Epidermal langerhans cell tumor. Medical search. Frequent questions

Langerhans cells utilize E-cadherin to localize in the epidermis via homotypic interaction with E-cadherin expressed by keratinocytes. (wikipedia.org)
Basal cell carcinoma (BCC) is a nonmelanocytic skin cancer (ie, an epithelial tumor) that arises from basal cells (ie, small, round cells found in the lower layer of the epidermis). (medscape.com)
Note the apoptotic sunburn cells in the epidermis. (medscape.com)
Ultraviolet exposure of human skin deletes the function of antigen-presenting Langerhans cells normally resident within the epidermis. (jamanetwork.com)
In view of the absence of inflammatory cells in the epidermis, keratinocytes appeared responsible for their own destruction through CD95-mediated and/or calcium-dependent apoptotic pathways. (spandidos-publications.com)
Location of cells exhibiting a specific marker of Langerhans cells--Langerin, and the 175 kD mannose receptor as a marker of dendritic cells of non-Langerhans type and macrophages, was studied using double staining in the normal human epidermis and in basal cell carcinomas. (archive.org)
The reactivation of T cells and local effects of cytokines in the dermis and epidermis lead to inflammation, cell-mediated immune responses, and epidermal hyperproliferation (Lui, 2022). (qualitywriters.org)
Langerhans cell (LC) is a skin-resident APC, which plays a sentinel role in maintaining the skin immune barrier as the first immune cell confronting the environmental insults in the epidermis (Deckers et al. (arcillaresearch.com)
This upward migration of new cells allows for the replacement of cells that are sloughed off and lost from more superficial layers of the epidermis. (bodyviz.com)
Toxic epidermal necrolysis (TEN) is a potentially life-threatening dermatologic disorder characterized by widespread erythema, necrosis, and bullous detachment of the epidermis and mucous membranes, resulting in exfoliation and possible sepsis and/or death. (aboutface.ca)

Hence cutaneous histiocytoma is a localized epidermal Langerhans cell tumor, and the rare examples of systemic spread of histiocytoma are best characterized as Langerhans cell histiocytosis (LCH) similar to that observed in humans. (wikipedia.org)
Langerhans cell histiocytosis is a rare disease involving clonal proliferation of langerhans cells seen in children and young adults. (scirp.org)
We report a rare case of adult Langerhans cell histiocytosis in the dorsal spine causing a spinal cord compression associated with a pulmonary process treated by surgery, radiotherapy and systemic therapy with good evolution. (scirp.org)
Final diagnosis was therefore Langerhans cell histiocytosis of the dorsal spine complicated by spinal cord compression. (scirp.org)
A chest CT scan revealed a tumoral process measuring 25 mm at the lower lobe of the left lung evoking a Langerhans cell histiocytosis ( Figure 3 ). (scirp.org)
Langerhans cell histiocytosis (LCH) is a group of idiopathic disorders characterized by the presence of cells with characteristics similar to bone marrow-derived Langerhans cells juxtaposed against a backdrop of hematopoietic cells, including T-cells, macrophages, and eosinophils. (medscape.com)
The term Langerhans cell histiocytosis is generally preferred to the older term, histiocytosis X. This newer name emphasizes the histogenesis of the condition by specifying the type of lesional cell and removes the connotation of the unknown ("X") because its cellular basis has now been clarified. (medscape.com)
The working group of the Histiocyte Society divided histocytic disorders into three groups: (1) dendritic cell histiocytosis, (2) macrophage-related disorders, and (3) malignant histiocytosis. (medscape.com)
More recently, histiocytic diseases have been reclassified into five groups: (1) Langerhans-related, (2) cutaneous and mucocutaneous, (3) malignant histiocytosis, (4) Rosai-Dorfman disease, and (5) hemophagocytic lymphohistiocytosis and macrophage activation syndrome. (medscape.com)
The pathogenesis of Langerhans cell histiocytosis (LCH) is unknown. (medscape.com)
We present a case of multiorgan, multisite Langerhans cell histiocytosis (LCH), positive for the oncogenic BRAF V600E mutation, in a preterm neonate. (thieme-connect.de)
Here, we outline the most likely diagnoses with this presentation and discuss a case of Langerhans cell histiocytosis (LCH) in a preterm neonate with severe multiorgan involvement. (thieme-connect.de)
JXG does not carry BRAF V600E mutation, except in patients with both Langerhans' cells histiocytosis (LCH) and JXG (non-Langerhan cells histiocytosis) diseases and in the aggressive forms of JXG. (eyewiki.org)
Juvenile Xanthogranuloma (JXG) is a non-Langerhans cell histiocytosis that is usually benign and self-limiting. (aboutface.ca)

