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  • polarity
  • A variety of molecules are located at the apical membrane, but only a few key molecules act as determinants that are required to maintain the identity of the apical membrane and, thus, epithelial polarity. (wikipedia.org)
  • Of these two complexes, the aPKC complex is the most important for epithelial polarity, being required even when the Crumbs complex is not. (wikipedia.org)
  • These three proteins all localize to the basolateral domain and are essential for basolateral identity and for epithelial polarity. (wikipedia.org)
  • In at least one cultured cell line, the MDCK cell, this system is required for epithelial polarity. (wikipedia.org)
  • The changes that occur in epithelial dysplasia include: Drop-shaped rete processes Basal cell hyperplasia Irregular epithelial stratification Nuclear hyperchromatism Increased nuclear-cytoplasmic ratio Increased normal and abnormal mitosis Enlarged nucleoli Individual cell keratinization Loss or reduction of cellular cohesion Cellular pleomorphism Loss of basal cell polarity Anisocytosis Koilocytosis Epithelial cell dysplasia is divided into three categories of severity: mild, moderate, and severe. (wikipedia.org)
  • phenotype
  • However, on the other hand, p53, a well-known tumor suppressor, represses EMT by activating the expression of various microRNAs - miR-200 and miR-34 that inhibit the production of protein ZEB and SNAIL, and thus maintain the epithelial phenotype. (wikipedia.org)
  • cancers
  • 2 ] Therefore, high-grade serous adenocarcinomas arising from the fallopian tube and elsewhere in the peritoneal cavity, together with most ovarian epithelial cancers, represent extrauterine adenocarcinomas of Müllerian epithelial origin and are staged and treated similarly to ovarian cancer. (cancer.gov)
  • The p63 factor is involved in inhibiting EMT and reduction of certain p63 isoforms may be important in the development of epithelial cancers. (wikipedia.org)
  • Waldeyer attempted to establish for the stomach his doctrine that all cancers are of epithelial origin. (dictionary.com)
  • EpCAM is frequently upregulated in carcinomas but is not expressed in cancers of non-epithelial origin. (wikipedia.org)
  • plasticity
  • Our work not only elucidates the nature of hybrid mesenchymal/epithelial states but also provides a general strategy to construct a topographic representation of phenotypic plasticity from gene expression data using statistical physics methods. (pnas.org)
  • transitions
  • Here, we construct a topographic map underlying epithelial-mesenchymal transitions using a combination of numerical simulations of a Boolean network model and the analysis of bulk and single-cell gene expression data. (pnas.org)
  • Epcam
  • Epithelial cell adhesion molecule (EpCAM) is a transmembrane glycoprotein mediating Ca2+-independent homotypic cell-cell adhesion in epithelia. (wikipedia.org)
  • Expression levels are substantially higher in small intestine, and in colon EpCAM is probably expressed at the highest levels among all epithelial cell types. (wikipedia.org)
  • basolateral
  • The principal function of this basolateral membrane is to take up metabolic waste products into the epithelial cell for disposal into the lumen where it is transported out of the body as urine. (wikipedia.org)
  • Cancer
  • This PDQ summary addresses the staging and treatment of ovarian epithelial cancer, fallopian tube cancer (FTC), and primary peritoneal cancer (PPC). (cancer.gov)
  • Cancer of bone always is secondary to cancer in some epithelial organ. (dictionary.com)
  • development
  • Snail and Slug are known to regulate the expression of p63 isoforms, another transcription factor that is required for proper development of epithelial structures. (wikipedia.org)
  • characteristics
  • In Epithelial Cell Culture Protocols, a team of well-versed experimenters and clinical researchers share their best methods for establishing and maintaining epithelial cell cultures, for analyzing and studying their characteristics, and for using them to set up models of critical biological systems. (springer.com)
  • properties
  • Each plasma membrane domain has a distinct protein composition, giving them distinct properties and allowing directional transport of molecules across the epithelial sheet. (wikipedia.org)