• Whereas the expression of syndecan-4 and glypican in intact skin was mostly in the pericellular regions of keratinocytes, the epidermal cells from the wound edge contained mostly intracellular PGs. (lu.se)
  • Psoriasis lesions are characterized by hyper-proliferation of epidermal keratinocytes associated with inflammatory cellular infiltrate in both dermis and epidermis. (springer.com)
  • Histologically, the dermatosis is characterized by hyperproliferation of keratinocytes, impaired epidermal barrier function at the sites of skin lesions, and skin infiltration by activated inflammatory cells [ 5 ]. (springer.com)
  • Successive stages of differentiation of the keratinocytes forming the epidermal layers are basal cell , spinous or prickle cell, and the granular cell. (online-medical-dictionary.org)
  • The expression of CD95R was present although restricted to the basal keratinocytes, while the L1-protein (Mac 387+) was diffusely present in the epidermis. (spandidos-publications.com)
  • The typical histopathologic pattern of skin lesions is named interface dermatitis and characterized by a lymphocytic infiltrate and necroptotic keratinocytes at the dermo-epidermal junction. (frontiersin.org)
  • Lupus erythematosus (LE) skin lesions typically feature a histopathologic pattern termed interface dermatitis, defined by the presence of necroptotic keratinocytes and an epitheliotropic cytotoxic lymphocytic infiltrate at the dermo-epidermal junction ( 7 , 8 ). (frontiersin.org)
  • 2 Although the basal cell keratinocytes are filled with melanin, there is no increase in the number of melanocytes present. (contemporarypediatrics.com)
  • Progenitors of keratinocytes reside and divide in the basal layer of the epidermis. (3hbiomedical.com)
  • Basal cell carcinomas arise from keratinocytes near the basal layer, which are sometimes called basaloid keratinocytes. (msdmanuals.com)
  • Waltz KM, Helm KF, Billingsley EM: The spectrum of epidermal nevi: a case of verrucous epidermal nevus contiguous with nevus sebaceus. (karger.com)
  • Usually, no symptoms of the nevi are present, with the exception of inflammatory linear verrucous epidermal nevus. (medscape.com)
  • Inflammatory linear verrucous epidermal nevus is a linear, persistent, pruritic plaque, usually first noted on a limb in early childhood. (medscape.com)
  • Inflammatory linear verrucous epidermal nevus, unlike the other types of epidermal nevi, demonstrates erythema and sometimes pruritus. (medscape.com)
  • Inflammatory linear verrucous epidermal nevus is characterized by tiny, discrete, erythematous, slightly warty papules, which tend to coalesce in a linear formation. (medscape.com)
  • Inflammatory linear verrucous epidermal nevus may occur with musculoskeletal abnormalities in a few children, prompting the classification of inflammatory linear verrucous epidermal nevus as part of epidermal nevus syndrome. (medscape.com)
  • One infant had inflammatory linear verrucous epidermal nevus with congenital dislocation of the ipsilateral hip and Fallot tetralogy of the heart. (medscape.com)
  • Another infant had congenital inflammatory linear verrucous epidermal nevus with congenital bony anomalies of the ipsilateral extremities. (medscape.com)
  • Nevus depigmentosus and inflammatory linear verrucous epidermal nevus may occur together, as may inflammatory linear verrucous epidermal nevus and melanodontia. (medscape.com)
  • Histologic examination of inflammatory linear verrucous epidermal nevus reveals a similar psoriasiform hyperplasia of the epidermis, alternating parakeratosis without a granular layer, and orthokeratosis with a thickened granular layer. (medscape.com)
  • These include linear sebaceous nevus, linear nevus comedonicus (NC), linear epidermal nevus (LEN), and inflammatory linear verrucous epidermal nevus (ILVEN). (medscape.com)
  • [ 3 ] delineated inflammatory linear verrucous epidermal nevus as a distinct entity in 25 patients. (medscape.com)
