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  • lesions
  • Dermal and epidermal are pretty easy to confuse when speaking which makes me lean heavily towards this supposition but epidermal inclusion cysts do not usually contain hair and are not usually congenital lesions. (vetinfo.com)
  • A classification system, based largely on the extent of epidermal detachment and morphology of the skin lesions, aids in differentiating opposite spectrums of the same disease entity. (medscape.com)
  • epidermis
  • Epidermal nevi originate from pluripotential germinative cells in the basal layer of the embryonic epidermis. (uptodate.com)
  • During epidermal morphogenesis, the sequential and coordinated action of transcription factors ultimately results in the formation of a mature epidermis that protects the organism from dehydration and environmental insults (reviewed in ref. 1 ). (pnas.org)
  • The critical role for p63 in regulating epidermal morphogenesis is illustrated by the phenotype of p63 −/− mice, which fail to develop an epidermis, other stratified epithelia, and epithelial appendages ( 4 , 5 ). (pnas.org)
  • Whereas TAp63 isoforms function during the initial stages of epidermal morphogenesis, the role of ΔNp63 isoforms, the predominantly expressed p63 isoforms during later stages of epidermal morphogenesis ( 11 , 13 ) as well as in mature epidermis ( 3 , 14 ) has remained largely elusive. (pnas.org)
  • The mammalian epidermis is derived from embryonic ectoderm, and this layer eventually gives rise to a very early epithelial cell that further commits to become epidermal tissue ( for review see refs . (springer.com)
  • embryonic
  • ΔNp63 isoforms are predominantly expressed during late embryonic and postnatal epidermal development, however, the function of these proteins remains elusive. (pnas.org)
  • Gene
  • One gene that is critical for controlling epidermal morphogenesis is p63 , a transcription factor that can be expressed as isoforms that contain (TA) or lack (ΔN) a transactivation domain ( 3 ). (pnas.org)
  • The epidermal growth factor (EGF) family of growth factors is comprised of the normal mammalian gene products of EGF, amphiregulin, betacellulin, heparin-binding EGF (HB-EGF), and transforming growth factor-α (TGF-α), plus pox virus EGF-like protein (PVGF), lin-3 from Caenorhabditis elegans , and spitz from Drosophila. (sigmaaldrich.com)
  • integrity
  • We propose that ΔNp63α initially induces expression of the extracellular matrix component Fras1, which is required for maintaining the integrity of the epidermal-dermal interface at the basement membrane. (pnas.org)
  • role
  • However, despite the striking phenotype of p63 −/− mice, the precise role of p63 in epidermal morphogenesis is controversial. (pnas.org)
  • known
  • also known as erythema multiforme major) is a manifestation of the same process involved in TEN, with the latter involving more extensive necrotic epidermal detachment. (medscape.com)
  • provide
  • There are many sites that provide pictures of epidermal cysts such as Dermnet.com, MedicineNet.com, Skinsight.com, EverydayHealth.com and DermNetNZ.org. (reference.com)