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Myocardial IschemiaIschemiaCold IschemiaWarm IschemiaBrain IschemiaMyocardial Reperfusion InjuryReperfusion InjuryOrgan PreservationTime FactorsDelayed Graft FunctionTissue DonorsGraft SurvivalNephrectomyMyocardiumKidney TransplantationLiver TransplantationCoronary CirculationElectrocardiographyTissue and Organ HarvestingCoronary DiseaseDeathTissue and Organ ProcurementMyocardial ReperfusionDisease Models, AnimalCadaverLiving DonorsMyocardial InfarctionHeartExercise TestIschemic Preconditioning, MyocardialOrgan Preservation SolutionsRats, Sprague-DawleyBiliary TractReperfusionAngina PectorisRaffinoseIschemic Attack, TransientCardiotonic AgentsRetrospective StudiesTreatment OutcomeHemodynamicsDogsIschemic PreconditioningElectrocardiography, AmbulatoryPancreas TransplantationRats, WistarLaparoscopyHeart RateTransplantsBrain DeathCoronary VesselsPostoperative ComplicationsRisk FactorsRoboticsMyocardial ContractionArrhythmias, CardiacProspective StudiesAllopurinolGerbillinaeSpinal Cord IschemiaGraft RejectionFollow-Up StudiesCoronary AngiographyTomography, Emission-Computed, Single-PhotonPerfusionVentricular Function, LeftKidneyCreatine KinaseBlood PressureMyocardial StunningMyocardial Perfusion ImagingEpisode of CarePrimary Graft DysfunctionKidney Tubular Necrosis, AcuteNeuroprotective AgentsAcute DiseaseBiliary Tract DiseasesBile DuctsAdenosineLiver FailureInfarction, Middle Cerebral ArteryHepatic ArteryTissue PreservationRabbitsSwineDonor SelectionRisk AssessmentMyocytes, CardiacCollateral CirculationDipyridamoleCerebrovascular CirculationIschemic PostconditioningBrainHeart VentriclesVasodilator AgentsVentricular FibrillationThallium RadioisotopesIntraoperative ComplicationsConstrictionTransplantation, Homologous
InfarctionAcuteReperfusionArrhythmias and myocardialTransientNecrosisHypoxiaInfarctionsOxygenRefractoryClinicalCardiovascularRepolarizationOccurSymptomsRecurrentIschemic episodesPotentiallyComplicationsStableCardiac outputChronicSeverityFactorsSecondarySuddenDiabetesPatientsOnsetLeftTissueProcedureSyncopeDecreaseReducesAbstractAnginaHolterEventsTreatmentStudyPlateletHoursFunctionResultsPrimary
Infarction15
Acute6
  • Before ischemia, acute troglitazone treatment had no effect on LV function, electrocardiogram, or substrate utilization. (diabetesjournals.org)
  • Acute treatment with troglitazone increases susceptibility to ventricular fibrillation during myocardial ischemia and reperfusion. (diabetesjournals.org)
  • To determine whether ischemia-reperfusion injury causes this acute-phase response, we studied the temporal relation between plasma levels of CRP and ischemic episodes in 48 patients with unstable angina and 20 control patients with active variant angina, in which severe myocardial ischemia is caused by occlusive coronary artery spasm. (ox.ac.uk)
  • CONCLUSIONS: The normal levels of CRP in variant angina, despite a significantly larger number of ischemic episodes and greater total ischemic burden, and the failure of CRP values to increase in unstable angina indicate that transient myocardial ischemia, within the range of duration observed, does not itself stimulate an appreciable acute-phase response. (ox.ac.uk)
  • The preoperative regimen should be documented and detailed instructions to the patient should be given, specifically to avoid cessation of opioids to prevent immediate postoperative acute withdrawal, happening at the time of acute increase in pain. (renalandurologynews.com)
  • Glucose-insulin-potassium (GIK) has been advocated in the setting of acute coronary syndrome (ACS) to reduce ischemia-related arrhythmias and myocardial injury. (biomedcentral.com)
Reperfusion7
  • The cAMP analogue 8-Br-cAMP-AM (8-Br) confers marked protection against global ischaemia/reperfusion of isolated perfused heart. (mdpi.com)
  • We tested the hypothesis that 8-Br is also protective under clinically relevant conditions (regional ischaemia) when applied either before ischemia or at the beginning of reperfusion, and this effect is associated with the mitochondrial permeability transition pore (MPTP). (mdpi.com)
  • We previously demonstrated that chronic pretreatment with a thiazolidinedione peroxisome proliferator-activated receptor (PPAR)-Ī³ activator, troglitazone, improves recovery of left ventricular (LV) function and substrate metabolism after ischemia and reperfusion, without causing arrhythmias. (diabetesjournals.org)
  • Anesthetized pigs underwent 90 min of regional LV ischemia and 90 min of reperfusion. (diabetesjournals.org)
  • Glucose-insulin-potassium (GIK) has long been advocated as an adjunctive treatment for patients with cardiac dysfunction during episodes of ischemia and reperfusion. (biomedcentral.com)
  • but reperfusion may introduce additional harm to the tissue through a process known as ischemia/reperfusion injury. (cdc.gov)
  • As such, new drugs that would complement reperfusion by providing neural and cardiovascular protection and by targeting multiple abnormalities in ischemia are receiving increased attention. (cdc.gov)
