Episodes insulin severe hyperglycemia or hypoglycemia. Medical search. Frequent questions

Diabetic hypoglycemia is a low blood glucose level occurring in a person with diabetes mellitus. (wikipedia.org)
Indeed, an estimated 2-4% of deaths of people with type 1 diabetes mellitus have been attributed to hypoglycemia. (wikipedia.org)
In individuals presenting with low glycemic levels and strokelike symptoms, diabetes mellitus may have been previously diagnosed, and recent changes in the doses of hypoglycemic agents and insulin may have been instituted. (medscape.com)
LEVEMIR is a long-acting human insulin analog indicated to improve glycemic control in adult and pediatric patients with diabetes mellitus ( 1 ). (nih.gov)
Young people with insulin- dependent diabetes mellitus (IDDM) may have a higher prevalence of eating disorders, such as anorexia nervosa and bulimia, and adults with longstanding diabetes and major medical complications have a higher prevalence of symptoms of depression and anxiety. (cdc.gov)
Elderly persons who have non-insulin-dependent diabetes mellitus (NIDDM) and other symptomatic medical conditions may also have a higher risk of developing psychological problems. (cdc.gov)
Diabetes mellitus (DM) is a metabolic disorder characterised by an increase in plasma glucose level due to insulin deficiency and/or resistance that can lead to damage to multiple organs. (hindawi.com)
If this happens often, though, it could be a sign of hypoglycemia without diabetes mellitus. (greatist.com)
Humalog (100 units/mL and 200 units/mL) and Insulin Lispro Injection (100 units/mL) are indicated to improve glycemic control in adults and children with diabetes mellitus. (drugtopics.com)
Humalog Mix75/25, Humalog Mix50/50 (insulin lispro protamine and insulin lispro injectable suspension, 100 units/mL) and Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 (100 units/mL) are indicated to improve glycemic control in patients with diabetes mellitus. (drugtopics.com)
Long-term studies (ge6 months) an indicator of the level of glucose in blood plasma fasting in patients with diabetes mellitus type 1 was better compared to isophane insulin, appointed in basis/bolus therapy. (otc-online-store.com)
Humalog Mix75/25 and Humalog Mix50/50 are mixtures of insulin lispro protamine, an intermediate-acting human insulin analog, and insulin lispro, a rapid-acting human insulin analog indicated to improve glycemic control in patients with diabetes mellitus. (humalog.com)
Diabetes mellitus (DM) is the metabolic homeostasis disorder regulated by insulin which causes abnormalities in the carbohydrate and lipid metabolism. (wikidoc.org)
Type 1 diabetes (also called juvenile-onset diabetes mellitus, DM1, T1DM, and insulin-dependent diabetes mellitus) is considered an immuno-mediated disease that results in a gradual destruction of insulin-producing pancreatic beta cells, and subsequently leads to their complete loss and total dependence on exogenous insulin. (wikidoc.org)
All children with type 1 diabetes mellitus require insulin therapy. (medscape.com)
Diabetes mellitus (DM) is a chronic metabolic disorder caused by an absolute or relative deficiency of insulin, an anabolic hormone. (medscape.com)
Type 2 diabetes mellitus (non-insulin-dependent diabetes mellitus [NIDDM]) is a heterogeneous disorder. (medscape.com)
Most patients with type 2 diabetes mellitus have insulin resistance, and their beta cells lack the ability to overcome this resistance. (medscape.com)
In the INSTRIDE 2 study, the clinical efficacy (mean change in HbA1c and FPG levels from baseline) of SEMGLEE is comparable to LANTUS in the treatment of hyperglycemia in patients with type 2 diabetes mellitus. (semgleehcp.com)
5. Diabetes mellitus and other pancreatic gland disorders disrupt the production of several hormones, including insulin, that regulate metabolism and digestion. (socialsecurityprofessionals.com)
Type 1 DM-previously known as "juvenile diabetes" or "insulin-dependent diabetes mellitus" (IDDM)-is an absolute deficiency of insulin production that commonly begins in childhood and continues throughout adulthood. (socialsecurityprofessionals.com)
With type 2 DM-previously known as "adult-onset diabetes mellitus" or "non-insulin-dependent diabetes mellitus" (NIDDM)-the body's cells resist the effects of insulin, impairing glucose absorption and metabolism. (socialsecurityprofessionals.com)
Insulin glulisine is used to improve blood sugar control in adults and children with diabetes mellitus . (drugs.com)
Management of non-insulin-dependent diabetes mellitus (NIDDM) requires teamwork. (who.int)
Is diabetes mellitus a hypoglycemia? (paleorecipediet.com)
Both are forms of diabetes mellitus, hence they both result in hyperglycemia (high blood sugar). (paleorecipediet.com)

Studies have suggested that the benefits of tight glycemic control may be at least partially offset by the increased risk of hypoglycemia ( 2 , 3 ). (diabetesjournals.org)
however, IV insulin increases the risk of hypoglycemia. (medscape.com)
The options continue to expand, but we continue to look for opportunities to further improve basal insulins, notably with regard to further reduction in the risk of hypoglycemia as well as more convenient dosing," observed Dr. Matthew C. Riddle, Oregon Health & Science University, Portland, Oregon. (mednet.ca)

How to treat hyperglycemia and hypoglycemia? (healththoroughfare.com)
1.Excess of insulin (the drug used to treat hyperglycemia). (biodifferences.com)
If we're able to prevent severe hypoglycemia, treat hyperglycemia, get the outcomes we want, this will translate into areas of cost saving. (glytecsystems.com)

citation needed] A co-morbidity is the issue of hypoglycemia unawareness. (wikipedia.org)
and in patients with renal impairment or hepatic impairment or hypoglycemia unawareness ( 5.3 ). (nih.gov)
They may also develop hypoglycemia unawareness, where they are unable to detect their blood glucose is dropping and may not have a chance to treat themselves to prevent their blood glucose from further dropping. (fda.gov)
Some people, especially those who've had diabetes for a long time, develop a condition known as hypoglycemia unawareness. (mayoclinic.org)
While both type 1 and type 2 DM are usually controlled, some persons do not achieve good control for a variety of reasons including, but not limited to, hypoglycemia unawareness, other disorders that can affect blood glucose levels, inability to manage DM due to a mental disorder, or inadequate treatment. (socialsecurityprofessionals.com)

