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  • SNPs
  • With the availability of genome-wide genotyping technologies, a large number of single nucleotide polymorphisms (SNPs) can be considered during epistasis detection (Heidema et al. (springeropen.com)
  • The interplay between promoter SNPs of CD39 and FAM134B results in an intercellular epistasis which influences the risk of a complex inflammatory disease. (beds.ac.uk)
  • interaction
  • These interacting gene pairs are significantly associated with survival time when co-altered in patients, indicating that genetic interaction mapping may be leveraged to improve risk assessment. (igsb.org)
  • Throughout the article, epistasis refers to the general definition by Fisher and is used synonymously with genetic interaction to refer to any unanticipated combinatorial effect. (beds.ac.uk)
  • functional
  • Leaving aside terminological issues, there are several problems with the use of epistasis as a way to uncover the functional structure of a biological system, which should make us concerned. (cam.ac.uk)
  • While this observation was in line with the epistasis data, it also implied that a functional link must exist. (beds.ac.uk)
  • Major
  • Although maize ( Zea mays ) is a major crop for food and feed worldwide, the genetic architecture of its primary metabolism is largely unknown. (plantcell.org)
  • Molecular
  • Taken together, much of the interconnected feedback loop appears to have been described at a molecular-genetic level of understanding. (plantcell.org)
  • disease
  • Stokes, M, Visweswaran, S . Application of a spatially-weighted Relief algorithm for ranking genetic predictors of disease. (pitt.edu)
  • data
  • This review highlights briefly the characteristics of the TTP-deficiency syndrome in mice and its possible genetic modifiers, as well as recent data on the characteristics of the TTP-binding site in the TNF-alpha and GM-CSF mRNAs. (nih.gov)
  • different
  • 3,000 tumors shows that co‐occurrence and mutual exclusivity between cancer driver alterations change extensively in different cancer types, thus indicating plasticity of epistasis across cell types. (embopress.org)
  • single
  • the loss of B in an A mutant, or the loss of A in a B mutant i.e the reaction of an established and adapted genetic system (the single mutant), one we know little about, to the loss of a gene. (cam.ac.uk)
  • Results
  • Our results reveal a metabolite-metabolite-agronomic trait network that, together with the genetic determinants of maize primary metabolism identified herein, promotes efficient utilization of metabolites in maize improvement. (plantcell.org)