KeratinocytesTumorMacrophagesProliferationS100HumansLangerinInfiltrateAntigen-PreseLangerhans Cell HistiocyActivated Langerhans cellsCD207DermisHistiocyticInflammatoryDendritic cellBasalPathogenesisEpidermalLesional skinCellularReactionInduceApoptosisInfectionInhibitionLymphoidSkinSignaling pathwaySelleckCytokinesEffectorMonocytesSystemicStromaHumanInfiltrationMacrophageLymphocytesExpressionDiseaseFoundVivoResponsesPlayCutaneousMajorPositivePercentageVitro
Keratinocytes4
- Langerhans cells utilize E-cadherin to localize in the epidermis via homotypic interaction with E-cadherin expressed by keratinocytes. (wikipedia.org)
- The expression of CD95R was present although restricted to the basal keratinocytes, while the L1-protein (Mac 387+) was diffusely present in the epidermis. (spandidos-publications.com)
- In view of the absence of inflammatory cells in the epidermis, keratinocytes appeared responsible for their own destruction through CD95-mediated and/or calcium-dependent apoptotic pathways. (spandidos-publications.com)
- Here, we demonstrate the effect of SGE of adult H. excavatum ticks on human skin keratinocytes HaCaT and mouse fibroblasts NIH-3T3, as representatives of two basal skin cell types. (vegfrinhibitors.com)
Tumor3
- Hence cutaneous histiocytoma is a localized epidermal Langerhans cell tumor, and the rare examples of systemic spread of histiocytoma are best characterized as Langerhans cell histiocytosis (LCH) similar to that observed in humans. (wikipedia.org)
- Of these, tumor-associated macrophages (TAMs) and regulatory T-cells (Tregs) create an immunosuppressive microenvironment through various pathways. (iiarjournals.org)
- For example, Paget's cells release soluble receptor activator of nuclear factor kappa-B ligand (sRANKL) into the tumor microenvironment, stimulating RANK + TAMs to produce CCL17, which recruits Tregs into the lesional skin of patients with extramammary Paget's disease (EMPD) ( 11 , 17 ). (iiarjournals.org)
Macrophages6
- Langerhans cell histiocytosis (LCH) is a group of idiopathic disorders characterized by the presence of cells with characteristics similar to bone marrow-derived Langerhans cells juxtaposed against a backdrop of hematopoietic cells, including T-cells, macrophages, and eosinophils. (medscape.com)
- Immunohistochemistry was used to identify activated T lymphocytes (CD45R0), monocyte-macrophages (Mac 387, CD68), DD (Factor XIIIa), and Langerhans cells (CD1a). (spandidos-publications.com)
- CD45RO+ T lymphocytes, CD68+ and Mac 387+ macrophages were absent in the epidermis. (spandidos-publications.com)
- Macrophages are important cells in the host immune response in fungal infections. (bvsalud.org)
- Lesions were characterized by inflammatory infiltrate of macrophages, lymphocytes, epithelioid and multinucleated giant cells with intense number of fungal forms. (bvsalud.org)
- Here we investigated how dermal dendritic cells (dDCs) and macrophages (dMs) react to DENV and impact on immunopathology. (cnrs.fr)
Proliferation4
- LCH is characterized by the proliferation of CD1a-positive activated Langerhans (not atypical Langerhans cell, morphologically)-like cells (LCH cells) generating inflammatory granuloma. (mayabouchenaki.com)
- Alteration of actin polymerization has been implicated in various cell responses, including proliferation find more and motility. (vegfrinhibitors.com)
- The proliferation of HaCaT cells was inhibited to a greater MK-1775 in vitro degree than NIH-3T3 fibroblasts by H. excavatum SGE. (vegfrinhibitors.com)
- The highest inhibition of proliferation of both cell lines was obtained by SGE prepared from 7-day-fed females, whereas treatment of cells with SGE of 3-day-fed females had comparatively little effect. (vegfrinhibitors.com)
S1001
- Histopathological analysis of a thick needle biopsy demonstrated, however, a dense infiltrate of S100, CD1a and CD207/Langerin positive histiocytes accompanied by many eosinophilic granulocytes (Fig. 2 A), compatible with a diagnosis of LCH. (biomedcentral.com)
Humans2
