Enzymes polymorphism genetic. Medical search. Frequent questions

Genotyping of 20 Single Nucleotide Polymorphisms (SNPs), divided in two groups, was performed by multiplex minisequencing preceded by multiplex PCR. (biomedcentral.com)
The focus is on various techniques for identifying the various Single Nucleotide Polymorphisms (SNPs). (routledge.com)
The application of pharmacogenetics in identifying single nucleotide polymorphisms (SNPs) in DNA sequences that cause clinically significant alterations in drug-metabolizing enzyme activities is discussed. (medscape.com)
We have focused on the most common single nucleotide polymorphisms (SNPs), the inherited nature of their deficiency, their frequency, and the clinical importance of drug-metabolizing-enzyme variants. (medscape.com)
No clinical studies have explored the effect of single nucleotide polymorphisms (SNPs) resulting in reduced activity enzymes (e.g. (aspetjournals.org)
We investigated whether high lipase activity-within the reference range and in the absence of pancreatitis-are associated with genetic single nucleotide polymorphisms (SNP), and whether these identified SNPs are also associated with clinical pancreatitis. (bmj.com)
Genotypes of three single nucleotide polymorphisms (SNPs) of LOXL1 (rs1048661, rs3825942, and rs2165241) were analyzed with direct sequencing, and a case-control association study was performed. (molvis.org)

Folate metabolism, which depends on genes variations and diet, is directly involved in genetic and epigenetic variations that can influence the changes of last growing period of development in human and the appearance of the TMD. (biomedcentral.com)
Different genotypes of several genetic polymorphisms of certain genes, at least in part, might be accounted for susceptibility to COVID-19 infection. (degruyter.com)
Genetic polymorphisms in low penetrance genes are responsible for the alterations in the gene expression of critical signal transduction proteins and metabolic enzymes. (routledge.com)
This book collates the reviews on the roles played by polymorphisms in critical metabolic, signal transduction, cell cycle or DNA repair genes either directly or indirectly in the disease mechanisms. (routledge.com)
Polymorphisms in other genes likely have smaller effects on clopidogrel activation. (medlineplus.gov)
Individuals with aberrant genes for these enzymes may experience diminished efficacy or increased toxicity in response to certain drugs because of the different levels of activities associated with variant genotypes. (medscape.com)
many drugs are metabolized by enzymes that are encoded by polymorphically expressed genes. (medscape.com)
Genetic polymorphism occurs in several genes that code drug metabolizing enzymes or drug transporters. (helsinki.fi)
Recent studies have shown that transporters can mediate drug-drug interactions, and transporter genes are subject to genetic polymorphism which may affect pharmacokinetic parameters of a drug, such as absorption, distribution, and excretion. (helsinki.fi)
Polymorphisms in phase I and phase II metabolism genes and risk of chronic benzene poisoning in a Chinese occupational population. (harvard.edu)
Inheritance being multifactorial, genetic variants in multiple genes interact both with each other and with the environment [ 13 - 20 ]. (hindawi.com)
Present study was designed to explore the genetic diversity of plasmodium vivax genotypes based on Pvmsp-3α and Pvmsp - 3β genes using allelic specific nested PCR and RFLP assays markers from field isolates in district Mardan, Pakistan. (scielo.br)
For analysis the genetic diversity of the sub allelic variants of Pvmsp3α and Pvmsp3β genes, Chi-Square test was performed by utilizing Minitab programming software 18. (scielo.br)
2 Several such genetic alterations have been characterized in candidate genes encoding molecules important for pain transmission, which result in impaired function of these gene products to ultimately impact the efficacy and side effect profiles of several analgesics, thus defining the active field of pharmacogenomics in pain medicine. (ahdbonline.com)
Certain common changes (polymorphisms) in the CYP2C9 and VKORC1 genes account for most of the variation in warfarin metabolism due to genetic factors. (medlineplus.gov)
Polymorphisms in other genes, some of which have not been identified, have a smaller effect on warfarin metabolism. (medlineplus.gov)
Additionally, people who have more than one polymorphism in a gene or polymorphisms in multiple genes associated with warfarin sensitivity have a lower tolerance for the drug's effect or take even longer to clear the drug from their body. (medlineplus.gov)
Every volunteer was genotyped for 10 genetic variants in different transporters' genes. (bvsalud.org)
Additionally, valsartan-treated volunteers were genotyped for 29 genetic variants in genes encoding for different metabolizing enzymes. (bvsalud.org)
Mutations in genes concerned with production of enzymes for metabolism of tobacco products may lead to increased risk of carcinogenesis with respect to oral mucosa. (bvsalud.org)
Therefore variations in the expression of these genes due to heritable genetic polymorphisms might modulate the process of carcinogenesis by altering the exposure levels of tobacco derived carcinogens. (bvsalud.org)
The polymorphic genes have subtle effect on cancer risk at individual level but may have a large population impact because the relevant polymorphism may be highly prevalent in a population. (bvsalud.org)
Various products of these genes are enzymes involved in the activation or degradation of carcinogens/pro-carcinogens. (bvsalud.org)
The mechanism of this arrest is under study, but in many cases, it involves the activation of abnormal genes through chromosomal translocations and other genetic abnormalities. (medscape.com)