These trials should measure HbA 1c (for modeling the effects on complications), blood glucose variability, hypoglycemia, quality of life, and cost effectiveness," they add. (medscape.com)
While significant improvements in insulin pump technology have been made over the past decade, a surprising number of complications still arise. (emdocs.net)
Insulin pump complications can be broadly divided into two categories: those that develop from insulin pump therapy itself, and those that develop from pump malfunctions. (emdocs.net)
The most common complications of insulin pump therapy involve the skin and soft tissue. (emdocs.net)
As a result, patients are protected from the severe complications resulting from changes in blood sugar levels, which can affect all body parts. (hospitalsmagazine.com)
Both types of DM cause hyperglycemia, which is an abnormally high level of blood glucose that may produce acute and long-term complications. (socialsecurityprofessionals.com)
Acute complications of hyperglycemia include diabetic ketoacidosis. (socialsecurityprofessionals.com)
Long-term complications of chronic hyperglycemia include many conditions affecting various body systems. (socialsecurityprofessionals.com)
It usually requires hospital treatment to correct the acute complications of dehydration, electrolyte imbalance, and insulin deficiency. (socialsecurityprofessionals.com)
Dr Barrett, who chaired the task force that developed the statement, said that, while the risk of microvascular complications can be reduced by tight glycemic and blood-pressure control, this can conversely place patients at risk of "dangerous" hypoglycemic episodes and cardiovascular complications. (medscape.com)
The statement notes that the vascular complications of diabetes result from interactions between systemic metabolic abnormalities such as hyperglycemia, dyslipidemia, and genetic and epigenetic modulators and local tissue responses to toxic metabolites. (medscape.com)
Alongside this, hypoglycemia causes the suppression of factors that are protective against microvascular complications, including insulinlike growth factor, antioxidant enzymes, platelet-derived and vascular endothelial growth factors, transforming growth factor beta, and activated protein C. (medscape.com)
The statement therefore points out that future treatments to prevent or delay diabetic microvascular complications "must" reverse hyperglycemia, inhibit the major mechanisms of vascular dysfunction, neutralize accelerants such as inflammation and oxidative stress, and activate protective factors. (medscape.com)
Discussing specific forms of microvascular complications, the authors highlight that diabetic retinopathy and diabetic nephropathy , which are common and may result in severe impairment and poor quality of life, "are considered the quintessential microvascular complications of diabetes. (medscape.com)

Basal insulin Tresiba hit blockbuster status in 2017, with sales of DKK 7.3 billion ($1.1 billion) rising 81% YOY as reported (85% operationally) from $601 million in 2016. (closeconcerns.com)
Interindividual variability in absorption is lower in the Levemir® Flexpen® compared to other drugs basal insulin. (otc-online-store.com)
Insulin replacement is accomplished by giving a basal insulin and a preprandial (premeal) insulin. (medscape.com)
The basal insulin is either long-acting (glargine or detemir) or intermediate-acting (NPH). (medscape.com)
Secondary Endpoint: Included changes from baseline in basal insulin dose as well as fasting plasma glucose (FPG), SMBG and immunogenicity. (semgleehcp.com)
The introduction of once-daily dosing of insulin through long-acting basal insulin analogs advanced the predictability and simplicity of blood glucose control, but subsequent advances have been focused on further reducing risk of abnormal glycemic excursions. (mednet.ca)
Lead author of the latebreaking EDITION 1 trial, which was updated at the ADA, Dr. Riddle said one of the most promising areas is improving the PK of the long-acting basal insulin analogs simply because these already have a well-established efficacy and safety profile. (mednet.ca)

In some patients with type 1 diabetes, these infused cells can produce enough insulin, so the patient no longer needs to take insulin (by injections or pump) to control their blood sugar levels. (fda.gov)
Hyperglycemia occurs due to the body not having enough insulin or insulin resistance. (healththoroughfare.com)
High blood sugar occurs when the body doesn't have enough insulin or can use it properly to process glucose from the bloodstream and turn it into energy. (diabeticwarehouse.org)
For those already diagnosed and living with diabetes, hyperglycemia might occur by not taking enough insulin, eating too many carbohydrates, or by missing an insulin injection. (diabeticwarehouse.org)
People with diabetes have issue creating or using enough insulin, which is blood sugar reading 324 the hormone that helps convert glucose into power Equipment used includes a lancet used to prick the pores and skin, a glucometer, and check strips These machines and apps record data and provide developments in glucose measurements undertaken If you may have sort 2 diabetes, your physique does not use insulin correctly. (esaunggul.ac.id)
In type 2 diabetes, either the pancreas does not produce enough insulin or the body cannot use it effectively. (paleorecipediet.com)
In Type 2 diabetes, the pancreas does not produce enough insulin, and the insulin it does produce does not always function properly. (paleorecipediet.com)

In view of all the available evidence from randomized controlled trials, artificial pancreas treatment significantly improves glycemic control while reducing the burden of hypoglycemia in outpatients with type 1 diabetes," Bekiari and colleagues write. (medscape.com)
Newly diabetic patients can have cutaneous allergic reactions or edema while the body adjusts to the tighter glycemic control provided by the insulin pump. (emdocs.net)
We've shown tighter glycemic control in the ICU setting on IV insulin, getting patients in range 80 to 120. (glytecsystems.com)

common in people whose body is not responding correctly to the insulin that they make in their pancreas (insulin resistance). (diabetes.org)
How can you deal with insulin resistance? (kasanahealth.com)
T1DM is caused by the destruction of the pancreatic β -cells due to an autoimmune reaction, leading to absolute insulin deficiency, whilst T2DM is characterised by insulin resistance, where the body fails to produce an appropriate physiological response to circulating insulin. (hindawi.com)
Instead, fasting hyperglucagonaemia appears to be more associated with hepatic insulin resistance or with hepatic steatosis. (easd-elearning.org)
The earliest abnormality being an insulin resistance which initially compensated with an increase in insulin secretion. (wikidoc.org)
Number two is the growing interest in metabolic health even without insulin resistance. (true-well.co)
And pretty much all insulin resistance conditions fall under that category. (true-well.co)
When insulin resistance is present, it's extremely helpful to know what your blood glucose or blood sugar levels are at all times, and especially after meals . (true-well.co)

Profile night glucose control is more flat and smooth in the drug Levemir® Flexpen® compared to isophane insulin, which is reflected in a lower risk of developing hypoglycemia at night. (otc-online-store.com)