Canine cutaneous histiocytoma (derived from specialised epidermic dendritic cells, the Langerhans cells) 2. (wikipedia.org)
Epidermal invasion in histiocytoma, or presence of simultaneous multiple histiocytomas, especially in aged dogs, can appear similar to MF or non-epidermotropic cutaneous lymphoma (NECL). (wikipedia.org)
UVR exposure also suppresses cutaneous cell-mediated immunity, which might contribute to nonmelanoma skin cancer and certain infections. (medscape.com)
Allergic contact dermatitis (ACD), a form of delayed-type hypersensitivity, is a typical T-cell-mediated skin inflammatory response that occurs after cutaneous exposure to an allergen. (aspetjournals.org)
The development of skin sensitization is associated with, and requires, the activation and clonal expansion of allergen responsive T lymphocytes and it is these cells that orchestrate the cutaneous allergic reaction. (cdc.gov)
A leukapheresis harvest containing the clonal, leukemic expansion of malignant CD4 + T cells was obtained from the blood of patients with cutaneous T cell lymphoma (CTCL). (biomedcentral.com)
Cutaneous T cell lymphoma (CTCL) is a malignant expansion of mature, clonal CD4 T cells with an affinity for epidermal localization [ 1 ]. (biomedcentral.com)
My research interests comprise cutaneous tumors with emphasis in lymphomas and melanoma. (mdanderson.org)
In lymphomas I have conducted studies in rare aggressive primary cutaneous tumors such as gamma/delta T cell lymphoma (expanding the description of the epidermotropic variant) as well as more indolent entities such as lymphomatoid papulosis (type D) and CD4-positive small to medium size T cell lymphoproliferative disorders. (mdanderson.org)
Pathophysiology: The specific pathogenesis is unknown, but is benign proliferation of the cutaneous basal cells that results in smooth or warty elevated lesions (McCance and Huether, 2014). (qualitywriters.org)
[13] Histologically, the cutaneous infiltrate includes a mixture of foamy histiocytes, lymphocytes, fibroblasts and multinucleated giant cells, including Touton-type giant cells, with a moderate amount of collagen deposition (Figures 4-5). (eyewiki.org)
Primary cutaneous apocrine carcinoma (PCAC) is a rare and highly aggressive tumor entity. (iiarjournals.org)
In this context, regulatory T cells (Tregs) hold a key role in balancing immune homeostasis and mediating cutaneous wound healing. (biomedcentral.com)
This function of the cutaneous system is mediated by a myriad of highly specialized immune cells. (biomedcentral.com)

In immunohistochemical study, these eosinophilic cells expressed CD1a and S100 protein. (scirp.org)
Notably, LCH cells have been found to express markers of both resting epidermal Langerhans cells (CD1a, intracellular major histocompatibility complex II [MHCII], Birbeck granules) and activated Langerhans cells (including CD54 and CD58). (medscape.com)
Immunohistochemistry was used to identify activated T lymphocytes (CD45R0), monocyte-macrophages (Mac 387, CD68), DD (Factor XIIIa), and Langerhans cells (CD1a). (spandidos-publications.com)
[16] JXG cells stain positive for CD68, have variable reactivity for factor XIIIa and stain negative for CD1a, S100, CD20716. (eyewiki.org)

[16] One theory proposed the coexistence of LCH and JXG could be the result of chemotherapy-induced maturation of Langerhans' cells into macrophages, in particular foamy cells. (eyewiki.org)
As we previously reported, receptor activator of nuclear factor kappa-B (RANK) ligand (RANKL)/RANK signaling on M2 macrophages promotes the production of chemokines and proinflammatory cytokines to maintain the immunosuppressive tumor environment of extramammary Paget's disease (EMPD). (iiarjournals.org)
Since EMPD is a skin adenocarcinoma of apocrine gland origin that expresses high levels of RANKL and matrix metalloproteinase (MMP) 7, and EMPD is associated with the presence of RANK + M2 macrophages, we hypothesized that tumor-associated macrophages (TAMs) in adenocarcinomas such as PCAC might also express RANKL and MMP7. (iiarjournals.org)
Of these, tumor-associated macrophages (TAMs) and regulatory T-cells (Tregs) create an immunosuppressive microenvironment through various pathways. (iiarjournals.org)
Eosinophils are granulocytes (white blood cells that contain granules in their cytoplasm) derived from the same progenitor cells as monocytes-macrophages, neutrophils, and basophils. (msdmanuals.com)

Ready access to both the DC and apoptotic cells provided by this system will allow extension to other malignancies through the addition of a variety of apoptotic tumor cells and maturation stimuli. (biomedcentral.com)
Dendritic cells (DC) play a central role in immunity/tolerance decision, depending on their activation/maturation state. (cnrs.fr)
As a result, the pathologic cells of LCH have been hypothesized to represent Langerhans cells in a state of arrested maturation. (medscape.com)
This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. (cancerindex.org)

