Eosinophilic airway inflammation and airway remodeling. Medical search. Frequent questions

Asthma in between disease status and IgE is stronger but on a group not man is defined as variable or intermittent airway obstruction on an individual basis (man: Liss et al. (cdc.gov)
Despite long-term therapy with corticosteroids, patients with severe asthma develop irreversible airway obstruction. (atsjournals.org)
It has been suggested that the subepithelial fibrosis in asthmatic lungs may contribute to thickening of the airway wall, which in turn may result in physiologic alterations, such as chronic airflow obstruction and airway hyperresponsiveness ( 1 ). (atsjournals.org)
Traditionally, asthma has been regarded as a disease characterised by chronic inflammation and remodelling, primarily of the large airways, which leads to airflow obstruction and asthma-specific symptoms. (ersjournals.com)
The obstruction of airways in acute fatal asthma is due to contraction of bronchial smooth muscle, thickening of airway wall and intraluminal mucus and debris. (edu.pk)
Asthma is a common disease, characterised by variable airflow obstruction and airway inflammation, leading to symptoms of breathlessness, wheeze, chest tightness and cough. (ersjournals.com)
Asthma is a clinical syndrome characterized by episodic reversible airway obstruction, increased bronchial reactivity, and airway inflammation. (medscape.com)
Emphysema, chronic bronchitis with airway obstruction, and compact airways illness are the distinct phenotypes of COPD, but most individuals show a combination. (lrrk2inhibitor.com)

Dermal sensitization (50% and 25% w/v) with TMA and an inhalation challenge of 15 mg/m3 TMA-induced apneas, laryngeal inflammation, increased numbers of eosinophils, neutrophils and macrophages in bronchoalveolar lavage (BAL), and increased immunoglobulin E levels in serum and lung tissue. (cdc.gov)
Anti-IL-5 therapy, including anti-IL-5Rα (benralizumab), rapidly depletes eosinophils in the blood and airways and also reduces asthma exacerbations and improves quality-of-life scores. (thorasys.com)
They evaluated markers of induced diabetes, levels of eosinophils and airway resistance ( PMC7747657 ). (ingridking.com)
Eosinophils are pivotal in the pathophysiology of most forms of chronic respiratory mucosal inflammation. (onlineasthmainhalers.com)
There is strong evidence for the crucial role of eosinophils in ongoing inflammation and tissue damage. (onlineasthmainhalers.com)
Granules of eosinophils contain toxic basic proteins, the major protein being eosinophilic cationic protein (ECP). (onlineasthmainhalers.com)
In addition, it has been demonstrated that recruited luminal airway eosinophils are distinct allergic "inflammatory" professional antigen-presenting cells able to activate primary CD4( ) T-cell responses in regional lymph nodes. (onlineasthmainhalers.com)
The presence of inflammation is attributed to T-helper type 2 (Th2) lymphocytes, eosinophils, mast cells, and neutrophils. (nursingce.com)
Neutrophils, eosinophils and inflammatory cells contribute to asthmatic inflammation. (biomedcentral.com)
Eosinophils are known to be an indirect marker of airway inflammation in asthma. (edu.pk)
Airway inflammation is present during an acute exacerbation of asthma, and is characterized by infiltration and activation of both eosinophils and neutrophils 2 . (edu.pk)
The primary granules contain lysophospholipase, associated with eosinophilic infiltrations 14 , and the secondary, or specific granules, contain major basic protein (MBP), eosinophils cationic protein (ECP), eosinophil peroxidase (EPO) and eosinophil protein X or eosinophil derived neurotoxin (EPX/EDN) 15,16 . (edu.pk)
In eosinophilic chronic bronchitis the sputum or bronchoalveolar lavage (BAL) fl uid presents far more eosinophils whereas in neutrophilic airway inflammation predominates the neutrophilic phenotype. (lrrk2inhibitor.com)
Finally, administration of monoclonal anti-CD109 antibody reduced airway eosinophils and significantly decreased AHR. (nagoya-u.ac.jp)

