• Gene expression at these histones regulated by epigenetic modifications is critical in restricting the embryonic stem cell to desired cell lineages and developing cellular memory. (wikipedia.org)
  • Histones modifications in chromatin were analyzed at various time intervals (along a 6-day period) following the initiation of in vitro embryonic stem cell differentiation. (wikipedia.org)
  • These results indicate a decrease in the level of active euchromatin epigenetic marks upon initiation of embryonic stem cell differentiation which is then followed immediately by reprogramming of the epigenome. (wikipedia.org)
  • citation needed] As the embryonic stem cell undergoes differentiation the markers for active euchromatin (histone acetylation and H3K4 methylation) are decreased after the removal of LIF showing that the cell is indeed becoming more differentiated. (wikipedia.org)
  • Cyclin-dependent kinase 2-associating protein 1 commits murine embryonic stem cell differentiation through retinoblastoma protein regulation. (nih.gov)
  • This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. (cancerindex.org)
  • We also begin to produce and characterize a new type of human stem cells, namely induced pluripotent cells that are obtained by converting somatic cells into stem cell through reprogramming. (ca.gov)
  • Here we use metabolic labelling with stable isotopes and mass spectrometry to quantitatively address the global turnover of genomic methylcytidine (mdC), hydroxymethylcytidine (hmdC) and formylcytidine (fdC) across mouse pluripotent cell states. (uni-muenchen.de)
  • In primed pluripotent cells the global mdC turnover rate is about 3-6% faster than can be explained by passive dilution through DNA synthesis. (uni-muenchen.de)
  • Thus, in pluripotent cells active mdC turnover involves both mdC oxidation-dependent and independent processes. (uni-muenchen.de)
  • Differentiate human pluripotent stem cells (hPSCs) to cells of the endoderm lineage with our specialized cell culture media. (stemcell.com)
  • Researchers have discovered what enables embryonic stem cells to differentiate into diverse cell types and thus to be pluripotent. (sciencedaily.com)
  • The molecule also plays a crucial role in the reprogramming of body cells into pluripotent stem cells. (sciencedaily.com)
  • Researchers of the Max DelbrĂĽck Center for Molecular Medicine (MDC) Berlin-Buch have discovered what enables embryonic stem cells to differentiate into diverse cell types and thus to be pluripotent. (sciencedaily.com)
  • In a second step the researchers investigated what happens when somatic cells that normally neither have E-cadherin nor are pluripotent are reprogrammed into a pluripotent stem cell state. (sciencedaily.com)
  • In this reprogramming technique, somatic cells are converted into induced pluripotent stem cells (iPSCs). (sciencedaily.com)
  • The MDC researchers found that in contrast to the original cells, the new pluripotent cells derived from mouse connective tissue contained E-cadherin. (sciencedaily.com)
  • E-Cadherin is necessary for maintaining pluripotent stem cells and also for inducing the pluripotent state in the reprogramming of somatic cells," Dr. Besser said. (sciencedaily.com)
  • If E-cadherin is absent, somatic cells cannot be reprogrammed into viable pluripotent cells. (sciencedaily.com)
  • Oct. 10, 2023 Generating specific cell lineages from induced pluripotent stem cells and embryonic stem cells is the holy grail of regenerative medicine. (sciencedaily.com)
  • Feb. 21, 2022 Embryonic stem cells and other pluripotent cells divide rapidly and have the capacity to become nearly any cell type in the body. (sciencedaily.com)
  • Induced pluripotent stem cells (iPSC), generated by introduction of a few defined factors in a somatic cell, provide an ideal patient-specific source for disease modeling, drug discovery and cellular therapies. (stanford.edu)
  • In addition to generating pluripotent stem cells, the team showed that mice bred using the cells grew up healthy. (sciencedaily.com)
  • We've demonstrated that we don't have to manipulate the pluripotent genes to get to the ground state, but rather that we can block all other options of where the cell 'wants' to go. (sciencedaily.com)
  • But they could still function as healthy pluripotent stem cells. (sciencedaily.com)
  • The recently disclosed plasticity properties of adult-derived stem cells, their ability to be reprogrammed by defined factors into pluripotent stem cells and the comprehension of "epi"-genetic mechanisms underlying stem cells differentiation process has opened unexpected avenues to attempt regeneration of tissues affected by degenerative disorders and prompted the birth of the new "regenerative medicine" concept. (mpi.nl)