  • They coined the name inflammatory linear verrucous epidermal nevus, labeling it a clinical and histopathologic type of linear verrucous nevus that is often inflammatory or psoriasiform. (medscape.com)
  • Inflammatory linear verrucous epidermal nevus accounts for approximately 5% of patients with epidermal nevi and has been described in a mother and daughter. (medscape.com)
  • In order to reduce morbidity associated with STSG harvesting, researchers have developed autologous dermo-epidermal substitutes (DESs) using cell culture, tissue engineering, and, more recently, bioprinting approaches. (frontiersin.org)
  • Dermo-epidermal cleavage, fibrosis and inflammation are the main histological findings. (cdlib.org)
  • Hyperkeratosis, epidermal atrophy, vacuolization of basal cells, dermal edema and sclerosis, perivascular lymphohistiocytic infiltrate, multifocal vesiculation and dermo-epidermal fends are seen in the scleroderma skin. (cdlib.org)
  • Histologic examination of the four types of epidermal nevi is variable. (medscape.com)
  • Historically, epidermoid cysts have been referred to by various terms, including follicular infundibular cysts, epidermal cysts, and epidermal inclusion cysts. (medscape.com)
  • Epithelial stem cells in adult mammalian skin are known to maintain epidermal, follicular and sebaceous lineages during homeostasis. (biologists.com)
  • One series of 155 cases of linear sebaceous nevus with clinicopathologic correlation could not identify any cases of authentic basal cell carcinoma or other malignancies, whereas several examples of primitive follicular induction and trichoblastomas were evident. (medscape.com)
  • Typically, the histologic examination of linear epidermal nevus reveals marked hyperkeratosis, papillomatosis, and acanthosis with rete ridge elongation in a psoriasiform pattern. (medscape.com)
  • Nervous system changes may also occur in patients with linear epidermal nevus syndrome. (medscape.com)
  • Linear epidermal nevus syndrome is a congenital neurocutaneous disorder characterized by linear epidermal nevus with significant involvement of the nervous, ophthalmologic, and/or skeletal systems. (medscape.com)
  • Jensen, K. B. & Watt, F. M. Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a regulator of stem cell quiescence. (nature.com)
  • Epidermoid cysts result from the proliferation of epidermal cells within a circumscribed space of the dermis. (medscape.com)
  • Using single-cell RNA sequencing coupled with RNAScope and fluorescence lifetime imaging, the team identified three non-proliferative and one proliferative basal cell state in homeostatic skin that differ in metabolic preference and become spatially partitioned during wound re-epithelialization, which is the process by which the skin and mucous membranes replace superficial epithelial cells damaged or lost in a wound. (sciencedaily.com)
  • Manifest illness stage (days to weeks postexposure)--The basal layer is repopulated through proliferation of surviving clonogenic cells. (cdc.gov)
  • When the epidermal turnover time is decreased, eliminated cells become noticeable and sloughed cells are observed and become obvious. (vin.com)
  • In the wound edge, syndecan-4 was predominantly expressed by epidermal basal layer cells. (lu.se)
  • The term organoid nevus may be used to emphasize the admixture of epidermal cells often evident in individual lesions of epidermal nevi. (medscape.com)
  • The stem cells within the basal layer, which contact the basement membrane, continually divide during the lifetime of the organism, providing a source of cells which progressively migrate upwards through the epidermis, differentiating and stratifying to form the barrier layer of the skin [ 11 , 14 ]. (springer.com)
  • Quantitative expression analysis of selected transcription factors in pavement, basal and trichome cells of mature leaves from Arabidopsis thaliana. (mpg.de)
  • Gene expression profiling of single epidermal, basal and trichome cells of Arabidopsis thaliana. (mpg.de)
  • Here, we have identified a previously undescribed population of epidermal progenitors that reside in the touch domes of hairy skin, termed touch dome progenitor cells (TDPCs). (biologists.com)
