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  • recurrent
  • It is often recurrent, causes significant morbidity and occasional mortality, limits maintenance of euglycemia, and impairs physiological and behavioral defenses against subsequent hypoglycemia. (diabetesjournals.org)
  • It impairs defenses against subsequent falling plasma glucose concentrations and can cause impaired awareness of hypoglycemia, therefore resulting in a vicious cycle of recurrent hypoglycemia. (diabetesjournals.org)
  • reduces
  • Nonsevere hypoglycemia episode (NSHE) reduces well-being and lowers quality of life by increasing anxiety and fear of repeated events, which can lead to negative lifestyle changes such as driving concerns and reduced work productivity [ 5 , 6 ]. (hindawi.com)
  • frequency
  • Among the metrics generated from CGM, time in range (TIR) refers to the time an individual spends within their target glucose range (usually 3.9-10.0 mmol/L), which provides valuable information about whether the frequency and duration of hypoglycemia or hyperglycemia improve over time. (diabetesjournals.org)
  • Our primary message is that diabetes control is all about optimization and balance between two key markers-frequency of hypoglycemia and HbA 1c reflecting average BG and primarily driven by the extent of hyperglycemia. (diabetesjournals.org)
  • adverse
  • Nonsevere hypoglycemia episodes (NSHEs) are associated with clinically adverse outcomes, lower health-related quality of life, increased burden of disease, and reduced work productivity. (hindawi.com)
  • Both severe and nonsevere hypoglycemia are associated with clinical adverse outcomes, lower health-related quality of life, and increased burden of disease [ 1 - 4 ]. (hindawi.com)
  • cause
  • Severe or long-lasting hypoglycemia may cause seizures and serious brain injury. (rochester.edu)
  • However, the reality is that if not treated effectively, or if first aid is not given quickly during an episode, diabetes can cause heart disease, stroke, amputation, kidney failure and blindness. (rmt.org.uk)
  • rate
  • For example, in a recent meta-analysis of four trials with the long-acting insulin detemir, a significant correlation between the inpatient variability (coefficient of variation) of fasting blood glucose and the rate of hypoglycemia was found [ 4 ]. (karger.com)