Other seven genetic polymorphisms different from SNPs (deletions, insertions, tandem repeat, null genotype) were achieved by a multiplex-PCR. (biomedcentral.com)
Polymorphism studies document the affect SNPs, and their expressions have upon the functionality of the enzymes, proteins. (routledge.com)
The risk alleles of these SNPs were similar to those of other Asian populations, such as Japanese or Chinese, but differed from non-Asian populations, suggesting that still unidentified genetic or environmental factors may contribute to disease expression. (molvis.org)

Lacko, M 2011, ' Genetic polymorphisms in some biotransformation enzymes and their impact on head and neck cancer susceptibility ', Doctor of Philosophy, Maastricht University, Maastricht. (maastrichtuniversity.nl)
Some of these polymorphisms are linked to increased susceptibility to various diseases especially cancers, cardiovascular diseases, immune disorders, neurological pathologies. (routledge.com)
CYP2C9 * 3 ) on drug clearance have been well characterized but much less is known about whether these polymorphisms alter susceptibility to drug-drug interactions. (aspetjournals.org)
In this review we define the field of occupational and environmental health (OEH) research as the study of interactions between the following domains: environment (the exposome), 4 individual (genetic) susceptibility (the (epi)genome), and biological outcomes (the responsome) 5 ( figure 1 ). (bmj.com)
Carcinogenesis is a multistep process and individual risk to development of cancer depends not only on environmental factors or extrinsic exposure to carcinogens but also on genetic susceptibility of an individual. (bvsalud.org)
Factors that influence the tobacco exposed individuals developing a malignancy may thus include a combination of total tobacco exposure and genetic susceptibility of the individual 12 . (bvsalud.org)
Polymorphic genotypes of these enzymes may serve as genetic biomarkers for susceptibility to certain malignancies and therefore may help predict individual cancer risk 8 . (bvsalud.org)

In this work we study the association between TMD and genetic polymorphisms of folate metabolism, neurotransmission, oxidative and hormonal metabolism. (biomedcentral.com)
Genetic polymorphisms within CYPs affect the metabolism of drugs as substrates for the particular enzymes, resulting in variations in plasma levels of the drugs, differences in drug response, or altered risk for adverse effects. (psychiatrist.com)
Genetic polymorphism of drug metabolism enzymes (GSTM1, GSTT1 and GSTP1) in the healthy Malian population. (harvard.edu)
Our laboratory is currently investigating the influence of individual variations in cytochrome P450 and UDP-glucuronosyltransferase enzymes on the metabolism and hepatotoxicity of tyrosine kinase inhibitors used in cancer therapy as well as the natural product cannabidiol used in epilepsy treatment. (unc.edu)
The Jackson laboratory utilizes human-relevant in vitro systems (hepatic cell cultures, tissue fractions, and recombinant enzymes) and liquid chromatography - mass spectrometry to study drug metabolism and disposition and address fundamental questions regarding the molecular mechanisms of drug toxicity and inter-individual variability in drug disposition. (unc.edu)
5 The CYP enzymes comprise a group of proteins that play an important role in the metabolism of several drugs, including those relevant to pain therapy. (ahdbonline.com)
CYP2D6 is a well-characterized P450 enzyme that is involved in the metabolism of approximately 25% of all drugs currently in therapeutic use, and it is implicated in the metabolism of several analgesics, including opioids. (ahdbonline.com)
Several CYP2C9 gene polymorphisms decrease the activity of the CYP2C9 enzyme and slow the body's metabolism of warfarin. (medlineplus.gov)
The activity of drug-metabolizing enzymes often varies widely among healthy people, making metabolism highly variable. (msdmanuals.com)

