These cells were therefore described as bone marrow derived endothelial progenitor cells (EPCs). (hindawi.com)
Nishiwaki, Y., Yoshida, M., Masuda, H. and Isobe, M. (2004) Recruitment of bone marrow-derived endothelial progenitor cells to vascular endothelium involves E-selectin dependent mechanism. (scirp.org)
Melero-Martin JM , Khan ZA , Picard A , In vivo vasculogenic potential of human blood-derived endothelial progenitor cells . (avma.org)
Circulating, bone marrow-derived endothelial progenitor cells (EPCs) were first described 8 years ago, yet the exact nature of these endothelial precursor cells remains unclear. (nutriforce.cn)
Bone marrow-derived endothelial progenitor cells (EPCs) contribute to tumour angiogenesis. (nutriforce.cn)
Progenitor cell2
For example, an endothelial progenitor cell (EPC) is more specialized than an ESC, and an EC is more specialized than an EPC. (wikipedia.org)
Circulating Endothelial Progenitor Cell Levels Predict Cardiovascular Events in End-Stage Renal Disease Patients on Maintenance Hemodialysis. (stem-kine.com)
Dysfunction8
MetS is associated with endothelial dysfunction, decreased circulating endothelial progenitor cells (EPCs), and a pro-inflammatory state. (sbir.gov)
Pulmonary arterial hypertension (PAH) is a progressive disease characterized by lung endothelial cell dysfunction and vascular remodeling. (surrey.ac.uk)
Several important points of the cause of stroke in migraine are hemodynamic changes, endothelial dysfunction, cervical artery dissection, vascular reactivity, hypercoagulability, and abortive migraine drugs. (springeropen.com)
Several mechanisms that may cause ischemic stroke in migraine have been described, of which CSD-induced endothelial dysfunction is the primary pathophysiology of ischemic stroke in migraine. (springeropen.com)
In migraine, endothelial dysfunction plays a part in the stroke process. (springeropen.com)
During CSD, proinflammatory cytokines promote endothelial dysfunction, which results in reduced vascular responsiveness, such as vasodilation and vasoconstriction. (springeropen.com)
Endothelial microparticles (EMP), endothelial progenitor cells (EPCs), high-sensitivity CRP (hs-CRP), and endothelin-1 are some of the biomarkers that indicate endothelial dysfunction in migraine (ET-1) [ 5 ]. (springeropen.com)
Decreased number of peripheral blood EPCs has been associated with endothelial dysfunction and high cardiovascular risk. (nutriforce.cn)
It is now known that new blood vessels originate from preexisting vessels by activation, proliferation and migration of endothelial cells through a process named "angiogenesis" [ 4 ]. (hindawi.com)
This suggested that EPCs are able to differentiate into endothelial cells and that such cells are incorporated into sites of active angiogenesis including ischemia, tumor angiogenesis, and metastasis in adult organisms [ 16 , 17 ]. (hindawi.com)
While both processes result in new blood vessel formation, vasculogenesis occurs mainly during embryonic development and is facilitated by EPCs, while angiogenesis takes place via "sprouting" of endothelial cells , which allows new blood vessels to take shape from already existing blood vessels. (naturalnews.com)
LINC00659 knock-down promoted the proliferation, migration, and angiogenesis ability of EPCs, while an pcDNA-eukaryotic translation initiation factor 4A3 (EIF4A3), a EIF4A3 overexpression vector, or fibroblast growth factor 1 (FGF1) small interfering RNA (siRNA) combined with LINC00659 siRNA could not enhance this effect. (biomedcentral.com)
An increasing number of studies have demonstrated that EPCs are of great value in regenerative medicine and clinical applications, which can not only directly participate in angiogenesis but also participate in vascularization and endothelial repair by differentiating into endothelial cells [ 7 ]. (biomedcentral.com)
Bone marrow-derived EPCs first enter the microcirculation, which is more abundant in veins and can repair damaged or missing endothelium, promote angiogenesis, and then favor venous vascular remodeling at LEDVT [ 10 ]. (biomedcentral.com)
