens in human colonic carcinomata by immunological tolerance and absorption techniques. (wikidoc.org)
SLC3A23
4F2 cell-surface antigen heavy chain is a protein that in humans is encoded by the SLC3A2 (solute carrier family 3 member 2) gene. (wikipedia.org)
SLC3A2 comprises the heavy subunit of the large neutral amino acid transporter (LAT1) that is also known as CD98 (cluster of differentiation 98). (wikipedia.org)
A functional LAT1 transporter is composed of two proteins encoded by two distinct genes: 4F2hc/CD98 heavy subunit protein encoded by the SLC3A2 gene (this gene) CD98 light subunit protein encoded by the SLC7A5 gene SLC3A2 has been shown to interact with SLC7A7. (wikipedia.org)
Lymphocytes1
Most strikingly, we describe in GO patients a peculiar, heterogeneous structure that we named FAPS (Favoring Antigen-Presenting Structure), a triad composed of DC, HEV and CD62L+ naïve lymphocytes, whose postulated role would be to favor tumor antigen (Ag) priming of incoming naïve lymphocytes. (bvsalud.org)
Liu X, Charrier L, Gewirtz A, Sitaraman S, Merlin D: CD98 and intracellular adhesion molecule I regulate the activity of amino acid transporter LAT-2 in polarized intestinal epithelia. (exbio.cz)
Our results indicate that rhythmic changes in mitochondrial calcium, which are associated with changes in mitochondrial morphology, regulate antigen processing. (biomed.news)
Activation2
Besides its roles in amino acid transport, CD98 is thus involved in cell fusion and activation. (exbio.cz)
Cho JY, Skubitz KM, Katz DR, Chain BM: CD98-dependent homotypic aggregation is associated with translocation of protein kinase Cdelta and activation of mitogen-activated protein kinases. (exbio.cz)
Cell5
CD98, linked to various light chains by disulfide bond, is responsible for cell surface expression and basolateral localization of this transporter complex in polarized epithelial cells and also interacts with beta1 integrins and increases their affinity for ligand. (exbio.cz)
Dalton P, Christian HC, Redman CW, Sargent IL, Boyd CA: Differential effect of cross-linking the CD98 heavy chain on fusion and amino acid transport in the human placental trophoblast (BeWo) cell line. (exbio.cz)
Proteomic analysis of the intestinal epithelial cell response to enteropathogenic Escherichia coli . (k-state.edu)
Gastritis represents a group of disorders characterized by gastric epithelial cell injury and regeneration together with the induction of inflammatory changes in the gastric mucosa [16]. (ukessays.com)
2012. Epithelial cell-intrinsic Notch signaling plays an essential role in the maintenance of gut immune homeostasis. (aai.org)
Heavy chain1
The antibody MEM-108 reacts with an extracellular epitope of CD98, a 125 kDa disulfide-linked heterodimer (80 kDa glycosylated heavy chain + 45 kDa non-glykosylated light chain). (exbio.cz)
Role1
Dendritic cells play a key role in processing and presenting antigens to naïve T cells to prime adaptive immunity. (biomed.news)
Normal1
Hammarstrom S. The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues. (wikidoc.org)
4F2hc2
A functional LAT1 transporter is composed of two proteins encoded by two distinct genes: 4F2hc/CD98 heavy subunit protein encoded by the SLC3A2 gene (this gene) CD98 light subunit protein encoded by the SLC7A5 gene SLC3A2 has been shown to interact with SLC7A7. (wikipedia.org)
The missense mutation abolishes y+LAT-1 amino-acid transport activity when co-expressed with the heavy chain of the cell-surface antigen 4F2 (4F2hc, also known as CD98) in Xenopus laevis oocytes. (nih.gov)
Inflammation1
16. Down-regulation of single immunoglobulin interleukin-1R-related molecule (SIGIRR)/TIR8 expression in intestinal epithelial cells during inflammation. (nih.gov)
Membrane1
A defect in the plasma membrane transport of dibasic amino acids has been demonstrated at the baso-lateral membrane of epithelial cells in small intestine and in renal tubules and in plasma membrane of cultured skin fibroblasts from LPI patients. (nih.gov)
Transition2
A positive correlation was observed between the expression of human pidermal growth factor receptor (HER) 3 and mesenchymal-to-epithelial transition factor (MET) on the cell surface of CRC cell lines. (kindai.ac.jp)
E-cadherin level changes in EMT ( epithelial-mesenchymal transition ) and MET ( mesenchymal-epithelial transition ). (wikidoc.org)
Protein3
4F2 cell-surface antigen heavy chain is a protein that in humans is encoded by the SLC3A2 (solute carrier family 3 member 2) gene. (wikipedia.org)
6. A human-specific TNF-responsive promoter for Goodpasture antigen-binding protein. (nih.gov)
Cadherin-1 also known as CAM 120/80 or epithelial cadherin (E-cadherin) or uvomorulin is a protein that in humans is encoded by the CDH1 gene . (wikidoc.org)
Cell-surface1
[ citation needed ] In adult tissues, E-cadherin is expressed in epithelial tissues, where it is constantly regenerated with a 5-hour half-life on the cell surface. (wikidoc.org)
Regulation1
3. Characterization of the human intestinal CD98 promoter and its regulation by interferon-gamma. (nih.gov)
Cells6
9. Activation of Nuclear Factor-κB by Tumor Necrosis Factor in Intestinal Epithelial Cells and Mouse Intestinal Epithelia Reduces Expression of the Chloride Transporter SLC26A3. (nih.gov)
19. Opposite effects of interferon regulatory factor 1 and osteopontin on the apoptosis of epithelial cells induced by TNF-α in inflammatory bowel disease. (nih.gov)
In epithelial cells, E-cadherin-containing cell-to-cell junctions are often adjacent to actin-containing filaments of the cytoskeleton . (wikidoc.org)
E-cadherin is a crucial type of cell-cell adhesion to hold the epithelial cells tight together. (wikidoc.org)
For example, the cancer cells can recognize differentiated epithelial cell features in the new sites and upregulate E-cadherin expression. (wikidoc.org)
Those cancer cells can form cell-cell adhesions again and return to an epithelial state. (wikidoc.org)
Member1
E-cadherin ( epithelial ) is the most well-studied member of the cadherin family. (wikidoc.org)