Epigenetic repressor. Medical search. Frequent questions

Here we show through systematic epigenetic studies that the histone acetyltransferase p300/CBP-associated factor (PCAF) promotes acetylation of histone 3 Lys 9 at the promoters of established key regeneration-associated genes following a peripheral but not a central axonal injury. (nature.com)
Our results show the first evidence of immediate retrograde signalling leading to long-term epigenetic reprogramming of gene expression of select genes whose modulation leads to axonal regeneration in the hostile spinal environment. (nature.com)
A local deficit of a repressor complex due to the contraction of D4Z4 may cause inappropriate expression of genes. (medscape.com)
It promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. It also acts as a transcription repressor of E2F1 target genes. (nih.gov)
Our data rule out a model suggesting that xKaiso is a direct repressor of Wnt signalling target genes in early Xenopus development via binding to promoter-proximal CTGCNA sequences as part of a xTcf3 repressor complex. (biologists.com)
Epigenetic involves biological mechanisms that switch genes on and off. (missouri.edu)
The accessibility and transcription of ribosomal genes is controlled at several levels, with their epigenetic regulation being one of the most important. (oncotarget.com)
DNA methylation is one of the key epigenetic modifications that play a role in regulating genes. (troscriptions.com)
REST also recruits a host of histone and chromatin modifying activities that can regulate the local epigenetic signature at REST target genes. (ox.ac.uk)
Our group is interested in characterization of several genes to reveal their roles in deposition of epigenetic marks, in chromatin remodeling, in genome transcription, and in regulation of plant growth and development. (cnrs.fr)
Global CpG island hypermethylation, which induces epigenetic silencing of tumor suppressor genes, is also a unique feature of EBVaGC and is considered to be crucial for its carcinogenesis. (spandidos-publications.com)
Furthermore, we discuss recent findings on EBV associated gastric carcinogenesis by focusing on the roles of latent genes, epigenetic abnormalities, genomic alterations, and post-transcriptional regulation by cellular and viral microRNAs (miRNAs). (spandidos-publications.com)
In 2009, Yehuda and Bierer posited that epigenetic modifications, such as DNA methylation, may occur in response to environmental influences such as trauma exposure, thus altering the functional expression of genes. (cdc.gov)

Direct and indirect evidence points to epigenetic modifications in the DNA. (medscape.com)
These modifications affect gene expression and are behind epigenetic memory. (jic.ac.uk)
[2] Critical enzymes for proper LC can be downregulated by aberrant epigenetic modifications caused by prenatal stress. (proteopedia.org)
Aberrant epigenetic modifications caused by prenatal stress can cause Crh promoters to be under methylated, preventing MeCp2 binding and subsequently causing overexpression of the Crh gene. (proteopedia.org)
We also discussed the epigenetic modifications associated with T cell differentiation related to cancer. (encyclopedia.pub)
Well-known epigenetic mechanisms include ATP-dependent chromatin remodeling, nucleosome assembly/disassembly, histone variant incorporation, covalent modifications of histones (e.g. acetylation, methylation and ubiquitylation) and DNA (e.g. methylation). (cnrs.fr)

Many STSs are considered as predominatly epigenetic diseases due to underlying chromatin deregulation. (raredis.org)
Discovery of deregulated functional antagonism between the chromatin remodeling BRG1/BRM-associated (BAFs) and the histone modifying Polycomb repressor complexes (PRCs) has provided novel actionable targets. (raredis.org)
The larger complex is a repressor and keeps the chromatin together. (missouri.edu)

As patients with MDS have widely variable prognosis, we need to stratify them according to chromosomal abnormalities, genetic alterations, and epigenetic deregulations associated with progression to AML in order to treat these patients appropriately. (karger.com)
Herein, we describe cytogenetic, genetic and molecular aberrations in MDS, focusing on epigenetic alterations through PcG. (karger.com)
It has been increasingly recognized that other types of alterations in the genome, known as epigenetic changes, can modulate its structure and function without affecting the underlying DNA sequence. (ernolaszlo.com)
Epigenetic alterations, acting both independently and together with increasing mutational burden, genomic instability, and stem cell exhaustion, can influence gene expression in ways that promote aging (Saul 2021). (ernolaszlo.com)
In this issue, we generally review the mechanisms of cellular senescence in diabetic nephropathy, which involve telomere attrition, DNA damage, epigenetic alterations, mitochondrial dysfunction, loss of Klotho, Wnt/ β -catenin signaling activation, persistent inflammation, and accumulation of uremic toxins. (hindawi.com)
Epigenetic alterations in response to toxic exposures - the need to determine effect modification by nutrient status. (cdc.gov)

Two new studies show how epigenetic data, including DNA methylation, can accurately predict chromosome folding in three dimensions. (biomedcentral.com)
In this issue of Genome Biology, Fortin and Hansen report how they have used such a principle to predict chromosomal compartments from epigenetic domains as defined by DNA methylation data [ 9 ]. (biomedcentral.com)
This article will discuss the three main epigenetic signatures (DNA methylation, Histone Modification, and noncoding RNA), how they are regulated, and how their disruption cause diseases. (troscriptions.com)
DNA methylation is also an inheritable symmetrical epigenetic mark. (troscriptions.com)
DNA methylation in the promoter regions acts as a repressor of gene expression. (troscriptions.com)

