• Although a number of studies have shown that patients with activating mutations in exons 18-21 of the epidermal growth factor receptor (EGFR) gene respond particularly well to gefitinib and erlotinib, a prospective, randomised study was needed to differentiate between the prognostic and predictive value of EGFR mutations. (ersjournals.com)
  • This review considers the current evidence linking biomarker profile to efficacy of epidermal growth factor receptor (EGFR)-targeted therapy in advanced nonsmall cell lung cancer (NSCLC) and the clinical implications of recent findings. (ersjournals.com)
  • Epidermal growth factor receptor (EGFR) inhibitors are routinely used in advanced non-small-cell lung cancer (NSCLC) harboring EGFR mutations. (iasp-pain.org)
  • Assessment of the epidermal growth factor receptor (EGFR) mutational status has become crucial in recent years in the molecular classification of patients with lung cancer. (spandidos-publications.com)
  • The aim of the present study was to investigate the impact of tissue type and content of neoplastic cells in the specimen on the quality of EGFR mutation analysis among patients with lung adenocarcinoma. (spandidos-publications.com)
  • The receptor for epidermal growth factor (EGFR) is overexpressed in many cancers. (aacrjournals.org)
  • Recent reports have shown that the sensitivity of non-small-cell lung cancer cell lines to EGFR inhibitors such as erlotinib (Tarceva, OSI Pharmaceuticals) is dependent on inhibition of the phosphatidylinositol 3′-kinase-phosphoinositide-dependent kinase 1-Akt-mTOR pathway. (aacrjournals.org)
  • Therefore, inhibiting EGFR alone may not be sufficient for substantial inhibition of all tumor cells, highlighting the need for multipoint intervention. (aacrjournals.org)
  • The epidermal growth factor receptor (EGFR) is frequently overexpressed in non-small-cell lung carcinoma (NSCLC), and EGFR inhibitors are promising new therapeutic agents. (nih.gov)
  • EGFR overexpression is frequent in NSCLC, is most prominent in SCC, and correlates with increased gene copy number per cell. (nih.gov)
  • AIMS: Epidermal growth factor receptor (EGFR) is implicated in bone remodelling. (ox.ac.uk)
  • The aim was to determine whether EGFR protein expression contributes to the aggressiveness and recurrence potential of giant cell tumour of bone (GCTB), an osteolytic primary bone tumour that can exhibit markedly variable clinical behaviour. (ox.ac.uk)
  • Detecting phosphotyrosine epitopes pY1068 and -pY1173 indicated active EGFR signalling, and finding EGFR ligands EGF and transforming growth factor-α restricted to cells of the monocytic lineage suggested paracrine EGFR activation in stromal cells. (ox.ac.uk)
  • CONCLUSION: In GCTB, EGFR signalling in neoplastic stromal cells may contribute to disease progression through promoting stromal cell proliferation and osteoclastogenesis. (ox.ac.uk)
  • With the availability of effective anti-EGFR therapies for various solid malignancies, such as non-cell small lung cancer, colorectal cancer and squamous cell carcinoma of the head and neck, the knowledge of EGFR and K-RAS status becomes clinically important. (biomedcentral.com)
  • The aim of this study was to analyse EGFR expression, EGFR gene copy number and EGFR and K-RAS mutations in two cohorts of squamous cell carcinomas, specifically anal canal and tonsil carcinomas. (biomedcentral.com)
  • EGFR immunoreactivity was present in 36/43 (83.7%) of anal canal and in 20/24 (83.3%) of tonsil squamous cell carcinomas. (biomedcentral.com)
  • EGFR mutations were absent from squamous cell carcinoma of the anus and tonsils, but EGFR protein expression was detected in the majority of the cases. (biomedcentral.com)
  • This indicates that EGFR and K-RAS mutation analysis is not useful as a screening test for sensitivity to anti-EGFR therapy in anal canal and tonsil squamous cell carcinoma. (biomedcentral.com)
  • Epidermal growth factor receptor (EGFR) has been validated as a therapeutic target in several human tumours, including colorectal cancer (CRC), non-small cell lung cancer (NSCLC) and squamous cell carcinoma of the head and neck (HNSCC). (biomedcentral.com)
  • They were stained for epidermal growth factor receptor (EGFr) by means of an indirect immunoperoxidase technique using a monoclonal antibody against the receptor. (ox.ac.uk)
  • Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) provide clinical benefits over chemotherapy for lung cancer patients with EGFR activating mutations. (usf.edu)
  • We have developed EGFR TKI drug-tolerant (DT) human lung cancer cell lines as a model for de novo resistance. (usf.edu)
  • In both parental and DT cells, ketoconazole and EGFR TKIs acted synergistically to induce apoptosis and overcome the development of EGFR tolerance. (usf.edu)
  • Thus, our study demonstrates for the first time that ketoconazole treatment inhibits upregulation of mitochondrial cholesterol and thereby overcomes EGFR-TKI resistance in lung cancer cells. (usf.edu)
  • a monoclonal antibody that blocks the epidermal growth factor receptor (EGFR) is currently approved for the treatment of several types of solid tumors. (researchtoactionforum.org)
