• The whole limb of a salamander or a triton will grow again and again after amputation. (wikipedia.org)
  • In mammals, a limb amputation or spinal cord transection is followed by inflammation and fibrotic scarring that leaves the animal with a permanent disability. (frontiersin.org)
  • We examined the bioelectric properties (resting potential gradients in the epidermis) of Xenopus laevis froglets undergoing hindlimb amputation and observed that the contralateral (undamaged) limb exhibits apparent depolarization signals immediately after the opposite hindlimb is amputated. (biologists.com)
  • Here we review recent insights into the biophysical, biochemical, and epigenetic processes that underlie regenerative healing in amphibians, focusing particularly on tail and limb regeneration in Xenopus . (frontiersin.org)
  • salamanders and newts), an order of tailed amphibians, is possibly the most adept vertebrate group at regeneration, given their capability of regenerating limbs, tails, jaws, eyes and a variety of internal structures. (wikipedia.org)
  • In urodele amphibians such as axolotls and newts, the same injury is followed by scarless regenerative healing that can fully restore both the lost tissue and its function (reviewed in Tanaka, 2016 ). (frontiersin.org)
  • Limited regeneration of limbs occurs in most fishes and salamanders, and tail regeneration takes place in larval frogs and toads (but not adults). (wikipedia.org)
  • Elegant experiments using heat-shock inducible expression of inhibitory proteins have further refined these observations to establish epistatic relationships, in which BMP acts upstream of Wnt, which in turn acts upstream of FGF during regeneration of the limb bud and tail ( Lin and Slack, 2008 ). (frontiersin.org)
  • After the limb or tail has been autotomized, cells move into action and the tissues will regenerate. (wikipedia.org)
  • Injuries that sever tissues such as the limb or spinal cord are met with radically different outcomes among vertebrates. (frontiersin.org)
  • The pattern of depolarization matches that of the amputated limb and is correlated to the position and type of injury, revealing that information about damage is available to remote body tissues and is detectable non-invasively in vivo by monitoring the bioelectric state. (biologists.com)
  • The case of autotomy, for example, serves as a defensive function as the animal detaches a limb or tail to avoid capture. (wikipedia.org)
  • Many arthropods can regenerate limbs and other appendages following either injury or autotomy. (wikipedia.org)
  • Some lower order vertebrates such as salamanders and newts have the ability to regrow severed limbs through a process called epimorphic regeneration. (nih.gov)
  • Some lower order vertebrates such as salamanders and newts are able regrow severed limbs through a process called e pimorphic regeneration . (nih.gov)
  • salamanders and newts), an order of tailed amphibians, is possibly the most adept vertebrate group at regeneration, given their capability of regenerating limbs, tails, jaws, eyes and a variety of internal structures. (wikipedia.org)
  • The current state of the science suggests that focused investment in research on key aspects of epimorphic regeneration is necessary for developing strategies to regenerate limbs in higher vertebrates and mammals including humans. (nih.gov)
  • Many arthropods can regenerate limbs and other appendages following either injury or autotomy. (wikipedia.org)
  • This initiative addresses the Aspirational Goal in the NICHD Strategic Plan titled advancing the ability to regenerate human limbs by using emerging technology to activate the body's own growth pathways and processes. (nih.gov)