Langerhans cells are capable of activating T-lymphocytes by presenting antigens (such as nickel or tumor antigens) to T-lymphocytes. (jamanetwork.com)
The transimmunization procedure was devised as a more effective modification of ECP and named to designate the transfer of tumor antigens to competent antigen presenting cells (APC) that could display the full complement of tumor antigens in the context of co-stimulatory and adhesion molecules. (biomedcentral.com)
2018). Activated epidermal LCs capture foreign antigens by extending their dendrites through epidermal tight junctions and initiate a preemptive humoral immunity against potentially pathogenic skin microbes, such as 0.0001, Table 1). (arcillaresearch.com)

The presence of professional antigen-presenting cells in tumours can influence their further spreading. (archive.org)
Langerhans antigen presenting cells in the skin, travel from the skin to the regional lymph nodes interacting with T-cells. (qualitywriters.org)

Within an hour of UVR exposure, mast cells release preformed mediators including histamine, serotonin, and tumor necrosis factor, leading to prostaglandin and leukotriene synthesis. (medscape.com)
We show that in poly-(I:C)-stimulated HaCaT cells, CBD elevates the levels of AEA and dose-dependently inhibits poly-(I:C)-induced release of MCP-2, interleukin-6 (IL-6), IL-8, and tumor necrosis factor- α in a manner reversed by CB 2 and TRPV1 antagonists 6-iodopravadoline (AM630) and 5′-iodio-resiniferatoxin (I-RTX), respectively, with no cytotoxic effect. (aspetjournals.org)
METHODS: Mice with K/BxN serum-induced arthritis, collagen-induced arthritis, and human tumor necrosis factor transgene insertion were studied. (cnrs.fr)

Both epidermal keratinocytes ("sunburn cells") and Langerhans cells undergo apoptotic changes as a consequence of UVR-induced DNA damage. (medscape.com)
On the other hand, it favors exaggerated tissue injury in sepsis, hypersensitivity or autoimmunity, by promoting inflammation or cytotoxicity of innocent bystander cells.1 In the skin, NO is produced by iNOS in several cells, namely in keratinocytes, fibroblasts, Langerhans cells and other dendritic cells. (pdffox.com)

Our work has clearly shown that histiocytomas have the phenotype of epidermal Langerhans cells. (wikipedia.org)
Therefore, in addition to epidermal Langerhans cells, other potential cellular origins for LCH include dermal langerin + dendritic cells, lymphoid tissue-resident langerin + dendritic cells, and monocytes that can be induced by local environmental stimuli to acquire a Langerhans cell phenotype. (medscape.com)
Hypoxia stimulates cancer cells to acquire a more malignant phenotype via activation of hypoxia-inducible factor 1 (HIF-1). (cancerindex.org)

The molecular mechanisms involved in the pathogenesis of toxic epidermal necrolysis (TEN) remain not fully understood. (spandidos-publications.com)
Paquet P, Jacob E, Pirson J and Pierard GE: Drug-induced toxic epidermal necrolysis and pancytopenia: A puzzling association. (spandidos-publications.com)

For a growing number of tumors the BRAF V600E mutation carries therapeutic relevance. (oncotarget.com)
Genotyping of 69 histiocytic lesions revealed that 23/48 Langerhans cell lesions were BRAF -V600E-mutant whereas all non-Langerhans cell lesions (including dendritic cell sarcoma, juvenile xanthogranuloma, Rosai-Dorfman disease, and granular cell tumor) were wild-type. (oncotarget.com)

In this work, we investigated the effect of dexamethasone on NO production induced by the epidermal cytokine granulocyte / macrophage colony-stimulating factor (GM-CSF) in a mouse fetal skin dendritic cell line.Methods: NO production was assessed by the method of Griess. (pdffox.com)

The steady deterioration of the dermal and epidermal layers of the skin with age is caused by a combination of factors including reduced cellular proliferation and collagen synthesis, extracellular matrix remodeling, and changes in epidermal morphology (Crane 2015). (ernolaszlo.com)
The subsequent wound healing processes aim to restore dermal and epidermal integrity and functionality. (biomedcentral.com)

3,4 That's because aged cells suffer an accumulation of mutations to genes that regulate their proliferation. (lifeextension.com)
Cancer is an unregulated proliferation of cells. (msdmanuals.com)

Juvenile Xanthogranuloma Involving the Eye and Ocular Adnexa: Tumor Control, Visual Outcomes, and Globe Salvage in 30 Patients. (eyewiki.org)