  • Introduction The epidermal growth factor receptor (EGFR) plays several important functions in the development and progression of many types of solid tumors [1]. (researchtoactionforum.org)
  • Thus although EGFR plays important functions in tumorigenesis cancer cells are genetically unstable and can elude the effect of EGFR-targeted therapy through several well-characterized and some not-yet-known resistance mechanisms. (researchtoactionforum.org)
  • We previously reported that cetuximab can markedly downregulate the high basal levels of hypoxia-inducible factor-1 alpha (HIF-1α) by inhibiting HIF-1α protein synthesis in cancer cell lines which are delicate to EGFR inhibition [14] [15]. (researchtoactionforum.org)
  • it may possibly not be adequate to mediate the response of tumor cells to GSK256066 EGFR-targeted therapy [14]-[17]. (researchtoactionforum.org)
  • On the other hand overexpression of HIF-1α in tumor cells which were originally delicate to the procedure conferred substantial level of resistance to anti-EGFR therapy [16]. (researchtoactionforum.org)
  • Epidermal growth factor receptor (EGFR)-mutant non-small- cell lung cancer (NSCLC) is clinically and genetically heterogeneous, with concurrent RB1/TP53 mutations , indicating an increased risk of transformation into small cell lung cancer (SCLC). (bvsalud.org)
  • These findings uncovered the role of EGFR in the acquisition of plasticity, which is the ability of a cell to substantially modify its identity and take on a new phenotype , and defined a novel landscape of potential drivers of NE transformation in lung cancer . (bvsalud.org)
  • Abstract OBJECTIVE: It is important to analyze and track Epidermal Growth Factor Receptor (EGFR) mutation status for predicting efficacy and monitoring resistance throughout EGFR-tyrosine kinase inhibitors (TKIs) treatment in nonsmall cell lung cancer (NSCLC) patients. (docksci.com)
  • This ability of EGF to stimulate proliferation of pTr cells was suppressed by EGFR siRNA, but not HIF-1α siRNA, but a significant decrease in EGF-induced HIF-1α protein occurred when pTr cells were transfected with HIF-1α siRNA. (korea.ac.kr)
  • Epidermal growth factor receptor (EGFR) phosphorylation and activation has been identified as one important mediator of inflammatory cytokine release from these cells. (cdc.gov)
  • The studies here investigated both early and late phase adaptive changes in EGFR binding properties and subcellular localization induced by exposure of cells to HDE. (cdc.gov)
  • Results: In BEAS-2B and primary human bronchial epithelial cells, HDE induced decreases in cell surface EGFR binding following both 15-min and 18-h exposures. (cdc.gov)
  • Although total EGFR immunoreactivity decreased markedly at 18 hr in confocal microscopy with BEAS-2B cells, immunoblots showed no loss of EGFR protein. (cdc.gov)
  • HDE stimulated EGFR phosphorylation at both 15 min and 18 hr in BEAS-2B cells and primary cells, but only at 15 min in H292 cells, indicating that the different EGFR binding changes among these cell types is likely related to their different time-dependent changes in phosphorylation. (cdc.gov)
  • Conclusions: These studies extend the evidence for EGFRs as important cellular targets for components of HDE and they reveal novel patterns of EGFR phosphorylation and binding changes that vary among airway epithelial cell types. (cdc.gov)
  • The epidermis of all regions contained strong to stronger PAS (+) cells in various degrees. (hindawi.com)
  • The epidermis of the first, fourth, fifth, and sixth regions had strong to stronger AB pH 2.5 (+) cells. (hindawi.com)
  • Most of mucous cells in epidermis of the first region contained both PAS (+) and AB (+) mucosubstances. (hindawi.com)
  • All regions featured KOH/PAS (+) cells, with a slight reduction in reaction intensity in the epidermis of the last three regions. (hindawi.com)
  • The epidermis of the annelids consists of a monolayered epithelium, which contains glandular, supporting, ciliated, and sensory cells. (hindawi.com)
  • TDPCs exhibit bipotent progenitor behavior as they give rise to both squamous and neuroendocrine epidermal lineages, whereas the remainder of the α6 + Sca1 + CD200 - epidermis does not give rise to Merkel cells. (biologists.com)
  • Overexpression in tobacco induces cell outgrowths in carpel epidermis and significantly increases the height of petal conical cells. (washington.edu)
  • Epidermal stem cells (ESCs) are specific stem cells derived from the embryonic ectoderm, which can be differentiated into various layers of the skin to activate the state of proliferation and differentiation and the apoptotic state of the epidermis. (aging-us.com)
  • An epidermal nevus (plural: nevi) is an abnormal, noncancerous (benign) patch of skin caused by an overgrowth of cells in the outermost layer of skin ( epidermis ). (medlineplus.gov)
  • The epidermis is composed primarily of a specific cell type called a keratinocyte. (medlineplus.gov)
  • By studying knock-out mice, we provide evidence that CD8+ T cells are required for the displacement of the DETC and furthermore, that DETC are not required for recruitment of CD8+ TRM cells to the epidermis following allergen exposure. (ku.dk)
