• The notion of epithelial cell plasticity derives largely from early studies of tissue regeneration in primitive experimental models. (jci.org)
  • The accessibility of skin, compared with lung or gastrointestinal tissue, has facilitated detailed investigations into mechanisms underlying epithelial barrier dysfunction in atopic dermatitis (AD). (jci.org)
  • Epithelial membranes are comprised of epithelial tissue and connective tissue. (wisegeek.com)
  • Epithelial tissue has several uses, including absorption of materials, protection from foreign sources, providing a sense of touch, secreting bodily fluids, and transporting materials between cells. (wisegeek.com)
  • A top layer of epithelial tissue is joined to underlying connective tissue by a basement membrane . (wisegeek.com)
  • This middle layer is created by proteins and carbohydrates secreted by both epithelial and connective tissue. (wisegeek.com)
  • When epithelial cells fold into the connective tissue, glands are formed. (wisegeek.com)
  • The outer portion of epithelial membranes - epithelial tissue - may be composed of a single layer of cells known as simple epithelium . (wisegeek.com)
  • The fluid is secreted by epithelial tissue and protects organs in close proximity from injuring each other. (wisegeek.com)
  • In this Review we focus on epithelial and innate immune cell interactions that mediate wound healing and restoration of tissue homeostasis in the skin and intestine. (jci.org)
  • This book offers a conceptual explanation of the interrelationships that exist between the stages in the progression of initiated epithelial cells in culture compared with the diverse tissue of organs and the progression of tumors from different organ sites. (routledge.com)
  • The goal of this meeting entitled "Innovative Molecular, Cellular and System Approaches in Basic and Translational Epithelial Biology" is to bring together up and coming scientists as well as eminent speakers at the forefront of epithelial development, stem cell biology, cell biology, pathology and therapy with leaders in areas such as immunity, tissue sensing, tissue cross-talk, evolution, gene expression regulation and promising novel technologies to drive therapy. (grc.org)
  • These are schematics showing the arrangement of cells in normal epithelial tissue (a), following the introduction of a topological defect (b) and the site of cell death and extrusion following. (eurekalert.org)
  • The video lecture can use some interactivity such as asking students to identify an image of an epithelial tissue sample. (merlot.org)
  • For studies of epithelial transport and the electrical properties of tissue. (adinstruments.com)
  • I have developed a novel in vitro assay to address how developmental cues, cell biological mechanisms, and tissue mechanics interact to govern the topological transition of epithelial tissues. (bu.edu)
  • We explore autofluorescence endomicroscopy as a potential tool for real-time visualization of epithelial tissue microstructure and organization in a clinical setting. (spiedigitallibrary.org)
  • Of the four major tissue types found in the human body (Figure 1), epithelial cells are by far the most prolific. (davidson.edu)
  • Epithelial cells are bound together in sheets of tissue called epithelia. (davidson.edu)
  • Epithelial ovarian, fallopian tube or primary peritoneal cancer is a cancer of the tissue covering the ovary or lining the fallopian tube or abdominal wall (peritoneum). (fda.gov)
  • Epithelial dysplasia becomes microinvasive squamous cell carcinoma once the tumor begins to invade nearby tissue. (wikipedia.org)
  • Despite the fact that the tissue forms in different patterns and at different times in development, these data suggest that smooth muscle can be used to shape epithelial tissues into a variety of final architectures. (aiche.org)
  • Based on the anatomy and biology of the airway epithelium, a variety of tissue engineering tools available could be utilized to overcome the barriers currently seen in airway epithelial generation. (psu.edu)
  • EMT, and its reverse process, MET ( mesenchymal-epithelial transition ) are critical for development of many tissues and organs in the developing embryo, and numerous embryonic events such as gastrulation , neural crest formation, heart valve formation, palatogenesis and myogenesis . (wikipedia.org)
  • An example of the first class is seen in the epithelial tissues. (dictionary.com)