See Full Prescribing Information for recommended starting dose in insulin naïve patients and patients already on insulin therapy ( 2.3 , 2.4 ). (nih.gov)
This makes it difficult to dose insulin. (fda.gov)
Insulin Correction: If you use insulin, you need to follow your healthcare team's advice on taking a correction dose to lower high blood sugar levels. (healththoroughfare.com)
Several drugs affect glucose metabolism and may necessitate insulin dose adjustment and particularly close monitoring. (buyinsulinonline.com)
The proportions of rapid-acting and intermediate-acting insulins in Humalog Mix75/25, Humalog Mix50/50, and Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 are fixed and do not allow for basal versus prandial dose adjustments. (drugtopics.com)
And in an accompanying editorial, Norman Waugh, MB ChB, professor of public health medicine and health technology assessment at the University of Warwick, UK, and colleagues write, "Closed-loop systems can improve control overnight, and reduce the burden of self-management during the day by reducing frequent decisions on adjustments to insulin dose. (medscape.com)
This allows them to administer the appropriate insulin dose at the right time with extreme precision. (hospitalsmagazine.com)
The aim of dietary management is to balance the child's food intake with insulin dose and activity and to keep blood glucose concentrations as close as possible to reference ranges, avoiding extremes of hyperglycemia and hypoglycemia. (medscape.com)
Secondary Endpoints - Included changes in FPG, insulin dose, SMBG and immunogenicity. (semgleehcp.com)
Secondary Endpoints: Change from baseline in fasting plasma glucose (FPG), eight-point self-monitored blood glucose (SMBG) profile and insulin dose per unit body weight, and immunogenicity at week 36, in addition to occurrence of hypoglycaemic events (30-day rate), nocturnal hypoglycaemic events, and adverse events (AEs). (semgleehcp.com)
To transfer insulin dose-related data automatically, the Tempo Smart Button™ must be connected to the app and within 9 feet (3 meters) of the Bluetooth ® wireless technology enabled mobile device. (lillytempo.com)
The Smart Button is intended to detect, store, and transfer insulin dose-related data from a Tempo Pen to a compatible application (App). (lillytempo.com)
The longer and flatter PK profile of Gla-300 relative to Gla-100 in that study of 30 patients with type 1 diabetes (DM1) was shown to exert tighter blood glucose control by greatly extending insulin concentrations in the therapeutic range for each once-daily dose. (mednet.ca)

You should consistently monitor your blood sugar levels, adhere to prescribed medications, and adopt a healthy lifestyle to effectively manage hyperglycemia and hypoglycemia. (healththoroughfare.com)
Sliding scale insulin remains very commonly the method to manage hyperglycemia in the hospital. (glytecsystems.com)
And we know we can safely manage hyperglycemia. (glytecsystems.com)
We can manage hyperglycemia. (glytecsystems.com)

Symptoms of diabetic hypoglycemia, when they occur, are those of hypoglycemia: neuroglycopenic, adrenergic (that is, activating adrenergic receptors, resulting e.g. in fast heartbeat), and abdominal. (wikipedia.org)
Diabetic hypoglycemia can occur in any person with diabetes who takes any medicine to lower their blood glucose, but severe hypoglycemia occurs most often in people with type 1 diabetes who must take insulin for survival. (wikipedia.org)
Symptoms caused by hypoglycemia can occur suddenly and fluctuate, suggesting a vascular etiology. (medscape.com)
Accidental mix-ups between insulin products can occur. (nih.gov)
Both the medical condition can occur in the person having diabetes, which develops due to improper functioning of the insulin. (biodifferences.com)
Stop taking the medication and seek immediate medical attention if any of the following occur: rash or blisters all over the body, seizures, symptoms of Anaphylaxis (severe allergic reaction) (e.g. (buyinsulinonline.com)
However, fluctuations can occur, leading to hypoglycemia (low blood sugar) or hyperglycemia (high blood sugar). (swiftdisability.ca)
It results from a severe insulin deficiency, which can occur due to missed or inadequate daily insulin therapy or in association with an acute illness. (socialsecurityprofessionals.com)
Hypoglycemia may also occur if an IV infusion of dextrose is abruptly interrupted. (msdmanuals.com)

In this study, we aimed to determine whether hypoglycemic episodes are associated with higher mortality in diabetic patients hospitalized in the general ward. (diabetesjournals.org)
Medication Adjustments: Collaborate with your healthcare team to review and adjust your diabetes medication dosages, meal timing, or even the exercise routine to prevent future hypoglycemic episodes. (healththoroughfare.com)
As if that weren't freaky enough, hypoglycemic episodes can happen at night, giving you nightmares or night sweats. (greatist.com)
Pancreatic tumors are rare, but their presence can trigger hypoglycemic episodes. (greatist.com)
D50 bolus), providing food with complex carbohydrates is important to prevent recurring hypoglycemic episodes. (iem-student.org)

Typically, hyperglycemia in the setting of acute stroke is treated with subcutaneous insulin on a sliding scale. (medscape.com)
The utilization of insulin pumps, or continuous subcutaneous insulin infusion (CSII), has been on the rise for the management of both Type 1 and Type 2 Diabetes. (emdocs.net)
Younger age, continuous subcutaneous insulin pump therapy, and change to MI were associated with higher probability of achieving target A1C levels. (cdc.gov)
Since the DCCT was conducted, significant advances in diabetes management have occurred, including newer and more physiologic insulin analogs, sophisticated blood glucose monitoring, and insulin delivery technologies such as continuous subcutaneous insulin pump therapy (CSII) and continuous glucose monitoring (CGM). (cdc.gov)

The incidence of severe hypoglycemia was very low in both the artificial pancreas and control groups (just six and three episodes, respectively). (medscape.com)
However, persons with type 2 diabetes are increasingly utilizing insulin, which may indicate an increase in the incidence of hypoglycemia in this population. (paleorecipediet.com)

