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  • neuronal
  • Besides, also controls neurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, such as HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation. (genecards.org)
  • Protein
  • Asbestos Induces Epigenetic Repression of Ras Association Domain-Containing Protein 1, p16 Kinase 4a Inhibitor, and p14 Alternative Reading Frame in Normal Human Mesothelial Cells. (nih.gov)
  • citation needed] Heterochromatin protein-1 (HP1) has an N-terminal domain that acts on methylated lysines residues leading to epigenetic repression. (wikipedia.org)
  • studies
  • Studies now indicate that specific epigenetic events contribute to programming for the development and progression of diabetic complications. (grc.org)
  • Development
  • This review elucidates the epigenetic consequences of EBV-host interactions during development of multiple EBV-induced B-cell lymphomas, which may lead to the discovery of novel therapeutic interventions against EBV-associated B-cell lymphomas by alteration of reversible patho-epigenetic markings. (mdpi.com)
  • modifiers
  • Therefore, epigenetic modifiers regulating imprinting at the Kcnq1ot1 domain were identified in embryo-derived stem cells using a positive selection, loss-of-function RNA interference (RNAi) screen. (uwo.ca)
  • regulate
  • In addition to body patterning in metazoans, members of the PcG are now known to regulate epigenetic cellular memory, pluripotency and stem cell self-renewal . (humpath.com)
  • 24:62-72, paper of the month Dec 2017), showing that MEF2 regulates cardiac function through metabolically-controlled changes in calcium homeostasis, this work points now to a new model how cardiac inflammation may regulate cardiac function through a PGE2-induced epigenetic signaling cascade in cardiac myocytes. (dzhk.de)
  • repressor
  • The hallmark of this vernalization response is the stable repression of FLC, a potent flowering repressor. (kaist.ac.kr)
  • In a collaboration with Mannheim (DZHK PI Thomas Wieland), DZHK professor Johannes Backs and his colleagues (first authors András Tóth and Richard Schell) found now that one specific mediator of pro-inflammatory signaling, prostaglandin E2 (PGE2), signals through EP3 receptors on cardiac myocytes via protein kinase D and a Rac1-dependent pathway to an epigenetic repressor complex partly consisting of histone deacetylase 5 (HDAC5). (dzhk.de)
  • Targeted transcriptional repression using a chimeric TALE-SRDX repressor protein. (edu.sa)
  • genetic
  • Understanding tumor heterogeneity based on genetic and epigenetic profiles, as well as evolution of these profiles between BE and EAC, would help refine treatment options for individual patients. (fredhutch.org)
  • With this goal in mind, Dr. Ming Yu and Mr. Sean Maden working in the group of Dr. William Grady (Clinical Research Division) and in collaboration with Dr. Stachler from Dana-Farber Cancer Institute and Brigham and Women's Hospital at Harvard Medical School, characterized genetic and epigenetic profiles in patients with BE or EAC. (fredhutch.org)
  • In this model, prostate carcinogenesis may progress through the initial accumulation of epigenetic alterations at the miR-31 locus, leading to miR-31 silencing and unfettered AR expression, or alternatively, through initial epigenetic/genetic changes that cause increased AR expression and subsequent miR-31 silencing, resulting in blockage of this regulatory loop. (minimanuscript.com)
  • Bitar M and Barry G (2018) Multiple innovations in genetic and epigenetic mechanisms cooperate to underpin human brain evolution. (edu.au)
  • stably inherited
  • Although the Science Express paper is based on heritability over just seven generations, other results with the Arabidopsis strains show that epigenetic traits are stably inherited for at least 20 generations. (eurekalert.org)
  • repressive
  • As the researchers reported, "The repressive epigenetic markers of H3K9 trimethylation can alter secretion and formation of extracellular matrix, mineralization of bone, angiogenesis, bone porosity, and connective tissue formation and may lead to the brittle bone formation, a hallmark of skeletal fluorosis. (whatisepigenetics.com)
  • We discovered that many bromodomain little molecule inhibitors raise the manifestation of mRNA and pre-mRNA without influencing repressive epigenetic signatures of extended alleles. (clarkfrancis.com)
  • Furthermore, latest empirical evidence shows that extended alleles are connected with repressive epigenetic markers including histone 3 lysine 9 tri-methylation (H3K9me3) and DNA hypermethylation of CpG islands inside the promoter and close by do it again series itself 4,5,13. (clarkfrancis.com)
  • inhibitors
  • Using an epigenetic pathway-targeted drug screen, we report that inhibitors of DNA methyltransferases (DNMTs), decitabine and FdCyd, block mutant huntingtin (Htt)-induced toxicity in primary cortical and striatal neurons. (wustl.edu)