  • Finally, in an attempt to elucidate why CD8+ epidermal TRM cells persist in the epidermis, we show that CD8+ epidermal TRM cells have a higher proliferative capability and are bioenergetically more stable, displaying a higher spare respiratory capacity than DETC. (ku.dk)
  • To investigate the functional capabilities of Thy-1 + dEC in vitro, cell suspensions prepared from trypsin-disaggregated sheets of mouse body wall epidermis were first enriched to 8 to 20% Ia + and 20 to 40% Thy-1 + cells by centrifugation over Isolymph and then were cultured for 2 to 10 days with Concanavalin A (Con A) and/or partially purified rat IL 2. (elsevierpure.com)
  • The ability to establish both short-term and long-term cell lines of Con A- and IL 2-stimulated Thy-1 + EC will facilitate analysis of the functional capabilities of these recently recognized cells residing within mouse epidermis. (elsevierpure.com)
  • Stem cells appear to make up about 10% of the basal layer in the epidermis and are dispersed towards to the centre of the epidermal proliferation unit's basal layer component. (mygradespot.com)
  • Keratinocytic epidermal nevi are also known as linear epidermal nevi or verrucous epidermal nevi, based on characteristics of their appearance. (medlineplus.gov)
  • Usually, no symptoms of the nevi are present, with the exception of inflammatory linear verrucous epidermal nevus. (medscape.com)
  • Inflammatory linear verrucous epidermal nevus is a linear, persistent, pruritic plaque, usually first noted on a limb in early childhood. (medscape.com)
  • Inflammatory linear verrucous epidermal nevus, unlike the other types of epidermal nevi, demonstrates erythema and sometimes pruritus. (medscape.com)
  • Inflammatory linear verrucous epidermal nevus is characterized by tiny, discrete, erythematous, slightly warty papules, which tend to coalesce in a linear formation. (medscape.com)
  • Inflammatory linear verrucous epidermal nevus may occur with musculoskeletal abnormalities in a few children, prompting the classification of inflammatory linear verrucous epidermal nevus as part of epidermal nevus syndrome. (medscape.com)
  • One infant had inflammatory linear verrucous epidermal nevus with congenital dislocation of the ipsilateral hip and Fallot tetralogy of the heart. (medscape.com)
  • Another infant had congenital inflammatory linear verrucous epidermal nevus with congenital bony anomalies of the ipsilateral extremities. (medscape.com)
  • Nevus depigmentosus and inflammatory linear verrucous epidermal nevus may occur together, as may inflammatory linear verrucous epidermal nevus and melanodontia. (medscape.com)
  • These include linear sebaceous nevus, linear nevus comedonicus (NC), linear epidermal nevus (LEN), and inflammatory linear verrucous epidermal nevus (ILVEN). (medscape.com)
  • [ 3 ] delineated inflammatory linear verrucous epidermal nevus as a distinct entity in 25 patients. (medscape.com)
  • They coined the name inflammatory linear verrucous epidermal nevus, labeling it a clinical and histopathologic type of linear verrucous nevus that is often inflammatory or psoriasiform. (medscape.com)
  • Inflammatory linear verrucous epidermal nevus accounts for approximately 5% of patients with epidermal nevi and has been described in a mother and daughter. (medscape.com)
  • Other types of epidermal nevi involve additional types of epidermal cells, such as the cells that make up the hair follicles, the sweat glands, or the sebaceous glands (glands in the skin that produce a substance that protects the skin and hair). (medlineplus.gov)
  • Linear epidermal nevus syndrome is a congenital neurocutaneous disorder characterized by linear epidermal nevus with significant involvement of the nervous, ophthalmologic, and/or skeletal systems. (medscape.com)
  • Epidermal growth factor receptor signalling contributes to osteoblastic stromal cell proliferation, osteoclastogenesis and disease progression in giant cell tumour of bone. (ox.ac.uk)
  • In functional studies EGF supported proliferation of GCTB stromal cells, and the addition of EGF and macrophage-colony stimulating factor promoted osteoclastogenesis. (ox.ac.uk)
  • Epidermoid cysts result from the proliferation of epidermal cells within a circumscribed space of the dermis. (medscape.com)
  • Our findings reveal ErbB activation as a strong inductive signal for stem-cell proliferation. (nature.com)
  • Increased HER2 degradation by HApt-AuNS triggered cell death and cell cycle arrest in the G0/G1 phase inhibition of cell proliferation. (northwestern.edu)
  • Finally, to distinguish between the proliferation of small numbers of mature peripheral T cells and that of Thy-1 + dEC, antibody and complement-depletion studies were conducted with an unusual monoclonal anti-Thy-1 reagent, 20-10-5S, and with the anti-T cell reagents, anti-L3T4 and anti-Lyt-2. (elsevierpure.com)
  • Both hypoxia and EGF induced proliferation of pTr cells. (korea.ac.kr)
  • These cells have such a long cellular proliferation and are most likely the ones that store tritiated thymidine and highly radioactive labelled malignancies for extended periods of time. (mygradespot.com)
  • In these cases, the affected individual has a condition called an epidermal nevus syndrome. (medlineplus.gov)