In search of key regulatory mechanisms that may clarify the molecular nature of this regenerative gene expression programme, we hypothesized that as an 'orchestrator of gene regulation' epigenetic changes would direct expression of genes crucial for regeneration only in the presence of pro-regenerative signalling following peripheral but not central damage. (nature.com)
Recent data show that these extrinsic environmental factors synergize with intrinsic age-related changes to influence epigenetic regulation of gene expression, ultimately contributing to the visible-and invisible-signs of skin aging (Chevalier 2019). (ernolaszlo.com)
Subsequent sections focus on the epigenetic regulation of gene expression and its relevance to skin aging. (ernolaszlo.com)
Interestingly, they observed down-regulation of Let7 microRNAs which corresponded with high expression of LIN28B, a known repressor of Let7. (fredhutch.org)
Using its proprietary epigenetic regulation platform, Sangamo has developed zinc finger transcriptional regulators (ZF-TRs) which it believes can specifically and potently block expression of the prion protein, the pathogenic driver of prion disease. (sangamo.com)
I'm excited to combine Sangamo's cutting-edge epigenetic regulation capabilities with the delivery abilities of Voyager's capsid to potentially create the first ever meaningful therapy for prion disease. (sangamo.com)
This entry briefly introduces the different stages of T cell differentiation and will discuss recent findings on the epigenetic regulation of this process. (encyclopedia.pub)
Epigenetic up-regulation of ribosome biogenesis and more aggressive phenotype triggered by the lack of the histone demethylase JHDM1B in mammary epithelial. (oncotarget.com)
To understand the role of the epigenetic co-repressor protein TRIM28 in the control of transposable elements (TEs) and how TEs control gene regulation in the developing and adult brain. (lu.se)
These findings are in line with the hypothesis that early-life conditions are especially important factors in epigenetic regulation of later-life health. (cdc.gov)

When sufficient time in the cold has passed, an epigenetic switch silences a flowering-repressor gene called FLC . (jic.ac.uk)
Throughout development, or in response to environmental stimuli, gene expression patterns are tightly regulated by the dynamic interplay between transcription activators and repressors. (escholarship.org)
They mediate epigenetic silencing of gene expression in a wide range of developmental and homeostatic processes in many tissues, including the brain. (escholarship.org)
ZF repressors, or ZF-Rs, are created by attaching a zinc finger array to a repression domain in order to down regulate or completely turn off a gene. (sangamo.com)

Researchers led by Professor Caroline Dean have uncovered the genetic basis for variations in the vernalization response shown by plants growing in very different climates, linking epigenetic mechanisms with evolutionary change. (jic.ac.uk)
Braun also believes there are some epigenetic mechanisms involved. (missouri.edu)
These differentiated subgroups are not necessarily definitive as some degree of plasticity can be observed, particularly if epigenetic control mechanisms are dysregulated (discussed below). (encyclopedia.pub)
Regulatory factors involved in these epigenetic mechanisms play crucial roles in many aspects of plant growth and development, including flowering time control, seed development, cell fate maintenance and plant responses to environmental factors. (cnrs.fr)
Our current focus is to study the role of epigenetic mechanisms and microRNAs. (lu.se)

Agherbi H, Gaussmann-Wenger A, Verthuy C, Chasson L, Serrano M, Djabali M (2009) Polycomb Mediated Epigenetic Silencing and Replication Timing at the INK4a/ARF Locus during Senescence. (plos.org)
A collaboration between the group of Professor Caroline Dean at the John Innes Centre and the group of Dr. Mariann Bienz at the Medical Research Council Laboratory of Molecular Biology, Cambridge, has shed new light on epigenetic silencing. (jic.ac.uk)
Nuclear receptor corepressor 1 (NCoR1) and silencing mediator for retinoid or thyroid-hormone receptors (SMRT) are the best characterized transcriptional co-repressors from a molecular point of view. (escholarship.org)

It uses transcription activator-like effector (TALE) technology combined with VP64 activator or Kruppel-associated box (KRAB) repressor, both of which are potent transcriptional regulators that modify the epigenetic state of endogenous DNA loci. (springer.com)

Understanding how multiple hierarchical levels of genome organization impact on epigenetic (re-)programming might thus largely rely on integrating Hi-C data together with epigenomic data through the development of bona fide computational approaches [ 2 , 8 ]. (biomedcentral.com)
Recent advances in genome-wide and comprehensive molecular analyses have demonstrated that both genetic and epigenetic changes contribute to EBVaGC carcinogenesis. (spandidos-publications.com)

Finally, we demonstrate that Polycomb proteins and associated epigenetic marks are crucial for the control of the replication timing of the INK4a/ARF locus during senescence. (plos.org)
Here, she is mainly interested in the role of the Polycomb Repressor Complex 1. (eupancreas.com)

