In the present study, we aimed to gain insight into this relationship by identifying DNA methylation marks that are candidate mediators of ovarian cancer genetic risk.We used 214 cases and 214 age-matched controls from the Mayo Clinic Ovarian Cancer Study. (unm.edu)
Epigenetic10
The extent to which development- and age-associated epigenetic changes are influenced by genetic, environmental and stochastic factors remains to be discovered. (nih.gov)
The genetic and epigenetic basis of type 2 diabetes and obesity. (ox.ac.uk)
Some of the familial aggregation not attributable to known genetic variation, as well as many of the effects of environmental exposures, may reflect epigenetic processes. (ox.ac.uk)
In this review, we discuss the evidence concerning the genetic contribution to individual risk of T2D and obesity, and explore the potential role of epigenetic mechanisms. (ox.ac.uk)
Integrative genomic analysis identifies epigenetic marks that mediate genetic risk for epithelial ovarian cancer. (unm.edu)
Both genetic and epigenetic factors influence the development and progression of epithelial ovarian cancer (EOC). (unm.edu)
Genetic and epigenetic regulation of genes relies on structural transitions in chromatin which are driven by intra- and inter-nucleosome dynamics and modulated by chemical modifications of the unstructured terminal tails of histones. (knaw.nl)
It brought together scientists working on different types of stem cell and covered the latest findings in stem cell biology, including the genetic and epigenetic mechanisms of reprogramming, maintenance of pluripotency and differentiation. (mdc-berlin.de)
Our results demonstrate a genetic mechanism contributing to CAD risk at the PPAP2B locus and highlight the value of studying epigenetic changes in disease processes involving pathogenic environmental stimuli. (ox.ac.uk)
Functional variation in allelic methylomes underscores a strong genetic contribution and reveals novel epigenetic alterations in the human epigenome. (childrensmercy.org)
Embryo1
As the development of a disease or disorder can be viewed as resulting from the interplay of genetic and environmental factors over the life span of the individual, potent environmental influences may manifest at many stages of life: as a gamete, as an embryo, during epigenesis, in utero , during childhood, during adulthood, or with aging. (nih.gov)
Genetics1
This debunking involves showing what studies of the sort "a gene causes/predisposes to/is a risk factor for trait x" have in fact found to date, and evaluating the validity of the genetic paradigm that underlies all such studies in light of advances in molecular genetics. (logosjournal.com)
Loci1
To date, more than 150 genetic loci are associated with the development of monogenic, syndromic, or multifactorial forms of T2D or obesity. (ox.ac.uk)
Predisposition1
And indeed, as innumerable studies appear to have shown, what is "in our genes" is not only the cause of, or "genetic predisposition" for, almost every conceivable physical and psychological malady, but almost all complex "normal" human behavior as well. (logosjournal.com)
Diseases1
There is considerable interest in the development of BET inhibitors with novel scaffolds to modulate the epigenesis of such diseases. (bvsalud.org)
Factors1
However, recent demonstrations of neural plasticity and epigenesis emphasize the significance of experience in brain development by suggesting that non-genetic, environmental factors can lead to dramatic changes in gene expression (e.g. (medscape.com)
Database of human genetic variants associated with longevity. (senescence.info)
Disorders1
6. Using your knowledge of X-linked inheritance, explain why males are more vulnerable than females to miscarriage, infant death, genetic disorders, and other problems. (mypapersupport.com)
Gene expression1
A curated database of genes associated with dietary restriction in model organisms either from genetic manipulation experiments or gene expression profiling. (senescence.info)
Adult1
A genetic process by which the adult organism is realized via mechanisms that lead to the restriction in the possible fates of cells, eventually leading to their differentiated state. (bvsalud.org)
The Causal Inference Test (CIT) was implemented to distinguish CpG sites that mediate genetic risk, from those that are consequential or independently acted on by genotype.Controlling for the estimated distribution of immune cells and other key covariates, our initial epigenome-wide association analysis revealed 1,993 significantly differentially methylated CpGs that between cases and controls (FDR, q (unm.edu)
Process1
5. Why is genetic counseling called a communication process? (mypapersupport.com)