This non systematic review summarizes current data available on the role of environment gene interaction in form of GSTM1 null polymorphism and oral carcinogenesis. (bvsalud.org)
Relevant data was selected in order to summarize the studies conducted on GSTM1 null polymorphism and oral cancer. (bvsalud.org)
Relationship between GSTM1 null polymorphism in oral cancer needs to be established to confirm the role of environment gene interaction in oral carcinogenesis. (bvsalud.org)

Genetic polymorphisms are important determinants of phenotypic variations and may modulate the risk to or even cause various diseases including genetic disorders and multifactorial diseases. (routledge.com)
The CYP2C19 gene is particularly important for the activation of clopidogrel, and certain common variations (polymorphisms) in this gene have been associated with clopidogrel resistance. (medlineplus.gov)
In one particular area of study, variations in DNA sequences (i.e., genetic polymorphisms) explain some of the variability in drug-metabolizing enzyme activities which contribute to alterations in drug clearance and impact patients' response to drug therapy. (medscape.com)
In addition to interindividual differences, interethnic differences that are attributable to genetic variations have also been documented. (ahdbonline.com)
Pharmacogenetics Pharmacogenetics involves variations in drug response due to genetic makeup. (msdmanuals.com)

Many of these genetic variants (i.e., genotypes) were discovered after observing adverse reactions (i.e., phenotypes) after administering common doses of drugs to patients. (medscape.com)
in individuals of the CYP2C9 * 1/ * 1, * 1/ * 3 , and * 3/ * 3 genotypes to characterize the magnitude of the drug interaction in subjects with different CYP2C9 polymorphisms. (aspetjournals.org)

Genetic polymorphisms of the drug-metabolising cytochrome P-450 (CYP) enzymes CYP2C9, CYP2C19 and CYP2D6 have been characterized, and several of these variants lead to reduced or absent activity. (tidsskriftet.no)
Genetic mutations play an important role in the activity especially of CYP2D6. (psychiatrist.com)
There are more than 80 unique alleles that have been described for the CYP2D6 enzyme, 5 and the different allele combinations yield phenotypic diversity in the general population. (ahdbonline.com)
these individuals show an increased frequency of CYP2D6*3, CYP2D6*4, CYP2D6*5, or CYP2D6*6 genetic alterations. (ahdbonline.com)

The pharmacogenetic differences in a number of phase-I enzymes, such as cytochrome P-450 (CYP) isoenzymes, dehydrogenases, and esterases, and phase-II (conjugating) enzymes have been extensively studied. (medscape.com)

From 189 healthy volunteers who were genotyped for CYP2C9 polymorphisms, 11 control subjects ( CYP2C9 * 1/ * 1 ), 9 heterozygous and 2 homozygous for the CYP2C9 * 3 allele participated in the pharmacokinetic drug interaction study. (aspetjournals.org)
The cytochrome P450 (P450) superfamily of enzymes plays an important role in the oxidation of numerous xenobiotics, with CYP2C9 accounting for 10 to 20% of the P450 protein content in human liver. (aspetjournals.org)
The CYP2C9 gene provides instructions for making an enzyme that breaks down various substances in the body. (medlineplus.gov)

Studies on the role of the angiotensin-converting enzyme (ACE) gene in the development of hypertension have yielded conflicting results. (nih.gov)
We aimed to identify the relationship between adiposity and blood pressure, independent of a robust set of lifestyle and metabolic factors, and to examine the modulating role of sex and Angiotensin-Converting Enzyme (ACE) insertion/deletion (I/D) polymorphisms. (lu.se)