CONCLUSIONS: Innate epithelial-derived mediators are sufficient to drive airway hyper-reactivity and remodeling in response to environmental insults in the absence of overt Th2-type inflammation in a model of noneosinophilic, noninflammed types of asthma. (ox.ac.uk)
Aerobic training can also positively modulate airway inflammation and remodeling mediators. (breathinglabs.com)
Indeed, inflammatory mediators in the lower airways are elevated in patients with postnasal drip syndrome, cough variant asthma, and gastroesophageal reflux disease (GERD). (medscape.com)
Nasal inflammation may influence lower airway inflammatory processes by the release of inflammatory mediators into the circulation or through an effect on BM progenitors or inflammatory cells. (onlineasthmainhalers.com)
Lavage fluid from the lumen of the asthmatic airway contains numerous mediators including histamine, prostaglandins (predominantly PGD2 and PGF2), leukotrienes, kinins, kallikrein, and eosinophil derived major basic protein. (edu.pk)
Asthma results from complex interactions among inflammatory cells, their mediators, airway epithelium and smooth muscle, and the nervous system. (medscape.com)
Repeated injuries can stimulate airway epithelial cells to produce inflammatory mediators that activate epithelial cells, immune cells, or the epithelial?mesenchymal trophic unit. (molcells.org)

RESULTS: Control mice exposed to inhaled OVA showed no evidence of pulmonary inflammation, indices of remodeling, or airway hyper-reactivity. (ox.ac.uk)
Many acute and chronic lung disorders with variable degrees of pulmonary inflammation and fibrosis are collectively referred to as interstitial lung diseases (ILDs) or diffuse parenchymal lung diseases. (atsjournals.org)

Aerobic exercise has been found to effectively reduce airway eosinophilic expression, which in turn reduces the inflammation, inhaled glucocorticoid (ICS) dosage, and acute exacerbations, under the premise of standardizing and optimizing ICS medication," the authors wrote. (breathinglabs.com)
Two recent therapies licensed for use in asthma are omalizumab, a humanized monoclonal antibody that binds circulating IgE antibody, and bronchial thermoplasty, which involves the delivery of radio frequency energy to the airways to reduce airway smooth muscle mass. (biomedcentral.com)
GCs, usually in the form of prednisolone, supposedly reduce airway inflammation and prevent fibrosis. (ingridking.com)

INTRODUCTION: Several studies have shown the importance of Rho-kinase in the modulation of smooth muscle contraction, airway hyperresponsiveness and inflammation. (usp.br)
METHODS: We evaluated the effects of chronic treatment with Y-27632, a highly selective Rho-kinase inhibitor, on airway hyperresponsiveness, oxidative stress activation, extracellular matrix remodeling, eosinophilic inflammation and cytokines expression in an animal model of chronic airway inflammation. (usp.br)
Pulmonary 129 Xe MRI ventilation defect percentage (VDP) also sensitively measures asthma airway dysfunction caused by airway hyperresponsiveness, remodeling, and luminal mucus occlusions. (thorasys.com)
It is characterized by airway hyperresponsiveness and recurrent episodes of acute symptoms such as wheezing, coughing, chest tightness, and shortness of breath (SOB) which affects approximately 262 million people and causes 455,000 annual deaths worldwide (World Health Organization [WHO], 2023). (nursingce.com)
Chronic asthma symptoms are related to a combination of inflammation and airway hyperresponsiveness. (nursingce.com)

These pollutants can induce oxidative stress and hyperreactivity of the airways. (scirp.org)
The vascular actions of corticosteroids contribute to controlling clinical symptoms of asthma primarily by influencing airway calibre in the lung periphery and airway hyperreactivity. (ersjournals.com)
TGF-β and its receptors play a key role in asthma pathogenesis, bronchial hyperreactivity and bronchial remodeling. (researchsquare.com)
CD109 on Dendritic Cells Regulates Airway Hyperreactivity and Eosinophilic Airway Inflammation. (nagoya-u.ac.jp)
Asthma is a chronic airway inflammatory disease characterized by airway hyperreactivity (AHR) and eosinophilic airway inflammation. (nagoya-u.ac.jp)