  • Using this type of direct conversion approach rather than making them from induced pluripotent stem cells, where they revert into a naĂŻve state, helps to retain the epigenetic age of the patient in the generated interneurons. (lu.se)
  • The cellular elements of blood originate from the pluripotent hematopoietic stem cell. (medscape.com)
  • Firstly, we present a robust 2-week protocol for the differentiation of human pluripotent stem cells (PSCs) into forebrain neural progenitor cells. (lu.se)
  • There has been multiple evidence suggesting that the maintenance of the lineage commitment of stem cells is controlled by epigenetic mechanisms such as DNA methylation, histone modifications and regulation of ATP-dependent remolding of chromatin structure. (wikipedia.org)
  • Current Research and Scholarly Interests The Wang lab takes an interdisciplinary approach to studying fundamental mechanisms controlling gene expression in mammalian cells, and how epigenetic mechanisms such as DNA methylation, chromatin modifications, and RNA influence chromatin dynamics to affect gene regulation. (stanford.edu)
  • LncRNA SNHG1 could inhibit osteogenic differentiation of bone marrow mesenchymal stem cells through p38 MAPK pathway [ 13 ]. (biomedcentral.com)
  • The pathogenesis of myelodysplastic syndrome (MDS) may be related to the abnormal expression of microRNAs (miRNAs), which could influence the differentiation capacity of mesenchymal stem cells (MSCs) towards adipogenic and osteogenic lineages. (techscience.com)
  • The bone marrow microenvironment (BMME) is a complex network system primarily comprising stromal cells such as mesenchymal stem cells (MSCs), osteoprogenitor cells, vascular endothelial cells, monocytes, macrophages, and cytokines. (techscience.com)
  • Over the last decades, mesenchymal stem cells (MSCs) have attracted extensive attention in the field of bone regeneration [ 4 - 7 ]. (hindawi.com)
  • Critical epigenetic regulation of primate embryogenesis entails DNA methylome changes. (nature.com)
  • This regulation of chromatin through epigenetic modifications is a molecular mechanism that determines whether the cell continues to differentiate into the desired fate. (wikipedia.org)
  • Embryonic stem cells containing reduced or elevation levels of methylation are viable but unable to differentiate and therefore require critical regulation of cytosine methylation for mammalian development. (wikipedia.org)
  • This gene thus plays a role in both cell-cycle and epigenetic regulation. (cancerindex.org)
  • We are interested in understanding the role of the extracellular matrix in regulating stem cell self-renewal and differentiation, and how this regulation goes awry in cancer. (stanford.edu)
  • Epigenetic regulation and transcriptional reprogramming both play critical roles during stem cell differentiation and lineage commitment. (stemcellsportal.com)
  • Our general focus is on stem cell fate choice by epigenetic regulation, transcription regulation via specific developmental transcription factors, and chromatin modifying factors. (ad-astra.ro)
  • More so, our results show that the epigenetic regulation of TE transcription is dynamically regulated throughout life (Paper II), upon the beginning of neuroinflammation (Paper III), and in a disease-driving polymorphic TE insertion (Paper IV). (lu.se)
  • examined the effects of epigenetic modifications on the chromatin structure and the modulation of these epigenetic markers during stem cell differentiation through in vitro differentiation of murine embryonic stem (ES) cells. (wikipedia.org)
  • This chapter explores the physiological effects of epigenetic modifications during cellular aging and transformation. (epigenie.com)
  • Exploring the effects of lncRNA SNHG1 in the process of osteogenic differentiation of periodontal ligament stem cells (PDLSCs) would provide novel therapeutic strategies for tissue regeneration. (biomedcentral.com)
  • The osteogenic differentiation of PDLSCs were assessed by ALP staining and Alizarin Red staining as well as the mRNA and protein levels of osteogenic marker genes osterix, osteocalcin, and alkaline phosphatase through qRT-PCR and western blot. (biomedcentral.com)
  • SNHG1 inhibited while KLF2 promoted osteogenic differentiation of PDLSCs. (biomedcentral.com)
  • SNHG1 directly interact with the histone methyltransferase enhancer of the zeste homolog 2 (EZH2) and modulate the histone methylation of promoter of Kruppel-like factor 2 (KLF2) and altered the progress osteogenic differentiation of PDLSCs. (biomedcentral.com)