Pharmacogenetics has elucidated the genetic basis for interindividual variability in drug response and will continue to play a key role in defining strategies to optimize drug therapy. (medscape.com)
An important goal of the laboratory is to identify the genetic and environmental factors that contribute to inter-individual variability in drug disposition, drug response, and drug toxicity. (unc.edu)

This review introduces the concept of pharmacogenetics in the context of drug-metabolizing enzymes and highlights the polymorphisms in DNA sequences that lead to clinically significant alterations in drug-metabolizing-enzyme activities. (medscape.com)

A cohort of 1162 patients with coronary artery disease were genotyped for genetic polymorphisms in the renin-angiotensin system. (bmj.com)
Genetic association studies demonstrated that MTHFD1L polymorphisms are associated with coronary artery disease, Alzheimer's disease and neural tube defects (NTDs). (dcu.ie)

CYP2C19 gene polymorphisms account for most of the variation in clopidogrel activation due to genetic factors. (medlineplus.gov)
The CYP2C19 gene provides instructions for making an enzyme that is found primarily in liver cells. (medlineplus.gov)
The CYP2C19 enzyme plays a role in the processing of many drugs, including clopidogrel. (medlineplus.gov)
The CYP2C19 enzyme helps to convert clopidogrel to its active form, which is necessary for the drug to function in the body. (medlineplus.gov)
The two most common CYP2C19 gene polymorphisms associated with clopidogrel resistance (known as CYP2C19*2 and CYP2C19*3 ) result in the production of a nonfunctional CYP2C19 enzyme that cannot convert clopidogrel to its active form. (medlineplus.gov)
Some people with clopidogrel resistance have a reduced ability to convert the drug to its active form because of a polymorphism in one copy of the CYP2C19 gene that results in decreased enzyme activity. (medlineplus.gov)

Objectives: The objective of this study was to explore potential drug-drug/food interactions of ciprofloxacin and grapefruit juice, known hepatic cytochrome P450 (CYP) 1A2 inhibitors, on single-dose oral pharmacokinetics of riluzole, a substrate of CYP 1A2 enzymes. (researchgate.net)
The cytochrome P450 (CYP) superfamily represents the most important phase I drug metabolizing enzyme system. (psychiatrist.com)
Bufuralol 1'-hydroxylation is a prototypical reaction catalyzed by cytochrome P450 (P450) 2D6, an enzyme known to show debrisoquine/sparteine-type genetic polymorphism in humans. (unboundmedicine.com)
In the present study we further examined the roles of several human P450 enzymes, as well as P450 2D6, in the hydroxylation of (+/-)-bufuralol, using liver microsomes from several human samples and human P450 enzymes expressed in human lymphoblastoid cell lines or Escherichia coli. (unboundmedicine.com)

To study the relationship between the ACE insertion/deletion (I/D) polymorphism, blood pressure and risk of hypertension in current, former and non-smokers in a population-based cohort. (nih.gov)
The rs66698963 polymorphism, a 22 bp insertion-deletion within FADS2 , is associated with basal FADS1 expression, and coordinated induction of FADS1 and FADS2 in vitro . (biorxiv.org)
MTHFD1L polymorphisms have been studied in relation to cleft disease and Melting Curve Analysis was developed for genotyping the Deletion Insertion Polymorphism rs3832406. (dcu.ie)

Relevance to Genetic Disease and Polymorphisms. (berkeley.edu)
Huntington's disease is an example of an autosomal dominant genetic disorder. (genome.gov)
Investigation of the human folate gene MTHFD1L: polymorphisms and disease risk. (dcu.ie)
Minguzzi, Stefano (2013) Investigation of the human folate gene MTHFD1L: polymorphisms and disease risk. (dcu.ie)
This project involves the characterization of MTHFD1L with a particular focus on genetic polymorphisms and disease risk. (dcu.ie)
Many common human diseases such as asthma, cancer, and cardiovascular disease are complex in nature, as they are influenced variably by environmental, physiologic, and genetic factors. (cdc.gov)
The genetic components most responsible for differences in individual disease risk are thought to be DNA variants (polymorphisms) that influence the expression or function of mediators involved in the pathological processes. (cdc.gov)
The purpose of this study was to estimate the combinatorial contribution of multiple genetic variants to disease risk. (cdc.gov)
We used a logistic regression model to help estimate the joint contribution that multiple genetic variants would have on disease risk. (cdc.gov)
Common diseases of a chronic inflammatory nature such as asthma, Alzheimer disease, and cardiovascular disease are complex in nature, as they are variably influenced by genetic inheritance as well as environmental, physical, and lifestyle factors. (cdc.gov)
Thus, for genetic variants to significantly affect disease severity or incidence, they must act cumulatively. (cdc.gov)
In light of this, a multiplicative gene-gene interaction model was developed to allow for estimating the combinatorial contribution of multiple genetic variants to disease risk. (cdc.gov)