As was noted, most of the studies performed over the past few decades on BM progenitors in lower airways inflammation have been in atopic, usually asthmatic individuals, with the inclusion, however, of all pertinent control groups (nonatopic, nonasthmatic). (onlineasthmainhalers.com)
Airway inflammation and basement membrane tenascin in newly diagnosed atopic and nonatopic asthma. (uaa.mx)

Provocative nasal allergen challenge has been used to help sort out the influences of allergic rhinitis on lower airways and specifically determine the influence of the upper airways on lower airway inflammation. (onlineasthmainhalers.com)
In this regard, we recently performed a study using repeated nasal challenges to determine if this can induce lower airway inflammation and to obtain a more accurate model of allergen exposure. (onlineasthmainhalers.com)
Our preliminary results show that a large number of patients with allergic rhinitis with or without asthma can have significant lower airway inflammation after repeated nasal challenge. (onlineasthmainhalers.com)
Our data showed that SLITOR was effective not only in terms of patient reported outcomes but an improvement of pulmonary function and decrease of lower airway inflammation were also observed. (biomedcentral.com)

The eosinophilic injury to the mucosa of the airways in the pathogenesis of bronchial asthma. (edu.pk)
iii) correlation of the SWI/SNF aberrations with epithelial cells and mucosa tissue remodeling observed in CRS. (actaitalica.it)
Chronic rhinosinusitis (CRS) is a multifactorial, heterogeneous disease characterized by persistent inflammation of the sinonasal mucosa and tissue remodeling, which can include basal/progenitor cell hyperplasia, goblet cell hyperplasia, squamous cell metaplasia, loss or dysfunction of ciliated cells, and increased matrix deposition. (molcells.org)
Tissue remodeling in CRS is the reorganization or renovation of nasal mucosa, which can be either physiological or pathological. (molcells.org)
Nasal mucosal inflammation induces remodeling processes within the mucosa characterized by changes in extracellular matrix (ECM) protein deposition, macrophage and lymphocyte infiltration, and histological structure. (molcells.org)

As most clinical trials have been performed during natural allergen exposure, studies evaluating the influence of upper airway disease on lower airways cannot properly assess the influence of nasal inflammation on lower airways. (onlineasthmainhalers.com)
In addition, Braunstahl et al have shown that segmental bronchial allergen challenge can produce nasal eosinophilic inflammation . (onlineasthmainhalers.com)
Apart from the broad repertoire of diseases involving their action, MCs, when activated, may promote eosinophilic inflammation in chronic rhinosinusitis with nasal polyps. (actaitalica.it)
They can be subdivided based on such as age of onset, presence of allergy (skin prick test or systemic allergen specific immunoglobulin E (IgE)), with or without nasal polyps and/or T helper (Th) cell 2 prominent inflammation. (encyclopedia.pub)
They also play a role in airway diseases such as IgE in allergy and CRS with nasal polyps (CRSwNP), antibody deficiency in CRS, and aberrant antiviral IgG responses in asthma exacerbations [ 5 ] [ 8 ] . (encyclopedia.pub)

eosinophilic (allergic) or neutrophilic (bronchial). (ingridking.com)
The inflammatory phenotype in chronic bronchitis is neutrophilic or eosinophilic. (lrrk2inhibitor.com)

In addition, a significant reduction in goblet cell hyperplasia, peribronchiolar collagen layer thickness and VEGF expression for airway remodeling was detected in the OVA + SEAC‑treated group compared with the OVA + vehicle‑treated group. (spandidos-publications.com)
Chronic bronchitis impacts the airways by airway inflammation, goblet cell hyperplasia and mucus hypersecretion. (lrrk2inhibitor.com)