- Our data identify dDCs and dMs as primary arbovirus target cells in humans and suggest that dDCs initiate a potent virus-directed T-cell response, whereas dMs fuel the inflammatory cascade characteristic of dengue fever. (cnrs.fr)
- Biotechnology is the use of cells or organisms to develop products for humans. (inhibitorlibraries.com)
Langerin4
- Therefore, in addition to epidermal Langerhans cells, other potential cellular origins for LCH include dermal langerin + dendritic cells, lymphoid tissue-resident langerin + dendritic cells, and monocytes that can be induced by local environmental stimuli to acquire a Langerhans cell phenotype. (medscape.com)
- Langerhans cell histiocytosis (LCH) is a rare haematological neoplasm characterized by the accumulation of CD1a + , CD207/Langerin + histiocytes within inflammatory lesions. (biomedcentral.com)
- Antigens targeted to DCs via the C-type lectin Langerin/CD207 are cross-presented to CD8(+) T cells in vivo. (cnrs.fr)
- We investigated the relative roles of Langerhans cells (LCs) and Langerin(+) dermal DCs (dDCs) in different vaccination settings. (cnrs.fr)
Infiltrate1
- Negligible CD3+ T cell infiltration as well as reduced NK cell infiltrate with low P content was found in Dapagliflozin PCa tissue and this could be responsible for the inefficient control of tumour invasion. (inhibitorlibraries.com)
Antigen-Prese1
- PSA, because of its glycoprotein structure, could GSI-IX mw support the local anti-inflammatory response and induce alternative activation of antigen-presenting cells, leading to inefficient activation of cell-mediated immunity [28]. (inhibitorlibraries.com)
Langerhans Cell Histiocy12
- The term Langerhans cell histiocytosis is generally preferred to the older term, histiocytosis X. This newer name emphasizes the histogenesis of the condition by specifying the type of lesional cell and removes the connotation of the unknown ("X") because its cellular basis has now been clarified. (medscape.com)
- The pathogenesis of Langerhans cell histiocytosis (LCH) is unknown. (medscape.com)
- Currently, the preferred term is Langerhans cell histiocytosis. (thedoctorsdoctor.com)
- Langerhans cell histiocytosis presenting in the neonatal period: a retrospective case series. (thedoctorsdoctor.com)
- OBJECTIVES: To describe the morphologic characteristics of skin lesions, extent of extracutaneous disease, and outcomes in patients with neonatal presentation of Langerhans cell histiocytosis (LCH), and to examine clinical predictors of disease prognosis. (thedoctorsdoctor.com)
- Epidemiologic study of Langerhans cell histiocytosis in children. (thedoctorsdoctor.com)
- OBJECTIVE: The etiology and pathogenesis of Langerhans cell histiocytosis (LCH) remain poorly understood. (thedoctorsdoctor.com)
- No consensus exists for the optimal therapy for Langerhans cell histiocytosis (LCH), particularly in the case of multisystem organ disease. (medscape.com)
- Single-agent chemotherapy with cladribine (2-chlorodeoxyadenosine/2-CdA) may be a promising treatment for single-system pulmonary Langerhans cell histiocytosis. (medscape.com)
- Sakata N, Toguchi N, Kimura M, Nakayama M, Kawa K, Takemura T. Development of Langerhans cell histiocytosis associated with chronic active Epstein-Barr virus infection. (mayabouchenaki.com)
- Murakami I, Gogusev J, Fournet JC, Glorion C, Jaubert F. Detection of molecular cytogenetic aberrations in langerhans cell histiocytosis of bone. (mayabouchenaki.com)
- Erdem AP, Kasimoglu Y, Sepet E, Gencay K, Sahin S, Dervisoglu S. Oral manifestations may be the first sign of Langerhans cell histiocytosis. (mayabouchenaki.com)
Activated Langerhans cells1
- Notably, LCH cells have been found to express markers of both resting epidermal Langerhans cells (CD1a, intracellular major histocompatibility complex II [MHCII], Birbeck granules) and activated Langerhans cells (including CD54 and CD58). (medscape.com)
CD2071
- Specifically, a variety of other cellular populations have been identified that possess phenotypic characteristics similar to Langerhans cells, including expression of CD207 and Birbeck granules. (medscape.com)
Dermis2