Conclusion: Genetic variants in HMOX1 (rs2071746), SERPING1 (rs78958998), TMPRSS2 (rs713400), CD69 (rs11052877), TRAF3IP2 (rs33980500), OAS1 (rs2660) and VIPR1 (rs896) could explain heterogeneity in SARS-CoV-2 viremia in our population. (bvsalud.org)
The present model provided an opportunity to estimate the relative change in risk associated with multiple genetic variants. (cdc.gov)

The pathophysiological link between adiposity and blood pressure is not completely understood, and evidence suggests an influence of sex and genetic determinants. (lu.se)

Uridine 5'-diphosphate glucuronosyltransferases are phase II detoxifying enzymes capable of tobacco-borne toxicant inactivation and cellular protection. (nih.gov)

The D allele of the ACE polymorphism is associated with a significantly increased SBP and risk of hypertension in smokers. (nih.gov)
Patients carrying the D allele of the angiotensin I converting enzyme (ACE) gene had greater coronary extent scores (defined as the number of coronary segments with 5% to 75% stenosis) than those not carrying this allele (p = 0.006 in non-parametric analysis and p = 0.019 in parametric analysis). (bmj.com)
The authors reported correlation between the frequency of the Del allele of the ACE Ins/Del polymorphism and prevalence and mortality rates of COVID-19 in 33 countries (25 European, three north-African and five Middle East countries). (degruyter.com)
The low detoxification activity UGT1A7*3 allele is identified as a novel risk factor of pancreatic diseases defining the interaction of genetic predisposition and environmentally induced oxidative injury. (nih.gov)
Ultrarapid metabolizers (UMs): individuals who have multiple copies of a functional allele and/or an allele with a promoter mutation and show increased enzyme activity. (ahdbonline.com)

Autosomal dominant is a pattern of inheritance characteristic of some genetic disorders. (genome.gov)
Autosomal recessive is a pattern of inheritance characteristic of some genetic disorders. (genome.gov)

Alterations in hepatic mRNA expression of phase II enzymes and xenobiotic transporters after targeted disruption of hepatocyte nuclear factor 4 alpha. (harvard.edu)
In this article, an overview of prominent genetic alterations underlying interpatient diversity and their clinical relevance in pain management is presented. (ahdbonline.com)
Like initiation, conversion requires genetic alterations in which cellular growth is further deregulated and thus proceeds uncontrolled 5,29 . (bvsalud.org)

The potential for a clinically significant event is enhanced if the drug is widely used and has a narrow therapeutic range, if the enzyme pathway plays a major role in the elimination of the drug, or if the number of therapeutic alternatives is limited. (medscape.com)
The VKORC1 enzyme helps turn on (activate) clotting proteins in the pathway that forms blood clots . (medlineplus.gov)

Drug removal is not only dependent on metabolic enzymes, but also on transporters. (helsinki.fi)
Transporters in the basolateral membrane of the hepatocyte facilitate drug entry and access to drug metabolizing enzymes. (helsinki.fi)
Nrf2-regulated phase-II detoxification enzymes and phase-III transporters are induced by thyroid hormone in rat liver. (harvard.edu)

Certain VKORC1 gene polymorphisms decrease the amount of functional VKORC1 enzyme available to help activate clotting proteins. (medlineplus.gov)
Individuals develop warfarin sensitivity because a lower warfarin dose is needed to inhibit the VKORC1 enzyme, as there is less functional enzyme that needs to be suppressed. (medlineplus.gov)