Asthma is a chronic inflammatory disease characterized by T-lymphocyte and eosinophil infiltration, mucus overproduction and airway hyper-responsiveness. (spandidos-publications.com)
Asthma Control, Airway Mucus, and 129Xe MRI Ventilation After a Single Benralizumab Dose. (thorasys.com)
In patients with severe asthma, eosinophilic inflammation-driven airway mucus occlusions have been measured using thoracic x-ray CT imaging. (thorasys.com)
Does 129 Xe MRI detect airway functional responses to eosinophil depletion after a single benralizumab dose and do airway mucus occlusions mediate this response? (thorasys.com)
Ciliated airway epithelium lining the airway lumen is impaired in its function as a consequence of the hypersecreted mucus, and in activation and damage by tobacco compounds. (lrrk2inhibitor.com)

These changes may contribute to the progressive decline in lung function and airway remodeling in patients with severe asthma. (atsjournals.org)
However, the mechanisms responsible for the initiation of airway remodeling, which contributes to decreased lung function, remain elusive. (ox.ac.uk)
Hence, Hogg and colleagues, who also first used the term "small airway disease" [ 7 ], described the distal airways as the "silent zone" of the airway tree as extensive disease can be present without symptoms or changes in conventional lung function tests [ 14 ]. (ersjournals.com)
SLIT showed an important influence on lung function and airway inflammation. (biomedcentral.com)
High efficiency delivery of such agents to the lung, therefore, will not only have a positive impact on lung inflammation, but will also have disease-modifying effects on the progressive loss of lung function caused by chronic degradation of lung tissue. (ddw-online.com)
Her work using human models of disease is uncovering the impact of airway inflammation on lung function using targeted inhibition to block key cellular pathways required for developing allergen-induced airway responses. (cictrials.ca)

Published data from our group indicate that HIF-1α regulation in airway epithelial cells (AEC) drives the acute inflammatory response following LC and GA. Metabolomic profiling and metabolic flux of Type II AEC following LC revealed marked increases in glycolytic and TCA intermediates in vivo and in vitro that were HIF-1α dependent. (jci.org)
The SWI/SNF complex is involved in epigenetic control of gene expression and plays an important role in the response of upper airway epithelial cells to infections. (actaitalica.it)

A Deficiency in the Cytokine TNFSF14/LIGHT Limits Inflammation and Remodeling in Murine Eosinophilic Esophagitis. (ucsd.edu)
INTRODUCTION cytokine production and eosinophilic inflammation of the airways. (cdc.gov)
CD109-deficient mice had reduced AHR and eosinophilic inflammation together with lower Th2 cytokine expression compared to WT mice. (nagoya-u.ac.jp)

An understanding of the mechanism of lung inflammaging is therefore important in determining whether treatments that modulate inflammaging may be beneficial in combating age-related airway diseases. (knowyourasthma.com)
Research advances over the past several years suggest that cysLT1 also mediates the ability of cysLTs to modulate inflammation, immune responses, and airway remodeling. (springer.com)

Numerous reviews on the importance of small airways in asthma and other airway diseases have been published in recent years, including the following [ 8 - 12 ]. (ersjournals.com)
In the 1970s, the first physiological studies using indirect measurements of the distal airways (primarily nitrogen washout) focused attention on the role of small airways in diseases like asthma and chronic obstructive pulmonary disease [ 15 - 17 ]. (ersjournals.com)
This paper reviews key mechanisms of inflammation in airway diseases. (knowyourasthma.com)
It discusses the role of mathematical and computational modeling in furthering our understanding of the complex inflammation mechanism in airway diseases. (knowyourasthma.com)
Eosinophilic and basophilic inflammation is present in a large number of allergic and nonallergic airway diseases. (onlineasthmainhalers.com)
Nitric oxide (NO) may play an essential role in regulating airway function and in the pathophysiology of inflammatory airway diseases [ 1 ]. (biomedcentral.com)
Monoclonal Antibodies and Airway Diseases" Encyclopedia , https://encyclopedia.pub/entry/3726 (accessed December 02, 2023). (encyclopedia.pub)

Eosinophilic cationic protein: is it useful in assessing control of childhood asthma? (who.int)
ABSTRACT This study evaluated peripheral eosinophil and serum eosinophilic cationic protein (s-ECP) levels as markers of asthma control. (who.int)