  • Taken together, SNHG1 inhibited the osteogenic differentiation of PDLSCs through EZH2-mediated H3K27me3 methylation of KLF2 promotor and provided a novel class of therapeutic targets for regenerate dental tissues. (biomedcentral.com)
  • Therefore, better understanding of the mechanism that governs PDLSCs osteogenic differentiation would greatly be beneficial to the development of novel therapeutic strategies for tissue regeneration. (biomedcentral.com)
  • Similarly, lncRNA H19 also was reported to promote osteogenic differentiation of rat ectomesenchymal stem cells through enhancing the expressions of osteogenic markers, beta-catenin, and target genes of Wnt/beta-catenin signaling pathway partly through sponging miR-22 and miR-141 [ 12 ]. (biomedcentral.com)
  • In brief, lncRNA plays an important role in osteogenic differentiation of PDLSCs and our study will further investigate the effects of lncRNA SNHG1 in osteogenic differentiation of PDLSCs and explore the underlying mechanism. (biomedcentral.com)
  • However, the function of SNHG1 and EZH2 in osteogenic differentiation of PDLSCs was still less reported. (biomedcentral.com)
  • The purpose of the current study was to investigate whether lncRNA SNHG1 was mechanistically involved in the osteogenic differentiation of PDLSCs. (biomedcentral.com)
  • Transfection of MDS-MSCs with the miR-103-3p mimic improved osteogenic differentiation and decreased adipogenic differentiation in vitro, while inhibition of miR-103-3p showed the opposite results in NOR-MSCs. (techscience.com)
  • The miR-103-3p mimics may boost MDS-MSCs osteogenic differentiation while weakening lipid differentiation, thereby providing possible target for the treatment of MDS pathogenesis. (techscience.com)
  • In this study, we verified that exosomes derived from osteogenically differentiated ADSCs can promote osteogenic differentiation of ADSCs. (hindawi.com)
  • Moreover, we found that these differentially expressed exosomal miRNAs connect osteogenic differentiation to processes such as axon guidance, MAPK signaling, and Wnt signaling. (hindawi.com)
  • This study confirms that alterations in the expression of exosomal miRNAs can promote osteogenic differentiation of ADSCs, which also provides the foundation for further research on the regulatory functions of exosomal miRNAs in the context of ADSC osteogenesis. (hindawi.com)
  • performed an experiment to determine the importance of deacetylation and acetylation for stem cell differentiation by looking at global acetylation and methylation levels at certain site-specific modification in histone sites H3K9 and H3K4. (wikipedia.org)
  • citation needed] The methylation of histone H3K4 also decreased after one day of LIF removal but showed a rebound between days 2-4 of differentiation, finally ending with a decrease in methylation on day five. (wikipedia.org)
  • Histone modifications of H3K9 position show a decrease in di- and tri-methylation of undifferentiated embryonic stem cells and had a gradual increase in methylation during the six-day time course of in vitro differentiation, which indicated that there is a global increase of inactive heterochromatin levels at this histone mark. (wikipedia.org)
  • In demyelinated young brains, new myelin synthesis is preceded by downregulation of oligodendrocyte differentiation inhibitors and neural stem cell markers, and this is associated with recruitment of histone deacetylases (HDACs) to promoter regions. (nih.gov)
  • So using MM-401 to block MLL1's normal activity in cells that had started down the path to adulthood meant that histone marks were missing before the cell needed them. (sciencedaily.com)
  • In cell epigenetics, DNA methylation and histone modification becomes altered during aging and in cancer. (epigenie.com)
  • Defective remyelination can be recapitulated in vivo in mice receiving systemic administration of pharmacological HDAC inhibitors during cuprizone treatment and is consistent with in vitro results showing defective differentiation of oligodendrocyte progenitors after silencing specific HDAC isoforms. (nih.gov)
  • In preparation to apply various toxicants to the developed in vitro human neuronal stem cells, the team has characterized a number of PCB's and PAH compounds for their ability to (a) induce various signal transduction mechanisms and (b) inhibit gap junctional intercellular communication regulating cell proliferation, differentiation, and apoptosis. (nih.gov)
  • In both in vitro and in vivo settings, steering pyruvate use toward glycolysis or OXPHOS differentially skews the hematopoietic output of HE cells toward either an erythroid fate with primitive phenotype, or a definitive lymphoid fate, respectively. (lu.se)