  • These models involve a variety of tissues, many of which have an epithelial component. (jci.org)
  • Unlike p53, which is dispensable for normal development, p63 is critical for the development of stratified epithelial tissues such as epidermis, breast, and prostate. (nih.gov)
  • Skin and intestinal epithelial barriers play a pivotal role in protecting underlying tissues from harsh external environments. (jci.org)
  • The palm and sole are good examples of tissues lined with keratinized epithelial strata. (chegg.com)
  • Tissues that undergo lot of abrasion, but must be kept moist are lined with non-keratinized epithelial strata. (chegg.com)
  • This property may have adaptive value for epithelial tissues in general, as an elegant response to injury, but may also promote cancer formation in premalignant epithelial tissues in which the tight junctions have become chronically leaky to growth factors. (sciencemag.org)
  • The epithelial to mesenchymal transition (EMT) plays crucial roles in the formation of the body plan and in the differentiation of multiple tissues and organs. (nih.gov)
  • In particular, the appearance of defects in the cellular patterns of epithelial layers promotes cell death and elimination from the tissues. (eurekalert.org)
  • We aim to use these insights to manipulate smooth muscle differentiation in the developing lung in order to direct epithelial morphogenesis, ultimately gaining precise mechanical control over these developing tissues. (aiche.org)
  • Epithelial swabs yielded, on average, lower quantities of DNA (170.32 ± 74.72 (SD) ng/μL) relative to DNA obtained from tissues collected using invasive or destructive techniques (310.95 ± 147.37 (SD) ng/μL. (bioone.org)
  • Researchers at the European Molecular Biology Laboratory (EMBL) used precise light-mediated control of protein activity in biological tissues to reconstruct epithelial folding in embryonic Drosophila tissues. (photonics.com)
  • Epithelial folding is a developmental process where cells move inward and fold into the embryo, eventually giving rise to internal tissues like muscles. (photonics.com)
  • In Epithelial Cell Culture Protocols, a team of well-versed experimenters and clinical researchers share their best methods for establishing and maintaining epithelial cell cultures, for analyzing and studying their characteristics, and for using them to set up models of critical biological systems. (springer.com)
  • The inclusion of FTC and PPC within the ovarian epithelial cancer designation is generally accepted because of much evidence that points to a common Müllerian epithelium derivation and similar management of these three neoplasms. (cancer.gov)
  • Pulmonary epithelial cell loss, failure to achieve pulmonary epithelium integrity, chronic inflammation, and deterioration of repair mechanisms following pulmonary epithelial injury can result in emphysema (3,5,6). (thefreedictionary.com)
  • Epithelial Strata or Stratified epithelium is made of layers of epithelial cells, usually found in areas in the body that is prone to constant wear and tear. (chegg.com)
  • Normal epithelial cells induce metabolic changes in neighboring transformed cells to force them out of the epithelium. (sciencemag.org)
  • About 85% to 90% of cases of the disease are referred to as epithelial ovarian cancer because the cancer develops from the cells covering the outer surface or epithelium of the ovary. (nurse.com)
  • Epithelial-stromal tumors are classified on the basis of the epithelial cell type, the relative amounts of epithelium and stroma, the presence of papillary processes, and the location of the epithelial elements. (bionity.com)
  • Evaluation of photodynamic therapy to prevent lens epithelial proliferation will require specific localization of the drug to lens epithelium. (springer.com)
  • Epithelial duct metaplasia, proliferation, and atypia may be seen in CP in association with obstruction and inflammation, but severe dysplasia is not common and could represent a premalignant lesion that should alert the pathologist to submit more sections in order to exclude an adjacent invasive carcinoma. (thefreedictionary.com)
  • The most common and visually significant complication of both extracapsular and endocapsular cataract extractions is the formation of a secondary cataract because of the proliferation of retained lens epithelial cells. (springer.com)
  • Natural History of Drusenoid Pigment Epithelial Detachment Associated with Age-Related Macular Degeneration: Age-Related Eye Disease Study 2 Report No. 17. (bioportfolio.com)