These cells form inflammatory infiltrates in the epithelium and smooth muscles of the airway, causing remodeling, including smooth muscle hypertrophy. (nursingce.com)

BHR, but factors such as airway remodeling also influence the potential of a chemical to induce respiratory allergy. (cdc.gov)
In contrast, nongenomic actions are mediated by rapid cellular mechanisms, and induce transient vasoconstriction in the airway, thereby reversing inflammatory hyperperfusion. (ersjournals.com)
Los mediadores inflamatorios liberados por estas células generan y mantienen un estado de inflamación crónica que induce broncoconstricción, hiperreactividad bronquial y cambios estructurales en las vías aéreas. (uaa.mx)
This persistent inflammation can consequently induce aberrant tissue remodeling. (molcells.org)

Airway remodeling in asthma refers to structural changes in the airway, including subepithelial fibrosis, smooth muscle hypertrophy, and blood vessel hyperplasia. (atsjournals.org)

Porter PC, Yang T, Luong A, Delclos GL, Abramson SL, Kheradmand F and Corry DB: Proteinases as molecular adjuvants in allergic airway disease. (spandidos-publications.com)

Corticosteroids are now known to exert their effects on the airway vasculature through genomic and nongenomic mechanisms. (ersjournals.com)
In this review article, recent advances into the understanding of cellular mechanisms and the clinical implications of the interaction of inhaled corticosteroids and the airway vasculature in asthma are reviewed. (ersjournals.com)
In: Celleular mechanisms in airway infl ammation. (edu.pk)
Her research interests include studying the mechanisms of allergic inflammation, and identification of novel therapeutic targets for treatment of allergic disease. (cictrials.ca)
Comprehensive tissue remodeling processes, in particular, require further investigation, highlighting the necessity of elucidating regulatory mechanisms underlying tissue remodeling based on endotype classification. (molcells.org)

To evaluate if there are structural and functional differences in the airway epithelium in severe asthma associated with airway remodeling. (atsjournals.org)
Airway epithelial and LR thickness was greater in subjects with severe asthma compared with those with mild asthma, normal subjects, and diseased control subjects (p = 0.009 and 0.033, respectively). (atsjournals.org)
There was a greater level of apoptotic activity in the airway biopsy in subjects with severe asthma as compared with the normal subjects using the TUNEL assay (p = 0.002), suggesting increased cell death. (atsjournals.org)
In subjects with severe asthma, as compared with subjects with mild asthma, normal subjects, and diseased control subjects, we found novel evidence of increased cellular proliferation in the airway contributing to a thickened epithelium and LR. (atsjournals.org)
Limited knowledge exists on airway remodeling in severe asthma. (atsjournals.org)
In severe asthma, there is increased cellular proliferation in the airway contributing to a thickened epithelium and lamina reticularis. (atsjournals.org)
However, subsequent physiological, imaging and pathological studies demonstrated that the small airways and even the lung parenchyma could be important contributors to the functional impairment seen in certain severe asthma patients, as some reports suggest asthma severity increases in proportion to the involvement of this compartment [ 5 , 6 ]. (ersjournals.com)
Distinguishing severe asthma phenotypes: role of age at onset and eosinophilic inflammation. (uaa.mx)
They are the most severe form of pathological tissue remodeling in CRS and require surgical intervention. (molcells.org)

Ongoing inflammation, airway injury, and healing are part of the remodeling process in asthma and perhaps lead to disordered repair and fibrosis as a consequence. (atsjournals.org)
Although less is known about an additional receptor, cysLT2, emerging evidence indicates that it likely also contributes to cysLT actions promoting inflammation, vascular permeability, and perhaps fibrosis. (springer.com)

and allergic rhinitis (AR), nonallergic rhinitis (NAR), and chronic rhinosinusitis (CRS) in the upper airways. (encyclopedia.pub)

Lee DY, Choo BK, Yoon T, Cheon MS, Lee HW, Lee AY and Kim HK: Anti-inflammatory effects of Asparagus cochinchinensis extract in acute and chronic cutaneous inflammation. (spandidos-publications.com)
download contemporary peace making conflict violence and peace processes concept presents acute airway of man and download professor approach by many molecular release freedoms. (cdmw.de)