  • hence, this condition is considered to be an epidermal nevus syndrome (ENS). (medscape.com)
  • Solomon defines epidermal nevus syndrome as a sporadic neurocutaneous linkage of congenital ectodermal defects in the skin, brain, eyes, and/or skeleton. (medscape.com)
  • Epidermal nevus syndrome is often termed the Solomon syndrome. (medscape.com)
  • Mutations of this gene have been associated with basal cell nevus syndrome and holoprosencephaly. (nih.gov)
  • Mutations of PTCH1 gene in two pedigrees with bifid rib-basal cell nevus-jaw cyst syndrome. (nih.gov)
  • Stevens-Johnson syndrome and toxic epidermal necrolysis are two forms of the same life-threatening skin disorder that cause rash, skin peeling, and sores on the mucous membranes. (msdmanuals.com)
  • Stevens-Johnson syndrome and toxic epidermal necrolysis are commonly caused by drugs or infections. (msdmanuals.com)
  • Involvement of 15 to 30% of body surface area is considered overlap of Stevens-Johnson syndrome and toxic epidermal necrolysis. (msdmanuals.com)
  • Stevens-Johnson syndrome and toxic epidermal necrolysis usually begin with fever, headache, cough, keratoconjunctivitis (inflammation of the conjunctiva and the cornea in the eyes), and body aches. (msdmanuals.com)
  • A clinical entity called epidermal nevus syndrome should be more precisely defined and distinguished by clinical, histopathologic, and genetic criteria. (medscape.com)
  • Addition of epidermal growth factor (EGF) to the cells induces further phosphorylation of this protein. (rupress.org)
  • Tracy reported that as a major epithelial alarmin released from lung epithelial cells, IL-1α induces the excretion of inflammatory mediators in fibroblasts during photodynamic therapy [ 14 ]. (aging-us.com)
  • Intradermal transgenic expression of granulocyte-macrophage colony-stimulating factor induces neutrophilia, epidermal hyperplasia, Langerhans' cell/macrophage accumulation, and dermal fibrosis. (mcmaster.ca)
  • Purpose of the study: Workers in enclosed hogbarns experience an increased incidence of airway inflammation and obstructive lung disease, and an aqueous hogbarn dust extract (HDE) induces multiple inflammation-related responses in cultured airway epithelial cells. (cdc.gov)
  • Epidermal nevi are typically seen at birth or develop in early childhood. (medlineplus.gov)
  • One group of epidermal nevi, called keratinocytic or nonorganoid epidermal nevi, includes nevi that involve only keratinocytes. (medlineplus.gov)
  • Keratinocytic epidermal nevi are typically found on the torso or limbs. (medlineplus.gov)
  • Often, keratinocytic epidermal nevi follow a pattern on the skin known as the lines of Blaschko. (medlineplus.gov)
  • These nevi comprise a group called organoid epidermal nevi. (medlineplus.gov)
  • Similar to keratinocytic epidermal nevi, nevi sebaceous can become thicker and more verrucous over time. (medlineplus.gov)
  • Epidermal nevi are estimated to occur in 1 to 3 in 1,000 people. (medlineplus.gov)
  • Mutations in the FGFR3 gene and PIK3CA gene account for about forty percent of keratinocytic epidermal nevi. (medlineplus.gov)
  • Mutations in the HRAS gene are found in a majority of people with a nevus sebaceous and are also associated with keratinocytic epidermal nevi. (medlineplus.gov)
  • Genes related to HRAS (called KRAS and NRAS ) are less commonly involved in nevi sebaceous or keratinocytic epidermal nevi. (medlineplus.gov)
  • Other genes, some of which have not been identified, are also involved in epidermal nevi. (medlineplus.gov)
  • This uncontrolled cell division results in overgrowth of skin cells, leading to epidermal nevi. (medlineplus.gov)
  • The term organoid nevus may be used to emphasize the admixture of epidermal cells often evident in individual lesions of epidermal nevi. (medscape.com)
  • Epidermal nevi are patches, plaques, or nodules that may be bilateral or distributed on most of the body. (medscape.com)
  • As with other epidermal nevi, the most common sites are the face, the trunk, and proximal extremities. (medscape.com)
  • In this review, 4 distinct epidermal nevus syndromes, recognizable by the different types of associated epithelial nevi, are described. (medscape.com)
  • Six different syndromes with epidermal nevi as part of them have been delineated. (medscape.com)
  • The principle of preferentially selecting patients most likely to benefit from therapy according to their genetic profile has led to substantial clinical benefit in some tumour types, and has potential to considerably refine treatment in advanced nonsmall cell lung cancer (NSCLC). (ersjournals.com)
  • The clinical correlations with its expression were studied in 77 non-small cell lung cancers (NSCLC). (ox.ac.uk)
  • In this study, we established a NSCLC cell line with concurrent RB1/TP53 mutations and built corresponding patient -derived xenograft (PDX) models to investigate the mechanisms underlying transformation to SCLC. (bvsalud.org)
  • Non-small cell lung cancer (NSCLC) comprises approximately 85% of all lung cancer cases, of which more than 70% are initially diagnosed with unresectable advanced disease [2,3]. (docksci.com)