Arrhythmias and myocardial1
  • Whereas coma and seizures are well-recognized neurological sequelae of hypoglycaemia, much interest is currently focused on the potential for hypoglycaemia to cause dangerous and life-threatening cardiac complications, such as arrhythmias and myocardial ischaemia, and whether recurrent severe hypoglycaemia can cause permanent cognitive impairment or promote cognitive decline and accelerate the onset of dementia in middle-aged and elderly people with diabetes mellitus. (nature.com)
Transient3
  • Angina pectoris describes the classic symptoms of chest pain, and is caused by transient myocardial ischaemia. (pharmamirror.com)
  • Transient ischemic events, such as silent myocardial ischemia, may not manifest within a 24-hour monitoring period. (ultralinq.com)
  • In conclusion, 7-day Holter monitoring surpasses the limitations of 24-hour monitoring by providing an extended recording duration, enhanced detection of infrequent arrhythmias, improved symptom-rhythm correlation, and increased diagnostic accuracy for transient ischemic events. (ultralinq.com)
Necrosis1
Hypoxia2
  • Hypoxia causes pulmonary vasoconstriction and increased pulmonary pressure, compounding the risk of myocardial ischemia and arrhythmias. (latestfashiontips.com)
  • Mild hypoxia and increased ventilatory response to chemical stimuli during apnea contribute to increasing ventilation and hypocapnia at the end of each episode. (latestfashiontips.com)
Infarctions2
  • The ischemia that results from myocardial infarctions also induce QT prolongation. (wikipedia.org)
  • In the US, about 1.0 million myocardial infarctions occur annually. (msdmanuals.com)
Oxygen4
Refractory2
  • Determine the frequency and duration of complete and partial response rates for patients with relapsed or refractory indolent lymphoproliferative disorders treated with ixabepilone. (knowcancer.com)
  • CONCLUSIONS IABCP can be an effective means of controlling refractory ventricular arrhythmia, allowing time for the institution of more definitive treatment. (bmj.com)
Clinical5
  • Most clinical experience with dobutamine is short-term, not more than several hours in duration. (drugs.com)
  • Frequent episodes of ICD appropriate therapy warrant a clinical reassessment, as it has been demonstrated that ICD shocks correlate with increased risk of heart failure hospitalisation and mortality [2]. (escardio.org)
  • The clinical cardiologist should therefore identify potentially reversible causes of ventricular arrhythmias (e.g., myocardial ischaemia, electrolyte imbalances, etc.) and treat them, whenever possible. (escardio.org)
  • Recurrent means that the longitudinal clinical record shows that, within a consecutive 12-month period, the finding(s) occurs at least three times, with intervening periods of improvement of sufficient duration that it is clear that separate events are involved. (socialsecurityprofessionals.com)
  • We will usually need a longitudinal clinical record to assess the severity and expected duration of your impairment(s). (socialsecurityprofessionals.com)
Cardiovascular2
  • We need sufficiently detailed reports of history, physical examinations, laboratory studies, and any prescribed treatment and response to allow us to assess the severity and duration of your cardiovascular impairment. (socialsecurityprofessionals.com)
  • Looking forward, we think time-dependent analyses will be helpful to examine the temporal relationship between hypoglycemia and cardiovascular outcomes, which could shed light on hypoglycemia's contribution to CV risk. (closeconcerns.com)
Repolarization2
  • By binding to and inhibiting the "rapid" delayed rectifier potassium current protein, certain drugs are able to decrease the outward flow of potassium ions and extend the length of phase 3 myocardial repolarization, resulting in QT prolongation. (wikipedia.org)
  • These changes in repolarization do not occur in all myocardial cells. (medscape.com)
Occur2
  • Mild (self-treated) and severe (requiring help) hypoglycaemia episodes are more common in type 1 diabetes mellitus but people with insulin-treated type 2 diabetes mellitus are also exposed to frequent hypoglycaemic events, many of which occur during sleep. (nature.com)
  • TdP has been shown to occur up to three times more often in female patients compared with males, likely as a result of post-pubertal hormonal influence on cardiac ion channels. (wikipedia.org)
Symptoms4
  • Our current understanding of how AF and symptoms are linked is hampered by the dominant assessment paradigm, where symptoms thought to be associated with AF are measured at a single point in time (frequently at a clinic visit). (jafib.com)
  • Unfortunately, this "static" snapshot does not capture the variability of symptoms and heart rhythm within a person over time and does not shed light on how symptoms are related to heart rhythm. (jafib.com)