More recently, evidence is emerging that hints at epigenetic abnormalities in HD brain. (ox.ac.uk)

It recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. (nih.gov)

Instead, we propose that mutual inhibition by Kaiso/TCF3 of their DNA-binding functions may be important in developmental or cancer contexts and acts as a regulatory node that integrates epigenetic and Wnt signalling pathways. (biologists.com)

Thus, the transcriptional activity of the SCL complex is maintained in check by the ETO2 co-repressor in hematopoietic stem cells and progenitors. (umontreal.ca)
CDH4 is a component of a complex within this epigenetic function. (missouri.edu)

In the scope of her project, she focuses on the elucidation of epigenetic changes in pancreatic carcinogenesis. (eupancreas.com)

The challenge and promise of utilizing epigenetic and biomarker data to explore the impact of prenatal exposures on offspring health are highlighted in a recent publication. (cdc.gov)

This study leveraged data from the Multi-Ethnic Study of Atherosclerosis (MESA) on experiences of threat and deprivation in participants' early lives (i.e., before the age of 18) to examine whether exposure to specific dimensions of early life adversity are associated with epigenetic profiles at older ages that are indicative of accelerated biological aging. (cdc.gov)
Epigenetic clocks can track both chronological age (cAge) and biological age (bAge). (cdc.gov)

We find experiences of deprivation, but not threat, are associated with later-life GrimAge epigenetic aging signatures that were developed to predict mortality risk. (cdc.gov)

More research is needed to determine exactly how these polymorphisms contribute to epigenetic memory, as the mechanism itself is still not fully understood. (jic.ac.uk)

This epigenetic switch is controlled by the stoichiometry between the SCL transcription factor and the ETO2 co-repressor. (umontreal.ca)

Our work reveals that the differentiation of erythroid progenitors is determined by an epigenetic switch which controls the transition between a proliferative state and a commitment towards teminal differentiation. (umontreal.ca)

Braun's talk focused on the epigenetic and transcriptional control involved in skeletal muscle regeneration. (missouri.edu)
Here we explored the JmjC domain-containing histone demethylase 1B (JHDM1B) function in the epigenetic control of rDNA transcription. (oncotarget.com)

We demonstrate that a direct interaction between the methyl-CpG-dependent transcription repressor Kaiso and xTcf3, a transducer of the Wnt signalling pathway, results in their mutual disengagement from their respective DNA-binding sites. (biologists.com)

The role of REST in transcriptional and epigenetic dysregulation in Huntington's disease. (ox.ac.uk)

In new research published in the journal Science , Professor Dean's team have worked out how different plants set the level at which this epigenetic switch is triggered. (jic.ac.uk)
Columbia needs four weeks of cold to trigger the epigenetic switch. (jic.ac.uk)

In this study that analyzed data from 2 US cohort studies, epigenetic measures of body mass index developed in adults were valid biomarkers of children's body mass index and were associated with socioeconomic and racialized inequalities experienced in childhood, especially at birth. (cdc.gov)
Epigenetic data can be particularly difficult to analyze and interpret in nutritional and environmental epidemiological studies. (cdc.gov)

This research provides an explanation for how the level at which an epigenetic state switches itself is determined in response to a quantitative stimulus. (jic.ac.uk)

Best practices in analyzing epigenetic data are evolving. (cdc.gov)

A cell type-specific expression map of NCoR1 and SMRT transcriptional co-repressors in the mouse brain. (escholarship.org)

Cong L, Zhou R, Kuo YC et al (2012) Comprehensive interrogation of natural TALE DNA-binding modules and transcriptional repressor domains. (springer.com)

TFIIIC as a Potential Epigenetic Modulator of Histone Acetylation in Human Stem Cells. (nih.gov)

To this end, we employed the first systematic approach to understand the epigenetic environment in DRG neurones. (nature.com)

Early-Life Adversity Associations With Later Life Epigenetic Aging Profiles in the Multi-Ethnic Study of Atherosclerosis. (cdc.gov)

A frequently affected pathway was the JAK/STAT pathway (18%) and a significant proportion of T-ALL patients harboured mutations in epigenetic regulators (33%), both predominantly found in the unfavourable subgroup of early T-ALL. (oncotarget.com)

Anatomy13

Organisms20

Chemicals and Drugs107

Analytical, Diagnostic and Therapeutic Techniques and Equipment29

Phenomena and Processes87

Information Science4

Health Care1

Genes13

Modifications6

Chromatin3

Alterations6

Methylation5

Regulation10

Gene4

Mechanisms5

Silencing3

Transcriptional regulators1

Genome2

Polycomb2

Abnormalities1

Repression1

Inhibition1

Complex2

Carcinogenesis1

Prenatal1

Biological2

Signatures1

Mechanism1

Transcription factor1

Transition1

Control2

Signalling pathway1

Role1

Switch2

Studies2

State1

Data1

Cell1

Domains1

Cells1

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