  • TDPCs exhibit bipotent progenitor behavior as they give rise to both squamous and neuroendocrine epidermal lineages, whereas the remainder of the α6 + Sca1 + CD200 - epidermis does not give rise to Merkel cells. (biologists.com)
  • Expression of Notch1 , Jagged1 , and Hes1 was found predominantly in the basal and immediate suprabasal cells. (molvis.org)
  • During neonatal corneal development, NotchIC was detected in occasional cells at P10 while at P15 and P90, it was found in the basal and early suprabasal layers. (molvis.org)
  • Epidermal cells which synthesize keratin and undergo characteristic changes as they move upward from the basal layers of the epidermis to the cornified (horny) layer of the skin . (online-medical-dictionary.org)
  • This maturation process is analogous to that of the basal epidermal cells that lead to the formation of the "dead" stratum corneum. (cosmeticsdesign.com)
  • In the last decade, trichoimmunology has expanded to include the study of immune-mediated capillary regeneration through direct manipulation of HFSCs and differentiation of dermal and epidermal wound cells. (cosmeticsdesign.com)
  • This finding entails that TEN treatments should target the keratinocyte metabolism rather than the circulating inflammatory cells which presumably play a limited role, if any, in the epidermal destructive process. (spandidos-publications.com)
  • Histological examination of leaf explants showed that the shoots were of sub-epidermal origin, confined to the sub-epidermal cells above the vascular traces. (ejbiotechnology.info)
  • Time-lapse analysis reveals (E, F) that there is no change in the shapes of wild-type epidermal cells (E). However, in pen/lgl2 mutants (F) the shape of epidermal cells dramatically changes over time, indicating their metastable cell fate. (zfin.org)
  • As epidermal basal cells flatten and develop lamellipodia like cell protrusions in pen/lgl2 , the cell area in apical view is increased in these larvae (G). However, average area of epidermal basal cells in these mutants is highly variable compared to wild types. (zfin.org)
  • Differentiated elongate basal cells markedly few in number, often present only near costa at extreme leaf base, arranged in regular rows, moderately thick-walled with the lumen/wall ratio about 2-4: 1, to 10 µm broad, 2-4: 1, with straight and not pitted lateral walls. (berkeley.edu)
  • Costa cross-section semicircular bulging dorsally, with a single layer of guide cells and with a strong dorsal stereid band but with the ventral area composed primarily of substereidal cells, with well differentiated epidermal cells on both surfaces. (berkeley.edu)
  • Characteristic changes in the epidermal cells with peculiar vacuolization are observed. (lu.se)
  • Basal cell carcinoma is a superficial, slowly growing papule or nodule that derives from certain epidermal cells. (msdmanuals.com)
  • Epidermal nevi(EN)represent a heterogeneous group of mosaic skin lesions frequently following the lines of Blaschko. (karger.com)
  • Happle R, Rogers M: Epidermal nevi. (karger.com)
  • Hafner C, van Oers JM, Vogt T, et al: Mosaicism of activating FGFR3 mutations in human skin causes epidermal nevi. (karger.com)
  • Solomon LM, Esterly NB: Epidermal and other congenital organoid nevi. (karger.com)
  • Epidermal nevi are patches, plaques, or nodules that may be bilateral or distributed on most of the body. (medscape.com)
  • As with other epidermal nevi, the most common sites are the face, the trunk, and proximal extremities. (medscape.com)
  • In this review, 4 distinct epidermal nevus syndromes, recognizable by the different types of associated epithelial nevi, are described. (medscape.com)
  • Six different syndromes with epidermal nevi as part of them have been delineated. (medscape.com)
  • Secondly, it consists of mainly one single cell type, the keratinocyte, which moves progressively from attachment to the epidermal basement membrane towards the skin surface. (uni-hamburg.de)