Cannabinoid type-2 (CB 2 ) receptor activation was shown to reduce the production of the monocyte chemotactic protein-2 (MCP-2) chemokine in polyinosinic-polycytidylic acid [poly-(I:C)]-stimulated human keratinocyte (HaCaT) cells, an in vitro model of allergic contact dermatitis (ACD). (aspetjournals.org)
As a result, her scientific stage was T4N0M1c stage IV, and epidermal development aspect receptor (EGFR) mutation check was positive with exon 18 (G719X, G719). (mingsheng88.org)
receptor-exhibiting cells were present. (archive.org)
The extraepithelial presence of Langerin-positive cells forming contacts with dendrite-like protrusions of 175 kD mannose receptor-exhibiting cells was found in connective tissue surrounding the tumour epithelium and indicates possible cooperation of both elements. (archive.org)
Epithelial tissues in which carcinomas develop often contain systemically derived T cell receptor (TCR)αβ + cells and resident intraepithelial lymphocytes that are commonly enriched in TCRγδ + cells. (silverchair.com)
We assessed the unique toity, take the role, and magnitude of the T cell rejoinder and related the degree of T cell receptor cross-reenergy in as a replacement throughoutmy JEV-exposed donors and recpasted JE patients. (ulisboa.pt)
For example, Paget's cells release soluble receptor activator of nuclear factor kappa-B ligand (sRANKL) into the tumor microenvironment, stimulating RANK + TAMs to produce CCL17, which recruits Tregs into the lesional skin of patients with extramammary Paget's disease (EMPD) ( 11 , 17 ). (iiarjournals.org)

These epidermal and connective tissue layers protect against mechanical and chemical harm and repel pathogenic invaders [ 19 ]. (biomedcentral.com)

In recent years, much has been learned of the characteristics of immune responses to skin sensitizing chemicals and of the roles played by dendritic cells, cytokines and chemokines. (cdc.gov)

A surgical biopsy showed an infiltrate of eosinophilic cells with oval, grooved and convoluted nucleus, associated with eosinophils, lymphocytes and plasma cells ( Figure 2 ). (scirp.org)
It consists of Langerhans cells with oval, grooved and convoluted nucleus and slightly eosinophilic cytoplasm, associated with eosinophils, lymphocytes and plasma cells (H & E × 400). (scirp.org)
Bronchoalveolar lavage fluid cytology indicated 5% neutrophils, 5% lymphocytes, 55% histocytes, 10% ciliated cells and 5% malignancy cells. (mingsheng88.org)
Skin-resident dendritic cells act as a first line of defense, ingesting foreign substances, processing them, and presenting them to lymphocytes to activate the immune system. (ernolaszlo.com)
Figure 5: High-power view reveals a mixture of multinucleated giant cells, including Touton-type giant cells, foamy histiocytes, lymphocytes, and fibroblasts with a moderate amount of collagen deposition. (eyewiki.org)

Immunohistochemical analysis revealed strong cytoplasmic immunoreactivity of dendritic melanocytes for proteinS-100, HMB-45 and melan-A.Positive staining for proliferative markers (MCM-2, MCM-5, Ki-67) was only observed in basal and suprabasal epithelial cells, confirming the reactive etiology of the lesion. (biomedcentral.com)
Scattered within the stratum basale are pigment-producing cells called melanocytes. (bodyviz.com)
Melanocytes and Langerhans cells (also termed dendritic cells) are frequently found within this layer. (bodyviz.com)
Nevomelanocytes are related to pigment-producing cells normally found in the skin, called melanocytes. (aboutface.ca)

It also helps maintain specialized immune cells in the skin that fight cancer, 12 while inhibiting collagen-destroying enzymes that contribute to skin aging. (lifeextension.com)

[ 5 ] Within 2 hours after UV exposure, damage to epidermal skin cells is seen. (medscape.com)
With repeated exposure to UVR, the skin thickens, primarily due to epidermal hyperplasia with thickening of the stratum corneum. (medscape.com)
activity in anergic T cells.18-20,35 Depsipeptide solubility dmso In accordance with these earlier studies, c-fos and c-jun activity was decreased in Th1 cells anergized by exposure to n-butyrate. (syksignaling.com)
Actinic keratosis is a premalignant lesion made of aberrant proliferations of epidermal caused by prolonged exposure to UV radiation (McCance and Huether, 2014). (qualitywriters.org)
Pathophysiology: It occurs following prolonged sun exposure to UV light that results in mutations in specific genes including TP53 and deletion of the gene coding for p16 tumor suppressor protein (Spencer, 2021). (qualitywriters.org)
The ultrastructure shows varying degrees of cell degeneration which becomes more pronounced the longer the exposure to mercuric chloride. (researchgate.net)
7,8 Like melanoma, the incidence of squamous cell carcinoma is related to aging and sun exposure. (lifeextension.com)
In study after study, this Polypodium fern is proving to decrease the consequences of acute sun exposure, such as redness and sunburn-cell formation. (lifeextension.com)

Immunohistochemistry (IHC) is best performed on frozen sections of tumor (not formalin fixed material! (wikipedia.org)