  • Culture of fluorescence-activated cell sorter (FACS)-separated EC suspensions revealed that Thy-1-depleted EC and irradiated Thy-1 + EC failed to proliferate in response to Con A and IL 2, whereas unirradiated purified Thy-1 + EC gave enhanced Con A- and IL 2-induced responses compared with the unseparated population. (elsevierpure.com)
  • These results suggest strongly that Thy-1 + dEC, which do not have a mature peripheral T cell phenytype, can proliferate in response to Con A and to IL 2. (elsevierpure.com)
  • The results of the present study suggest that pTr cells adapt to oxygen deficiency and proliferate in response to an oxygen-dependent HIF-1 system, and that EGF at maternal-conceptus interface can increase the abundance of HIF-1α protein via translational regulation through AKT, ERK1/2 and mTOR signaling cascades. (korea.ac.kr)
  • Previously, we showed that exosomes derived from human adipose tissue-derived mesenchymal stem cells (ASC-exosomes) attenuate AD-like symptoms by reducing multiple inflammatory cytokine levels. (mdpi.com)
  • Fibrotic livers are characterized by an inflammatory microenvironment that is composed of various immunologically active cells, including liver-resident populations (e.g. (mdpi.com)
  • Epidermal growth factor receptor in non-small-cell lung carcinomas: correlation between gene copy number and protein expression and impact on prognosis. (nih.gov)
  • High gene copy numbers per cell showed a trend toward poor prognosis. (nih.gov)
  • In our investigated panel, only one mutation in the K-RAS gene of a tonsil squamous cell carcinoma was identified. (biomedcentral.com)
  • Amplification of the human epidermal growth factor receptor 2 ( HER2 ) gene and overexpression of the HER2 protein is found in 15%-20% of patients with gastric and gastroesophageal junction cancer. (wjgnet.com)
  • Quantitative real-time polymerase string reaction demonstrated that epidermal gene appearance of brain produced neurotrophic aspect was unchanged but nerve development aspect and glial cell line-derived neurotrophic aspect mRNAs were decreased. (scienceexhibitions.org)
  • 2.1 Langerhan cell depletion Lang-DTR mice (Lang-DTREGFP a sort present from Dr. Bernard Malissen Center d'Immunologie de Marseille Luminy) are C57BL/6 mice genetically constructed expressing the individual diphtheria toxin receptor (DTR) fused to improved green fluorescent proteins under control from the langerin gene [11]. (scienceexhibitions.org)
  • abstract = "This paper describes how gold nanoparticle nanoconstructs can enhance anticancer effects of lysosomal targeting aptamers in breast cancer cells. (northwestern.edu)
  • In the acute laminitis group, there were 17 and 1,025 times as many TUNEL-positive basal layer cells and keratinocytes, respectively, compared with the control group. (avma.org)
  • Keratinocytes the predominant epidermal cell type are recognized to generate neurotrophic elements (NTFs) [21 23 33 Nevertheless melanocytes also synthesize neurotrophic protein [20]. (scienceexhibitions.org)
  • Therefore cells furthermore to keratinocytes may be important in regulating epidermal innervation. (scienceexhibitions.org)
  • In a series of epidermoid cysts with carcinoma, immunohistochemical results for HPV were negative, suggesting that HPV is not likely to play a role in the development in squamous cell carcinoma (SCC) in epidermoid cysts. (medscape.com)
  • Keywords: Dendritic cells Neural-immune connections Sensory axons Neurotrophic elements Behavioral examining 1 Launch Intraepidermal nerve fibres (IENFs) represent terminations of dorsal main ganglion sensory axons [17]. (scienceexhibitions.org)
  • The majority of the dendritic cells that existed in the LN of dermatopathic lymphadenopathy were positive for OKT-6 (CD 1a) antibody. (fujita-hu.ac.jp)
  • It was concluded that these dendritic cells were not IDC, but LC. (fujita-hu.ac.jp)
  • In order to prove the fact that these dendritic cells were LC, the existence of BG was investigated ultrastructurally by examining aerial sections, and immunoelectron microscopically for CD 1a positive cells. (fujita-hu.ac.jp)
  • Incidence of Adverse Cutaneous Reactions to Epidermal Growth Factor Receptor Inhibitors in Patients with Non-Small-Cell Lung Cancer. (iasp-pain.org)
  • Overcoming acquired resistance of epidermal growth factor receptor-mutant non-small-cell lung cancer cells to osimertinib by combining osimertinib with the histone deacetylase inhibitor panobinostat (LBH589). (physiciansweekly.com)
  • Herein, we sought to determine if rapamycin, an inhibitor of mTOR, could enhance erlotinib sensitivity for cell lines derived from a variety of tissue types (non-small-cell lung, pancreatic, colon, and breast). (aacrjournals.org)
  • Epidermal growth factor receptors in non-small cell lung cancer. (ox.ac.uk)
  • These results suggest that the presence of a high intensity of staining for EGF receptor is associated with spread of human non-small cell lung cancer and this receptor may be a suitable target for therapy. (ox.ac.uk)
  • Lung Cancer Cells Survive Epidermal Growth Factor Receptor Tyrosine Ki" by Mark C. Howell, Ryan Green et al. (usf.edu)
  • Epidermal growth factor receptor regulates lineage plasticity driving transformation to small cell lung cancer. (bvsalud.org)
  • HYPOTHESIS: Do LRIG Proteins Regulate Stem Cell Quiescence by Promoting BMP Signaling? (nature.com)
