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  • cellular
  • Enzymes are a type of protein, so membrane enzyme proteins are enzymes that are attached to a cellular membrane. (enotes.com)
  • The ER membrane protein complex (EMC) is a newly described transmembrane domain (TMD) insertase linked with various phenotypes, but whose clients and cellular responsibilities remain incompletely understood. (ox.ac.uk)
  • By facilitating insertion of TMDs that permit essential mammalian sterol-regulating enzymes to mature accurately, the EMC is an important biogenic determinant of cellular robustness to fluctuations in cholesterol availability.This article has an associated First Person interview with the first author of the paper. (ox.ac.uk)
  • Tethering PPT1 to the lysosomal membrane is a viable strategy to prevent "cross-correction" and will allow for the study of specific cellular contributions in INCL pathogenesis. (springer.com)
  • Bible E, Gupta P, Hofmann SL, Cooper JD (2004) Regional and cellular neuropathology in the palmitoyl protein thioesterase-1 null mutant mouse model of infantile neuronal ceroid lipofuscinosis. (springer.com)
  • Fluid bilayers of phospholipids studded with a Mosaic of proteins - provide boundaries in cellular organisation. (brainscape.com)
  • retinal
  • For example, we have performed NMR on photochemical intermediates of bacteriorhodopsin trapped at low temperature to study the mechanism of proton pumping and the origin of the opsin shift in the optical spectrum of retinal in this protein. (mit.edu)
  • PURPOSE: Advanced glycation endproduct (AGE) formation on the basement membrane of retinal capillaries has been previously described but the impact of these adducts on capillary endothelial cell function vascular repair remains uncertain. (biomedsearch.com)
  • synthase
  • Lipidomic and proteomic analyses revealed defective biogenesis and concomitant loss of the TMD-containing ER-resident enzymes sterol-O-acyltransferase 1 (SOAT1) and squalene synthase (SQS, also known as FDFT1), which serve strategic roles in the adaptation of cells to changes in cholesterol availability. (ox.ac.uk)
  • dynamics
  • In order to understand the diverse functions of membrane proteins and to engineer these functions for biomedical or biotechnological purposes, it is necessary to determine their high-resolution structure and to describe their dynamics. (umich.edu)
  • The development of NMR methods and their applications to determine the structure and describe the dynamics of membrane associated proteins and amyloid proteins are the main goals of the research program. (umich.edu)
  • Integrated description of protein dynamics from room-temperature X-ray crystallography and NMR. (virginia.edu)
  • catalytic
  • Encapsulation of catalytic enzymes inside the stomatocytes allowing the formation of nanomotors propelled by naturally occurring chemical fuel. (tue.nl)
  • modification
  • Post-translational modification by ubiquitin plays a key role in the regulation of endocytic degradation in which ubiquitinated plasma membrane cargos are transported to the vacuole for degradation dependent on the ESCRT (endosomal sorting complex required for transport) machinery. (uni-konstanz.de)
  • Syk inhibitors interfere with erythrocyte membrane modification during P falciparum growth and suppress parasite egress. (purdue.edu)
  • Structure
  • Theoretical part: Different structure motifs of proteins. (liu.se)
  • The enzyme renders microcystins 160 times less toxic by linearizing their structure. (plos.org)
  • One of these, an 11-mer from the protein transthyretin, is illustrated in the bottom part of the figure and is the initial structure of a peptide in an amyloid fibril. (mit.edu)
  • genes
  • The genome comparison reported here reveals clustering of M. kandleri with other methanogens in phylogenetic trees based on concatenated alignments of ribosomal proteins, which is mimicked by congruence of the sets of predicted genes, suggesting monophyly of this group. (pnas.org)
  • transmembrane
  • Transmembrane ATPases harness the chemical potential energy of ATP, because they perform mechanical work: they transport solutes in a direction opposite to their thermodynamically preferred direction of movement-that is, from the side of the membrane where they are in low concentration to the side where they are in high concentration. (wikipedia.org)
  • Proteomics
  • Top-down proteomics reveals a unique protein S-thiolation switch in Salmonella Typhimurium in response to infection-like conditions. (virginia.edu)
  • Chemical
  • Project part: Studies of physico-chemical properties of proteins and methodology for studies of these properties. (liu.se)
  • Selective permeability allows chemical gradients to be maintain across membranes, and the membrane surface is often the location of complex reactions. (brainscape.com)
  • This dephosphorylation reaction releases energy, which the enzyme (in most cases) harnesses to drive other chemical reactions that would not otherwise occur. (wikipedia.org)
  • nuclear
  • Therefore, correct and efficient targeting of these membrane proteins, which are encoded by the nuclear genome and translated in the cytosol, is critically important for organellar function. (frontiersin.org)
  • organelle
  • Viral protein nanocages, such as that of the cowpea chlorotic mottle virus (CCMV), are promising carriers for drug delivery applications or capsules for artificial organelle construction. (tue.nl)
  • stability
  • In order to enhance the stability of the ELP-CCMV capsid in vivo, while maintaining its reversible disassembly behavior, the N-terminal ELP block can be modified via protein engineering. (tue.nl)
  • Via the protein engineering toolbox, these variants can be produced and their assembly behavior and stability should then be evaluated and compared to the currently available variants. (tue.nl)
  • involves
  • Direct activation of a g-protein involves a biochemical attaching to the receptor having a direct effect on the g-protein. (enotes.com)
  • Indirect activation involves a series of signalling events being required to activiate the g-protein. (enotes.com)
  • hydrolase
  • In this study, we present a strategy to limit "cross-correction" of palmitoyl-protein thioesterase-1(PPT1), a lysosomal hydrolase deficient in Infantile Neuronal Ceroid Lipofuscinosis (INCL, Infantile Batten disease) to the lysosomal membrane via the C-terminus of lysosomal associated membrane protein-1 (LAMP1). (springer.com)
  • suggests
  • This evidence suggests that these two membrane protein's functions are strictly interconnected and that the NGF/TrkA signaling pathway is involved in AD pathogenesis and can be used as a therapeutic target. (jneurosci.org)