  • To investigate the natural history and genetic associations of drusenoid pigment epithelial detachment (DPED) associated with age-related macular degeneration (AMD). (bioportfolio.com)
  • Epithelial carcinoma of the ovary is one of the most common gynecologic malignancies, with 50% of all cases occurring in women older than 65 years. (cancer.gov)
  • Clinical appearance of conjunctival melanosis: (a) freckle, (b) racial, (c) melanocytic intra-epithelial neoplasia (C-MIN) (d) invasive melanoma, and (e) pigmented squamous cell carcinoma. (nature.com)
  • Epithelial-myoepithelial carcinoma (EMC) is a malignant salivary gland neoplasm comprised of a biphasic arrangement of inner luminal ductal cells and outer myoepithelial cells. (ingentaconnect.com)
  • The World Health Organization system uses epithelial cellular atypia as well as the ratio of epithelial cells to lymphocytes to classify TET into types A, AB, B1, B2, B3, and carcinoma. (frontiersin.org)
  • Lanzini M, Curcio C, Colabelli-Gisoldi RA, Mastropasqua A, Calienno R, Agnifili L, et al.In Vivo and Impression Cytology Study on the Effect of Compatible Solutes Eye Drops on the Ocular Surface Epithelial Cell Quality in Dry Eye Patients. (thefreedictionary.com)
  • AGE-albumin) and in particular carboxymethyllysine (CML) are known to play a central role in diabetic nephropathy, we studied the activation of nuclear factor κB (NF-κB) in tubular epithelial cells in vivo and in vitro by AGE-albumin and CML. (diabetesjournals.org)
  • The experiment was done in developing fruit flies, but since epithelial folding is a conserved process across evolution, De Renzis believes that the methods used in the EMBL experiment could be applicable in other organisms and ex vivo stem cell culture systems. (photonics.com)
  • Also described in step-by-step detail are co-culture techniques valuable in developing models for investigating many different in vitro systems, including the blood-brain barrier, drug uptake, and the interaction of epithelial cells with bacteria. (springer.com)
  • While asthma is a complex disease caused by multiple factors, epithelial barrier damage is a cardinal feature. (nih.gov)
  • These findings suggest that GC inhalation therapy can improve epithelial barrier integrity and might contribute to the therapeutic effects of GCs for treating asthma. (nih.gov)
  • The activity of surfactant components that line this mucosal barrier towards Cryptococcus and the metabolic and transcriptional reaction of cryptococci when encountering epithelial cells will also be discussed. (mdpi.com)
  • The air-blood barrier is mainly formed by two epithelial cell types: alveolar type I (ATI) and alveolar type II (ATII) cells. (thefreedictionary.com)
  • Allergic diseases have in common a dysfunctional epithelial barrier, which allows the penetration of allergens and microbes, leading to the release of type 2 cytokines that drive allergic inflammation. (jci.org)
  • This Review examines current epithelial barrier repair strategies as an approach for allergy prevention or intervention. (jci.org)
  • Our primary study includes identifying key molecules which regulate CEC/microorganism interaction, CEC/lamina propria cell interaction and intestinal epithelial cell barrier function. (massgeneral.org)
  • ATCC has employed CRISPR/Cas9 gene editing to develop new reporter lines designed to enable the real-time monitoring of the changing status of cells from epithelial to mesenchymal. (atcc.org)
  • Researchers from the Mechanobiology Institute, Singapore (MBI) at the National University of Singapore have discovered the primary mechanism driving the extrusion of dying cells from epithelial monolayers. (eurekalert.org)
  • As we discuss in this Personal Perspective, we believe that context and various changes in plasticity biomarkers can help identify at least three types of EMT and that using a collection of criteria for EMT increases the likelihood that everyone is studying the same phenomenon - namely, the transition of epithelial and endothelial cells to a motile phenotype. (jci.org)
  • Wide-ranging and highly practical, Epithelial Cell Culture Protocols offers both novices and expert investigators alike a step-by-step guide toward a deeper understanding of cellular and molecular mechanisms in general, as well as a set of robust techniques for specifically evaluating the nature and behavior of epithelial cells. (springer.com)