Patients with eosinophilic asthma often report poor symptomatic control and quality of life. (thorasys.com)
Cats and humans share many of the same airway damage in either category of symptomatic asthma. (ingridking.com)

Inflammation may exist without obvious symptoms and can affect the trachea, bronchi, or the smaller bronchioles. (nursingce.com)
Tiny airways illness primarily affects the bronchioles featuring airway inflammation and metaplasia of Clara cells.Oxidants and proteinasesMechanisms that may contribute for the pathogenesis involve disturbed oxidant-antioxidant and proteinase-antiproteinase balances. (lrrk2inhibitor.com)

Because of these results, the authors concluded that exercise is an effective strategy for COPD patients to reduce pulmonary and systemic inflammation, alleviate symptoms, and prevent disease progression. (breathinglabs.com)

Using 129 Xe MRI and CT imaging together, it is feasible to measure both airway luminal occlusions and airway ventilation in relationship to anti-IL-5 therapy to ascertain the direct impact of therapy-induced eosinophil depletion on airway function. (thorasys.com)

Asthma is an inflammatory disease of the airways characterized by its reversible, reactive nature. (edu.pk)
Asthma is a disease of diffuse airway inflammation caused by a variety of triggering stimuli resulting in partially or completely reversible bronchoconstriction. (msdmanuals.com)

There has been considerable interest in sophisticated mass spectrometry techniques, which can be applied for example to skin secretions, in order to detect airway infection in CF . The true test of the utility of these techniques will be whether they can differentiate children with non-specific respiratory symptoms from true asthmatics, and predict steroid responsiveness in the asthmatics. (knowyourasthma.com)

She showed that this occurs because mice treated with Acinetobacter Iwoffii have reduced levels of Interleukin 13, an inflammatory marker produced by their T cells, which protected them from airway hyper-responsiveness. (wikipedia.org)

We additionally postulate that the role of other immune cells like macrophages, NK, dendritic, and T and B cells 4 should be evaluated more carefully in CRS, although the current EPOS 2020 guidelines sub-classify CRS based on the eosinophil infiltration as non-eosinophilic (neCRS) or eosinophilic (eCRS) 5 . (actaitalica.it)

The bronchiolar inflammation and airway constriction lead to resistance and the hallmark symptoms of cough, wheezing, and SOB (see Figure 1). (nursingce.com)
Underdiagnosis risks daily symptoms, (potentially serious) exacerbations and long-term airway remodelling. (ersjournals.com)

The authors conclude that parameters for lung remodeling can be a valuable tool in hazard identification of LMW respiratory allergens. (cdc.gov)
This hypertrophy leads to airway narrowing and increases the reactivity of the airway to the presence of asthma triggers such as allergens, infections, or other irritants. (nursingce.com)
Dendritic cells (DCs) are essential for the development of asthma via presenting allergens, causing Th2 skewing and eosinophil inflammation. (nagoya-u.ac.jp)

To better understand respiratory disease, she makes use of airway samples from children, as well as neonatal mouse models. (wikipedia.org)
Asthma is a chronic inflammatory disease of the airways that affects over 300 million individuals worldwide [ 1 ]. (biomedcentral.com)
This phenomenon of Th2-mediated Eo/B progenitor mobilization and differentiation has also been established to occur in vitro/ex vivo and as a correlate in vivo, lending even more credence to the clinical relevance of progenitor changes and resultant eosinophilic inflammation in Th2-driven disease. (onlineasthmainhalers.com)
Asthma is a chronic inflammatory airway disorder that causes the narrowing of the airways and is the most common chronic disease diagnosed in children. (nursingce.com)
Asthma is a chronic disease of the airways characterized by inflammation and bronchial remodeling. (biomedcentral.com)
Asthma is a chronic airway inflammatory disease with a complex and varied clinical presentation, including wheezing, chest tightness and dyspnea. (biomedcentral.com)
Chronic rhinosinusitis (CRS) is an inflammatory disease of the nose and paranasal sinuses that lasts longer than 12 weeks and is the most common upper respiratory tract disease associated with tissue remodeling. (molcells.org)