The contributions of circulating EPCs to angiogenesis in tumours, ischaemic injury and other diseases as well as their usefulness in the repair of wounded hearts and limbs remain under intense investigation. (nutriforce.cn)
This study aimed to explore the effects of chemerin on the functions of human endothelial progenitor cells (EPCs) and to investigate its role in lipid accumulation in ApoE-knockout (ApoE−/−) mice. (biomedcentral.com)
VEGF10
Important signaling factors for vasculogenesis are TGF-β, BMP4, and VEGF, all of which promote pluripotent stem cells to differentiate into mesoderm, endothelial progenitor cells, and then into mature endothelium. (wikipedia.org)
Not only is VEGF critical for mesoderm cells to become an EC, but also for EPCs to differentiate into mature endothelium. (wikipedia.org)
To evaluate the effect of cytokines CD34+ cells were cultured with various cytokine combinations such as stem cell factor (SCF) flt3-ligand (FL) and thrombopoietin (TPO) with vascular endothelial growth factor (VEGF) interleukin-1β fibroblast growth factor-basic (FGF-b) as basic cytokines. (cancerrealitycheck.com)
to see the effects of varied cytokines such as for example JNJ-38877605 VEGF IL-1β FGF-b SCF FL and TPO in the advancement of EPCs to ECs and lastly to determine the specialized and theoretical history to permit the therapeutic usage of EPCs. (cancerrealitycheck.com)
The mass media was supplemented with several cytokine combinations that's 10 ng/mL of stem cell aspect (SCF) 10 ng/mL flt3-ligand (FL) and 5ng/mL thrombopoietin (TPO) with 10 ng/mL vascular endothelial development aspect (VEGF) 10 ng/mL IL-1β 5 ng/mL fibroblast growth factor-basic (FGF-b) as the basic combination. (cancerrealitycheck.com)
Specific growth factors, such as vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), stimulate the proliferation and migration of naturally quiescent endothelial cells, resulting in the formation of new vessel structures during embryonic development and tumor growth [ 7 ]. (hindawi.com)
Upon culture in endothelial growth media, these cells expressed endothelial lineage markers, such as CD31, Tie2, and VEGF receptor 2 (VEGFR2), and incorporated into blood vessels in ischemic tissues. (hindawi.com)
Mice deficient in eNOS (Nos3(-/-)) show reduced vascular endothelial growth factor (VEGF)-induced mobilization of endothelial progenitor cells (EPCs) and increased mortality after myelosuppression. (nih.gov)
Myofibroblasts also secrete vascular endothelial growth factor (VEGF), which induces the differentiation of EPCs into endothelial cells, subsequently forming the neo-vasculature. (shu.edu)
These cells are induced to leave the bone marrow and enter the vasculature by circulating angiogenic factors such as vascular endothelial growth factor (VEGF). (nutriforce.cn)
Neovascularization4
Endothelial progenitor cells (EPCs) have already been reported to possess the capacity to colonize vascular grafts and hold promise for therapeutic neovascularization. (cancerrealitycheck.com)
In addition, EPCs can also play a crucial role in neovascularization, blood vessel and tissue repair, and so on, by secreting a variety of cytokines and angiogenic growth factors [ 8 ]. (biomedcentral.com)
Endothelial nitric oxide synthase (eNOS) is essential for neovascularization. (nih.gov)
Endothelial progenitor cells (EPC) are a subtype of stem cells with high proliferative potential that are capable of differentiating into mature endothelial cells, thus contributing to neovascularization in tumors. (nutriforce.cn)
Cytokines2
Thus, it has been shown that early EPCs release cytokines that promote tissue regeneration and neovasculogenesis, whereas late EPC and endothelial colony forming cells (ECFCs) contribute to the formation of blood vessels and stimulate tube formation. (intechopen.com)
In response to tumor-secreted cytokines, EPCs mobilize from the bone marrow to the peripheral blood, home to the tumor site, and differentiate to mature endothelial cells and secrete proangiogenic factors to facilitate vascularization of tumors. (nutriforce.cn)