Arguments supporting the reactive nature of LCH include the occurrence of spontaneous remissions, the extensive elaboration of multiple cytokines by dendritic cells and T-cells (the so-called cytokine storm) in LCH lesions, and the good survival rate in patients without organ dysfunction. (medscape.com)
Pathophysiology: Psoriasis is a complex inflammatory disorder, that involved reactive abnormal epidermal differentiation and hyperproliferation, the current research reflects that the mechanisms are immune based and involves the T-cells in the dermis (Lui, 2022). (qualitywriters.org)

Deletion of the function of Langerhans cells does not result in abrogated epidermal antigen presentation since ultraviolet irradiation simultaneously induces the appearance of another epidermal antigen-presenting cell population that is distinct from the Langerhans cell population and seems to induce suppression of the immune response. (jamanetwork.com)

Histiocytic sarcoma complex (immunohistochemical features of dendritic cells, possibly interdigitating or perivascular DCs) 3.a. (wikipedia.org)
In conclusion, BRAF mutations in histiocytic proliferations are restricted to lesions of the Langerhans-cell type. (oncotarget.com)
Histiocytic tumors are derived from the mononuclear-phagocytic and histiocyte system[ 1 - 3 ]. (oncotarget.com)

The addition of supportive cytokines further enhanced the number of DC that contained apoptotic malignant T cells. (biomedcentral.com)
Different properties such as the efficient Ag processing machinery, the high levels of expression of costimulatory molecules and peptide-MHC complexes, and the production of cytokines contribute in making DCs potent stimulators of naive T cell responses. (aai.org)
The T-cells are then activated and cytokines are released resulting in co-stimulatory signals from the T-cell CD2 and LFA-1 receptors that interact with adhesion molecules of lymphocyte function-associated antigen (LFA)-3 and intercellular adhesion molecule-1 (Lui, 2022). (qualitywriters.org)

Myeloproliferative neoplasms are clonal proliferations of bone marrow stem cells, which can manifest as an increased number of platelets, red blood cells (RBCs), or white blood cells (WBCs), alone or in combination, in the circulation and sometimes with fibrosis in the bone marrow and extramedullary hematopoiesis (cell production outside the marrow). (msdmanuals.com)

Recently we have observed that DCs are able to produce IL-2 following bacterial stimulation, and we have demonstrated that this particular cytokine is a key molecule conferring to early bacterial activated DCs unique T cell priming capacity. (aai.org)

Mechanisms of skin sensitization and allergic epidermal Langerhans cells (LC), although other cuta- contact dermatitis neous (dermal) dendritic cells (DC) may also contrib- ute. (cdc.gov)

Dendritic cells (DCs) are professional APCs able to initiate innate and adaptive immune responses against invading pathogens. (aai.org)
Lichen planus is a cell-mediated immune response of unknown origin (Chuang, 2021). (qualitywriters.org)
One possible explanation may be that intramuscular injection, which has been the most studied route of DNA vaccine administration in humans, tends to elicit mostly cell-mediated immune responses (53), which is likely due to significantly lower APC populations residing in muscles and antigen presentation dominated by MHC I (51). (arcillaresearch.com)
It is also clear that psychological stressors lead to aberrant barrier function, with decreased epidermal lipid and structural protein synthesis, decreased hydration of the stratum corneum, and increased transepidermal water loss (Maarouf 2019), and can also result in immune system dysfunction leading to systemic and local inflammation (Liu 2017). (ernolaszlo.com)
Cancer stroma contains various immune cells. (iiarjournals.org)
For example, TAMs suppress effector T-cells through immune checkpoint molecules, such as those of the programmed cell death 1 (PD-1) ( 7 ) and cytotoxic T-lymphocyte-associated protein 4 (CTLA4) ( 8 , 9 ) pathways. (iiarjournals.org)
Langerhans cells contribute to the immune response of the skin against skin cancers and pathogens that have penetrated the skin. (bodyviz.com)
To this end, multiple tissue-resident cells and recruited immune cells cooperate to efficiently repair the injured tissue. (biomedcentral.com)
In interaction with other non-immune cells, such immune cell subsets ensure the functionality and integrity of the skin layers [ 1 ]. (biomedcentral.com)
Loss of tissue is then repaired in a complex process that involves tissue-resident immune, stromal, and epithelial cells, as well as infiltrating immune cells [ 2 ]. (biomedcentral.com)
Specifically, the timely orchestration of pro- and anti-inflammatory responses, based on the activation and inhibition of various cell types, such as tissue-resident cells and different types of immune cells, can significantly impact wound repair [ 7 ]. (biomedcentral.com)
To this end and within their broad functionality and operationality, Tregs are able to adopt unique features of skin cells and contribute to the skin's role as an immune barrier. (biomedcentral.com)

