InsulinPrevalence of obesityCardiovascular riskIntergenerationalGeneticInflammationOxidative stressAbnormalitiesDisordersDiabetesMetabolismEndocrineIncreases the riskDysfunctionCardiometabolicGeneticsMicrobiotaDiseasesMechanismsRegulationGeneMechanismSevereConsequencesTranscriptionChildhood2023ResistanceResearchImmunePreventionImpairmentModulationColonDiscussesAccumulationEffectsMainPlaysHealthPromoteFact
Insulin5
- The primary characteristics of this syndrome include: hyperandrogenism, anovulation, insulin resistance, and neuroendocrine disruption. (wikipedia.org)
- Metabolic syndrome: This appears as a tendency towards central obesity and other symptoms associated with insulin resistance, including low energy levels and food cravings. (wikipedia.org)
- A new theory suggests that gut microbiota contribute to the regulation of energy homeostasis, provoking the development of an impairment in energy homeostasis and causing metabolic diseases, such as insulin resistance or TDM2. (frontiersin.org)
- PCOS is a heterogeneous disease characterized by hyperandrogenism, dysfunctional ovulation, and polycystic ovary morphology, accompanied by metabolic abnormalities, such as insulin resistance (IR) and obesity. (biomedcentral.com)
- reach the shop Laser Capture in to communicate compared, compared syndrome, contribute and identify to the insulin of the Ligand. (green-frontier.de)
Prevalence of obesity2
- Genetic, physiological and psychological factors, as well as dietary habits, physical activity, lifestyle and social and environmental factors are responsible for the significant increase in the prevalence of obesity and its consequences [ 1 - 4 ]. (medsci.org)
- The prevalence of obesity and its associated disorders, such as type 2 diabetes mellitus (TDM2), has increased substantially worldwide over the last decades. (frontiersin.org)
Cardiovascular risk3
- Women with PCOS have higher risk of multiple diseases including Infertility, type 2 diabetes mellitus (DM-2), cardiovascular risk, metabolic syndrome, obesity, impaired glucose tolerance, depression, obstructive sleep apnea (OSA), endometrial cancer, and nonalcoholic fatty liver disease/nonalcoholic steatohepatitis (NAFLD/NASH). (wikipedia.org)
- From this perspective, dedicating time during the consultation to promoting the acquisition of heart-healthy habits would be indicated in all individuals, regardless of cardiovascular risk classification, the role of the internist being fundamental. (bvsalud.org)
- We propose the use of the name 'Temple syndrome' for this condition and suggest that improved diagnosis and long-term monitoring, especially of growth and cardiovascular risk factors, is required. (bmj.com)
Intergenerational1
- We consider the effects of the environment and both intergenerational and transgenerational epigenetic inheritance on biology, disease and evolution. (nature.com)
Genetic5
- 2 In 2020, diabetes mellitus is still likely a syndrome with many genetic, epigenetic, and pathophysiologic abnormalities, different complication profiles, and multiple environmental influences such as infections, nutrients, exercise regimens, and the gut microbiome. (ccjm.org)
- Genetic and epigenetic changes, hyperandrogenaemia, and obesity aggravate IR. (biomedcentral.com)
- Primary ovarian insufficiency is primarily idiopathic, but it can also be seen in association with chromosomal and genetic defects, including Turner syndrome (45,X karyotype) and FMR1 premutation. (lecturio.com)
- Using genomics approaches, Dr. Nobrega has identified the gene IRX3 as the strongest association to polygenic obesity in humans, and characterized the mechanisms by which mutations altering the expression of a gene called TCF7L2 also represent the strongest genetic link to type 2 diabetes in humans. (agbt.org)
- Genome-wide survival analysis for macular neovascularization development in central serous chorioretinopathy revealed shared genetic susceptibility with polypoidal choroidal vasculopathy , 129 (9): 1034-1042, 2022. (csml.org)
Inflammation3
- Some members of Rhododendron genus are traditionally used as medicinal plants for arthritis, acute and chronic bronchitis, asthma, pain, inflammation, rheumatism, hypertension and metabolic diseases. (medsci.org)
- Cardiovascular (CV) risk factors such as hypercholesterolemia, hyperglycaemia, obesity, hypertension, smoking, and aging promote vascular inflammation and endothelial activation [ 7 - 9 ]. (hindawi.com)
- Although cellular senescence plays an important role in tissue homeostasis, the dramatic accumulation of senescent cells in old age has deleterious effects on damage repair and systemic inflammation [ 11 ]. (biomedcentral.com)
Oxidative stress1
- Both of these factors have received increased attention in relation to the COVID-19 pandemic as they both take part in regulation of the main metabolic processes, i.e., lipid/glucose/energy homeostasis, oxidative stress, redox balance, and cell fate, as well as in the healthy regulation of the immune system. (bvsalud.org)
Abnormalities1
- Sirius Pixels UHDe HEVC Encoder also, when the epub nuclear receptors as molecular targets for cardiometabolic and central nervous system diseases solvay pharmaceuticals conferences is not marketed, the code's abnormalities trigger sequentially shown. (siriuspixels.com)
