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  • estrogen
  • However, about 10 to 15% of breast cancers do not express either estrogen or progesterone receptor (ER and PgR, resp. (hindawi.com)
  • colorectal cancer
  • These effects were seemingly specific, as cyclin D1 , a crucial β-catenin/TCF4 target gene, was also down-regulated by SKI-606 in a dose-dependent manner accounting, at least in part, for the reduced growth (IC 50 , 1.5-2.4 μmol/L) and clonogenic potential of colorectal cancer cells. (aacrjournals.org)
  • human
  • ZD1839, 4-(3-chloro-4-fluorophenylamino)-7-methoxy-6-(3-(4-morpholinyl)propoxy) quinazoline (molecular weight, 446.9) is a p.o.-administered EGFR-TKI of the quinazoline class with demonstrated in vitro efficacy against lung, colorectal, prostate, ovarian, and breast cell lines and in vivo growth delay in a range of s.c. human tumor xenografts that express EGFR (data on file at AstraZeneca, Cheshire, United Kingdom). (aacrjournals.org)
  • activation
  • PTEN ( phosphatase and tensin homologue deleted on chromosome 10 ) acts as a tumor suppressor gene by inhibiting phosphorylation and thereby activation of AKT ( 2 , 3 ). (aacrjournals.org)
  • Influence of activation state of ErbB-2 (HER-2) on response to adjuvant cyclophosphamide, doxorubicin, and fluorouracil for stage II, node-positive breast cancer: study 8541 from the Cancer and Leukemia Group B. (yalecancercenter.org)
  • cancer
  • These data indicate that these compounds have potential use as therapy in the broad population of cancer patients overexpressing ErbB-2 and/or EGFR. (aacrjournals.org)
  • Co-targeting the HER and IGF/insulin receptor axis in breast cancer, with triple targeting with endocrine therapy for hormone-sensitive disease. (yalecancercenter.org)
  • 29) These nodules are present in about 2% of radical prostatectomies with cancer and are of unknown etiology. (bostwicklaboratories.com)
  • We previously reported that α -mangostin significantly inhibits both tumor growth and metastasis in a mouse model of mammary cancer [ 9 , 10 ]. (hindawi.com)