AnatomyOrganismsDiseasesAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and Processes
Notophthalmus viridescensAmbystoma mexicanumSalamandridaeExtremitiesRegenerationAmbystomaForelimbEpidermisTriturusLimb BudsUrodelaAmputationTurbellariaTailAnimal FinsNotophthalmusPlanariansLimb SalvagePlant EpidermisLimb Deformities, Congenital
Regenerate limbsFrogs and toadsXenopusZebrafishAmputationSalamandersTissuesOccursStructuresCasesProgenitor cellsRegenerationStumpRegenerateCellsGrowProcessModel
Regenerate limbs1
  • Many arthropods can regenerate limbs and other appendages following either injury or autotomy. (wikipedia.org)
Frogs and toads1
Xenopus4
  • Xenopus tadpoles can regenerate their tails, limb buds and the lens of the eye, although the ability of the latter two organs to regenerate diminishes with advancing developmental stage. (biomedcentral.com)
  • Activation of this transgene blocks regeneration of the tail and limb of Xenopus tadpoles. (biomedcentral.com)
  • Gene over-expression analyses in Xenopus limb and tail regeneration have indicated that successful regeneration requires the re-activation of developmental FGF or BMP signalling pathways [ 8 - 12 ]. (biomedcentral.com)
  • We examined the bioelectric properties (resting potential gradients in the epidermis) of Xenopus laevis froglets undergoing hindlimb amputation and observed that the contralateral (undamaged) limb exhibits apparent depolarization signals immediately after the opposite hindlimb is amputated. (biologists.com)
Zebrafish1
  • Using Affymetrix Gene Chip analysis, we have identified genes linked to regenerative success downstream of BMP signalling, including the BMP inhibitor Gremlin and the stress protein Hsp60 ( no blastema in zebrafish). (biomedcentral.com)
Amputation3
  • The whole limb of a salamander or a triton will grow again and again after amputation. (wikipedia.org)
  • The wound epithelium of N1 transgenic hindlimb buds, which forms over the cut surface of the limb bud after amputation, does not transition normally into the distal thickened apical epithelial cap. (biomedcentral.com)
  • N1 transgenic hindlimbs, which do not regenerate, do not form an apical epithelial cap or cone shaped blastema following amputation. (biomedcentral.com)
Salamanders1
  • salamanders and newts), an order of tailed amphibians, is possibly the most adept vertebrate group at regeneration, given their capability of regenerating limbs, tails, jaws, eyes and a variety of internal structures. (wikipedia.org)
Tissues4
  • After the limb or tail has been autotomized, cells move into action and the tissues will regenerate. (wikipedia.org)
  • Many of the genes that are involved in the original development of tissues are reinitialized during the regenerative process. (wikipedia.org)
  • Once the wound is healed, the cells of the stump must mobilise under the wound epidermis and begin the process of replacing lost tissues, by forming a proliferating blastema. (biomedcentral.com)
  • The pattern of depolarization matches that of the amputated limb and is correlated to the position and type of injury, revealing that information about damage is available to remote body tissues and is detectable non-invasively in vivo by monitoring the bioelectric state. (biologists.com)
Occurs1
Structures1
  • While all vertebrates are capable of some types of tissue regeneration, most, including humans, have lost the ability to regenerate whole structures such as limbs ( epimorphic regeneration ), [ 1 ]. (biomedcentral.com)
Cases1
  • In some cases a shed limb can itself regenerate a new individual. (wikipedia.org)
Progenitor cells2
  • Salamanders capable of limb regeneration form a blastema (a mass of lineage-restricted progenitor cells 4 ) after limb loss, and our findings suggest that ear tissue regeneration in Acomys may proceed through the assembly of a similar structure. (nature.com)
  • Upon injury the axolotl generates a population of regeneration-competent limb progenitor cells known as the blastema, which will grow, establish pattern, and differentiate into the missing limb structures. (nih.gov)
Regeneration12
  • salamanders and newts), an order of tailed amphibians, is possibly the most adept vertebrate group at regeneration, given their capability of regenerating limbs, tails, jaws, eyes and a variety of internal structures. (wikipedia.org)
  • Limited regeneration of limbs occurs in most fishes and salamanders, and tail regeneration takes place in larval frogs and toads (but not adults). (wikipedia.org)
  • Regeneration is the ability to restore lost or damaged tissues, organs or limbs. (academickids.com)
  • Aside from being used to generally describe any number of specific healing processes, regeneration also is a specific method of healing that is noted for its ability to regrow lost limbs, severed nerve connections, and other wounds that mammals cannot heal. (academickids.com)
  • Limb regeneration in the axolotl has been extensively studied. (academickids.com)
  • If the processes behind regeneration are fully understood, it is believed this would lead to better treatment for individuals with nerve injuries, broken backs, paralysis, and missing limbs. (academickids.com)
  • Notably, we found that regenerative capacity in Acomys was extended to ear holes, where the mice exhibited complete regeneration of hair follicles, sebaceous glands, dermis and cartilage. (nature.com)
  • This study underscores the importance of investigating regenerative phenomena outside of conventional model organisms, and suggests that mammals may retain a higher capacity for regeneration than was previously believed. (nature.com)
  • As re-emergent interest in regenerative medicine seeks to isolate molecular pathways controlling tissue regeneration in mammals, Acomys may prove useful in identifying mechanisms to promote regeneration in lieu of fibrosis and scarring. (nature.com)
  • Cells keep a memory of their tissue origin during axolotl limb regeneration. (nature.com)
  • We also discuss how the presence of cells from the different axes of the limb is required for the continued growth and establishment of pattern in the blastema as described in the polar coordinate model, and how this positional information is reprogrammed in blastema cells during regeneration. (nih.gov)
  • Multiple cell types from the mature limb stump contribute to the blastema at different stages of regeneration, and we discuss the contribution of these types to the regenerate with reference to whether they are "pattern-forming" or "pattern-following" cells. (nih.gov)
Stump1
Regenerate3
  • After the limb or tail has been autotomized, cells move into action and the tissues will regenerate. (wikipedia.org)
  • In some cases a shed limb can itself regenerate a new individual. (wikipedia.org)
  • Many arthropods can regenerate limbs and other appendages following either injury or autotomy. (wikipedia.org)
Cells1
  • This results in the formation of a blastema - or a layer of dedifferentiated cells. (academickids.com)
Grow2
  • The whole limb of a salamander or a triton will grow again and again after amputation. (wikipedia.org)
  • Motor neurons grow with the regenerated limb, and innervate the same target muscles they originally controlled. (academickids.com)
Process1
  • The entire process takes around 3 month in the adult - and the limb becomes fully functional. (academickids.com)
Model1
  • The hydra and the planarian flatworm have long served as model organisms for their highly adaptive regenerative capabilities. (wikipedia.org)