Differentiation8
And it had been possibly recommended that TPO has a major function in differentiation from EPCs to ECs. (cancerrealitycheck.com)
Although human induced pluripotent stem cells (hiPSCs) are an alternative cell source of ECs and EPCs, the differentiation and purification processes have not been optimized. (nih.gov)
Here we report the development of relatively simple differentiation and purification methods for hiPSC-derived EPCs (iEPCs). (nih.gov)
Vascularization or vasculogenesis is defined as the differentiation of epithelial progenitor cells (EPCs) into mature epithelial cells to enable the formation of new blood vessels. (naturalnews.com)
In their previous study, the researchers found that epimedin C could induce endothelial-like (but not osteogenic) differentiation of C3H/10T1/2 cells in vitro. (naturalnews.com)
Based on these results, the researchers concluded that epimedin C effectively promotes vascularization both in the BMP2-dependent bone formation model and in the 4T1 mammary tumor-bearing model by inducing the endothelial-like differentiation of C3H/10T1/2 in vivo. (naturalnews.com)
Increased HO-1 expression and HO-1 activity is associated with an increase in adiponectin secretion that prevent differentiation and enlargement of adipocytes resulting in the stimulation of nitric oxide (NO) bioavailability and improved endothelial function and glucose tolerance. (nymc.edu)
Integrin/cytokine receptor interaction provides permissive signals leading to neoangiogenesis, and integrins are crucial for differentiation of endothelial progenitor cells (EPCs). (unito.it)
Different phenotypes and subtypes of endothelial progenitor cells (EPCs), such as early and late EPCs, have been described according to their functionality. (intechopen.com)
Endothelial cells can be found throughout the whole vascular system and they also play a vital role in the movement of white blood cells ECs were first thought to arise from extraembryonic tissues because blood vessels were observed in the avian and mammalian embryos. (wikipedia.org)
After a month of culture adherent cells expressed endothelial specific markers such as for example KDR CD62E and CD31. (cancerrealitycheck.com)
Subsequent studies described a VEGFR2 and AC133 expressing subpopulation of these CD34 positive circulating cells that could form endothelial colonies in vitro [ 14 , 15 ]. (hindawi.com)
Endothelial progenitor cells (EPCs) are bone marrow-derived haematopoietic progenitor cells that have been implicated in vasculogenesis. (scirp.org)
The cells, known as endothelial progenitor cells (EPCs), not only elongate in the direction of the grooves, but also align themselves along the grooves. (sciencedaily.com)
The researchers believe the technique works best with EPCs because they are relatively immature cells. (sciencedaily.com)
Specifically, we study the ability of endothelial progenitor cells (EPCs) to enhance bone regeneration. (rambam.org.il)
Currently our research expanded to investigate the mechanism of EPCs in bone and blood vessel formation and to analyze the phenotype and genotype of these cells. (rambam.org.il)
Endothelial cells (ECs) and endothelial progenitor cells (EPCs) play crucial roles in maintaining vascular health and hemostasis. (nih.gov)
Another statement showed the preadipocyte- and endothelial cell-derived stromal-derived element-1 (CXCL12), mediated early infiltration of CD4+ T lymphocytes in obesity, which preceded the increase of macrophages in adipose cells of mice on HFD (101). (exposed-skin-care.net)
Edwards N , Langford-Smith AWW , Wilkinson FL , Endothelial progenitor cells: new targets for therapeutics for inflammatory conditions with high cardiovascular risk . (avma.org)
Cigarette smoking depletes and impairs the function of endothelial progenitor cells (EPCs). (stem-kine.com)
Diabetes is associated with a low level of endothelial progenitor cells (EPCs). (stem-kine.com)
Endothelial progenitor cells (EPCs) play an important role in vascular repair and a decrease in the number of EPCs is observed in type 2 diabetes. (biomedcentral.com)