  • 1983) and the multipotent progenitor cells from fetal disease (Bjorklund and Lindvall, 2000). (lu.se)
  • [ 18 ] Arylsulfatase A deficiency leads to defective glial and neuronal differentiation from neural progenitor cells. (medscape.com)
  • It maintains normal hematopoietic function by interacting with hematopoietic stem cells (HSCs) to control their proliferation and differentiation ( Morrison and Scadden, 2014 ). (techscience.com)
  • Hematopoietic stem cells (HSCs) emerge from hemogenic endothelial (HE) cells, through endothelial-to-hematopoietic transition (EHT). (lu.se)
  • MSCs are a population of nonhematopoietic adult stem cells that have the property of self-renewal and can differentiate into multiple lineages [ 8 - 10 ]. (hindawi.com)
  • However, the full promise of regenerative medicine has been difficult to achieve so far, partly due to our incomplete understanding of the genetic and epigenetic mechanisms regulating differentiation of stem cells to specific lineages and tissues. (confex.com)
  • Here, we show that the emergence of blood is regulated by multiple metabolic pathways that induce or modulate the differentiation toward specific hematopoietic lineages during human EHT. (lu.se)
  • The Stem Cells Portal provides coverage of the latest research, clinical applications, policies, and developments in the stem cell and regenerative medicine fields. (stemcellsportal.com)
  • More specifically, regenerative medicine has recently emerged as a promising therapeutic strategy for treating degenerating tissues using different types of stem cells. (confex.com)
  • Thus, my research interests are to develop novel single-cell genomics methods to better understand how changes in the epigenetic landscape during normal development regulates cellular differentiation, information that is critical towards realizing the full potential of regenerative medicine. (confex.com)
  • For instance, NCoR1 and SMRT regulate neuronal stem cell proliferation and differentiation during brain development and they have been implicated in learning and memory. (escholarship.org)
  • The myelodysplasia syndromes (MDSs) are clonal stem cell disorders characterized by progressive cytopenia or cytopenias, usually in the presence of a hypercellular bone marrow and multilineage dysplasia. (medscape.com)
  • Cancer stem cells are a selective clonal subset of tumour cells that have avoided various cell regulatory mechanisms, including terminal differentiation, and yet have retained the self-renewal properties and proliferative potential of adult stem cells. (who.int)
  • A cell type-specific expression map of NCoR1 and SMRT transcriptional co-repressors in the mouse brain. (escholarship.org)
  • We show that human and chimpanzee cells differentiate in a similar man¬ner and that the difference in interspecies protein abundance is higher than transcript-level differences, suggesting that post-transcriptional mechanisms play a role in the difference between human and chim¬panzee brain development. (lu.se)
  • Next, the MDC researchers want to find out to what extent E-cadherin also regulates human embryonic stem cells. (sciencedaily.com)
  • BRD4, an epigenetic regulator and transcription factor, binds to acetylated histones in super-enhancer regions and regulates the expression of essential pluripotency genes. (stemcellsportal.com)
  • To understand how the genome and epigenome regulates cellular function, development of high-throughput sequencing methods, known as next-generation sequencing, are beginning to unravel genome-wide correlations between the genome, epigenome and transcriptome within a large population of cells or tissues. (confex.com)
  • Recombinant human collagen XV regulates cell adhesion and migration. (nih.gov)
  • However, robust and large-scale genome-wide reprogramming of DNA methylome occurs during two critical developmental processes: (1) development of primordial germ cells and (2) pre-implantation embryogenesis. (nature.com)
  • The analysis of the signals controlling stem cell differentiation and reprogramming has recently drawn much attention, due to potential medical applications. (igbmc.fr)
  • Our goal is to study the molecular and the epigenetic events controlling cell differentiation and reprogramming. (igbmc.fr)
  • During his Ph.D. studies at Imperial College London (supervised by Professor Amanda Fisher), Dr. Bagci investigated the roles of DNA methylation in epigenetic reprogramming, and signalling pathways involved in stem cell renewal and differentiation. (imperial.ac.uk)
  • Andreas Bruzelius defended his Ph.D. thesis 'Generating GABAergic interneurons through reprogramming and differentiation strategies' on Friday, 20 October 2023. (lu.se)