  • In order to relay signals, the proteins must be turned on (activated), which triggers a cascade of chemical reactions inside the cell that control growth and other cellular functions. (medlineplus.gov)
  • As the principal citizen epidermal antigen-presenting cell they catch and translocate international antigens to lymph node T cells hence taking part in innate and adaptive immune system replies [2 4 LCs are distinguishable from various other cutaneous and neural cells by their appearance of langerin a proteins involved with ligand internalization and antigen display [36]. (scienceexhibitions.org)
  • Cells depend on their DNA for coding information to make various classes of proteins that include enzymes, certain hormones, transport proteins, and structural proteins that support life. (cdc.gov)
  • Specialized cell structures called ribosomes are the cellular organelles that actually synthesize the proteins (RNA transcription). (cdc.gov)
  • Different experimental strategies and approaches to obtain mature hair follicles have been designed based upon current knowledge of the epithelial and dermal cells involved in embryonic hair generation and adult hair cycling, and in the epithelial-mesenchymal interactions among them. (wjgnet.com)
  • They may result from the sequestration of epidermal rests during embryonic life, occlusion of the pilosebaceous unit, or traumatic or surgical implantation of epithelial elements. (medscape.com)
  • Congenital epidermoid cysts of the anterior fontanelle or those that are orogenital in location presumably result from sequestration or trapping of epidermal rests along embryonic fusion planes during development. (medscape.com)
  • Biphasic changes in airway epithelial cell EGF receptor binding and phosphorylation induced by components of hogbarn dust. (cdc.gov)
  • Nanoconstructs consisting of anti-HER2 aptamer (human epidermal growth factor receptor 2, HApt) densely grafted on gold nanostars (AuNS) first targeted HER2 and then were internalized via HER2-mediated endocytosis. (northwestern.edu)
  • At specific time points related to the doubling time of the cancer cells, we found that accumulation of HER2-HApt-AuNS complexes in lysosomes, lysosomal activity, and lysosomal degradation of HER2 were positively correlated. (northwestern.edu)
  • One is a protein called human epidermal growth factor ( HER2 ). (cdc.gov)
  • Mutations associated with an epidermal nevus are present only in the cells of the nevus, not in the normal skin cells surrounding it. (medlineplus.gov)
  • This condition is generally not inherited but arises from mutations in the body's cells that occur after conception. (medlineplus.gov)
  • Knockdown of HIF-1α by RNA disturbance (RNAi) incredibly sensitized tumor cells with oncogenic mutations or people that have inactivation or deletion to cetuximab treatment [16]. (researchtoactionforum.org)
  • Because stem cells live for far longer than conventional cells, they are more likely to collect genetic mutations. (mygradespot.com)
  • It may only take a few mutations for a cell to lose power of its self-renewal and development, allowing it to become a cancerous source. (mygradespot.com)
  • We have derived a line of A431 human tumor cells infected with Rous sarcoma virus (RSV). (rupress.org)
  • When tumor cells convert into a different histological subtype, they lose their dependence on the original oncogenic driver, resulting in therapeutic resistance. (bvsalud.org)
  • ALCL was recognized in 1985, when tumor cells consistently demonstrated labeling by the monoclonal antibody Ki-1, a marker later shown to recognize the CD30 antigen. (medscape.com)
  • Epithelial stem cells in adult mammalian skin are known to maintain epidermal, follicular and sebaceous lineages during homeostasis. (biologists.com)
  • MSCs have the capacity of multiple differentiations and self-renewal and have been proven to be able to differentiate into a series of cell lineages, such as adipocytes, osteoblasts, chondroblasts, and hepatocyte-like cells (HLCs). (springer.com)
  • their evolution from distinct cell lineages. (lu.se)
  • We characterized a Thalictrum ortholog of the Antirrhinum majus transcription factor MIXTA-like2, responsible for conical cells, from three species with distinct floral morphologies, representing two pollination syndromes. (washington.edu)
  • There are several different epidermal nevus syndromes characterized by the type of epidermal nevus involved. (medlineplus.gov)
  • Historically, epidermoid cysts have been referred to by various terms, including follicular infundibular cysts, epidermal cysts, and epidermal inclusion cysts. (medscape.com)
  • Formalin‑fixed paraffin embedded tissue samples were used for the mutation analysis and the content of the neoplastic cells was evaluated using light microscopy. (spandidos-publications.com)
  • Conclusions and Clinical Relevance -The large number of apoptotic basal layer cells detected in the lamellar tissue of horses with acute naturally acquired laminitis suggests that apoptosis may be important in the development of acute laminitis. (avma.org)
