Acyl-carrierMembraneSecretorySynthesisEnzymesAdvancesReceptorsAffinityPolypeptidesProlineVirusesCellularAntibodiesFunctionalVariantsSequencesRegulationCoding sequenceSubsequentEnzymeMolecularComplexFormCell surfaceFactorsClassActionResultDomainReviewRequiresEffectsLevelsPreventFoundSpecificallyContinued expression
Acyl-carrier2
- The systematic name of this enzyme class is (3R)-3-hydroxyacyl-[acyl-carrier-protein]:NADP+ oxidoreductase. (wikipedia.org)
- to get instant updates about '3-Oxoacyl-(Acyl-Carrier-Protein) Reductase' on your MyPage . (rediff.com)
Membrane4
- The 30-kDa membrane-bound c-type cytochrome protein of mitochondria that functions as an electron donor to CYTOCHROME C GROUP in the mitochondrial and bacterial RESPIRATORY CHAIN. (lookformedical.com)
- The synergistic action of 2 secretory proteins form pores in the membrane of host defense cells and are encoded by 2 cotranscribed genes ( LukS-PV and LukF-PV ) on a prophage integrated into the S. aureus chromosome [ 13 ]. (walshmedicalmedia.com)
- The trimeric Sec61/SecY complex is a protein-conducting channel (PCC) for secretory and membrane proteins. (cipsm.de)
- Membrane proteins must be threaded co-translocationally into the lipid bilayer to become membrane-integrated, often with complex topologies and typically form hetero- or homo- oligomers. (stanford.edu)
Secretory3
- The vast majority of proteins entering the secretory pathway are synthesized on ribosomes docked at ER translocons and are co-transationally translocated into the ER lumen. (stanford.edu)
- This highly complex 'protein biogenesis' process is assisted by a diverse network of folding catalysts and protein-modifying enzymes and is scrutinized by molecular chaperones and other 'quality control' factors which ensure that only correctly folded and assembled proteins exit the ER and proceed to distal compartments of the secretory pathway. (stanford.edu)
- Our goal is to elucidate the functional networks that coordinate protein synthesis and quality control in the early secretory pathway. (stanford.edu)
Synthesis4
- The conspicuous absence of nearly all the nucleotide biosynthetic enzymes encoded by the alpha and gammaherpesviruses indicates the pos sibility that the betaherpesviruses are hyper dependent on cellular enzymology for nucleotide synthesis and metabo lism. (thrombin-inhibitor.com)
- This work was based upon Ochoa's earlier studies, yielding the latter the Nobel Prize in Physiology or Medicine in 1959 for work on the enzymology of RNA synthesis. (mercinewyork.com)
- It is typically discussed using the "codons" found in mRNA, as mRNA is the messenger that carries information from the DNA to the site of protein synthesis. (mercinewyork.com)
- During protein synthesis, ribosomes become stalled on polyproline-containing sequences, unless they are rescued in archaea and eukaryotes by the initiation factor 5A (a/eIF-5A) and in bacteria by the homologous protein EF-P. While a structure of EF-P bound to the 70S ribosome exists, structural insight into eIF-5A on the 80S ribosome has been lacking. (cipsm.de)
Enzymes4
- These enzymes are found in a variety of biosynthetic contexts, which include fatty-acid activating enzymes, type I or type III polyketide synthases, dialkylresorcinol-generating enzymes, monooxygenases or Rieske proteins. (biomedcentral.com)
- This subclass includes only those enzymes in which some other redox carrier is the acceptor. (lookformedical.com)
- Under this hypothesis, any model for the emergence of the genetic code is intimately related to a model of the transfer from ribozymes (RNA enzymes) to proteins as the principal enzymes in cells. (mercinewyork.com)
- However, it is also used in other cellular processes, notably as a substrate of enzymes that add or remove chemical groups from proteins, in posttranslational modifications . (wikidoc.org)
Advances1
- Advances in Enzymology and Related Areas of Molecular Biology. (wikipedia.org)
Receptors2
- IGF 1 effects are transduced by way of the cell surface IGF one receptors belonging on the tyrosine kinase receptor relatives. (thrombin-inhibitor.com)
- Protein-protein interactions among SARS-CoV-2 spike protein, human receptors and antibodies are key determinants of the potency of this virus and its ability to evade the human immune response. (bvsalud.org)
Affinity3
- Consequently, only the imidazole will be exposed to lymphocytes, which commonly results in generation of antibodies that recognize protein-bound histamine with only limited affinity and sensitivity for free histamine. (justia.com)
- We compare the effectiveness of these models in predicting the binding affinity and expression of SARS-CoV-2 spike protein sequences. (bvsalud.org)
- We also explore how effective these predictive methods are when trained on laboratory-created data and are tasked with predicting the binding affinity of the in-the-wild SARS-CoV-2 spike protein sequences obtained from the GISAID datasets. (bvsalud.org)
Polypeptides1
- Both PPAE isozymes were proteins composed of two polypeptides (heavy and light chains) that are linked by disulfide linkage(s) and glycosylated serine proteases. (lookformedical.com)
Proline2
- Proteins synthesized at the ER are subject to covalent modifications that include N- and O-glycosylation, disulfide bond formation, and in some cases, proline and lysine hydroxylation. (stanford.edu)
- In the oral cavity, polyphenols (particularly flavanols and proanthocyanidins), partially released from the food matrix, are able to interact with salivary proteins rich in proline. (docksci.com)
Viruses1
- Viruses belonging to the largest cluster acquired an amino acid substitution in the receptor binding domain of the Spike protein (position 486), evolved faster and spread longer and more widely. (bvsalud.org)
Cellular1
- To characterize the proteins involved in cell clump/cell adhesion of insect cellular defense reactions, we induced the cell clump/cell adhesion reaction in vitro with the hemolymph of larvae of the coleopteran insect, Tenebrio molitor. (lookformedical.com)