  • Thus, the long, C-terminal collagenous domain of this basal keratinocyte protein projects into the basal lamina and may function as a site of interaction with an extracellular matrix component. (unboundmedicine.com)
  • Mall V, Heinen F, Uhl M, Wellens E, Korinthenberg R. CNS lipoma in patients with epidermal nevus syndrome. (medscape.com)
  • Solomon LM, Fretzin DF, Dewald RL: The epidermal nevus syndrome. (karger.com)
  • Hodge JA, Ray MC, Flynn KJ: The epidermal nevus syndrome. (karger.com)
  • hence, this condition is considered to be an epidermal nevus syndrome (ENS). (medscape.com)
  • Solomon defines epidermal nevus syndrome as a sporadic neurocutaneous linkage of congenital ectodermal defects in the skin, brain, eyes, and/or skeleton. (medscape.com)
  • Epidermal nevus syndrome is often termed the Solomon syndrome. (medscape.com)
  • A clinical entity called epidermal nevus syndrome should be more precisely defined and distinguished by clinical, histopathologic, and genetic criteria. (medscape.com)
  • Basal cell nevus syndrome (Gorlin syndrome) is an autosomal dominant disorder that results in multiple basal cell carcinomas as well as in medulloblastomas, meningiomas, breast cancers, non-Hodgkin lymphomas, and ovarian cancers. (msdmanuals.com)
  • Bazex syndrome is a rare genodermatosis that can result in the early onset of multiple basal cell carcinomas. (msdmanuals.com)
  • The epidermis has a lower, basal part with dermal infoldings, termed rete-ridges. (uni-hamburg.de)
  • The epidermis is composed of four layers: basal layer (stratum basale), spinous layer (stratum spinosum), stratum granulosum and stratum corneum. (springer.com)
  • Whereas patients with MF had hyperconvoluted cerebriform lymphocytes aligned in the epidermal basal layer at the dermoepidermal junction, the 11 with LR had similar-looking lesions dispersed throughout the upper epidermis. (medscape.com)
  • It can be challenging to distinguish between a squamous cell carcinoma and a basal cell carcinoma, as the two can look similar under the microscope. (trustedhealthproducts.com)
  • Squamous cell carcinoma can be a more serious type of cancer than basal cell carcinoma and generally needs appropriate skin cancer treatments . (trustedhealthproducts.com)
  • Basal cell carcinoma, squamous cell carcinoma, or keratoacanthoma are most common in adulthood. (medscape.com)
  • Congenital epidermoid cysts of the anterior fontanelle or those that are orogenital in location presumably result from sequestration or trapping of epidermal rests along embryonic fusion planes during development. (medscape.com)
  • Happle R: Epidermal nevus syndromes. (karger.com)
  • Basal cell carcinomas are also associated with genetic syndromes and may arise in a nevus sebaceous. (msdmanuals.com)
  • Malignant degeneration, usually of the superficial basal cell type, is frequent. (lu.se)
  • Nodular and superficial basal cell carcinomas can produce pigment (sometimes called pigmented basal cell carcinomas). (msdmanuals.com)
  • Basal cell carcinoma manifests typically as a superficial, slowly growing papule or nodule that may ulcerate. (msdmanuals.com)
  • The clinical manifestations and biologic behavior of basal cell carcinomas are highly variable. (msdmanuals.com)
  • Nodular (about 60% of basal cell carcinomas): These types are small, shiny, firm, almost translucent to pink nodules with telangiectases, usually on the face. (msdmanuals.com)
  • MammaPrint/BluePrint subtyping classified patients into four molecular subgroups: Luminal A, Luminal B, HER2 (human epidermal growth factor receptor 2), and Basal type. (nih.gov)
  • This relationship was statistically significant in the Basal (p = 0.026, OR 0.46, 95 % CI 0.23, 0.91) and HER2 (p = 0.039, OR 0.36, 95 % CI 0.14, 0.95) subgroups. (nih.gov)
  • With the addition of trastuzumab, a monoclonal antibody targeting the human epidermal growth factor receptor-2 (HER2), improvements in overall survival have been observed among patients with advanced HER2-positive disease. (carcinogenesis.com)