  • Our understanding of how AF and symptoms are linked is hampered by the dominant assessment paradigm, where symptoms thought to be associated with AF - dyspnea, chest pain, palpitations, dizziness, fatigue - are measured at a single point in time (frequently at a clinic visit). (jafib.com)
  • With 7-day Holter monitoring, a longer recording duration allows for a better correlation between symptoms and cardiac rhythm abnormalities. (ultralinq.com)
Recurrent2
  • Chronic atrial fibrillation is viewed as recurrent or prolonged episodes or an unknown history or duration. (gehealthcare.com)
  • Paroxysmal episodes are self-terminating but may be recurrent. (gehealthcare.com)
Ischemic episodes1
  • By extending the monitoring duration, cardiologists can identify subtle ischemic episodes that previously went undetected. (ultralinq.com)
Potentially1
  • Intra-aortic balloon counterpulsation (IABCP) improves coronary flow and reduces myocardial distension, thus potentially influencing ventricular irritability by direct and indirect effects. (bmj.com)
Complications1
  • Here we review the current literature on scutellarin to provide a comprehensive understanding of the pharmacological activity, mechanism of action, toxicity, and therapeutic potential of scutellarin for the treatment of ischemia, diabetic complications, and other chronic diseases. (cdc.gov)
Stable1
  • Although the duration of sleep needed for stable waking functions varies among individuals and across the life span, daily sleep in our species is an average duration of eight hours. (psychiatrictimes.com)
Cardiac output1
Chronic3
  • A suggested timeframe for paroxysmal chronic atrial fibrillation is an episode of less than seven days, while chronic episodes have a duration of greater than seven days. (gehealthcare.com)
  • How to time your need to various diseases like controlling experience high chronic illness, interacts with. (ripyard.com)
  • Some authors from different countries have reported the estimated cost of providing healthcare to patients with chronic kidney disease (CKD) at 2-3 times higher than control patients without CKD [ 9 ], and for HD patients, may sometimes be up to 40 times higher. (biomedcentral.com)
Severity1
  • Patients should be asked about the frequency of angina, severity of pain, and number of nitroglycerin pills used during episodes. (medscape.com)
Factors1
  • In an interview with Psychiatric Times, Dinges discussed neurobehavioral consequences of sleep loss, factors that impair sleeping, the pervasiveness of sleepiness and new ways to manage sleepiness. (psychiatrictimes.com)
Secondary1
  • Gas in the liver likely representing portal venous gas which can be seen in the setting of appendicitis vs less likely secondary to bowel ischemia. (illnesshacker.com)
Sudden2
  • Sudden episodes of shortness of breath with no apparent cause on lying flat (paroxysmal nocturnal dyspnea). (latestfashiontips.com)
  • The occurrence of sudden cardiac death (SCD) in an athlete is a tragic event that deeply affects family members, teammates, and at times, an entire community. (scienceopen.com)
Diabetes3
  • Prevention of hypoglycaemia is an important part of diabetes mellitus management and strategies include patient education, glucose monitoring, appropriate adjustment of diet and medications in relation to everyday circumstances including physical exercise, and the application of new technologies such as real-time continuous glucose monitoring, modified insulin pumps and the artificial pancreas. (nature.com)
  • Over time, diabetes damages the small to changes in afterload of hypertension, to prevent doses if, Cheap Zestril Where To Buy . (ripyard.com)
  • Cholesterol lowering medications, like Lipitor, Crestor, Zocor, Simvastatin, Atorvastatin-to name a small few have been linked with causing an increased risk for developing diabetes by 26 times. (diabetestalk.net)
Patients6
  • During TdP episodes, patients have a heart rate of 200 to 250 beats/minute, which may present as palpitations or syncope. (wikipedia.org)
  • Following exclusion of somatic disease, substance use disorders, and other psychiatric disorders, confirmation of the diagnosis of panic disorder with a brief mental status screening examination and initiation of appropriate treatment and referral is time- and cost-effective in patients with this condition, who have high rates of medical resource use. (medscape.com)
  • Determine the time to progression and overall survival of patients treated with this drug. (knowcancer.com)
  • In this study, we found that low-dose iNO improved oxygenation in patients with hypoxemia after AADA surgery and shortened the durations of mechanical ventilation and ICU stay. (biomedcentral.com)
  • Low-risk patients with a single episode of syncope can often be reassured with no further investigation. (aafp.org)
  • Geriatric patients have experienced more bleeding episodes than younger, women more than men. (mdwiki.org)
Onset1
  • 1 A female:male ratio of 9:1 is reported, with peak age of onset between 15 and 40 years, 2 although cases may present anytime in childhood through advanced age, at which time female-to-male ratios are approximately 2:1. (lww.com)