  • I've worked specifically with generating interneurons in the lab, using reprogramming and differentiation strategies. (lu.se)
  • Define the basis of eukaryotic cell biology. (uaeu.ac.ae)
  • Develop a biological knowledge base common to contemporary biologists, encompassing microscopy, cell structure, cellular membranes, and nucleic acids biology. (uaeu.ac.ae)
  • From the basic biology perspective, these findings have revealed that cell fates are inherently plastic and are dynamically regulated. (stanford.edu)
  • A major challenge in developmental biology is to understand how cell diversity is generated and how cells interact to build the sophisticated metazoan architecture. (igbmc.fr)
  • Current Research and Scholarly Interests We employ an interdisciplinary approach to studies of biological systems, combining synthetic chemistry with biochemistry, cell biology, and structural biology. (stanford.edu)
  • Quantitative Biology of Development & Stem Cells, Hubrecht Institute, The Netherlands. (confex.com)
  • To overcome this limitation, recent advances in molecular biology have enabled genome-wide single-cell measurements of the transcriptome, genome or certain epigenetic marks that capture this cell-to-cell heterogeneity. (confex.com)
  • Combining cell biology and electrophysiology, his work has the potential to create personalized disease models for future research. (lu.se)
  • Expression of cell-cycle regulator CDK2-associating protein 1 (p12CDK2AP1) in transgenic mice induces testicular and ovarian atrophy in vivo. (nih.gov)
  • Single cells in these populations exhibit different com- binations of regulator activity that suggest the presence of multiple configurations of a potential differentiation network as a result of multiple entry points into the committed state. (lu.se)
  • We demonstrate that glycolysis-mediated differentiation of HE toward primitive erythroid hematopoiesis is dependent on the epigenetic regulator LSD1. (lu.se)
  • Our findings reveal that during EHT, metabolism is a major regulator of primitive versus definitive hematopoietic differentiation. (lu.se)
  • Epigenetic plasticity underpins cell potency, but the extent to which active turnover of DNA methylation contributes to such plasticity is not known and the underlying pathways are poorly understood. (uni-muenchen.de)
  • We are currently investigating the mechanistic details of these epigenetic pathways in Osteoarthritis. (stanford.edu)
  • Genome-wide Epigenetic Study of Chronic Rhinosinusitis Tissues Reveals Dysregulated Inflammatory, Immunologic and Remodeling Pathways. (cdc.gov)
  • This process accelerates upon acquisition of primed pluripotency and returns to low levels in lineage committed cells. (uni-muenchen.de)
  • This pluripotency depends on a molecule -- E-cadherin -- hitherto primarily known for its role in mediating cell-cell adhesion. (sciencedaily.com)
  • If E-cadherin is absent, the stem cells lose their pluripotency. (sciencedaily.com)
  • In a first step they showed that the pluripotency of these stem cells is directly associated with the cell-adhesion molecule E-cadherin. (sciencedaily.com)
  • Thus, we have double proof that E-cadherin is directly associated with stem-cell pluripotency. (sciencedaily.com)
  • Writing in the journal Cell Stem Cell , the team reports that more than half of mouse epiblast stem cells treated with the drug reversed course within three days, and regained an embryonic "be anything" state, also called pluripotency. (sciencedaily.com)
  • Past attempts by other teams to restore pluripotency to mouse cells from the epiblast stem cell state have yielded far lower amounts, or non-viable cells. (sciencedaily.com)
  • Abstract title:Stem cells from the mammalian blastocyst-How similar are mouse and human? (csh-asia.org)
  • Understanding the molecular relationships is essential for using human somatic cells to develop stem cell therapy for diseases such as heart attack, Alzheimer's or Parkinson's disease or diabetes," Dr. Besser said. (sciencedaily.com)
  • Sex differences at the genetic/epigenetic level in early development. (ubc.ca)
  • Specifically, epigenetic alterations driven by chromatin modifying drugs or by genetic disruption of certain DNA methyltransferases cause distinct changes in miRNA expression profiles in cancer cells. (epigenie.com)
  • Because tissues are composed of several cell-types and even cells within the same cell-type have been shown to display dramatic cell-to-cell variability in gene expression, bulk measurements obscure quantification of how genetic or epigenetic features directly influence the function of individual cells. (confex.com)