Investigating the role of cell membrane proteins has increased over the last decade, as drugdrug interactions and genetic polymorphisms have been found to cause changes in drug pharmacokinetics and dynamics. (helsinki.fi)
but these polymorphisms resulted in expression of inactive proteins that should not be subject to inhibition. (aspetjournals.org)
Warfarin prevents (inhibits) the action of the VKORC1 enzyme and slows the activation of clotting proteins and clot formation. (medlineplus.gov)

Methods of multilocus enzyme electrophoresis for bacterial population genetics and systematics. (cdc.gov)

Environmental carcinogens and certain other endogenous factor (genetic alteration and mutation) interacting in a complex manner can give rise to development of cancer. (bvsalud.org)
These are termed xenobiotic-metabolizing enzymes (XMEs) found especially in the liver but also in the mucosa of the upper aerodigestive tract, and several are polymorphic and strongly influence individual biological responses to carcinogens. (bvsalud.org)
More subtle genetic disorders, including polymorphisms of enzymes that metabolize carcinogens, also predispose patients to AML. (medscape.com)

This study analyzes UGT1A7 gene polymorphisms in pancreatic diseases. (nih.gov)
Pancreatic enzyme supplementation may be helpful in reducing pain. (medscape.com)
When exogenous pancreatic enzymes are taken with a meal, CCK-releasing factors are degraded and CCK release in response to a meal is reduced. (medscape.com)
In patients with a dilated pancreatic duct, a Roux-en-Y side-to-side pancreaticojejunostomy is indicated. (medscape.com)

Prevalent polymorphism in thyroid hormone-activating enzyme leaves a genetic fingerprint that underlies associated clinical syndromes. (bvsalud.org)

Due to differences in enzyme presence and availability, human adults and fetuses process ethanol through different pathways. (wikipedia.org)
To estimate TMD risk, in those polymorphisms that shown significant differences, odds ratio (OR) with a 95% of confidence interval were calculated. (biomedcentral.com)

Increased risk of acute myeloid leukaemia due to polymorphisms in detoxification and DNA repair enzymes. (harvard.edu)
CPF-oxonase) detoxification of OPs, results in the expression of a range of enzyme activities within humans. (cdc.gov)

The role of genetic factors is incompletely defined. (nih.gov)

Selective neutrality of 6PGD allozymes in E. coli and the effects of genetic background. (cdc.gov)
The effects of genetic polymorphisms in drug-metabolizing enzymes (e.g. (aspetjournals.org)

Likewise, polymorphisms in glutathione S -transferase are associated with secondary AML after chemotherapy for other malignancies. (medscape.com)

545 - 7 .Genetic diversity and structure in Escherichia coli populations. (cdc.gov)
Multilocus genetic structure in natural populations of Escherichia coli . (cdc.gov)
Enzyme polymorphism and genetic structure in Escherichia coli and Shigella . (cdc.gov)

part of that variance may be due to genetic polymorphisms in drug-metabolizing enzymes. (cdc.gov)
The frequency of variant alleles for drug-metabolizing enzymes often differs among ethnic groups. (medscape.com)
The in vitro method developed in this study remains in the research team as a tool to investigate the polymorphisms of the SLCO1B1-gene, the inhibition of the transporter and possible drug interactions. (helsinki.fi)
However, genetic polymorphisms in drug-metabolizing enzymes are not routinely evaluated for their impact on drug interactions during clinical studies. (aspetjournals.org)
The most important class of drug-metabolizing enzymes for analgesics is CYP, which is mainly responsible for type I reactions, the modification reactions that inactivate or activate an analgesic administered as an inactive or less active prodrug. (ahdbonline.com)
2,8 The lower enzyme activity renders the PM subgroup at increased risk for drug overdose when the parent compound is responsible for the analgesic effect, or therapeutic failure if the parent compound is a prodrug that needs to be converted to an active metabolite. (ahdbonline.com)

The common polymorphisms of the gene ABCG2 coding the efflux transporter BCRP and the gene SLCO1B1 coding the influx transporter OATP1B1 are associated with the interindividual variation in the effectiveness and tolerability of the cholesterol-lowering statins. (helsinki.fi)