On the other hand, the infiltration of organs by a monoclonal population of aberrant cells, the possibility of lethal evolution, and the cancer-based modalities of successful treatment are all consistent with a neoplastic process. (medscape.com)

We have demonstrated that adherence and release of monocytes from a plastic surface drives their differentiation into immature dendritic cells (DC,) that can mature further during overnight incubation in the presence of apoptotic malignant T cells. (biomedcentral.com)
CTCL cell apoptosis, DC differentiation and apoptotic malignant T cell ingestion were measured by immunostaining. (biomedcentral.com)
They are extremely versatile APCs involved in the initiation of both innate and adaptive immunity ( 1 ), but also in the differentiation of regulatory T cells ( 2 ) required for the maintenance of self-tolerance. (aai.org)
these cells are able to secrete soluble factors that stimulate the migration, mitosis, and differentiation of local stem cells. (biomedcentral.com)

The unique structure of the tissue of this benign tumour, containing cells with cystic contents, causes interpretative difficulties already at the stage of an imaging diagnosis where the tumour needs to be differentiated from other intraosseous pathology. (hindawi.com)
Seborrheic keratosis is the most common benign tumor in older individuals. (qualitywriters.org)

The principal injury responsible for sunburn is direct damage to DNA by UVR, resulting in inflammation and apoptosis of skin cells. (medscape.com)
In particular, following first application to the skin, epidermal Langerhans cells (LCs) take up the allergen, process it, and migrate toward the regional lymph nodes, where the antigen is presented to naïve T cells, which, once activated, migrate toward peripheral tissues. (aspetjournals.org)
In the vast majority of cases, basal cell skin cancer can be cured. (healthyskinworld.com)
Unlike other cancers, basal and squamous cell skin cancers are not tracked by cancer registries, so the statistics are not available. (healthyskinworld.com)
Infiltrative basal cell carcinoma is a variant of basal cell carcinoma , the most frequently diagnosed form of non-melanoma skin cancer. (healthyskinworld.com)
Basal cell carcinoma is the most common form of skin cancer and the most frequently occurring form of all cancers. (healthyskinworld.com)
Three most common skin cancers · basal cell carcinoma · squamous cell carcinoma · malignant melanoma · share this article · related pages · related news and articles. (healthyskinworld.com)
There are three major types of skin cancers: Basal cell carcinoma, squamous cell carcinoma and melanoma. (healthyskinworld.com)
The different types of skin cancer are named for the skin cell where the cancer develops: Basal cell carcinoma , squamous cell carcinoma , and melanoma. (healthyskinworld.com)
These results suggest that dexamethasone is a potent inhibitor of intracellular events that are involved on NO synthesis, in skin dendritic cells. (pdffox.com)
Thus, ultraviolet irradiation of human skin may facilitate the growth of human neoplasms, and the spreading of skin-associated infections due to induction of suppressor T cells. (jamanetwork.com)
Photocarcinogenesis in hairless mice induced tumors harbors more UVA than UVB fingerprint by ultraviolet A tanning devices with or without mutations: A role for UVA in human skin car- subsequent solar-simulated ultraviolet irradia- cinogenesis. (who.int)
Br J mous cell carcinoma of the skin. (who.int)
risk of basal and squamous cell skin cancer. (who.int)
L-Carnitine - Increases skin cell turnover & transports fatty acids into the mitochondria assisting energy production. (mdcosmeticandskin.com.au)
The presence of a great number of Factor XIIIa+ DD without any possible recent recruitment from bone marrow suggests that these cells differentiated from resident cells of the skin. (spandidos-publications.com)
Langerhans cells (LCs) are antigen-presenting dendritic cells located in the skin. (transhumanist.ru)
ASC treatment upregulated granulocyte-macrophage colony stimulating factor (GM-CSF) at the gene level, which may contribute to the recruitment of cells that participate in skin repair to the site of injury. (biomedcentral.com)
At the same time, dermicidin and antibacterial substances in sebum kill bacteria directly, and skin cells also secrete natural antibiotics, the defensins, that perforate and kill bacteria. (ernolaszlo.com)
The physical barrier of the skin largely arises from the structure of the stratum corneum, which consists of multiple layers of dead, flattened cells and glycolipids that together defend against mechanical insults and work with the acid mantle and other substances secreted by the skin to ward off bacterial invasion. (ernolaszlo.com)
Immunohistochemical staining of MMP1 and MMP25 as well as chemokine (C-C motif) ligand (CCL) 5 in the lesional skin from five patients with PCAC showed a substantial number of MMP1-bearing cells and MMP25-bearing cells, as well as CCL5-producing cells, that were distributed in the lesional skin. (iiarjournals.org)
Accordingly, investigating the characteristics of cancer-related factors is important to determine the immunological background of the tumor microenvironment in each type of skin cancer. (iiarjournals.org)
This is the last layer of the skin where all of the cells possess a visible and functioning nucleus. (bodyviz.com)
Nevus is a condition characterized by common skin growth, or 'mole', composed of special pigment-producing cells called nevomelanocytes. (aboutface.ca)
As you will read, an orally ingested plant extract has been discovered to confer remarkable protection against sunburn and solar ray skin cell damage. (lifeextension.com)
It is called Polypodium leucotomos and has been used for centuries to treat tumors, skin diseases (including psoriasis), and sunburn. (lifeextension.com)
Additional research shows that this special fern decreases the infiltration of damaging inflammatory cells in skin 12,14 and increases survival of healthy skin cells. (lifeextension.com)
Ultraviolet radiation directly damages DNA and impairs normal skin cell functions by generating enormous bursts of free-radical activity. (lifeextension.com)
Oral Polypodium leucotomos supplements, taken in doses of 500-750 mg/day, have been shown to protect human skin from sunburn, cell death, DNA damage, and oxidant activity from both natural and artificial ultraviolet light. (lifeextension.com)