Diabetic hypoglycemia can be mild, recognized easily by the patient, and reversed with a small amount of carbohydrates eaten or drunk, or it may be severe enough to cause unconsciousness requiring intravenous dextrose or an injection of glucagon. (wikipedia.org)
Like a red traffic light, insulin stops the spread of glucose in your bloodstream, and glucagon green-lights its release. (greatist.com)
Your pituitary gland and adrenal glands affect insulin and glucagon production. (greatist.com)
Two hormones that are secreted by the pancreas and that regulate blood glucose levels are insulin and glucagon. (pms-menopause-progesterone.org)
Because prevention of hypoglycemia is vital for the body, several hormones from the adrenal glands and pituitary back up glucagon function. (pms-menopause-progesterone.org)
While the recent 100th anniversary of the discovery of insulin was widely acknowledged in the diabetes community, much less attention has been paid to the centenary of its vital counter-regulatory hormone, glucagon. (easd-elearning.org)
They called this 'glucose agonist' - later known as glucagon - for its ability to oppose the hypoglycaemic effect of insulin. (easd-elearning.org)
Today, glucagon is used as a treatment for severe hypoglycaemia, although this has only come into general use relatively recently. (easd-elearning.org)
Traditionally this has involved studying both central and peripheral molecules involved in hunger and satiety, such as leptin, orexin (also known as hypocretin), insulin, alpha-melanocyte-stimulating hormone (α-MSH), glucagon-like peptide -1 (GLP-1), amylin, glucose-dependent insulinotropic polypeptide (GIP, also known as a gastric inhibitory polypeptide), adiponectin and cholecystokinin (CCK). (frontiersin.org)
Newer insulins are being designed to deliver flatter steady state pharmacokinetics (PK), while drugs from new therapeutic classes, particularly activators of the glucagon-like peptide-1 (GLP-1) incretin, show promise for adjunctively preserving the simplicity of a once-daily treatment regimen when insulin alone is insufficient. (mednet.ca)

Make changes to a patient's insulin regimen (e.g., insulin strength, manufacturer, type, injection site or method of administration) under close medical supervision with increased frequency of blood glucose monitoring ( 5.2 ). (nih.gov)
Instruct patients to check insulin labels before injection ( 5.4 ). (nih.gov)
Adverse reactions associated with LEVEMIR include hypoglycemia, allergic reactions, injection site reactions, lipodystrophy, rash and pruritus ( 6 ). (nih.gov)
Non-branded versions of Humalog® Mix75/25™ KwikPen® (insulin lispro protamine and insulin lispro injectable suspension 100 units/mL) and Humalog® Junior KwikPen® (insulin lispro injection 100 units/mL) are available for order in pharmacies. (drugtopics.com)
Lilly also continues to offer Insulin Lispro Injection 100 units/mL (U-100) launched in May 2019, at a 50 percent lower list price. (drugtopics.com)
The prolonged action of Levemir® Flexpen® due to the pronounced self-Association of insulin detemir molecules at the injection site, and binding molecules of the drug to albumin through a connection to a side chain. (otc-online-store.com)
Humalog, Insulin Lispro Injection, Humalog Mix75/25, Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25, and Humalog Mix50/50 are contraindicated during episodes of hypoglycemia and in patients who are hypersensitive to these insulins or any of their excipients. (humalog.com)
Never share a Humalog, Insulin Lispro Injection, Humalog Mix75/25, Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25, or Humalog Mix50/50 prefilled pen, cartridge, reusable pen compatible with Lilly 3 mL cartridges, or syringe between patients as it poses a risk for transmission of blood-borne pathogens. (humalog.com)
Insulin glulisine is a fast-acting insulin that starts to work about 15 minutes after injection, peaks in about 1 hour, and keeps working for 2 to 4 hours. (drugs.com)
Read and carefully follow any Instructions for Use provided with your medicine and injection pen or insulin pump. (drugs.com)
If you use an injection pen, use only the pen that comes with insulin glulisine. (drugs.com)
Humalog ® Mix75/25™ [75% insulin lispro protamine suspension and 25% insulin lispro injection, (rDNA origin)] is a mixture of insulin lispro solution, a rapid-acting blood glucose-lowering agent and insulin lispro protamine suspension, an intermediate-acting blood glucose-lowering agent. (nih.gov)
Humalog Mix75/25 vials and Pens contain a sterile suspension of insulin lispro protamine suspension mixed with soluble insulin lispro for use as an injection. (nih.gov)
Each milliliter of Humalog Mix75/25 injection contains insulin lispro 100 units, 0.28 mg protamine sulfate, 16 mg glycerin, 3.78 mg dibasic sodium phosphate, 1.76 mg Metacresol, zinc oxide content adjusted to provide 0.025 mg zinc ion, 0.715 mg phenol, and Water for Injection. (nih.gov)
Figure 1: Serum Immunoreactive Insulin (IRI) Concentrations, After Subcutaneous Injection of Humalog Mix75/25 or Humulin 70/30 in Healthy Nondiabetic Subjects. (nih.gov)

The primary mechanism of action of Lantidra is believed to be the secretion of insulin by the infused allogeneic islet beta cells. (fda.gov)
Acute alcohol consumption, especially in combination with sugar, augments insulin secretion and causes temporary hypoglycemia (9). (pms-menopause-progesterone.org)
Thereafter, T2DM develops due to a defect in insulin secretion that prevents such secretion from matching the increased requirements imposed by an initial insulin-resistant state. (wikidoc.org)
Those with type 1 diabetes have trouble with insulin secretion in their pancreas. (sugarprotalk.com)

Insulin lispro protamine suspension (NPL component) is a suspension of crystals produced from combining insulin lispro and protamine sulfate under appropriate conditions for crystal formation. (nih.gov)
The late phase represents the prolonged action of insulin lispro protamine suspension. (nih.gov)

The etiology of hypoglycemia in ICU patients may be different from that in patients hospitalized in the general ward. (diabetesjournals.org)

Measures should be undertaken to decrease the frequency of hypoglycemia in this high-risk patient population. (diabetesjournals.org)

Impaired awareness of hypoglycaemia (IAH) is a common, frustrating, and potentially dangerous problem for people with diabetes who use insulin. (ihsgonline.com)
This phenomenon, known as impaired awareness of hypoglycaemia (IAH), affects about a quarter of people with type 1 diabetes and 10% of those with type 2 diabetes who use insulin. (ihsgonline.com)
1 In addition, differences in operculum activation in the IAH group raised the possibility that this group may be less driven to eat than those with intact awareness of hypoglycaemia. (ihsgonline.com)
Another study involving people with type 1 diabetes found even more striking discrepancies: those with preserved awareness of hypoglycaemia showed changes in prefrontal cortex and angular gyrus activity in response to mild hypoglycaemia, but those with IAH failed to show any such changes. (ihsgonline.com)
3 Another study saw brain levels of the non-glucose metabolic fuel lactate fall by about 20% in subjects with IAH-but not in those with normal awareness of hypoglycaemia and people without diabetes. (ihsgonline.com)
Impaired awareness of hypoglycaemia (IAH) is a major risk for severe hypoglycaemia in insulin treatment of type 1 diabetes (T1D). (nature.com)
18 A key risk factor for severe hypoglycaemia is impaired awareness of hypoglycaemia (IAH)-loss of subjective awareness of a falling blood glucose in time to take action to avoid a severe episode 16 , 19 . (nature.com)