  • We will further characterize molecular changes during directed cell differentiation and identify the cells that exhibit a pattern of DNA modification, namely DNA methylation, similar to primary neural cells in human brain. (ca.gov)
  • The results of these analyses revealed that the differentially expressed exosomal miRNAs participate in multiple biological processes, such as gene expression, synthesis of biomolecules, cell development, differentiation, and signal transduction, among others. (hindawi.com)
  • Recent discoveries have shown that aberrant expression of miRNAs may contribute to the development and progression of human cancer, and are regulated by different mechanisms like transcription factor binding, epigenetic alterations, or chromosomal abnormalities. (epigenie.com)
  • Among these, adipose-derived stem cells (ADSCs) are a type of mesenchymal stem cell isolated from adipose tissue, which has the advantages of abundant storage in vivo , easy acquisition, and expansion [ 13 - 15 ]. (hindawi.com)
  • Recently, a number of studies have confirmed that ADSCs possess the ability to differentiate into adipocytes, osteoblasts, and chondrocytes [ 16 - 18 ], suggesting that a broader source of stem cells is available for application in tissue engineering. (hindawi.com)
  • Hair follicle stem cells reside in their niche in a quiescent state, but become rapidly activated in response to homeostatic and injury signals to regenerate the tissue. (ad-astra.ro)
  • In both processes, rapid proliferation gives rise to new tissue, cell fate has to be specified within that tissue, and distinct positional identities have to be established to generate a properly patterned structure. (frontiersin.org)
  • For mammalian cells, the maintenance of cytosine methylation is catalyzed by DNA methyltransferases and any disruption to these methyltransferases will cause a lethal phenotype to the embryo. (wikipedia.org)
  • Embryonic stem cells are capable of self-renewing and differentiating to the desired fate depending on their position in the body. (wikipedia.org)
  • Since there is also an increase throughout the six-day period in H3K9me, a marker for active heterochromatin, once differentiation occurs it is concluded that the formation of heterochromatin occurs as the cell is differentiated into its desired fate making the cell inactive to prevent further differentiation. (wikipedia.org)
  • The role and effect of 5hmC on 5mC turnover and hence DNA demethylation, on gene expression per se and stem cell fate and differentiation is a topic of vigorous interest. (stanford.edu)
  • By transporting "cargos" such as proteins, RNAs, DNAs, and lipids [ 26 ], exosomes regulate the eventual fate of recipient cells. (hindawi.com)
  • The focus of my laboratory is the understanding of basic mechanisms that regulate the fate of stem cells within tissues. (ad-astra.ro)
  • The slight rebound in each of these marks allows for further differentiation to occur by allowing another opportunity to decrease the markers once again, bringing the cell closer to its mature state. (wikipedia.org)
  • It's the first time that scientists have shown they can get stem cells to revert to their original state by erasing specific labels called epigenetic markers. (sciencedaily.com)
  • CD133+), but are rarely codetected with the neural stem dents, very few human-specific NSC markers have been cell (NSC) marker CD15. (lu.se)
  • 2000). In *Correspondence to: Perrine Barraud, Department of Veterinary Medi- contrast, several cell surface markers have been used to cine, Neurosciences, Madingley Road, Cambridge CB3 OES, United enrich for NSCs in the rodent CNS. (lu.se)
  • The therapeutic application of stem cells requires the elucidation of how epigenetic factors control lineage commitment. (stemcellsportal.com)
  • A stochastic epigenetic switch controls the dynamics of T-cell lineage commitment. (crossref.org)
  • Here, we characterize epigenetic features of active promoter proximal regions and candidate distal regulatory elements to construct high-resolution chromatin interaction maps for maize via long-read chromatin interaction analysis by paired-end tag sequencing (ChIA-PET). (nature.com)
  • Stem cell homeostasis is maintained through epigenetic mechanisms that are highly dynamic in regulating the chromatin structure as well as specific gene transcription programs. (wikipedia.org)
  • Burst-Like Transcription of Mutant and Wildtype MYH7-Alleles as Possible Origin of Cell-to-Cell Contractile Imbalance in Hypertrophic Cardiomyopathy. (crossref.org)