This specific type presents differently than other basal cell carcinomas, in that it forms in thin, small clusters, making it less apparent to spot. (healthyskinworld.com)
A low incidence of Langerin-positive cells was found in tumours and 1/3 of studied carcinomas were even Langerhans cell-free. (archive.org)

A Touton giant cell is a multinucleated cell that contains a wreath of nuclei surrounding homogeneous cytoplasm, with a rim of foamy cytoplasm peripheral to the nuclei. (eyewiki.org)

Postoperative radiation can also be a useful adjunct when patients have aggressive tumors that were treated surgically or when surgery has failed to clear the margins of the tumor. (medscape.com)

During tumor development, stromal cells are co-opted to the tumor milieu and provide favorable conditions for the tumor. (cancerindex.org)

Description Pachyonychia congenita (PC) is an autosomal dominant genodermatosis with the main clinical features of hypertrophic nail dystrophy, painful and highly debilitating plantar keratoderma, oral leukokeratosis, and a variety of epidermal cysts. (findzebra.com)

Delayed tanning results from increased synthesis of epidermal melanin and requires a longer period of time to become visible (24-72 h). (medscape.com)

Based on these results, we sought to develop a clinically, practical, rapid means for producing DC loaded with malignant cells. (biomedcentral.com)
CTCL cells were purified with a CD3-magnetic bead column where CD3 engagement rendered the malignant T cells apoptotic. (biomedcentral.com)
Apoptotic malignant T cells were avidly engulfed by the phagocytic transitioning DC. (biomedcentral.com)
After CD8 T cells were stimulated by DC loaded with malignant cells, they mediated increased apoptosis of residual CTCL cells and TNF-α secretion indicating development of enhanced cytolytic function. (biomedcentral.com)
We report a simple one-step procedure where maturing DC containing apoptotic malignant T cells can be prepared rapidly for potential use in vaccine immunotherapy. (biomedcentral.com)
DCLDs are the effect of a malignant procedure seldom, that are supplementary to metastases from adenocarcinomas from the gastrointestinal system [2, 3] and sarcomas of varied cell types [4, 5]. (mingsheng88.org)
Leukemia is a malignant condition involving the excess production of immature or abnormal leukocytes, which eventually suppresses the production of normal blood cells and results in symptoms related to cytopenias. (msdmanuals.com)

The capacity to produce IL-2 following a microbial stimuli encounter is a feature shared by diverse DC subtypes in vivo, such as CD8α + and CD8α − splenic DCs and epidermal Langerhans cells. (aai.org)
The plasticity of these cells allows them to undergo a complete genetic reprogramming in response to external microbial stimuli ( 3 ). (aai.org)

This free radical acts as a cytotoxic agent against exogenous microorganisms, by stimulating macrophage-induced inflammation and death of infected cells. (pdffox.com)
DR+ epidermal macrophage induction, and noma in young women: An evaluation of the Langerhans cell depletion. (who.int)

Figure 4: Low power view of eyelid biopsy shows epidermal surface of the eyelid represented by keratinizing stratified squamous epithelium. (eyewiki.org)

There were singular lesions revealed under the dura mater, forming part of the tumour and measuring approximately 2-3 mm in dimension on the surface of the arachnoidea above the area of the bone foramen, which were removed and coagulated, preserving the venous system intact. (hindawi.com)
The bone flap with the tumour and the dura mater were excised. (hindawi.com)
In fact, adipose mesenchymal stem cells (ASCs) are being used, especially in small breeds where the amount of bone marrow that can be harvested is limited and the collection is more laborious and painful. (biomedcentral.com)
Red blood cell (RBC) production (erythropoiesis) takes place in the bone marrow under the control of the hormone erythropoietin (EPO). (msdmanuals.com)