Disorders4
- I sincerely hope all of us will continue to work hard on finding practical solutions for all of these metabolic disorders. (endocrineconferences.com)
- Obesity and its associated disorders are a major public health concern. (frontiersin.org)
- Recent insight suggests that an altered composition and diversity of gut microbiota could play an important role in the development of metabolic disorders. (frontiersin.org)
- Gestational diabetes mellitus (GDM), characterized by hyperglycemia that develops during pregnancy, increases the risk of fetal macrosomia, childhood obesity and cardiometabolic disorders later in life. (biomedcentral.com)
Diabetes8
- This review discusses research aimed at understanding the role of gut microbiota in the pathogenesis of obesity and type 2 diabetes mellitus (TDM2). (frontiersin.org)
- However, the contribution of gut microbiota to obesity and diabetes in humans is unclear. (frontiersin.org)
- Zinc status is also tightly associated with risk factors for severe COVID‑19 including ageing, immune deficiency, obesity, diabetes, and atherosclerosis, since these are known risk groups for zinc deficiency. (spandidos-publications.com)
- Understanding the many faces of the diabetes syndrome can make a difference in how clinicians select glucose-lowering therapy. (ccjm.org)
- The importance of the prevention and control of non-communicable diseases, including obesity, metabolic syndrome, type 2 diabetes, cardiovascular diseases, and cancer, is increasing as a requirement of the aging population in developed countries and the sustainability of healthcare. (bvsalud.org)
- Dr. Nobrega has modeled the impact of mutations implicated in various human diseases, such as congenital heart defects, heart failure, cancer, type 2 diabetes, obesity, and asthma. (agbt.org)
- Obesity-related diseases including heart disease, stroke, type 2 diabetes, and cancer are a leading cause of preventable death. (cshlpress.com)
- Obesity was reported in 49% of cases, and three patients developed type 2 diabetes mellitus. (bmj.com)
Metabolism1
- Professor Hamer said: "The impaired glucose and lipid metabolism (how the body uses types of fat and sugar) appears to be a plausible cause: the links between obesity and COVID-19 infection may be more complex than simple mechanical aspects of excess fat on the diaphragm. (debuglies.com)
Endocrine2
- Polycystic ovary syndrome, or polycystic ovarian syndrome (PCOS), is the most common endocrine disorder in women of reproductive age. (wikipedia.org)
- Endocrine Meeting 2018 welcomes all the Endocrinologists , Diabetologists, and other medical & clinical experts working the arena of Endocrinology , Metabolic Syndrome and related field to this upcoming Euro Endocrinology Meeting at Paris, France. (endocrineconferences.com)
Increases the risk1
- Obesity increases the risk of a number of health problems, including coronary disease, particular types of carcinoma, respiratory system complications and osteoarthritis of small and large joints [ 1 ]. (medsci.org)
Dysfunction1
- Diseases associated with ZO-1 dysfunction include Celiac Disease and Congenital Nephrotic Syndrome. (thermofisher.com)
Cardiometabolic1
- These epub nuclear receptors as molecular targets for cardiometabolic and central nervous system diseases solvay pharmaceuticals bloodletting polypeptides have increased generally generally of cardiac eye and blood response. (siriuspixels.com)
Genetics2
- From the abstract: ' In this Review, we discuss advances in the genetics of obesity from the past decade-with emphasis on developments from the past 5 years-with a focus on metabolic consequences, and their potential implications for precision management of the disease. (cdc.gov)
- We also provide an overview of the potential role of genetics in guiding weight loss strategies. (cdc.gov)
Microbiota2
- The metabolic endotoxemia, modifications in the secretion of incretins and butyrate production might explain the influence of the microbiota in these diseases. (frontiersin.org)
- This review discusses the research conducted in understanding the role of gut microbiota in the pathogenesis of obesity and TDM2. (frontiersin.org)
Diseases3
- Correspondingly, alteration of zinc status significantly affects immune response resulting in increased susceptibility to inflammatory and infectious diseases including acquired immune deficiency syndrome, measles, malaria, tuberculosis, and pneumonia ( 5 ). (spandidos-publications.com)
- In our recent work, we summarized the role of two central factors, i.e., appropriate levels of vitamin D and SIRT1, which are connected to adequate lifestyles with beneficial effects on the prevention and control of non-communicable diseases. (bvsalud.org)
- Mucosal-associated invariant T (MAIT) cells have been implicated in various inflammatory diseases of barrier organs, but so far, their role in kidney disease is unclear. (inims.de)
Mechanisms2
- Fig. 1: Epigenetic mechanisms that maintain cell identities during development and throughout life. (nature.com)
- However, further research is required in this direction to elucidate the mechanisms by which orexins play a role in different testicular functions and effect of orexins on semen quality. (researchgate.net)
Regulation2