  • developmental
  • Both reprogramming processes are regulated by epigenetic regulators, such as miRNAs and histone methyltransferases, which play a role in conferring a great deal of developmental plasticity. (kaist.ac.kr)
  • Our results implicate distinct repression mechanisms that operate in a transposon-selective and developmental stage-specific fashion. (ru.nl)
  • active DNA demethylation
  • While the role of 5-methylcytosine (5mC) in FMR1 gene silencing has been studied extensively, the role of 5-hydroxymethylation (5hmC), a newly discovered epigenetic mark produced through active DNA demethylation, has not been previously investigated in FXS neurons. (miami.edu)
  • Our data reveal that major events of epigenetic reprogramming during pronuclear maturation, including mechanisms of active DNA demethylation, are apparently conserved among mammalian species. (biomedcentral.com)
  • assays
  • Here, we used two complementary epigenetic assays, hydroxymethylation sensitive restriction digest and TET-assisted bisulfite pyrosequencing, to quantify FMR1 5mC and 5hmC levels. (miami.edu)
  • polycomb
  • I am currently investigating the consequences of Polycomb group (PcG) inhibition in tumor cells to uncover novel functions of PcG mediated repression and possible resistance mechanisms. (nki.nl)
  • pathway
  • Future studies could investigate the potential to leverage this epigenetic pathway to restore FMR1 expression and discern whether levels of 5hmC correlate with phenotypic severity. (miami.edu)
  • The publication describes how iadademstat activates the NOTCH pathway, resulting in the repression of SCLC tumorigenesis in vitro and in patient-derived xenograft (PDX) models. (houstonnews.net)
  • This signaling pathway leads to de-repression of the myocyte enhancer factor 2 (MEF2), which represents a transcription factor that is crucial for the development of heart failure. (dzhk.de)
  • complexes
  • Furthermore, new data regarding the recruitment of PcG complexes and maintenance of PcG repression in plants have revealed important differences to what has been reported so far. (nih.gov)
  • changes
  • This opens the door to epigenetic inheritance in plants: epigenetic changes that are acquired in one generation tend to be stably passed on to the next generation', explains Frank Johannes, assistant professor at the GBIC and co-lead scientist for the Science Express study. (eurekalert.org)
  • As such, traits caused by epigenetic variation may make an independent contribution to changes in a species. (eurekalert.org)
  • Now, Maejima and others are starting to home in on the epigenetic mechanisms that drive the neurological changes brought on by physical activity. (body-perfect-pilates.co.uk)
  • The specific aims of this proposal are (1) to characterize the epigenetic changes occurring during a typical wild-type SV40 infection leading to the initiation of early transcription and (2) to characterize the initiation of infection and early transcription in epigenetically dysregulated SV40. (grantome.com)
  • These changes are linked to mislocalization of the maintenance DNA methyltransferase (DNMT1) in cells approaching senescence, altered replication-coupled DNA methylation and de-repression of repetitive satellite sequences. (omicsdi.org)
  • Consequently, if senescent cells escape the proliferative barrier, they already harbor epigenetic changes likely to promote malignancy. (omicsdi.org)
  • histones
  • Half of the histones that are deposited during replication are from the parental chromatin and carry the parental epigenetic information, while the other half of the histones are newly-synthesized. (biomedcentral.com)
  • It has been of growing interest to understand how the parental pattern of epigenetic marks is re-established on the newly-synthesized histones, in a DNA sequence-specific manner, in order to maintain the epigenetic information through cell divisions. (biomedcentral.com)
  • We also discuss the recent evidence that histone-modifying enzymes, rather than the parental histones, are themselves epigenetic factors that remain associated with the DNA through replication to re-establish the epigenetic information on the newly-assembled chromatin. (biomedcentral.com)
  • markers
  • In the new study, Johannes and his French colleagues have successfully linked variation in epigenetic markers to complex traits such as flowering time and plant architecture in these Arabidopsis strains. (eurekalert.org)
  • The epigenetic markers may also affect evolution, independent of DNA sequence. (eurekalert.org)
  • senescence
  • Normal human diploid fibroblast TIG-3 cells were often used in cellular senescence research, however, their epigenetic profiles were not fully understood. (omicsdi.org)