- Immunolabeled cells were quantified in nine randomized fields in the dermis. (bvsalud.org)
- Yet, the role of human dermis-resident immune cells in dengue infection and disease remains elusive. (cnrs.fr)
Histiocytic1
- Histiocytic sarcoma complex (immunohistochemical features of dendritic cells, possibly interdigitating or perivascular DCs) 3.a. (wikipedia.org)
Inflammatory2
- This finding entails that TEN treatments should target the keratinocyte metabolism rather than the circulating inflammatory cells which presumably play a limited role, if any, in the epidermal destructive process. (spandidos-publications.com)
- DC-SIGN(+) cells are abundant in inflammatory skin with scabies infection or Th2-type dermatitis, suggesting that skin reactions to mosquito bites heighten the risk of infection and subsequent immunopathology. (cnrs.fr)
Dendritic cell4
- The working group of the Histiocyte Society divided histocytic disorders into three groups: (1) dendritic cell histiocytosis, (2) macrophage-related disorders, and (3) malignant histiocytosis. (medscape.com)
- We show that both CD1c(+) and CD14(+) dDC subsets were infected, but viral load greatly increased in CD14(+) dDCs upon IL-4 stimulation, which correlated with upregulation of virus-binding lectins Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Nonintegrin (DC-SIGN/CD209) and mannose receptor (CD206). (cnrs.fr)
- Dendritic cell as sentinel of the immune system plays an irreplaceable role. (medsci.org)
- We focus on the essential functions of dendritic cell in severe SARS-CoV-2 infection. (medsci.org)
Basal1
- Langerhans cells (LC) are members of the dendritic cells family, residing in the basal and suprabasal layers of the epidermis and in the epithelia of the respiratory, digestive and urogenital tracts. (mayabouchenaki.com)
Pathogenesis1
- In conclusion, our findings showed that the low frequency of P+ lymphocytes, including T, NKT and NK cells, in prostate tissue of patients with BPH and, particularly, PCa could be the consequence of local tissue microenvironment and one of the mechanisms involved in the pathogenesis of prostate hyperplasia following malignant alteration. (inhibitorlibraries.com)
Epidermal5
- Epidermal invasion by cells of histiocytoma frequently occurs and intra-epidermal nests of histiocytes resemble Pautrier's aggregates, characteristically found in epidermotropic lymphoma (Mycosis Fungoides or MF). (wikipedia.org)
- Our work has clearly shown that histiocytomas have the phenotype of epidermal Langerhans cells. (wikipedia.org)
- In 1868, Paul Langerhans discovered the epidermal dendritic cells that now bear his name. (medscape.com)
- Although the epidermal Langerhans cell has been presumed to be the cell of origin in LCH, recent studies have called this belief into question. (medscape.com)
- [ 3 ] Taken together, these findings have led some to speculate that LCH is not a specific disease of epidermal Langerhans cells, but rather one of mononuclear phagocyte dysregulation. (medscape.com)
Lesional skin2
- Immunohistochemical staining of MMP1 and MMP25 as well as chemokine (C-C motif) ligand (CCL) 5 in the lesional skin from five patients with PCAC showed a substantial number of MMP1-bearing cells and MMP25-bearing cells, as well as CCL5-producing cells, that were distributed in the lesional skin. (iiarjournals.org)
- In this study, the average number of CD1a positive Langerhans cells was highest (54.92±5.26) in perilesional skin compared to lesional skin (30±3.96), which was statistically significant (p-value=0.04). (njlm.net)
Cellular4
- In order to contribute to the comprehension of immune mechanisms in JLD human lesions, we studied the cytotoxic immune response, focusing on TCD8+ and NK cells, and granzyme B. Forty skin biopsies of lower limbs were selected and an immunohistochemistry protocol was developed to detect CD8+ T cells, NK cells and Granzyme B. In order to compare the cellular populations, we also performed a protocol to visualize TCD4+ cells. (bvsalud.org)
- Research in fields studying cellular response to surface tension and mechanical forces necessitates cell culture tools with tunability of substrate stiffness. (mdpi.com)