They all share histologically a significant infiltration of affected tissues by langerhans cells. (scirp.org)
Imiquimod induced an IFN signature and led to reduced infiltration of inflammatory cells. (cnrs.fr)

Specifically, a variety of other cellular populations have been identified that possess phenotypic characteristics similar to Langerhans cells, including expression of CD207 and Birbeck granules. (medscape.com)

The monocyte fraction was simultaneously activated by column passage, re-added to the apoptotic CTCL cells and co-cultured overnight. (biomedcentral.com)
In addition, DC loaded with apoptotic CTCL cells stimulated an increase in the percentage and absolute number of CD8 T cells compared to co-cultivation with non-loaded DC. (biomedcentral.com)
The cross-link formation is a lethal defect and replicating cells are rendered apoptotic. (biomedcentral.com)
In the ECP treatment, both apoptotic CTCL cells and transitioning DC are re-infused into the patient immediately and association of the DC and apoptotic tumor cells occurs inefficiently in vivo . (biomedcentral.com)

The cellular levels of endocannabinoids [anandamide (AEA), 2-arachidonoylglycerol] and related molecules (palmitoylethanolamide, oleoylethanolamide) were quantified in poly-(I:C)-stimulated HaCaT cells treated with CBD. (aspetjournals.org)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
This layer is composed of dead cells that possess a very thick cellular membrane, lack any organelles or nucleus, and possess a high amount of keratin. (bodyviz.com)

DNA replication allowing time for DNA repair.30,31 p21Cip1 interaction with PCNA results in the inhibition of PCNA and thereby causes G1 and G2 block in T cells.14,32 There was some association of p21Cip1 with PCNA in stimulated control Th1 cells, but the functional significance of this low-level interaction was not determined. (syksignaling.com)

Mapping cytoskeletal protein function in cells by means of nanobodies. (scriptiebank.be)

How dangerous is infiltrative basal cell carcinoma? (healthyskinworld.com)

Cells within the deepest part of the stratum spinosum continue to undergo mitosis, contributing to the thickness of this layer. (bodyviz.com)

Epidermal invasion by cells of histiocytoma frequently occurs and intra-epidermal nests of histiocytes resemble Pautrier's aggregates, characteristically found in epidermotropic lymphoma (Mycosis Fungoides or MF). (wikipedia.org)

Given that cancer cells and astrocytes in glioblastomas coexist in a hypoxic microenvironment, we examined whether astrocytes affect the adaptation of glioblastoma cells to hypoxia. (cancerindex.org)
Conclusion: Our study suggests that the RANKL/RANK pathway contributes to the development and maintenance of the immunosuppressive tumor microenvironment and denosumab may be a promising adjuvant therapy targeting TAMs in cancer of apocrine origin. (iiarjournals.org)

The public has been alerted to the grave dangers of melanoma, but remain largely in the dark about another deadly cancer (squamous cell carcinoma) that strikes almost four times as many Americans. (lifeextension.com)

This finding entails that TEN treatments should target the keratinocyte metabolism rather than the circulating inflammatory cells which presumably play a limited role, if any, in the epidermal destructive process. (spandidos-publications.com)
Other inflammatory cells may be present to varying degrees. (eyewiki.org)

The ultrastructural hallmark of the Langerhans cell, the Birbeck granule, was described a century later. (medscape.com)

Regulatory T cells (Tregs) play a pivotal role in this context. (biomedcentral.com)

Anatomy13

Organisms4

Diseases25

Chemicals and Drugs18

Analytical, Diagnostic and Therapeutic Techniques and Equipment8

Phenomena and Processes6

Disciplines and Occupations1

Health Care1

Epidermis10

Histiocytosis14

Cutaneous14

CD1a4

Macrophages5

Maturation4

Antigens3

Antigen prese2

Necrosis factor3

Keratinocytes2

Phenotype3

Toxic epidermal2

BRAF V600E2

Dendritic cell1

Dermal and epidermal2

Proliferation2

Juvenile xanthogranuloma1

Receptor7

Connective tissue1

Chemokines1

Lymphocytes5

Melanocytes4

Collagen1

Exposure8

Immunohistochemistry1

Reactive2

Induces1

Histiocytic3

Cytokines3

Clonal1

Cytokine1

Allergic1

Immune12

Aberrant1

Differentiation4

Benign2

Skin29

Carcinomas2

Cytoplasm1

Aggressive1

Stromal1

Cysts1

Synthesis1

Malignant7

Stimuli2

Macrophage2

Epithelium1

Bone4

Infiltration2

CD2071

Apoptotic4

Cellular3

Functional1

Protein1

Infiltrative1

Undergo1

Histiocytes1

Microenvironment2

Squamous1

Inflammatory cells2

Ultrastructural1

Regulatory T cel1