• EphA5, also known as Ehk1, Bsk, Cek7, Hek7, and Rek7 (1), is a member of the Eph receptor family which binds members of the ephrin ligand family. (rndsystems.com)
  • Ephrin ligands and their receptors, the Eph receptor (Eph) tyrosine kinases, are cell surface molecules that mediate commu-nication between cells. (123dok.org)
  • Catalytic domain of the Protein Tyrosine Kinase, Ephrin Receptor A2. (umbc.edu)
  • This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. (creativebiomart.net)
  • Ephrin receptor A2 (EphA2) plays dual functions in tumorigenesis through ligand-independent tumor promotion or ligand-dependent tumor suppression. (bvsalud.org)
  • Merrimack has announced positive data from preclinical studies evaluating MM-310, an antibody directed nanotherapeutic (ADN) that encapsulates a newly engineered form of the highly potent chemotherapy docetaxel as a prodrug in an ephrin receptor A2 (EphA2)-targeted liposome. (drugtargetreview.com)
  • Finally, we have studied the role of nanoarchitecture of ephrin ligands in Eph receptor activation. (5dok.org)
  • Over-expression of endogenous fly Eph and RNAi-mediated knock-down of Eph and its ligand ephrin affected sleep architecture and neurophysiology. (sdbonline.org)
  • Binding of the ephrin ligand to EphR requires cell-cell contact since both are anchored to the plasma membrane. (umbc.edu)
  • Eph binds to respective ephrin ligand, through the ligand binding domain and forms a tetrameric complex to activate the kinase domain. (genominfo.org)
  • Unified nomenclature for Eph family receptors and their ligands, the ephrins. (wikipedia.org)
  • In general, class EphA receptors bind GPI-anchored ephrin-A ligands. (umbc.edu)
  • There are ten vertebrate EphA receptors (EphA1-10), which display promiscuous interactions with six ephrin-A ligands. (umbc.edu)
  • The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. (creativebiomart.net)
  • This gene encodes a protein that binds ephrin-A ligands. (creativebiomart.net)
  • Ephrin-A2 is a protein that in humans is encoded by the EFNA2 gene. (wikipedia.org)
  • Recent studies in the hippocampus and cerebral cortex show that Eph receptors and ephrins are important in the regulation of synaptic morphology and plasticity. (123dok.org)
  • Therefore, considering the importance of Eph-ephrin class of protein in tumorigenesis, 7,620 clinically reported missense mutations belonging to the class of variables of unknown significance were retrieved from cBioPortal and evaluated for pathogenicity. (genominfo.org)
  • EphRs contain an ephrin binding domain and two fibronectin repeats extracellularly, a transmembrane segment, and a cytoplasmic tyr kinase domain. (umbc.edu)
  • A trans-interaction of Eph-ephrin followed by heterotetramer formation activates the signaling cascade and transforms the kinase domain from closed to open conformation which in-turn, expose the ATP binding pocket [ 5 ]. (genominfo.org)
  • Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. (wikipedia.org)
  • The overall domain organization of EphAs and EphBs are similar, however, ephrin A is GPI anchored to the membrane, whereas ephrin B has an intracellular PDZ binding domain. (genominfo.org)
  • Eph and ephrin are membrane-bound and thus regulate cell-cell interaction, migration, partitioning, and cell adhesion [ 3 ]. (genominfo.org)
  • This withdrawal seems to be distinct from the immediate repulsive effect of ephrin-A2 (ELF-1) and ephrin-A5 (RAGS) seen in the stripe assay because (1) the withdrawal-inducing factor was diffusible, whereas ephrin-A2 and -A5 are membrane-bound, and (2) the withdrawal-inducing factor appeared later in development than ephrin-A2 and -A5. (mpg.de)
  • Eph-ephrin regulates many downstream pathways that lead to physiological events such as cell migration, proliferation, and growth. (genominfo.org)
  • The extracellular domain facilitates binding to ephrin. (genominfo.org)