- This newer name emphasizes the histogenesis of the condition by specifying the type of lesional cell and removes the connotation of the unknown (\"X\") because its cellular basis has now been clarified. (mayabouchenaki.com)
- One of the key cellular components with functional roles in both innate and adaptive arms of the immune response are Langerhans cells (LCs) (2). (mayabouchenaki.com)
Reaction3
- The photoconjugation of psoralens with DNA produces an antiproliferative reaction in the skin, generates programmed cell death (apoptosis), and induces down-regulation of the cutaneous immune system. (medscape.com)
- It is characterized by a granulomatous reaction with multinucleated giant cells and high number of fungal cells. (bvsalud.org)
- Based on the observations in this study, a strong positive reaction of CD1a in perilesional skin can be used to diagnose psoriasis in the early clinical stages, before full-blown clinical psoriatic plaques have appeared. (njlm.net)
Induce1
- Annexin-V/PI movement cytometric experiments had been performed to determine if 17-AAG alone or in combination with cisplatin could induce A549 cell apoptosis. (hsp90-inhibitors.com)
Apoptosis1
- We asked regardless of whether the antiproliferative action of 17-AAG was as a consequence of cell cycle arrest, apoptosis, or each. (hsp90-inhibitors.com)
Infection2
- IL-4 also enhanced T-cell activation by dDCs, which was further increased upon dengue infection. (cnrs.fr)
- Dendritic cells-based therapeutic approach may be a potential strategy for SARS-CoV-2 infection. (medsci.org)
Inhibition1
- The findings of this study imply that B7-H1-mediated inhibition of T-cell responses is, at least partly, due to its capacity to contribute to the induction of IL-35 production. (agckinases.com)
Lymphoid1
- Using a more sensitive technique for detection of mutant BRAF alleles (droplet digital PCR) [ 9 ], BRAF V600E was not detected in DNA extracted from myeloid or lymphoid cells isolated by flowcytometric sorting from a peripheral blood sample collected at the time of the fourth bone sample. (biomedcentral.com)
Skin5
- The presence of a great number of Factor XIIIa+ DD without any possible recent recruitment from bone marrow suggests that these cells differentiated from resident cells of the skin. (spandidos-publications.com)
- To evaluate the utility of immunoexpression of CD1a in the early diagnosis of psoriasis and to study the histopathology of skin biopsies from clinically diagnosed cases of psoriasis. (njlm.net)
- Histopathological features in early psoriasis were studied, and CD1a immunoexpression in lesional, perilesional, and distant skin was analysed. (njlm.net)
- Langerhans cells are dendritic but unpigmented and are found nearer the skin surface than melanocytes. (mayabouchenaki.com)
- It showed remarkable cell promiscuity, being active in human skin dendritic cells, hepatoma cell lines and Vero cells, and was active against all four DENV serotypes, with an IC50 in the low micromolar range. (cnrs.fr)
Signaling pathway1
- These neoplastic cells are the result of sporadic activating mutations in genes of the mitogen-activated protein kinase (MAPK) signaling pathway expressed by multipotent hematopoietic stem/progenitor cells or committed myeloid precursors [ 1 ]. (biomedcentral.com)
Selleck2
- These heterozygous somatic mutations most regularly consist of a point mutation within exon 21, leading to an amino acid substitution or in-frame deletions within exon 19.Kinase domain mutations result in constitutive activation of EGFR by jak2 inhibitors selleck chemicals destabilization in the autoinhibited conformation on the receptor.In mutant EGFR tumors, cell survival is dependent on EGFR signaling, a phenomenon termed ?oncogene addiction? (hsp90-inhibitors.com)
- This advised that 17-AAG induced cell cycle arrest by preventing Ponatinib selleck chemicals A549 cells from entering mitosis. (hsp90-inhibitors.com)
Cytokines1