In each group, we assessed the relationship between the ACE I/D polymorphism, systolic (SBP) and diastolic (DBP) blood pressures and risk of hypertension. (nih.gov)
AIH usually develops in individuals with a genetic background mainly consisting of some risk alleles of the major histocompatibility complex (HLA). (wjgnet.com)
The impact of polymorphism rs7646 on miR-197 binding suggests a mechanistic explanation of the previous association of this SNP with NTD risk. (dcu.ie)
Incorporating the influence of genetic variation in the risk assessment process is often considered, but no generalized approach exists. (cdc.gov)
This will facilitate identification of susceptible populations and help provide a framework to model the genetic contribution in probabilistic risk assessment. (cdc.gov)
Applying the composite genetic contribution to the risk assessment process would allow for identifying the most genetically susceptible groups in the population. (cdc.gov)
For example, polymorphisms of NAD(P)H:quinone oxidoreductase (NQO1), an enzyme that metabolizes benzene derivatives, are associated with an increased risk of AML. (medscape.com)
3. Genetic Polymorphisms in Metabolising Enzymes as Lung Cancer Risk Factors (Angela Risch, Heike Dally and Lutz Edler). (who.int)

Gene variation in these enzymes can lead to variation in catalytic efficiency between individuals. (wikipedia.org)

Certain amino acid sequences in the enzymes used to oxidize ethanol are conserved (unchanged) going back to the last common ancestor over 3.5 bya. (wikipedia.org)

[ 8 ] A study by Chamorro et al of 175 patients reached a similar conclusion about slow acetylation (although these investigators did not find a link between hepatotoxicity and CYP2E1 polymorphisms). (medscape.com)

Within the liver endogenous and exogenous compounds are eliminated through many metabolizing enzymes. (helsinki.fi)
Vegans rely almost exclusively on endogenous synthesis to generate LCPUFA and we hypothesized that an adaptive genetic polymorphism would confer advantage. (biorxiv.org)

The enzymes required for the oxidation reactions are confined to certain tissues. (wikipedia.org)
oxidation modification of the genetic material may also participate in the progression of benign to malignant neoplasms. (bvsalud.org)

A case-control study was designed to evaluate the impact of genetic polymorphisms above described on TMD. (biomedcentral.com)
I read with great interest the study by Delanghe and his colleagues entitled "COVID-19 infections are also affected by human ACE1 D/I polymorphism" that was published in Clinical Chemistry and Laboratory Medicine [ 1 ]. (degruyter.com)
Genetic polymorphisms also serve as important genetic, population and evolutionary markers that allow the study of genetic and evolutionary aspects of individuals, populations and organisms and aid in tracing the evolutionary and parental lineages. (routledge.com)
The Sf9 cell line is isolated from Spodoptera frugiperda insect and is one of the standard in vitro tools in a genetic engineering study. (helsinki.fi)
The results of this study will contribute in future studies about the genetic structure of parasite and vaccine development against the malaria. (scielo.br)
The purpose of this study was to evaluate association profiles of lysyl oxidase-like 1 ( LOXL1 ) gene polymorphisms with pseudoexfoliation syndrome (XFS) in a Korean population. (molvis.org)

Monte Carlo analysis of the human chlorpyrifos-oxonase (PON1) polymorphism using a physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) model. (cdc.gov)

Diseases5

Chemicals and Drugs32

Analytical, Diagnostic and Therapeutic Techniques and Equipment25

Psychiatry and Psychology1

Phenomena and Processes46

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena1

Information Science5

Named Groups3

Health Care11

Geographicals7

Single Nucleotide Po7

Genes24

SNPs3

Susceptibility7

Metabolism9

GSTM13

Variations5

Genotypes2

CYP2D64

Cytochrome P-41

CYP2C93

Angiotensin-conver2

Variability2

Pharmacogenetics1

Coronary artery2

CYP2C196

P4504

Deletion3

Disease12

Variants2

Determinants1

Phase II detoxif1

Allele5

Inheritance2

Alterations3

Pathway2

Transporters3

Functional2

Proteins3

Methods1

Carcinogens3

Pancreatic4

Prevalent1

Differences2

Detoxification2

Role of genetic1

Effects of genetic2

GLUTATHIONE1

Escherichia3

Drug6

Interindividual1

Risk8

Variation1

Sequences1

Patients1

Endogenous2

Oxidation2

Study6

Pharmacodynamic1