Signs and symptoms of hypoglycemia may be reduced or absent. (nih.gov)

Most pediatric patients with diabetes have type 1 and a lifetime dependence on exogenous insulin. (medscape.com)

This can cause temporary hypoglycemia. (greatist.com)

Type 1 diabetes is a chronic autoimmune disease that requires lifelong care including requiring insulin, either through multiple daily injections or continuous infusion using a pump, every day to live. (fda.gov)
We are proud to have an insulin pump capable of remote software updates that can make access to future integrations possible for in-warranty t:slim X2 users at the time of release without requiring a new pump. (gabio.org)
Tandem's t:slim X2™ insulin pump was the first to receive U.S. Food and Drug Administration (FDA) clearance in a new device category called alternate controller enabled (ACE) infusion pumps in 2019. (gabio.org)
Artificial pancreas treatment, also known as closed-loop glucose control, involves the combination of an insulin pump, continuous glucose monitor (CGM), and control algorithm that enables the system to automatically deliver appropriate insulin doses. (medscape.com)
It requires careful management and monitoring of blood glucose levels through insulin injections or an insulin pump. (swiftdisability.ca)
Individuals must regularly check their blood sugar, administer insulin injections or use an insulin pump, and carefully balance their carbohydrate intake. (swiftdisability.ca)
Of note, his mother states he had an insulin pump placed 1 week ago, and they do not understand how it works. (emdocs.net)
The insulin pump is located in the right lower quadrant, with mild edema around the insertion site. (emdocs.net)
Besides standard DKA treatment, how do you manage this patient with an insulin pump? (emdocs.net)
Insulin pumps consists of a reservoir, a pump, and an infusion set. (emdocs.net)
2 The reservoir holds a 2-3 day supply of regular or short-acting insulin 2 the battery-powered pump encases the reservoir, and the infusion set consists of tubing (typically smaller in diameter than normal IV tubing) that connects the reservoir to a subcutaneous cannula. (emdocs.net)
Insulin pump software can be calibrated to individualize insulin delivery to the patient based on that patient's needs, activity levels, food intake, and time of day, typically delivering a continuous basal rate of insulin along with preset boluses before meals. (emdocs.net)
Recent models integrate the insulin pump with a continuous glucose monitoring patch, which can further fine-tune the pump's insulin output throughout the day. (emdocs.net)
If you use insulin glulisine with an IV or insulin pump, do not mix or dilute insulin glulisine with any other insulin. (drugs.com)
Do not transfer the insulin from the pen into a syringe or infusion pump. (drugs.com)

Type 1 Diabetes is a chronic condition in which the pancreas produces little to no insulin. (swiftdisability.ca)
Type 1 diabetes is a chronic illness characterized by the body's inability to produce insulin due to the autoimmune destruction of the beta cells in the pancreas. (medscape.com)
In Type 1 diabetes, the pancreas produces no insulin. (paleorecipediet.com)

The action profile of Levemir® Flexpen® is much less variable compared with isophane insulin and insulin glargine. (otc-online-store.com)
Treated with once-daily insulin glargine for more than 3 months and with HbA1c ≤9.5% at screening. (semgleehcp.com)
Patients began a 6-week run-in period and were titrated with first reference insulin glargine and then insulin lispro, as needed, to ensure good diabetes control as determined by the investigator. (semgleehcp.com)
At randomization, there was a 1:1 (unit for unit) conversion of reference insulin glargine to SEMGLEE (100 U/mL of insulin glargine) and of prestudy mealtime insulin to insulin lispro. (semgleehcp.com)
In the INSTRIDE 1 clinical trials, SEMGLEE demonstrated non-inferiority to reference insulin glargine in both adult and pediatric patients with Type 1 Diabetes. (semgleehcp.com)
In the INSTRIDE 1 trial, the mean change in HbA1c from the baseline to week 24 among Type 1 diabetic patients was not non-inferior between SEMGLEE and the reference insulin glargine groups. (semgleehcp.com)
Change in 7-point self-monitored blood glucose (SMBG) profile from baseline to week 24 in all and insulin-naive patients with SEMGLEE and reference insulin glargine. (semgleehcp.com)
Individuals who successfully completed 52 weeks of reference insulin glargine treatment in the INSTRIDE 1 study and provided written informed consent were eligible, for a total of 127 participants with T1DM randomized: 64 to MYL-1501D and 63 to reference insulin glargine, 77 males, 50 females, aged 18-65 years, BMI 18.5-40 kg/m2. (semgleehcp.com)
The reference insulin glargine sequence group continued reference insulin glargine for 36 weeks. (semgleehcp.com)
In the study, a new insulin glargine formulation of 300 U/mL (Gla-300) was compared to the standard. (mednet.ca)

Some people with type 1 diabetes have trouble managing the amount of insulin needed every day to prevent hyperglycemia (high blood sugar) without causing hypoglycemia. (fda.gov)
The device continuously pumps insulin into the human body and is programmed by the treating physician to deliver the required amount of insulin the patient needs. (hospitalsmagazine.com)
Hypoglycemia may result by taking an excessive amount of insulin or oral diabetic medications. (paleorecipediet.com)

In particular, aggressively tight glucose control, either patient driven or clinician directed, may give rise to chronic or recurrent episodes of hypoglycemia. (medscape.com)
Hyperglycemia is serious chronic medical condition than Hypoglycemia, as in this sugar level increases and if not treated may give rise to another disease like coma, urinary excretion, nerve damage, unconsciousness, infertility, blurred vision. (biodifferences.com)
Chronic heavy drinking, in contrast, has been associated with excessive blood glucose levels (hyperglycemia). (pms-menopause-progesterone.org)
Chronic alcohol abuse can reduce the body's responsiveness to insulin and cause glucose intolerance in both healthy individuals (11) and alcoholics with liver cirrhosis (12). (pms-menopause-progesterone.org)

Chemically, insulin lispro is Lys(B28), Pro(B29) human insulin analog, created when the amino acids at positions 28 and 29 on the insulin B-chain are reversed. (nih.gov)

Overtreatment does not speed recovery, and will simply produce hyperglycemia afterwards, which ultimately will need to be corrected. (wikipedia.org)
Does diabetes type 2 produce hyperglycemia? (paleorecipediet.com)