- Recent research also has thrown lights upon a significant role of orexins, especially orexin A, in regulation of male reproductive functions owing to their receptor expressions in vital testicular cells, such as Leydig cells, Sertoli cells as well as spermatozoa at different developmental stages, even in the epididymis and penis. (researchgate.net)
- Recent review papers show that many obesity researchers are converging on a model for the development of obesity that includes excessive food reward*, in addition to other factors such as physical inactivity, behavioral traits, and alterations in the function of the hypothalamus (a key brain region for the regulation of body fatness). (blogspot.com)
Gene1
- Genomic imprinting is an epigenetic marking mechanism that regulates gene expression dependent on parent of origin. (bmj.com)
Mechanism1
- Reports suggest that orexins may be the key brain components to mediate the mechanism of obesity resistance. (researchgate.net)
Severe2
- This was evident from those overweight, even if only slightly, through to severe obesity, when compared to those of normal weight. (debuglies.com)
- Obesity is a risk factor for both susceptibility to infections including postoperative infections and other nosocomial infections and the occurrence of a more severe disease course. (hrb.ie)
Consequences1
- Obesity is a condition when fat accumulation is excessive to the extent that it produces adverse health consequences [ 1 ]. (medsci.org)
Transcription1
- Epigenetic components (for example, Polycomb PRC1/2 and Trithorax group proteins) maintain the 'off' states of certain genes and the 'on' states of others, in a cell-type- and time-specific manner (the bottom panels show three genes, depicted schematically as chromatinized templates, in which transcription is triggered by specific transcription factors and silent or active states are maintained by PRC1/2 or Trithorax proteins, respectively). (nature.com)
Childhood1
- A section is included about starting CVD promotion and prevention measures at an early age, childhood and adolescence, also mentioning epigenetic aspects related to CVD. (bvsalud.org)
20231
Resistance1
- Indeed, the obesity and cellular leptin resistance of [diet-induced obese] animals are reversed by replacing the palatable calorie-dense chow used to promote obesity with standard chow. (blogspot.com)
Research2
- Epigenetic research has accelerated rapidly in the twenty-first century, generating justified excitement and hope, but also a degree of hype. (nature.com)
- The journal Cell just published a review paper by Drs. Karen Ryan, Randy Seeley and Stephen Woods-- Drs. Seeley and Woods are leaders in obesity research ( 2 ). (blogspot.com)
Immune2
- At the same time, the most critical role of zinc is demonstrated for the immune system. (spandidos-publications.com)
- In these missions, physiological adaptation to the new environment leads to changes in different body systems, such as the cardiovascular and musculoskeletal systems, metabolic and neurobehavioral health and immune function. (frontiersin.org)
Prevention1
- These data call for a paradigm shift, where health promotion and cardiovascular prevention will acquire a central role in health policies. (bvsalud.org)
Impairment1
- Alzheimer disease (AD) is an acquired disorder of cognitive and behavioral impairment that markedly interferes with social and occupational functioning. (medscape.com)
Modulation1
- Zinc plays a signaling role involved in the modulation of inflammatory responses ( 3 ). (spandidos-publications.com)
Discusses2
- Penn Medicine cardiovascular imaging specialist Frank Silvestry, MD, discusses the role of interventional echocardiography and three new imaging options: 3D TEE, fusion imaging, and 3D ICE. (pennmedicine.org)
- Penn Medicine cardiovascular imaging specialist Tiffany Chen, MD, discusses the role of imaging in tricuspid valve disease with a focus on pre-procedural imaging. (pennmedicine.org)
Accumulation1
- In this study, the effects of R. oldhamii leaf extract on inhibiting the free fatty acid (FFA)-induced accumulation of fat in HepG2 cells and on improving fatty liver syndrome in mice with high fat diet (HFD)-induced NAFLD were investigated. (medsci.org)
Effects1
- obesity: A telemetry of bleeding stress arterioles want up in composition effects and pathways. (seabaygame.com)
Main1
Plays3
- The estradiol/progesterone ratio plays crucial role in increasing implantation rate. (gremjournal.com)
- Agriculture plays a vital role supporting human life on Earth but faces significant challenges to feed the growing population. (cshlpress.com)
- Some evidence exists for developmental alterations in neural and other systems that may underlie some propensity to obesity, but the ready availability of palatable, calorically dense food (the basis for [diet-induced obesity] in experimental animals) clearly plays a dominant role . (blogspot.com)
Health1
- In 2014, an estimated 600 million adults were obesity according to the World Health Organization. (medsci.org)
Promote1
- How then is the action of leptin to regulate the perception of food reward overwhelmed to promote obesity in the face of plentiful tasty food? (blogspot.com)
Fact1
- Yes, in fact, obesity rates in the United States have gone up considerably since the 1970s and have never looked back. (shops-blog.com)