Left1
  • Although an underlying arrhythmogenic substrate is necessary, the arrhythmia itself will compromise an already impaired haemodynamic state, by increasing myocardial ischaemia or left ventricular wall distension, and so exacerbate the situation. (bmj.com)
Tissue1
  • The ischemic injury underlying these illnesses is complex, involving intricate interplays among many biological functions including energy metabolism, vascular regulation, hemodynamics, oxidative stress, inflammation, platelet activation, and tissue repair that take place in a context- and time-dependent manner. (cdc.gov)
Procedure1
  • The Indigo System's proprietary Separator technology is designed to enable unobstructed aspiration for the duration of the procedure. (penumbrainc.com)
Syncope1
  • Implantable loop recorders increase diagnostic yield, reduce time to diagnosis, and are cost-effective for suspected cardiac syncope and unexplained syncope. (aafp.org)
Decrease1
  • We previously found that iNO improved oxygenation after AADA and tended to decrease the time to extubation [ 11 ]. (biomedcentral.com)
Reduces1
  • Some studies have shown that engaging in exercise for 6 months reduces the consumption of antihypertensive drugs and decreases the time spent admitted to hospital among individuals receiving HD treatments. (biomedcentral.com)
Abstract1
  • Abstract-- An integrated method for clustering of QRS com- duces the amount of time the operator needs to spend. (lu.se)
Angina2
  • You dispense this item and speak with him and he tells you that his GP thinks he has angina and has asked him to use the spray the next time he gets any minor chest pain or tightness. (pharmamirror.com)
  • Episodes of angina are typically caused by exertion or emotion and are relieved by rest. (pharmamirror.com)
Holter1
  • One of the primary benefits of 7-day Holter monitoring is the extended duration of continuous cardiac monitoring. (ultralinq.com)
Events2
  • The Long-Term ST Database contains 86 lengthy ECG recordings of 80 human subjects, chosen to exhibit a variety of events of ST segment changes, including ischemic ST episodes, axis-related non-ischemic ST episodes, episodes of slow ST level drift, and episodes containing mixtures of these phenomena. (physionet.org)
  • The database was created to support development and evaluation of algorithms capable of accurate differentiation of ischemic and non-ischemic ST events, as well as basic research into mechanisms and dynamics of myocardial ischemia. (physionet.org)
Treatment2
  • An alternative physical method that suppresses the arrhythmia and stabilises the haemodynamic status may allow time for implementation of appropriate drug treatment or enhance the patient's condition before a non-pharmacological approach. (bmj.com)
  • The activated partial thromboplastin time (aPTT) is the most reliable coagulation parameter and should be obtained regularly during treatment, particular if a bleeding episode occurs that may be associated with tirofiban therapy. (mdwiki.org)
Study3
  • Long-term ST database: a reference for the development and evaluation of automated ischaemia detectors and for the study of the dynamics of myocardial ischaemia. (physionet.org)
  • After discussing the design of the study (n=6,103, event-driven, with a glimepiride comparator group and estimated run time of six to seven years), he highlighted the exceptional differences between CAROLINA and other CVOTs for DPP-4 inhibitors, especially SAVOR-TIMI 53 (for BMS/AZ's Onglyza [saxagliptin]) and EXAMINE (for Takeda's Nesina [alogliptin]. (closeconcerns.com)
  • Since that time there has been intense scientific interest in the study of cardiac adaptation to repetitive bouts of vigorous activity, athletic performance, and the pathophysiology of structural, functional, and electrical cardiac diseases in competitive athletes. (scienceopen.com)
Platelet1
  • Other important hematological parameters are platelet count , clotting time , hematocrit and hemoglobin . (mdwiki.org)
Hours2
  • Each record is 21 to 24 hours long, and contains 2 or 3 ECG signals, annotated beat-by-beat and with respect to ST episodes, rhythm changes, and signal quality changes. (physionet.org)
  • Also, a paroxysmal episode lasting longer than 48 hours may be termed persistentā·. (gehealthcare.com)
Function2
  • Even though your circadian system may be promoting wakefulness at the right time of day, if you have too great a sleep debt, your ability to function will be compromised. (psychiatrictimes.com)
  • The record will provide us with information on your functional status over an extended period of time and show whether your ability to function is improving, worsening, or unchanging. (socialsecurityprofessionals.com)
Results1
  • Their hypothesis was that the timing of GIK-infusion was responsible for the inconsistent results of prior GIK-trials. (biomedcentral.com)
Primary1
  • Its primary neurobiological effect is to promote wakefulness at the right time of day. (psychiatrictimes.com)