  • For example, in EphB1/ EphB2/EphB3-deficient mice dendritic spines (the small protru-sions bearing postsynaptic structures) have reduced density and size [3,7,8] while activation of EphB receptors by ephrins induces rapid dendritic spine formation [7,9]. (123dok.org)
  • Based on sequence homology, Eph and ephrin have been classified into EphA/EphrinA and EphB/EphrinB class of families [ 2 ]. (genominfo.org)
  • Eph-ephrin as a family is ubiquitously expressed in different tissues [ 4 ]. (genominfo.org)
  • Eph over-expression led to stronger circadian morning anticipation while ephrin knock-down impaired memory. (sdbonline.org)
  • Ephrin/EphR interaction mainly results in cell-cell repulsion or adhesion, making it important in neural development and plasticity, cell morphogenesis, cell-fate determination, embryonic development, tissue patterning, and angiogenesis. (umbc.edu)
  • Utilising fly genetics, this study generated the first Drosophila model of human wild-type and P460L mutant EphA1 and tested the effects of Eph /ephrin signalling on AD-relevant behaviour and neurophysiology. (sdbonline.org)
  • An ephrin that was originally identified as the product of an early response gene induced by TUMOR NECROSIS FACTORS. (umassmed.edu)
  • The resulting downstream signals occur bidirectionally in both EphR-expressing cells (forward signaling) and ephrin-expressing cells (reverse signaling). (umbc.edu)
  • The Eph-ephrin complex follows an exclusive signaling pattern wherein either Eph activates Ephrin for reverse signaling, or Ephrin activates Eph for forward signaling [ 4 ]. (genominfo.org)
  • The Eph/ephrin families also appear to play a role in angiogenesis (3). (rndsystems.com)
  • These results demonstrate a role of Eph/ephrin signalling in a range of behaviours affected in AD. (sdbonline.org)
  • Ephrins and Eph receptors are especially highly expressed in the embryonic nervous system, where their signalling is important for proper axonal pathfinding and to establish topographic projections [1-3]. (123dok.org)
  • To understand the mechanisms through which EBV infects epithelial cells, we integrated microarray and RNA interference screen analyses and found that Ephrin receptor A2 (EphA2) is important for EBV entry into the epithelial cells. (houstonmethodist.org)
  • The EphA2 Ephrin-binding domain and fibronectin type III repeats domain were essential for EphA2-mediated EBV infection, while the intracellular domain was dispensable. (houstonmethodist.org)
  • The erythropoietin-producing hepatoma A2 receptor (EphA2) is a tyrosine kinase overexpressed by tumor stroma and cancer cells. (nih.gov)
  • 2. The clinical significance of EphA2 and Ephrin A-1 in epithelial ovarian carcinomas. (nih.gov)
  • 9. C1GALT1 is associated with poor survival and promotes soluble Ephrin A1-mediated cell migration through activation of EPHA2 in gastric cancer. (nih.gov)
  • 17. The ephrin-A1 ligand and its receptor, EphA2, are expressed during tumor neovascularization. (nih.gov)
  • 19. Higher expression of EphA2 and ephrin-A1 is related to favorable clinicopathological features in pathological stage I non-small cell lung carcinoma. (nih.gov)
  • On epithelial cells the receptors for EBV have been identified as the ephrin receptor A2 (EphA2) and intergrins avb5, avb6, and avb8. (fredhutch.org)
  • EphA4 activation leads autophosphorylation of Tyr-596 and Tyr-602, and the conserved sites in EphA2 are required for binding to the GEFs, Vav2 and Vav3, and ephrin-induced cell migration. (ecmbio.com)
  • Ephrin-B1, also known as LERK-2, ELK-L, EFL-3, Cek5-L, and STRA-1 (1), is a member of the ephrin ligand family which binds members of the Eph receptor family. (rndsystems.com)
  • EphA7, also known as Mdk1, Hek11, Ehk3, Ebk, and Cek11 (1), is a member of the Eph receptor family which binds members of the ephrin ligand family. (rndsystems.com)
  • Ephrin-A2 also known as EFNA2 or EPH-related receptor tyrosine kinase ligand 6, is a member of the ephrin family. (betalifesci.com)
  • Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. (wikipedia.org)
  • Measured by its ability to compete with Biotinylated Recombinant Human Ephrin‑A5 Fc Chimera (Catalog # BT374 ) for binding to immobilized recombinant mouse Eph-A3 Fc Chimera in a functional ELISA assay. (novusbio.com)
  • 13. Human endometrial epithelial cells express ephrin A1: possible interaction between human blastocysts and endometrium via Eph-ephrin system. (nih.gov)
  • 15. Bifunctional role of ephrin A1-Eph system in stimulating cell proliferation and protecting cells from cell death through the attenuation of ER stress and inflammatory responses in bovine mammary epithelial cells. (nih.gov)
  • Eph receptors are classified into 10 EphA and 6 EphB receptors, which preferentially bind to the type A and type B ephrins, respectively. (ecmbio.com)
  • Ephrin‑A5 preferentially interacts with receptors in the EphA family but also with EphB2 (3). (novusbio.com)
  • Ephrin-A2 regulates the position-specific affinity of limb mesenchyme and is involved in cartilage pattern formation in the limb. (betalifesci.com)
  • 4. Eph-ephrin A system regulates human choriocarcinoma-derived JEG-3 cell invasion. (nih.gov)
  • Eph/ephrin interactions are implicated in axon guidance, neural crest cell migration, establishment of segmental boundaries, and formation of angiogenic capillary plexi. (betalifesci.com)
  • It interacts in cis with EphA3 on retinal axon growth cones which reduces axonal sensitivity to Ephrin‑A5 in trans (13). (novusbio.com)
  • Eph‑Ephrin interactions are widely involved in the regulation of cell migration, tissue morphogenesis, and cancer progression (1, 2). (novusbio.com)
  • Ephrin‑A5 repels migrating axons by inducing growth cone collapse and neurite retraction and by inhibiting the neurotrophic effects of NGF and BDNF (3, 11, 12). (novusbio.com)
  • Rac1 mediated endocytosis during ephrin-A2 and Semaphorin 3A induced growth cone collapse. (umn.edu)
  • This is evidence of species specific ephrin receptor usage by a henipavirus, and implicates additional ephrin receptors in potential zoonotic transmission. (rcsb.org)
  • Structural and functional analyses reveal promiscuous and species specific use of ephrin receptors by Cedar virus. (anl.gov)
  • The CedV G receptor-binding site is structurally distinct from other henipaviruses, underlying its capability to accommodate additional ephrin receptors. (rcsb.org)
  • This gene encodes a member of the ephrin family. (wikipedia.org)
  • Ephrin-A2 and their Eph family of receptor tyrosine kinases are expressed by cells of the SVZ. (betalifesci.com)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Aldehyde Dehydrogenase 1 Family, Member A2 (ALDH1A2) in serum, plasma, tissue homogenates and other biological fluids. (lipidx.org)
  • Description: A sandwich ELISA kit for detection of Aldehyde Dehydrogenase 1 Family, Member A2 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (lipidx.org)
  • PVDF membrane was probed with 1 µg/mL of Rat Anti-Mouse Ephrin-B1 Monoclonal Antibody (Catalog # MAB4731) followed by HRP-conjugated Anti-Rat IgG Secondary Antibody (Catalog # HAF005 ). (rndsystems.com)
  • A GLYCOINOSITOL PHOSPHOLIPID MEMBRANE ANCHOR -containing ephrin with a high affinity for the EPHA3 RECEPTOR. (bvsalud.org)
  • 14. Mapping the Universe of Eph Receptor and Ephrin Ligand Transcripts in Epithelial and Fiber Cells of the Eye Lens. (nih.gov)
  • We demonstrate that CedV also enters cells through additional B- and A-class ephrins (ephrin-B1, ephrin-A2, and ephrin-A5) and report the crystal structure of the CedV G ectodomain alone and in complex with ephrin-B1 or ephrin-B2. (rcsb.org)
  • We demonstrate that CedV also enters cells through additional B- and A-class ephrins (ephrin-B1, ephrin-A2, and ephrin-A5) and report the crystal This web page summarizes information in PubChem about patent US-8324283-B2. (netlify.app)
  • Ephrin‑A5 is expressed in multiple tissues during development, particularly in the brain (5, 6). (novusbio.com)