  • The mammalian epigenome undergoes global remodeling during early stem cell development that requires commitment of cells to be restricted to the desired lineage. (wikipedia.org)
  • DNA methylation is an epigenetic mark associated with long-term gene silencing during early development and lineage specification. (stanford.edu)
  • During development, many cells move as cohorts to attain their final destination and shape both tissues and organs. (igbmc.fr)
  • But it also plays a much more mundane role in regular cell development, and the formation of blood cells and the cells that form the spinal cord in later-stage embryos. (sciencedaily.com)
  • Similarly, in specific cases, such as cancers, viral infections and in certain cell-types during normal development, mutations and other structural variations within the genome also influences cellular functions. (confex.com)
  • The ability to rapidly change gene expression patterns is essential for differentiation, development, and functioning of the brain. (escholarship.org)
  • During the development of multicellular organisms, precursor cells for specialized organs need to differentiate in reproducible proportions and in spatially coherent domains. (biologists.com)
  • We are analyzing the physiological role of several genes implicated in different aspects of stem cell activation, self-renewal, and differentiation. (ad-astra.ro)
  • Current Research and Scholarly Interests The main focus of our research is to understand how cells maintain genome integrity by checkpoint mechanisms during chromosome replication. (stanford.edu)
  • The genome within all cell-types of a multicellular organism is identical, yet different cell-types display varied functions within an organism due to differences in other factors, collectively termed as the epigenome. (confex.com)
  • Distinct homeostatic cell interactions control directionality, coordination and integrity of the migratory unit. (igbmc.fr)
  • These novel observations are corroborated by single cell transcriptomics and emphasize how NCoR1 and SMRT may contribute to distinct biological functions, suggesting an exclusive role of NCoR1 in innate immune responses in the brain. (escholarship.org)
  • May 20, 2020 In the bone marrow, blood stem cells via precursor cells give rise to a variety of blood cell types with various functions: white blood cells, red blood cells, or blood platelets. (sciencedaily.com)
  • Phosphoinositide 3-kinase (PI3K) signaling contributes to a variety of processes, mediating many aspects of cellular function, including nutrient uptake, anabolic reactions, cell growth, proliferation, and survival. (mdpi.com)
  • The present review will cover light and shaded areas in the cardiovascular cellular therapy field, and will discuss about recent advances and related patents designed to enhance efficiency of stem cell therapy in patients with cardiovascular disease. (mpi.nl)
  • Dr. Daniel Besser, Prof. Walter Birchmeier and Torben Redmer from the MDC, a member of the Helmholtz Association, used mouse embryonic fibroblasts (MEFs) in their stem cell experiments. (sciencedaily.com)
  • One way we did this was by converting adult fibroblasts, or skin cells, into interneurons. (lu.se)
  • Other techniques can reprogram "adult" cells in the human body taken from skin, for example -- but the cells still carry baggage from their previous state. (sciencedaily.com)
  • In the adult, HSC quiescence, maintenance, and differentiation are closely linked to changes in metabolism. (lu.se)
  • Nat Rev Mol Cell Biol 1-18 (2019) doi:10.1038/s41580-019-0159-6. (uni-muenchen.de)
  • The bone marrow stromal cell (BMSC) population, which makes up a large part of the hematopoietic microenvironment, encompasses a variety of adherent cell types. (techscience.com)
  • Thus, we suggest that inefficient epigenetic modulation of the oligodendrocyte differentiation program contributes to the age-dependent decline in remyelination efficiency. (nih.gov)
  • Here we review recent insights into the biophysical, biochemical, and epigenetic processes that underlie regenerative healing in amphibians, focusing particularly on tail and limb regeneration in Xenopus . (frontiersin.org)
  • Phenotypic variation between siblings with MLD suggests that a number of biochemical and epigenetic factors contribute to the clinical phenotype. (medscape.com)
  • Andreas' research focuses on generating brain cells, specifically interneurons, in the lab, which has significant implications for the study of neurodegenerative and neuropsychiatric disorders. (lu.se)
  • To directly differentiate to pancreatic cells, use our pancreatic progenitor kit to generate functional PDX1 + /NKX6.1 + cells that can be matured into insulin-producing beta cells. (stemcell.com)