Nevertheless, it is possible to experience hypoglycemia without diabetes. (paleorecipediet.com)
Then after the umbilical cord is clamped, the source of incoming glucose is cut off and the newborn can experience hypoglycemia (low blood sugar). (evidencebasedbirth.com)

In general, hypoglycemia occurs when a treatment to lower the elevated blood glucose of diabetes inaccurately matches the body's physiological need, and therefore causes the glucose to fall to a below-normal level. (wikipedia.org)
Severe hypoglycemia rarely, if ever, occurs in people with diabetes treated only with diet, exercise, or insulin sensitizers. (wikipedia.org)
As said above Hypoglycemia, occurs suddenly and so the action for treating it should also be quick, as if left untreated it can be life threatening or can lead to coma , mental disturbance, confusion. (biodifferences.com)
In acromegaly, a pituitary gland tumor at the base of the brain causes extreme production of growth hormone, resulting in hyperglycemia In Cushing s syndrome, the adrenal glands produce an excess of cortisol, which promotes blood sugar elevation Many individuals are unaware that they have diabetes, especially in its early stages when signs will not be current The weight lack of diabetes occurs regardless of a rise in appetite. (esaunggul.ac.id)
Diabetic hypoglycemia occurs when a person with diabetes has insufficient glucose (sugar) in his or her blood. (paleorecipediet.com)

Symptoms and effects can be mild, moderate or severe, depending on how low the glucose falls and a variety of other factors. (wikipedia.org)
In North America a mild episode of diabetic hypoglycemia is sometimes termed a "low" or an "insulin reaction," and in Europe a "hypo", although all of these terms are occasionally used interchangeably in North America, Europe, Australia and New Zealand. (wikipedia.org)
Symptoms vary from person to person and depend on the intensity and degree of the blood sugar level drop - mild, moderate, or severe. (greatist.com)
Side effects can be mild or severe, temporary or permanent. (buyinsulinonline.com)
As previously, the new statement will classify DKA by mild, moderate, and severe but now for the first time there are recommendations of care for each of those levels, as well as for HHS. (medscape.com)
Typically, mild to severe hypoglycemia may be treated on your own. (paleorecipediet.com)

IV dextrose (Choice C) is the best next step in management for this patient's hypoglycemia. (iem-student.org)

BBI, Basal/Bolus insulin, managed with Glucommander SubQ, getting patients in range with no severe hypoglycemia in this particular study. (glytecsystems.com)
If the patient continues to have persistent hypoglycemia despite an IV dextrose bolus and food, a continuous IV dextrose infusion (i.e. (iem-student.org)

Overall, 21 participants did not need to take insulin for a year or more, with 11 participants not needing insulin for one to five years and 10 participants not needing insulin for more than five years. (fda.gov)
In patients with diabetes who take insulin or antihyperglycemic. (msdmanuals.com)

In a counter-intuitive manifestation, hypoglycemia can trigger a Somogyi effect, resulting in a rebounding high blood sugar or hyperglycemia. (wikipedia.org)
On the other hand, since the excess of insulin over the amount required to normalize blood sugar may continue to reduce blood sugar levels after treatment has produced an initial normalization, continued monitoring is required to determine if further treatment is necessary. (wikipedia.org)
Lantidra is approved for the treatment of adults with type 1 diabetes who are unable to approach target glycated hemoglobin (average blood glucose levels) because of current repeated episodes of severe hypoglycemia (low blood sugar) despite intensive diabetes management and education. (fda.gov)
Although hyperglycemia (aka high blood sugar) and hypoglycemia (aka low blood sugar) are both conditions related to blood sugar levels, they differ in terms of the direction and severity of the imbalance. (healththoroughfare.com)
Medication Adherence: you have to take your prescribed diabetes medications consistently to prevent high blood sugar episodes. (healththoroughfare.com)
In reference with diabetes - Hypoglycemia refers to the low blood sugar, while Hyperglycemia is high blood sugar. (biodifferences.com)
Unless you're a vampire, you're most likely just experiencing an isolated bout of low blood sugar (aka hypoglycemia) from either skipping a meal or completing a heavy workout. (greatist.com)
Hyperglycemia happens when your blood sugar level spikes, which is a defining feature of diabetes. (greatist.com)
Reactive hypoglycemia happens when your blood sugar plummets within a few hours after you eat a meal. (greatist.com)
In severe cases, your blood sugar can fall so low that you may pass out or have a seizure. (greatist.com)
Reactive (also called postprandial) hypoglycemia happens after a meal when the digested and absorbed food is met by an onslaught of insulin that lowers your blood sugar. (greatist.com)
This fast-acting insulin effectively lowers blood sugar levels after a meal and can reduce the chances of developing severe diabetes conditions. (buyinsulinonline.com)
Many people with diabetes experience low blood sugar episodes ( hypoglycemia ) that can also lead to headaches. (diabeticwarehouse.org)
Causes of low blood sugar can be administering too much insulin, performing strenuous physical activity, or skipping a meal. (diabeticwarehouse.org)
Individuals may need to plan meals and snacks carefully, adhere to specific dietary restrictions, and time their activities around insulin injections or blood sugar monitoring. (swiftdisability.ca)
Some of the antibodies seen in type 1 diabetes embrace anti islet cell antibodies, anti insulin antibodies and anti glutamic decarboxylase antibodies These antibodies could be detected within the majority of patients, and should assist decide which individuals are at risk for growing sort 1 diabetes The early symptoms of untreated diabetes are associated to elevated blood sugar levels, and lack of glucose within the urine. (esaunggul.ac.id)
Hypoglycemia is common, almost 20% of patients stays, they have a blood sugar reading less than 70. (glytecsystems.com)
We've shown improved time to target five hours, medium time to target blood sugar for patients with DKA on IV insulin. (glytecsystems.com)
If you have diabetes, dangerously high blood sugar (hyperglycemia) or dangerously low blood sugar (hypoglycemia) can lead to a diabetic coma. (mayoclinic.org)
In severe cases, low blood sugar (hypoglycemia) may cause you to pass out. (mayoclinic.org)
Low blood sugar can be caused by too much insulin or not enough food. (mayoclinic.org)
You should not use insulin glulisine if you are allergic to it, or if you are having an episode of hypoglycemia (low blood sugar). (drugs.com)
Recognizing Hypoglycemia Low blood sugar is referred to medically as hypoglycemia (low blood glucose). (paleorecipediet.com)
Certain devices may monitor and inform you of hypoglycemia, as well as halt insulin administration in the event of low blood sugar. (paleorecipediet.com)
A person with type 2 diabetes might develop hyperglycemia, a condition characterized by elevated blood sugar levels. (paleorecipediet.com)
Hypoglycemia is always caused by low blood sugar or glucose levels in the body. (paleorecipediet.com)
Hypoglycemia is a disorder characterized by low levels of blood glucose (blood sugar). (paleorecipediet.com)
When the birthing person has hyperglycemia (high blood sugar) during labor, the baby compensates by secreting more of the hormone insulin, which can result in fetal hyperinsulinemia. (evidencebasedbirth.com)

