Loading...
  • genes
  • All types of ovarian cancer show wide-spread aberrant epigenetic changes, leading to changes in expression of genes involved in all the hallmarks of cancer, as well as genes involved in how tumours will respond to chemotherapy. (springer.com)
  • The Human Epigenetic Chromatin Modification Enzymes RT² Profiler PCR Array profiles the expression of 84 key genes encoding enzymes known or predicted to modify genomic DNA and histones to. (qiagen.com)
  • In papers published in Nature Neuroscience , the UK team identified seven genes especially affected by epigenetic changes ( doi.org/t8t ), while the US team found 11 ( doi.org/t8s ). (newscientist.com)
  • A significant number of diseases are known to change the expression of genes within the body, and epigenetic involvement is a plausible hypothesis for how they do this. (wikipedia.org)
  • Epigenetic marks (epi-marks) are temporary "switches" that control how our genes are expressed during gestation and after birth. (wikipedia.org)
  • A "gay" gene does not produce homosexuality, rather, epigenetic modifications act as temporary "switches" that regulate how the genes are expressed Of the pairs of identical twins in which one twin is homosexual, only twenty percent of the other twins are homosexual, which leads to the hypothesis that even though identical twins share the same DNA, homosexuality is created by something else rather than the genes. (wikipedia.org)
  • Epigenetic transformation allows the on and off switching of certain genes, subsequently shaping how cells respond to androgen signaling, which is critical in sexual development. (wikipedia.org)
  • rather, it is the epigenetic changes to the genes. (wikipedia.org)
  • There are also 184 genes that are conserved at the protein level between human and chimpanzees, but have epigenetic differences. (wikipedia.org)
  • Physical exercise has been shown to reduce and even reverse these epigenetic mutations, increasing expression levels of tumor-suppressing genes and decreasing expression levels of oncogenes. (wikipedia.org)
  • The hypermethylation in the promoter regions of the tumor suppressing genes APC and RASSF1A are common epigenetic markers for cancer. (wikipedia.org)
  • alterations
  • Researchers at the USDA/ARS Children's Nutrition Research Center at Baylor College of Medicine and Texas Children's Hospital have now created a mouse model providing the first in vivo evidence that epigenetic alterations alone can cause cancer. (redorbit.com)
  • Given the lack of distinction between germ-line and somatic cells in the plant kingdom, this is doubly so, since alterations to the genetic and epigenetic code will be more easily inherited. (wikipedia.org)
  • methyl
  • Outside influences and DNA methyl ation can cause epigenetic effects, but there are much more vivid examples of epigenesis found in the cytoplasm of the cell. (everything2.com)
  • A common epigenetic tag found in DNA is the covalent attachment of a methyl group to the C5 position of the cytosine found in CpG dinucleotide sequences. (wikipedia.org)
  • changes
  • 2009). Minireview: epigenetic changes in ovarian cancer. (springer.com)
  • Two independent teams, one in the UK and one in the US, now suggest that these factors can raise the risk by triggering epigenetic changes. (newscientist.com)
  • Epigenetic changes have previously been linked to cancer and mental disorders. (newscientist.com)
  • We knew that epigenetic changes are associated with cancer, but didn't know whether these were a cause or consequence of cancer. (redorbit.com)
  • This also has profound implications for future studies, because epigenetic changes are potentially reversible. (redorbit.com)
  • If we can identify epigenetic changes that predispose people to cancer, these may actually be treatable or preventable, so this opens up a lot of optimism in new ways to deal with cancer," said Dr. Robert Waterland, associate professor of pediatrics at Baylor, who was also involved in the study. (redorbit.com)
  • plasticity
  • In this review, we discuss evidence for an "epigenetic code" in the central nervous system that mediates synaptic plasticity, learning, and memory. (nih.gov)
  • disorders
  • Epigenetic processes play a central role in a broad spectrum of diseases, such as cardiovascular disease, neurodegenerative disorders and cancer. (eurekalert.org)
  • variation
  • known only from a few studies, mostly in Caenorhabditis elegans Epigenetic variation may take one of four general forms. (wikipedia.org)
  • Epigenetic variation within multicellular organisms may be endogenous, generated by cell-cell signaling (e.g. during cell differentiation early in development), or exogenous, a cellular response to environmental cues. (wikipedia.org)
  • It also hinted that epigenetic variation alone could result in rapid evolution. (wikipedia.org)
  • stem cells
  • This paper covers these epigenetic aspects in stem cells, differentiation, and reprogramming and discusses their importance for the safety of in vitro engineered cell types. (hindawi.com)
  • Epigenetic manipulations may allow for restoration of totipotency in stem cells or cells more generally, thus generalizing regenerative medicine. (wikipedia.org)
  • therapeutic
  • Major challenges remain in the delivery of epigenetic therapy, the maintenance of a pharmacodynamic response and the achievement of a clear therapeutic index. (springer.com)
  • include
  • Examples of epigenetic effects include size of the offspring , which can be controlled by the diet of the parent. (everything2.com)
  • Salient features of Horvath's epigenetic clock include its high accuracy and its applicability to a broad spectrum of tissues and cell types. (wikipedia.org)
  • effects
  • Indeed, some of the epigenetic effects were as pronounced in those who had shown no symptoms of Alzheimer's as they were in people who died with the disease. (newscientist.com)
  • However, epigenetic theories tangle a multiplicity of initiating causes and of resulting final effects and will never lead to a single cause or a single result. (wikipedia.org)
  • In a study on the epigenetic effects of physical exercise on breast cancer in women, blood samples from breast cancer patients were collected before and after 6 months of moderate-intensity aerobic exercise. (wikipedia.org)
  • cell
  • Organismal growth (and concomitant cell division) leads to a high ticking rate of the epigenetic clock that slows down to a constant ticking rate (linear dependence) after adulthood (age 20). (wikipedia.org)
  • The less precise term "epigenetic inheritance" may be used to describe both cell-cell and organism-organism information transfer. (wikipedia.org)
  • During replication, DNA polymerases working on the leading and lagging strands are coupled by the DNA processivity factor proliferating cell nuclear antigen (PCNA), which has also been implicated in patterning and strand crosstalk that allows for copy fidelity of epigenetic marks. (wikipedia.org)