Additionally, our research approach proved to be a powerful tool in the identification of novel biomarkers for cardiovascular and metabolic disease (e.g. circulating endothelial cells and progenitor stem cells [EPCs] for better prognosis). (nymc.edu)
The results displayed that LINC00659 is upregulated in IVC tissues and isolated endothelial group cells (EPCs) of patients with LEDVT. (biomedcentral.com)
At present, with the in-depth understanding of endothelial progenitor cells (EPCs) and the increase of research, it has become the focus of medical research [ 6 ]. (biomedcentral.com)
Therefore, EPCs may serve as potential seed cells for new approaches to biological treatment of LEDVT. (biomedcentral.com)
Our primary research involves endothelial progenitor cells (EPC): isolation, cell culture, characterization, and local transplantation of EPCs to enhance bone healing in several bone pathologies (e.g: extra-cortical bone formation, bisphosphanate osteonecrosis of the jaw, peri-implantitis and healing of large jaw bone defects). (rambam.org.il)
Dr. Neil Riordan discusses the roles of EPCs within the body and how a low level of these cells may correlate with a wide variety of degenerative disease. (neilriordan.com)
Although the aetiology of these disorders remains unknown, in this review we analyse the pathogenic mechanisms by cell of interest (fibroblast, fibrocyte, myofibroblast, endothelial and alveolar epithelial cells and immune competent cells). (ersjournals.com)
During embryogenesis endothelial cells exhibit substantial plasticity that contribute to cardiac development by undergoing endothelial-to-mesenchymal transition (EndoMT). (surrey.ac.uk)
We determined the presence of EndoMT in the pulmonary vasculature in vivo and the functional effects on pulmonary artery endothelial cells (PAECs) undergoing EndoMT in vitro. (surrey.ac.uk)
Histologic assessment of patients with systemic sclerosis-associated PAH and the hypoxia/SU5416 mouse model identified the presence von Willebrand factor/α-smooth muscle actin-positive endothelial cells in up to 5% of pulmonary vessels. (surrey.ac.uk)
Induced EndoMT cells exhibited up-regulation of mesenchymal markers, including collagen type I and α-smooth muscle actin, and a reduction in endothelial cell and junctional proteins, including von Willebrand factor, CD31, occludin, and vascular endothelial-cadherin. (surrey.ac.uk)
Myofibroblasts, transdifferentiated from stromal fibroblasts by PDGF, secretes chemokines that recruit endothelial precursor cells (EPC) in to the stroma. (shu.edu)
Recent evidence indicates that circulating endothelial progenitor cells (EPCs), a population of bone marrow-derived cells, have an important role in the process of vascular repair, by promoting re-endothelialization following vascular injury [1]. (nutriforce.cn)
EPCs are primarily identified by the expression of cell-surface antigenic markers, including CD133, CD34 and vascular endothelial growth factor receptor 2 (VEGFR-2), and have the ability to differentiate into mature cells with an endothelial phenotype [2]. (nutriforce.cn)
Endothelial progenitor cells (purple circles) arise in the bone marrow as CD34+CD133+VEGFR2+ cells. (nutriforce.cn)
Circulating bone-marrow-derived cells, named endothelial progenitor cells (EPCs), are capable of maintaining, generating, and replacing terminally differentiated cells within their own specific tissue as a consequence of physiological cell turnover or tissue damage due to injury. (nutriforce.cn)
The ability of the fusion proteins to interfere with IL-3Rβc/β1 integrin interaction was assessed on endothelial cells (ECs), EPCs and murine-derived ECs. (unito.it)
Endothelium1
Endothelium maintenance and restoration of normal endothelial cell function is guaranteed by a complex physiological procedure in which EPCs play a significant role. (nutriforce.cn)
Vitro3
An in vitro study on the effect of hyperglycemia on the proliferation and viability of the cultured EPCs was also performed. (biomedcentral.com)