  • The book provides access to knowledge of molecular and cellular aspects of lung homeostasis and repair, including the molecular basis of lung epithelial intercellular communication and lung epithelial channels and transporters. (elsevier.com)
  • Pleomorphic variations of thymic epithelial hyperplasia are similar to the spectrum of cellular forms of thymoma. (nih.gov)
  • We investigate the basic cellular and molecular mechanisms involved in the functional modulation of colonic epithelial cells (CEC) during the development of inflammatory bowel disease (IBD). (massgeneral.org)
  • Epithelial cell transforming 2 (Ect2) protein activates Rho GTPases and controls cytokinesis and many other cellular processes. (rcsb.org)
  • Individual cellular features of dysplasia are called epithelial atypia. (wikipedia.org)
  • In the digital videos presented above, normal pig kidney (LLC-PK1 line) epithelial cells labeled with mEmerald fluorescent protein fused to microtubule EB3 (a protein that binds to the positive ends of microtubules) and mCherry fused to human histone H2B (highlighting the chromosomes) are visualized undergoing mitosis in laser scanning confocal microscopy. (microscopyu.com)
  • Each plasma membrane domain has a distinct protein composition, giving them distinct properties and allowing directional transport of molecules across the epithelial sheet. (wikipedia.org)
  • Molecular properties of epithelial, amiloride-blockable Na+ channels. (ebi.ac.uk)
  • Also included is coverage of lung epithelial biology as it relates to fluid balance, basic ion/fluid molecular processes, and human disease. (elsevier.com)
  • Currently we still lack a coherent overview of the molecular and biochemical mechanisms inducing cells to enter various states along the epithelial-mesenchymal phenotypic spectrum. (mit.edu)
  • Research in the Epithelial Systems Biology Laboratory, led by Dr. Mark A. Knepper, concentrates on the physiology and pathophysiology of the kidney, with particular focus on regulation of water and salt transport by the peptide hormone vasopressin. (nih.gov)
  • Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease provides a one-stop resource capturing developments in lung epithelial biology related to basic physiology, pathophysiology, and links to human disease. (elsevier.com)
  • This meeting is considered to be the leading epithelial biology Gordon conference. (grc.org)
  • G. M. Verghese, M. F. Gutknecht, and G. H. Caughey, "Prostasin regulates epithelial monolayer function: cell-specific Gpld1-mediated secretion and functional role for GPI anchor," American Journal of Physiology , vol. 291, no. 6, pp. (hindawi.com)
  • Hand2 regulates epithelial format. (mendeley.com)
  • Borderline epithelial tumors are also known as atypical proliferating tumors and used to be called low malignant potential tumors . (cancer.org)
  • Surface epithelial-stromal tumors are a class of ovarian neoplasms that may be benign or malignant . (bionity.com)
  • 5 We have also devised a system for histological scoring for conjunctival melanocytic intra-epithelial neoplasia (C-MIN), which in our institution has replaced the term primary acquired melanosis (PAM) with varying (subjectively evaluated) degrees of atypia. (nature.com)
  • During the course of these events the extravillous cytotrophoblast acquires a distinct phenotype, losing some typical epithelial components (e.g. (biomedsearch.com)
  • Treatment with retinoic acid induces a change in epithelial topology where the apical membrane domain splits up into multiple spherical structures, which is explained as a multiple cyst phenotype. (bu.edu)
  • Detection of cells expressing both sets of markers makes it impossible to identify all mesenchymal cells that originate from the epithelia via EMT, as many mesenchymal cells likely shed all epithelial markers once a transition is completed. (jci.org)
  • In contrast, embryos with reduced Gata5 function exhibit polarized myocardial epithelia despite a similar reduction in myocardial precursor number, indicating that proper cell number is not required for epithelial formation. (mendeley.com)
  • On microscopic examination, wide areas of atrophy, ulceration, and squamous metaplasia of the epithelial duct lining were seen, as was a surrounding patchy chronic inflammatory infiltrate with extensive fibrosis. (thefreedictionary.com)
  • The emphasis is on the analysis and assessment of epithelial cells, for example, by looking at apoptosis and integrins or by measuring membrane capacitance and confluence. (springer.com)