  • One type of breast cancer is identified by the human epidermal growth factor receptor 2 (HER2) gene amplification. (carcinogenesis.com)
  • In this study, we aimed to determine the pattern of immunohistochemical profiles of IDC using oestrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor 2 receptor (HER2) and proliferative index (Ki-67) biomarkers in our tertiary healthcare facility in Uyo, Akwa Ibom State, Nigeria given the dearth of its data in our environment. (bvsalud.org)
  • Distinct collagen bundles parallel to basal epidermal layer. (cdc.gov)
  • Our research uncovered at least four distinct transcriptional states in the epidermal basal layer as part of a 'hierarchical-lineage' model of the epidermal homeostasis, or stable state of the skin, clarifying a long-term debate in the skin stem cell field," said Dai. (sciencedaily.com)
  • Exposure to radiation can damage the basal cell layer of the skin and result in inflammation, erythema, and dry or moist desquamation. (cdc.gov)
  • In this document, the absorbed dose refers to that dose received by at least 10 cm2 of the basal cell layer of the skin. (cdc.gov)
  • It occurs on the epidermal (outer layer) and is very similar to basal cell carcinoma in many ways. (trustedhealthproducts.com)
  • The epidermal layer of the skin provides an essential function as a protective barrier against insults from the external environment. (3hbiomedical.com)
  • The study, titled, "Defining epidermal basal cell states during skin homeostasis and wound healing using single-cell transcriptomics," was published this week in Cell Reports . (sciencedaily.com)
  • Syndecan-1 was less expressed at the epidermal wound margins. (lu.se)
  • severity progressively increased and all epidermal layers were affected. (europa.eu)
  • True epidermal inclusion cysts result from the implantation of epithelial elements in the dermis. (medscape.com)
  • Nevus Marginatus: A Distinct Type of Epidermal Nevus or Merely a Variant of Nevus Sebaceus? (karger.com)
  • In nevus comedonicus, rudimentary hair follicles are dilated to form epidermal invaginations, which are filled with keratin in concentric lamellae. (medscape.com)
  • Paller AS, Syder AJ, Chan YM, et al: Genetic and clinical mosaicism in a type of epidermal nevus. (karger.com)
  • They may result from the sequestration of epidermal rests during embryonic life, occlusion of the pilosebaceous unit, or traumatic or surgical implantation of epithelial elements. (medscape.com)
  • The work of this Junior Research Group (JRG) aims at developing a systems biological model able to predict properties of epidermal tissue in healthy and diseased state. (uni-hamburg.de)
  • The models are validated by their ability to predict epidermal morphology, tissue kinetics and molecular concentrations reported in literature. (uni-hamburg.de)
  • The extracellular calcium concentration is an important factor for central molecular processes of epidermal function. (uni-hamburg.de)
  • The molecular mechanisms involved in the pathogenesis of toxic epidermal necrolysis (TEN) remain not fully understood. (spandidos-publications.com)
  • We performed a cost-minimization analysis to compare the cost of biomarker analysis for estrogen receptor, progesterone receptor and human epidermal growth factor receptor-2 status with immunohistochemistry versus STRAT4. (bvsalud.org)
  • however, such operational efficiencies are unlikely, and more laboratories are pursuing human epidermal growth factor receptor-2 analysis as targeted therapies become increasingly available. (bvsalud.org)
  • Identification of Subtypes in Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer Reveals a Gene Signature Prognostic of Outcome. (lu.se)
  • Importance of epidermal growth factor receptor signaling in establishment of adenomas and maintenance of carcinomas during intestinal tumorigenesis. (nature.com)
  • Protein profiling of single epidermal cell types from Arabidopsis thaliana using surface-enhanced laser desorption and ionization technology. (mpg.de)