For all patients with hyperglycemic crisis, the hyperglycemia cutoff is now lowered to 200 mg/dL (11.1 mmol/L) from the previous 250 mg/dL. (medscape.com)

Corticosteroids in the treatment of severe sepsis and septic shock in adults: a systematic review. (jamanetwork.com)
Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. (jamanetwork.com)
Intensive insulin therapy and pentastarch resuscitation in severe sepsis. (jamanetwork.com)
Finally, hypoglycemia can be due to malposition of an umbilical catheter or sepsis. (msdmanuals.com)

The primary activity of insulin, including Humalog Mix75/25, is the regulation of glucose metabolism. (nih.gov)
Insulin lispro, the rapid-acting component of Humalog Mix75/25, has been shown to be equipotent to Regular human insulin on a molar basis. (nih.gov)
Studies in nondiabetic subjects and patients with type 1 (insulin-dependent) diabetes demonstrated that Humalog, the rapid-acting component of Humalog Mix75/25, is absorbed faster than Regular human insulin (U-100). (nih.gov)

Hypoglycemia is difficult to define in neonates but is generally considered a serum glucose concentration 40 mg/dL ( 2.2 mmol/L) in symptomatic term neonates, 45 mg/dL ( 2.5 mmol/L) in asymptomatic term neonates between 24 hours and 48 hours of life, or 30 mg/dL ( 1.7 mmol/L) in preterm neonates in the first 48 hours. (msdmanuals.com)
Both groups will be offered insulin if fasting hyperglycaemia (=5.3mmol/L) and/or postprandial hyperglycaemia (=7.8mmol/L) persists. (who.int)

Let's look a little closer at the financial benefits of optimal glycemic management, preventing severe hypoglycemia, treating persistent hyperglycemia. (glytecsystems.com)
Neonatal hypoglycemia may be transient or persistent. (msdmanuals.com)

however, recurrent episodes of hypoglycaemia may blunt this response on various levels, with the result that the affected person does not experience the expected warning signals in a timely fashion. (ihsgonline.com)

For people with insulin-requiring diabetes, hypoglycemia is one of the recurrent hazards of treatment. (wikipedia.org)
Hypoglycemia is a true medical emergency, which requires prompt recognition and treatment to prevent organ and brain damage. (wikipedia.org)
Hyperglycemia is associated with adverse clinical outcomes, and randomized controlled trials in intensive care units (ICUs) have shown that aggressive treatment of elevated blood glucose improves outcomes. (diabetesjournals.org)
The safety and efficacy of IV insulin in the treatment of hyperglycemia in patients with acute stroke are being determined by ongoing/planned clinical trials. (medscape.com)
They recommend optimizing insulin therapy for the prevention of hemorrhagic transformation during the treatment of acute ischemic stroke. (medscape.com)
Today's approval, the first-ever cell therapy to treat patients with type 1 diabetes, provides individuals living with type 1 diabetes and recurrent severe hypoglycemia an additional treatment option to help achieve target blood glucose levels. (fda.gov)
Parker R. "Systematic review: pentoxifylline for the treatment of severe alcoholic hepatitis. (pearls4peers.com)
Treatment of diabetes by tight control of blood glucose levels is difficult in alcoholics, and both hypoglycemic and hyperglycemic episodes are common (4). (pms-menopause-progesterone.org)
Treatment of type 1 DM always requires lifelong daily insulin. (socialsecurityprofessionals.com)
Treatment of type 2 DM generally requires lifestyle changes, such as increased exercise and dietary modification, and sometimes insulin in addition to other medications. (socialsecurityprofessionals.com)
To explore the hypothesis that unhelpful health beliefs create barriers to regaining awareness, we conducted a multi-centre, randomised, parallel, two-arm trial (ClinicalTrials.gov NCT02940873) in adults with T1D and treatment-resistant IAH and severe hypoglycaemia, with blinded analysis of 12-month recall of severe hypoglycaemia at 12 and/or 24 months the primary outcome. (nature.com)
The SEARCH for Diabetes in Youth study has reported that insulin treatment regimens were cross-sectionally associated with sociodemographic, clinical, and metabolic characteristics among youth with type 1 diabetes ( 6 ). (cdc.gov)

3 The researchers speculated that "an increase in global cerebral blood flow may enhance nutrient supply to the brain, hence suppressing symptomatic awareness of hypoglycemia. (ihsgonline.com)
People with T1DM have an average of two bouts of symptomatic hypoglycemia every week, which amounts to thousands of episodes over the course of a lifetime with diabetes. (paleorecipediet.com)

Hypoglycemia is common in diabetic patients hospitalized in the general ward. (diabetesjournals.org)
Insulin pumps are very suitable for diabetic patients, especially children, according to studies in this regard, which have confirmed an improvement in their quality of life compared to their peers who follow traditional methods in treating diabetes. (hospitalsmagazine.com)

1 UNIT contains 142 g of salt-free insulin detemir, which corresponds to 1 unit of human insulin (IU). (otc-online-store.com)
Insulin detemir compared with isophane insulin to peripheral tissues-targets goes slowly. (otc-online-store.com)
The average Vd of insulin detemir (approximately 0.1 l/kg) indicates that a high fraction of insulin detemir is circulating in the blood. (otc-online-store.com)
Biotransformation of insulin detemir was similar with that of human insulin preparations, all metabolites formed are inactive. (otc-online-store.com)

Most require 2 or more injections of insulin daily, with doses adjusted on the basis of self-monitoring of blood glucose levels. (medscape.com)
When nondiabetic subjects received equivalent doses of Regular human insulin, peak insulin concentrations occurred between 50 to 120 minutes after dosing. (nih.gov)