- Arguments supporting the reactive nature of LCH include the occurrence of spontaneous remissions, the extensive elaboration of multiple cytokines by dendritic cells and T-cells (the so-called cytokine storm) in LCH lesions, and the good survival rate in patients without organ dysfunction. (medscape.com)
Effector2
- For example, TAMs suppress effector T-cells through immune checkpoint molecules, such as those of the programmed cell death 1 (PD-1) ( 7 ) and cytotoxic T-lymphocyte-associated protein 4 (CTLA4) ( 8 , 9 ) pathways. (iiarjournals.org)
- There is abundant evidence that different viruses abuse B7-H1 to BMN673 turn-off effector T-cell responses 26-28. (agckinases.com)
Monocytes1
- Our data from micro-dissected LC in both dermatopathic lymphadenopathy [12] and LCS [13] suggest that monocytes, precursor Langerhans cells, or Langerhans cells are one of the reservoir cells for MCPyV. (mayabouchenaki.com)
Systemic1
- In such cases, tumour cells could deeply invade surrounding tissues and enter systemic circulation. (inhibitorlibraries.com)
Stroma2
- Cancer stroma contains various immune cells. (iiarjournals.org)
- be a contributory factor facilitating the transendothelial migration of CD56+ NK cells to the stroma of BPH tissue and support their P expression [16]. (inhibitorlibraries.com)
Human2
- Complete human CD1a deficiency on Langerhans cells due to a rare point mutation in the coding sequence. (ox.ac.uk)
- Clonal integration of a polyomavirus in human Merkel cell carcinoma. (mayabouchenaki.com)
Infiltration1
- On the other hand, the infiltration of organs by a monoclonal population of aberrant cells, the possibility of lethal evolution, and the cancer-based modalities of successful treatment are all consistent with a neoplastic process. (medscape.com)
Macrophage1
- We could observe high number of cells expressing Arginase1, CD163 and c-MAF that correspond to elements of the M2 profile of macrophage, over iNOS and RBP-J (elements of the M1 profile). (bvsalud.org)
Lymphocytes1
- Psoriasis is a long-lasting autoimmune disease mediated by T-lymphocytes and dendritic cells. (njlm.net)
Expression2
- Amongst leukocytes, E-cadherin expression is unique to Langerhans cells. (wikipedia.org)
- We found IL-17A receptor expression levels in LCH cells are important for defining LCH subclasses. (mayabouchenaki.com)
Disease1
- Despite multiple surgical interventions, she unexpectedly experienced progressive disease manifestation with significant soft tissue extension to the surrounding musculature, subcutis and epidermis. (biomedcentral.com)
Found1
- Langerhans cells are a unique population of dendritic cells found in the epidermis, where they can be identified by Cluster of Differentiation 1a (CD1a) positivity. (njlm.net)
Vivo1
- 107] demonstrated that IL-1 production and signaling from the IL-1 receptor are necessary components of Raf-induced transformation of NIH 3 T3 cells, which exclude other factors involvement in the vivo model [85]. (mayabouchenaki.com)
Responses1
- ability to mount memory T-cell responses to these pathogens. (agckinases.com)
Play1
- We may suggest that, although CD4+ T cells are essential for host defense in JLD, CD8+ T cells could play a role in the elimination of the fungus. (bvsalud.org)
Cutaneous1
- Canine cutaneous histiocytoma (derived from specialised epidermic dendritic cells, the Langerhans cells) 2. (wikipedia.org)
Major1
- PDGF stimulates rearrangement of actin filaments that comprise the major cytoskeletal components in eukaryotic cells. (vegfrinhibitors.com)
Positive1
- Results: The scores for the density buy MG-132 of α-SMA- and ED-1-positive cells, the staining of MCP-1 and osteopontin, interstitial collagen deposition and amounts of TGF-β1 were significantly reduced by MMF or Trip. (vegfrinhibitors.com)
Percentage1
- percentage of P+ cells and P-expressing T and NK cells in the prostate tissue was observed only in PCa patients, suggesting that the low percentage of P+ cells in the prostate tissue could be responsible for an increased risk of tumour development and progression. (inhibitorlibraries.com)
Vitro1
- and NIH-3T3 cells in vitro (Table 2). (vegfrinhibitors.com)