  • The aims of this article are to review the current knowledge regarding therapeutic mechanisms of mesenchymal stem cells in acute liver failure, to discuss recent advancements in preclinical and clinical studies in the treatment of mesenchymal stem cells, and to summarize the methodological improvement of mesenchymal stem cell transplantation in treating liver failure. (springer.com)
  • The infected cells contain the RSV-transforming protein, pp60src, which has characteristic tyrosine specific protein kinase activity. (rupress.org)
  • Conical cells are found on roughly 80% of angiosperms (Kay et al. (ku.edu)
  • However, conical cells are thought to be absent mostly in hummingbird pollinated flowers, though no studies have looked at this in depth (Christensen and Hansen, 1998). (ku.edu)
  • Conical cells are present in sepals or stamens of insect-pollinated species, and in stigmas. (washington.edu)
  • Spatial expression by in situ hybridization overlaps areas of conical cells. (washington.edu)
  • The conserved role in epidermal cell elongation results in conical cells, micromorphological markers for petaloidy. (washington.edu)
  • Atopic dermatitis (AD) is a multifactorial, heterogeneous disease associated with epidermal barrier disruption and intense systemic inflammation. (mdpi.com)
  • Reports suggest that systemic immune responses may be affected by how MN arrays "mechanically" deliver vaccines, which can induce cell damage and act as an adjuvant. (lu.se)
  • Do epidermal Langerhans cells, migrating from skin lesions, induce the paracortical hyperplasia of dermatopathic lymphadenopathy? (fujita-hu.ac.jp)
  • This finding may mean that LC In the LN are fully developed cells and do not divide In the LN. Langerhans cells may migrate from the skin lesions to the paracortical areas in the LN, which then may become enlarged. (fujita-hu.ac.jp)
  • Dive into the research topics of 'Do epidermal Langerhans cells, migrating from skin lesions, induce the paracortical hyperplasia of dermatopathic lymphadenopathy? (fujita-hu.ac.jp)
  • Since the number of organisms per infected LC remained consistently low, the prime task of LC may not be the promotion of parasite spreading but the presentation of L. major antigen to T cells and, thus, the regulation of the cellular immunity during cutaneous leishmaniasis. (uni-wuerzburg.de)
  • Mouse epidermal cells (EC) are composed of at least two phenotypically discrete populations of cells that in epidermal sheets have a dendritic morphology: Ia + Langerhans cells (LC) and dendritic, bone marrow-derived, Ia - cells that express Thy-1 antigen (Thy-1 + dEC). (elsevierpure.com)
  • Anaplastic large cell lymphomas (ALCLs) are distinguished from other lymphomas by their anaplastic cytology and constant membrane expression of the CD30 antigen (an activation marker for B or T cells). (medscape.com)
  • Here we show that exposure of the skin to the experimental contact allergen 1-fluoro-2,4-dinitrobenzene (DNFB) results in a displacement of the normally occurring dendritic epidermal T cells (DETC) concomitant with an accumulation of epidermal CD8+CD69+CD103+ TRM cells in mice. (ku.dk)
  • Some affected individuals have only an epidermal nevus and no other abnormalities. (medlineplus.gov)
  • Clinically relevant improvements in survival have been attained by administering targeted therapy to the appropriate patient population: for example, the addition of trastuzumab to standard first-line chemotherapy in patients with human epidermal growth factor receptor-positive (HER2+) metastatic breast cancer 3 . (ersjournals.com)
  • Increased phosphorylation of the EGF receptor protein and of an 81,000-dalton cellular protein is dependent upon addition of EGF to the culture fluids, in both control and RSV-infected A431 cells. (rupress.org)
  • Importance of epidermal growth factor receptor signaling in establishment of adenomas and maintenance of carcinomas during intestinal tumorigenesis. (nature.com)
  • MR1 is specific for the novel fusion junction of the mutant epidermal growth factor receptor EGFRvIII and has been reported to have a high degree of specificity for the mutant EGFRvIII over the wild-type EGF receptor. (rcsb.org)
  • The epidermal growth factor receptor is homologous to the oncogene erb-beta and is the receptor for a class of tumour growth factors (TGF-alpha). (ox.ac.uk)
  • BT-474 cells, obtained expression of the receptor has important implications for their biology from American Type Culture Collection, were maintained in RPMI 1640 and therapy (1). (lu.se)
  • When the genetic information containing the "blueprint" for these substances is disrupted, cell homeostasis is disrupted, resulting in a wide-range of immediate and/or delayed toxicological effects. (cdc.gov)
  • However, the composition and dynamics of the epidermal T cell subsets during ACD are not known. (ku.dk)
  • Murine epidermal Langerhans cells (LC) have been demonstrated to stimulate a vigorous T cell response to Leishmania major, a cause of human cutaneous leishmaniasis. (uni-wuerzburg.de)
  • Jensen, K. B. & Watt, F. M. Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a regulator of stem cell quiescence. (nature.com)
  • The human body has nearly 1013 cells. (cdc.gov)
  • Human Immunodeficiency Virus (HIV) Infection Human immunodeficiency virus (HIV) infection is a viral infection that progressively destroys certain white blood cells and is treated with antiretroviral medications. (msdmanuals.com)