Those with type 1 diabetes take treatments like insulin injections daily. (sugarprotalk.com)

analyzed the results of 7 trials involving 1296 participants (639 in the intervention group and 657 in the control group) and concluded that the administration of intravenous insulin to maintain serum glucose levels in the first hours after an acute ischemic stroke did not provide any benefit in terms of function, death, or improvement in final outcome. (medscape.com)
Even brief periods of low glucose levels (hypoglycemia) can cause brain damage. (pms-menopause-progesterone.org)
The discovery of insulin in 1921 was accompanied by the observation that pancreatic extracts and crude insulin preparations induce a brief episode of hyperglycaemia before glucose levels decrease. (easd-elearning.org)
As a result of this, it was discovered higher insulin levels were visible between 15 and 30 minutes after consuming the juice, compared to water. (sugarprotalk.com)
Conversely, the D 2 R agonist bromocriptine, which has been used for over 40 years to treat Parkinson's disease and hyperprolactinemia ( 6 ), was found to lower blood glucose levels and improve insulin sensitivity in patients with T2DM ( 7 ). (frontiersin.org)
Increasing dopamine levels/signals are associated with improved insulin sensitivity, while decreasing dopamine and serotonin levels/signals are associated with weight gain and T2DM development. (frontiersin.org)
A1C has been known as the gold standard of diabetes management outcomes, but it does not provide information about hypoglycemia, hyperglycemia, or daily fluctuations in glucose levels," she added. (diatribe.org)
Insulin is a hormone that works by lowering levels of glucose (sugar) in the blood. (drugs.com)
In terms of future research, he believes that one important focus needs to be the development of a way of preventing the deleterious effects of hyperglycemia without having to keep lowering glucose levels and thus risk triggering hypoglycemia and without "using a lot of insulin to do that. (medscape.com)

Recombinant insulin analogs, insulin pumps, and newer devices for home monitoring have drastically improved the ability to control glucose concentrations in patients with DM. (wikidoc.org)

Waugh and colleagues note that none of the 17 trials in children or adolescents in the review included children younger than 5 years, "a group in which closed-loop technology might reduce parental anxiety about nocturnal hypoglycemia. (medscape.com)
As expected, reductions in HbA 1c at 6 months did not differ between study arms (-0.83% in both groups), but the percentage of patients reporting at least 1 severe or confirmed nocturnal hypoglycemic event from month 3 to 6 was 36.1% in the Gla-300 group and 46% in the Gla-100 group. (mednet.ca)

Abbott is working with our partners to bring integrated technologies at an affordable price for people with diabetes who rely on using insulin pumps," said Jared Watkin, senior vice president, Diabetes Care, Abbott. (gabio.org)
By combining our glucose sensing technology with Tandem's proven insulin delivery systems, we will be able to create a cohesive ecosystem for people with diabetes that can fit easily into their daily lives. (gabio.org)

thereby achieving the full metabolic normalization not yet possible and making some degree of hyperglycemia persists in virtually all patients with diabetes. (wikidoc.org)

Administration of IV hypertonic 3% NaCl (Choice B) would be helpful in a patient with severe hyponatremia with altered mental status or seizure. (iem-student.org)
In a recent publication from a long-term follow-up of a large trial of intensified insulin therapy in T1D, while 54% of participants reported no severe hypoglycaemia (defined as coma or seizure) over 32 years, 8% reported more than five events 17 . (nature.com)
On average, they have one episode of severe, at least momentarily debilitating hypoglycemia, often accompanied by seizure or coma, every year [1,2]. (paleorecipediet.com)

Preexisting hyperglycemia worsens the clinical outcome of acute stroke. (medscape.com)
Because hyperglycemia may accelerate the ischemic process in stroke, it is possible that characteristic features of acute stroke will appear on computed tomography (CT) or magnetic resonance imaging (MRI) scans sooner than they would in patients without hyperglycemia. (medscape.com)
Patients with acute stroke and hyperglycemia are often kept NPO (nothing by mouth), because of the complicating effects of feeding on the blood glucose level. (medscape.com)
Intensive glucose control with insulin in patients with an acute coronary syndrome reduces platelet reactivity during hospitalization, compared to conventional control. (revespcardiol.org)
180 mg/dL), on platelet reactivity after hospital discharge in patients with an acute coronary syndrome and hyperglycemia. (revespcardiol.org)
The System also detects trends and tracks patterns and aids in the detection of episodes of hyperglycemia and hypoglycemia, facilitating both acute and long-term therapy adjustments. (gabio.org)
In addition, studies in healthy subjects (10) and insulin-dependent diabetics (3) have shown that acute alcohol consumption can impair the hormonal response to hypoglycemia. (pms-menopause-progesterone.org)

Never Share a LEVEMIR FlexPen, insulin syringe, or needle between patients, even if the needle is changed ( 5.1 ). (nih.gov)
These combined mechanisms of delayed distribution gives a more reproducible profile of the adsorption and action of the drug Levemir® Flexpen® compared to isophane insulin. (otc-online-store.com)

This medication is typically prescribed with long-acting type insulin medications or other diabetes medications. (buyinsulinonline.com)
Insulin glulisine may also be used for purposes not listed in this medication guide. (drugs.com)

Anatomy15

Organisms8

Diseases32

Chemicals and Drugs73

Analytical, Diagnostic and Therapeutic Techniques and Equipment31

Psychiatry and Psychology2

Phenomena and Processes22

Technology, Industry, Agriculture3

Named Groups1

Health Care10

Diabetes mellitus26

Risk of hypoglycemia3

Treat hyperglycemia3

Unawareness5

Complications14

Basal insulin7

Enough insulin7

Glycemic control3

Resistance8

Developing hypoglycemia at night1

Dose13

Manage hyperglycemia4

Occur9

Hypoglycemic episodes5

Subcutaneous insulin4

Incidence2

Glucagon10

Injection15

Secretion4

Lispro protamine2

Etiology1

Frequency of hypoglycemia1

Awareness of hypoglycaemia7

Symptoms of hypoglycemia1

Dependence on exogenous insulin1

Temporary hypoglycemia1

Pump15

Pancreas3

Glargine10

Amount of insulin3

Chronic4

Human insulin analog1

Produce hyperglycemia2

Experience hypoglycemia2

Occurs5

Mild6

Patient's1

Bolus2

Take insulin2

Blood sugar28

Hyperglycemic crisis1

Sepsis4

Humalog Mix753

Mmol2

Persistent2

Recurrent episodes1

Treatment12

Symptomatic2

Diabetic patients2

Detemir4

Doses2

Injections1

Levels9

Analogs1

Nocturnal2

People with diabetes2

Patients with diabetes1

Seizure3

Acute7

LEVEMIR FlexPen2

Medication2