Antibodies2
- Current, antibody-based diagnostical methods utilize antibodies against histamine raised by conjugating histamine to a large immunogenic protein carrier, such as bovine serum albumin (BSA) or ovalbumin (OVA) via its primary amine group. (justia.com)
- Here we report the selection of camelid-derived single-domain antibodies (nanobodies) that modulate the conformation and spectral properties of the green fluorescent protein (GFP). (cipsm.de)
Functional1
- Here we demonstrate that PSRP1 is not a bona fide ribosomal protein, but rather a functional homologue of the Escherichia coli cold-shock protein pY. (cipsm.de)
Variants1
- Our best performing codon variants exhibited a minimum 50-fold increase in PKS protein levels, which also enabled the production of an unnatural polyketide in each of these hosts. (bvsalud.org)
Sequences2
- Predicting protein properties from amino acid sequences is an important problem in biology and pharmacology. (bvsalud.org)
- We observe that TR is a better method when the sample size is small and test protein sequences are sufficiently similar to the training sequence. (bvsalud.org)
Regulation3
- the tri6 gene, encoding a zinc finger protein involved in the regulation of trichothecene biosynthesis, from Fusarium sporotrichioides (Proctor et al. (justia.com)
- The heterochromatin-enriched HP1 proteins play a critical role in regulation of transcription. (cipsm.de)
- Plastid-specific ribosomal proteins (PSRPs) have been proposed to play roles in the light-dependent regulation of chloroplast translation. (cipsm.de)
Coding sequence1
- 12] These errors, mutations, can affect an organism's phenotype, especially if they occur within the protein coding sequence of a gene. (mercinewyork.com)
Subsequent1
- As a result, the ribosome stops working on that protein and all subsequent codons are not transcribed! (mercinewyork.com)
Enzyme1
- This enzyme belongs to the family of oxidoreductases , specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. (rediff.com)
Molecular1
- The protein has a molecular weight of approximately 16,000, contains a single copper atom, is intensively blue, and has a fluorescence emission band centered at 308nm. (lookformedical.com)
Complex2
- In this study, we confirmed that both GrmH and GrmL, which were shown to constitute a protein complex by a co-purification experiment, were required to catalyze the dehydration, epimerization, and proteolytic cleavage of a precursor peptide GrmA by in vivo experiments. (hokudai.ac.jp)
- It is a complex of copper-containing proteins that acts also on a variety of substituted catechols. (lookformedical.com)
Form1
- Instead, damaged or incorrectly synthesized proteins must be rapidly and efficiently destroyed lest they form toxic aggregates. (stanford.edu)
Cell surface1
- The ER is the 'port of entry' for proteins destined for the cell surface and beyond. (stanford.edu)
Factors1
- Protein conformation is critically linked to function and often controlled by interactions with regulatory factors. (cipsm.de)
Class2
- PVL causes leukocytosis and tissue necrosis by means of pore formation on the target cells, and its toxicity involves two soluble, non-associated but synergic exoproteins a slow-eluting from the ion exchange column (class S protein) and a fasteluting from the ion exchange column (class F protein) [ 12 ]. (walshmedicalmedia.com)
- Grisemycin, salinipeptin, and cypemycin belong to the linaridin class of ribosomally synthesized and posttranslationally modified peptides that contain multiple dehydrobutyrine and D-amino acid residues. (hokudai.ac.jp)
Action1
- Thus it appears likely that HHV 6 and 7 a minimum of phosphorylate Rb as a result of the action of their virally encoded protein kinase. (thrombin-inhibitor.com)
Result2
- On top of that, some HCMV proteins are muta genic and consequently may result in genomic instability lead ing to cancer by means of a hit and run mechanism. (thrombin-inhibitor.com)
- IGF 1 reduces amyloid burden by expanding its clearance as a result of Ab carrier proteins like albumin and transthyretin. (thrombin-inhibitor.com)
Domain1
- These proteins contain two related domains known as the chromo- and the chromoshadow-domain. (cipsm.de)
Review1
- This Topical Collection entitled "Feature Papers in Enzymology" aims to collect high-quality research articles, review articles, and communications on all aspects of enzymology. (mdpi.com)
Requires1
- N-Formimidoylation/-iminoacetylation modification in aminoglycosides requires FAD-dependent and ligand-protein NOS bridge dual chemistry. (hokudai.ac.jp)
Effects1
- Although controversial, choosing the wrong codon optimization strategy can have detrimental effects on the protein and product levels. (bvsalud.org)
Levels1
- VR book at VFS having the latest duodenal levels and has the approach of protein-mediated reviews for Potential Individuals, n't founded years and own today seconds in American Fall. (wise-biz.net)
Prevent2
- Moreover, HCMV encodes a number of anti apoptotic proteins and infection is proven to prevent the death of some cancerous cells. (thrombin-inhibitor.com)
- The co-chaperone Hep1 is required to prevent the aggregation of mitochondrial Hsp70 proteins. (cipsm.de)
Found2
- In terms of pathogenesis, several research have found HCMV, HHV 6, and HHV 7 genomes or proteins in can cerous cells or tissues. (thrombin-inhibitor.com)
- We found that the 72 kDa protein was an activated phenoloxidase from Tenebrio pro-phenoloxidase. (lookformedical.com)
Specifically1
- The 72 kDa protein was specifically enriched in the residues of cell clump/cell adhesion and was purified to homogeneity. (lookformedical.com)
Continued expression1
- pro prolifera tive or anti apoptotic proteins were for being driving forces behind oncogenesis, their continued expression in tumors would appear to get necessary to keep the transformed phenotype. (thrombin-inhibitor.com)