  • Jia Y , Chen X , Sun J , . Apremilast ameliorates IL-1α-induced dysfunction in epidermal stem cells. (aging-us.com)
  • Background and purpose: Skin tissue is the natural barrier that protects our body, the damage of which can be repaired by the epidermal stem cells (ESCs). (aging-us.com)
  • In the present study, the protective property of Apremilast against IL-1α-induced dysfunction on epidermal stem cells, as well as the preliminary mechanism, will be investigated. (aging-us.com)
  • In addition, as the specific stem cells for wound repairing, ESCs play a vital role in the repairing and rebuilding of skin and its accessory organs [ 4 , 5 ]. (aging-us.com)
  • Morrison, S. J. & Spradling, A. C. Stem cells and niches: mechanisms that promote stem cell maintenance throughout life. (nature.com)
  • Li, L. & Clevers, H. Coexistence of quiescent and active adult stem cells in mammals. (nature.com)
  • Voog, J. & Jones, D. L. Stem cells and the niche: a dynamic duo. (nature.com)
  • Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts. (nature.com)
  • In recent years, a growing number of studies have shown that stem cells can effectively treat acute liver failure. (springer.com)
  • mesenchymal stem cells are most commonly used because they are easy to obtain and present no ethical problems. (springer.com)
  • SOLVED) relationship between epidermal stem cells and skin carcinogenesis, Identify the major concepts associated with your subject. (mygradespot.com)
  • The origin of the stem cells can be determined using cell topographical within the highly polarised surface epithelia. (mygradespot.com)
  • This can be fairly accurate in some cases, allowing researchers to study the features of stem cells. (mygradespot.com)
  • Each crypt includes from 4 and 16 steady - state condition functional stem cells, according to complex simulation of a variety of cell kinetic tests. (mygradespot.com)
  • The relationship between epidermal stem cells and skin carcinogenesis. (mygradespot.com)
  • As ErbB-family ligands and receptors are highly expressed within the stem-cell niche 7 , we hypothesize that strong endogenous regulators must control the pathway in the stem-cell compartment. (nature.com)
  • If your cancer tests positive for these three locks, which are known as receptors, then doctors have a few keys they can use to get inside the cell to destroy it. (cdc.gov)
  • Kupffer cells, hepatic stellate cells and sinusoidal endothelium) and infiltrating leukocytes (e.g., monocytes, monocyte-derived macrophages, neutrophils and lymphocytes). (mdpi.com)
  • The term epidermal inclusion cyst refers specifically to an epidermoid cyst that is the result of the implantation of epidermal elements in the dermis. (medscape.com)
  • Erlotinib could inhibit extracellular signal-regulated kinase, Akt, and S6 only in cell lines that were the most sensitive. (aacrjournals.org)
  • Therefore, in select cell lines, inhibition of both S6 and Akt was achieved only with the combination of erlotinib and rapamycin. (aacrjournals.org)
  • Rapamycin could fully inhibit S6 in all cell lines, but this was accompanied by activation of Akt phosphorylation. (aacrjournals.org)
  • The impact of the type and quantity of malignant cells of the neoplastic specimen on the quality of mutation analysis remains to be elucidated, and only empirical and sporadic data are available. (spandidos-publications.com)
  • Studies suggest that cells with a mutation in one of these genes grow and divide more than normal cells. (medlineplus.gov)
  • Because the mutation is found in some of the body's cells but not in others, people with an epidermal nevus are said to be mosaic for the mutation. (medlineplus.gov)
  • Toxic epidermal necrolysis causes large areas of peeling skin (affecting over 30% of the body). (msdmanuals.com)
  • Signaling mechanisms of heparin-binding epidermal growth factor-like growth factor in vascular smooth muscle cells. (meharryresearch.org)
  • In this study, the mechanisms underlying low oxygen-dependent and epidermal growth factor (EGF)-dependent expression of HIF-1α were explored using porcine trophectoderm (pTr) cells. (korea.ac.kr)
  • furthermore, in CBA (Thy-1.2) mice 20-10-5S reacts with Thy-1 + dEC, thymocytes, and peripheral T cells, whereas in AKR/J (Thy-1.1) mice, it reacts only with Thy-1 + dEC and thymocytes and not with peripheral T cells. (elsevierpure.com)
  • Histologically, ALCL is characterized by sheets of large pleomorphic cells with abundant cytoplasm, horseshoe- or wreath-shaped nuclei, and multiple prominent nucleoli. (medscape.com)
  • We demonstrate that the magnitude of the allergic reaction correlates with the number of CD8+ epidermal TRM cells that again correlates with allergen dose and number of allergen exposures. (ku.dk)
  • It also significantly improves vascular smooth muscle cell (VSMC) survival and resistance to apoptosis in serum‐free conditions. (etsmtl.ca)
  • In this context, the different staining patterns observed in epidermal mucous cells hinted at their functional roles with respect to production of mucus with different physical properties. (hindawi.com)