When glucose was supplemented in the culture in vitro , there was a negative effect on the proliferation and viability of EPCs, in a dose-dependent manner, whereas the enhancement of apoptosis was observed. (biomedcentral.com)
In vitro hyperglycemic effect using various glucose concentrations on the viability, proliferation and apoptosis of cultured EPCs from both diabetic patients and healthy controls were also performed. (biomedcentral.com)
CD311
Finally, the researchers reported that the mRNA levels of endothelial markers - namely, the platelet endothelial adhesive factor-1 (CD31), the endothelial cell-specific molecule-1 (ESM-1), and the vascular von Willebrand factor (vWF) in mouse 4T1 mammary tumor tissue - significantly increased after epimedin C treatment. (naturalnews.com)
The EPCs were cultured and characterized by the expression of UEA-I, CD34, VEGFR2, vWF and Dil-Ac-LDL engulfment, as well as the ability to form capillary-like structures. (biomedcentral.com)
Progenitors1
Medina RJ , Barber CL , Sabatier F , Endothelial progenitors: a consensus statement on nomenclature . (avma.org)
Apoptosis3
Changes in migration, adhesion, proliferation and the apoptosis rate of EPCs were detected. (biomedcentral.com)
The data showed that chemerin enhanced the adhesion and migration abilities of EPCs, and reduced the apoptosis ratio and that this effect might be mediated through the p38 MAPK pathway. (biomedcentral.com)
In conclusion, chemerin can enhance the adhesion and migration abilities of human EPCs and reduce the apoptosis ratio. (biomedcentral.com)
Circulating4
Since then, the study of circulating EPCs has generated considerable interest and controversy. (hindawi.com)
We studied the number of the circulating EPCs in patients with type 2 diabetes as divided into good and poor glycemic control groups in order to study the effect of glycemic control. (biomedcentral.com)
However, for nitrite responses, the administration of the AT1R blocker was able to increase circulating levels of NO (p = 0.03) Blockade of AT1R appears to prevent the decrease in endothelial function by reducing low shear stress and maintaining the vasoactive substances balance after MS in overweight/obese men. (bvsalud.org)
Function2
Only recently TRT was not clearly associated with adverse cardiovascular (CV) events, but its impacts on endothelial function are still controversial. (usp.br)
The number of EPCs in type 2 diabetes was significantly decreased compared with healthy controls and there was an inverse correlation between the EPC numbers and plasma glucose, as well as HbA1 C . The number and function of EPCs in patients with good glycemic control were recovered compared with those with poor glycemic control. (biomedcentral.com)
Migration2
In conclusion, this study showed that chemerin enhances the adhesion and migration abilities of EPCs and increases the instability of plaques and abnormal lipid accumulation in ApoE−/− mice. (biomedcentral.com)
However, the number of EPCs in the body and the migration ability to the thrombus site are limited and vulnerable to the in vivo microenvironment, such as high glucose, advanced age, etc., which are the key issues that hinder the clinical application of EPCs [ 11 ]. (biomedcentral.com)
Inflammatory1
Muller, W.A. (2003) Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response. (scirp.org)
Roles1
Yoshida, M. and Gimbrone, M.A. Jr. (1997) Novel roles for E-selectin in endothelial-leukocyte adhesion. (scirp.org)
Adhesion1
Kakkar, A.K. and Lefer, D.J. (2004) Leukocyte and endothelial adhesion molecule studies in knockout mice. (scirp.org)
Clinical1
In this review, we initially report current knowledge with regard to the role of EPCs in healthy subjects and the clinical value of EPCs in different disease populations such as arterial hypertension, obstructive sleep-apnea syndrome, obesity, diabetes mellitus, peripheral arterial disease, coronary artery disease, pulmonary hypertension, and heart failure. (nutriforce.cn)
Vessel formation1
EPCs have proliferation capacity, immaturity and participate in vessel formation in the pre and post-natal periods. (rambam.org.il)