The present study examined the therapeutic effects and action mechanism of a saponin-enriched extract of Asparagus cochinchinensis (SEAC) on airway inflammation and remodeling in an ovalbumin (OVA)-induced asthma model. (spandidos-publications.com)
CD109 deficient mice (CD109-/- mice) were sensitized with house dust mite (HDM) or ovalbumin and compared to wild-type (WT) mice for induction of AHR and allergic inflammation. (nagoya-u.ac.jp)

FeNO measurement is currently the only validated non-invasive method for assessing asthma-related eosinophilic inflammation in clinical practice. (biomedcentral.com)
Since their introduction about five decades ago, a wide range of monoclonal antibodies are nowadays commercially available and have been largely used in basic and clinical science of airways. (encyclopedia.pub)

Multiscale models could be employed to understand the tissue microenvironment effects on inflammation mechanism in young and aged lungs. (knowyourasthma.com)
Stopping the downward cycle of inflammation-induced tissue damage is the true goal for treating asthmatic cats. (ingridking.com)
Deficiency of the SMARCA4/BRG1 central ATPase subunit disrupts function of the SWI/SNF complex and triggers a hybrid epithelial/mesenchymal state which may lead to tissue remodeling upon RSV infection 9 . (actaitalica.it)
In this review, we summarize the roles of PCs in CRS-associated tissue remodeling and discuss the therapeutic potential of targeting PCs for CRS treatment. (molcells.org)

Whole genome analysis of lung, sampled 24 hours after challenge, showed expression changes of not only genes belonging to several Gene Ontology groups with up-regulation of inflammatory-associated genes and those associated with lung remodeling but also genes involved in downsizing these processes. (cdc.gov)
Drugs that are currently in use for asthma management promote symptom relief by controlling the inflammatory processes of the airway. (openrespiratorymedicinejournal.com)

In contrast to current anti-inflammatory respiratory therapeutics, certain small molecule and protein protease inhibitors also have the capacity to inhibit directly the chronic airway remodelling and lung degeneration mediated by uncontrolled proteolytic activity. (ddw-online.com)

Because of this, the ciliated epithelium may well be partly replaced by other epithelial cell forms like squamous and goblet cells, further contributing for the airway dysfunction. (lrrk2inhibitor.com)

In addition to inflammatory cell infiltration in the bronchial wall 1 , histological analysis of endobronchial biopsy specimens and new methods of blood flow measurements have revealed prominent alterations of the tracheobronchial (airway) vasculature in patients with asthma. (ersjournals.com)

ERS technical standard on bronchial challenge testing: pathophysiology and methodology of indirect airway challenge testing. (cictrials.ca)

Anatomy38

Organisms15

Diseases37

Chemicals and Drugs93

Analytical, Diagnostic and Therapeutic Techniques and Equipment45

Psychiatry and Psychology1

Phenomena and Processes34

Disciplines and Occupations2

Technology, Industry, Agriculture1

Health Care9

Obstruction8

Eosinophils14

Mediators7

Pulmonary inflammation2

Reduce airway3

Hyperresponsiveness5

Hyperreactivity5

Atopic2

Lower airway inflammation4

Mucosa5

Nasal5

Neutrophilic2

Goblet cell hyperplasia2

Mucus5

Lung function6

Epithelial cells2

Cytokine3

Modulate2

Diseases7

Cationic protein2

Epithelium and smooth1

Induce4

Smooth muscle hypertrophy1

Allergic airway disease1

Mechanisms5

Severe9

Fibrosis2

Nonallergic1

Acute2

Symptomatic2

Bronchioles2

Systemic inflammation1

Luminal1

Reversible2

Detect airway1

Hyper-responsiveness1

Eosinophil infiltration1

Symptoms2

Allergens3

Disease7

Ovalbumin2

Clinical2

Tissue4

Processes2

Respiratory1

Dysfunction1

Methods1

Pathophysiology1