Enzyme with systematic name oxidative. Medical search. Frequent questions

These results therefore clarified blood oxidative stress profile in children with ASD, strengthening clinical evidence of increased oxidative stress implicating in pathogenesis of ASD. (nature.com)
Indeed, an increased oxidative stress was observed in the brains of ASD patients 18 . (nature.com)

There is increasing awareness that oxidative stress may be implicated in the pathophysiology of autism spectrum disorder (ASD). (nature.com)
Here we aimed to investigate blood oxidative stress marker profile in ASD children by a meta-analysis. (nature.com)
The human brain is especially vulnerable to oxidative stress because it accounts for only 2% of body mass but consumes 20% of oxygen 14 . (nature.com)
Therefore, it has been proposed that oxidative stress in the developing brains contributes to neuronal damage in genetically susceptible children, which is important in the pathophysiology of ASD. (nature.com)
Finally, the positive effects of individualized supplementation are discussed in the context of diminishing anxiety and oxidative stress, neuroprotection and in the reversal of neurodegeneration, and also in alleviating/reducing neuromuscular symptoms. (spandidos-publications.com)
Ab-TrSOD, when compared to TrSOD, promoted a decrease in the formation of ROS of 19 and 14% at the concentrations of 1 and 6 μmol/L, respectively, indicating that this joplinks Recombinant Human Regulator of G-protein form was more effective in reducing oxidative stress compared to SOD without the cell penetrating peptide (CPP). (pimac.org)
The information on body weight, food intake, oxidation stress parameters in blood and antioxidant enzymes activity in liver and small intestine was obtained. (olsztyn.pl)
Bartikova H., Skalova L., Valentova K., Matouskova P., Szotakova B., Martin J., Kvita V., Bousova I., Effect of oral administration of green tea extract in various dosage schemes on oxidative stress status of mice in vivo. (olsztyn.pl)
Del Rio D., Stewart A.J., Pellegrini N., A review of recent studies on malondialdehyde as toxic molecule and biological marker of oxidative stress. (olsztyn.pl)
The underlying mechanisms involved in genomic stability, apoptosis and oxidative stress-related signaling were further analyzed by Western blotting, flow cytometry and immunofluorescence assays. (biomedcentral.com)
Several studies have shown oxidative stress (OS) to be one of the major factors in the pathogenesis of diabetic complications. (nature.com)
This observation, and the enzyme's localization at the entrance to the mitochondrial matrix, suggest that it may function to protect mitochondria against oxidative stress associated with the highly reactive retinal produced from dietary β-carotene by EC 1.13.11.63 (β-carotene 15,15′-dioxygenase) [2]. (enzyme-database.org)
Oxidative Stress-regulating Enzymes and Endometrial Cancer Survival in Relation to Metformin Intake in Diabetic Patients. (nih.gov)
A total of 119 biomarkers were reported, categorized into: genetic and microRNAs (n = 64), oxidative stress (n = 10), energy metabolism (n = 18), inflammation (n = 7), enzyme (n = 4), hormone (n = 7), bone (n = 3), vitamin (n = 2), and cytokine (n = 4) markers) and seven lower limb muscle measures predominately focused on strength. (lincoln.ac.uk)
In normal cell biology, ROS levels increase with a decreasing antioxidant response, resulting in oxidative stress which threatens sperm biology. (mdpi.com)
Oxidative stress has numerous effects, including increased apoptosis, reduced motion parameters, and reduced sperm integrity. (mdpi.com)
Hemolysis begins 24-72 hours after exposure to oxidative stress. (medscape.com)
The clinical presentation of G6PD deficiency includes a spectrum of hemolytic anemia ranging from mild to severe hemolysis in response to oxidative stress. (medscape.com)
If Cu is allowed to cycle through between its oxidation states unchecked, it can cause significant damage through oxidative stress. (duke.edu)
Oxidative stress, nitric oxide (NO) dysregulation, and endothelial dysfunction play an essential role in the deterioration of HF. (hindawi.com)
This study aimed to investigate the in vitro and in vivo protective effects of DHEA against high glucose-induced oxidative stress in tenocytes and tendons. (biomedcentral.com)
On the other hand, oral administration of MSNs disturbed inflammatory factors and metabolites of ribose-5-phosphate, 6-phosphogluconate, GSSG, and NADP+ associated with the pentose phosphate pathway, glutathione synthesis and oxidative stress albeit to a lesser extent than intravenous injection despite the administration of a ten-fold greater dose. (frontiersin.org)
Overall, systematic biological data suggested that intravenous injection of nanoparticles of pharmaceutical excipients substantially affected hepatic metabolism function and induced oxidative stress and inflammation, whereas oral administration exhibited milder effects compared with intravenous injection. (frontiersin.org)
Dolutegravir-associated changes to maternal physiology, such as weight change, hyperglycaemia, and folate metabolism, along with changes to adipose tissue, oxidative stress, and potential interference with metal-binding enzymes, might affect fetal development and influence metabolic health in the child. (natap.org)
Exercise promotion for adolescents with Down syndrome requires attention to motivators and facilitators of exercise adherence as it may limit risk of increased neurological consequences associated with oxidative stress and improve quality of life. (who.int)
En effet, une activité physique régulière permetterait de limiter le risque de conséquences neurologiques accrues associées au stress oxydatif et d'améliorer la qualité de vie. (who.int)
ing high levels of oxidative stress [1]. (who.int)
Oxidative stress is a term used to de- tion. (who.int)
A study by Hashem et al using induced pluripotent stem cell-derived cardiomyocytes indicated that LAMP2 protein deficiency in Danon disease results in autophagic flux impairment, which in turn causes excessive oxidative stress and, subsequently, cardiomyocyte apoptosis. (medscape.com)

Patients may experience episodes of intravascular hemolysis and consequent anemia, triggered by infections, medicines that induce oxidative stresses, fava beans, and ketoacidosis. (medscape.com)

A genetic predisposition to altered biotransformation of environmental chemicals, drugs, and metals, and of endogenous low-molecular weight metabolites, caused by polymorphisms of genes coding for xenobiotic metabolizing enzymes, their receptors and transcription factors appears to be involved in the susceptibility to these environment-associated pathologies, along with epigenetic factors. (niscpr.res.in)
Free radical/antioxidant homeostasis may also be heavily implicated, indirectly by affecting the regulation of xenobiotic metabolizing enzymes, and directly by causing increased levels of oxidative products, implicated in the chronic damage of cells and tissues, which is in part correlated with clinical symptoms. (niscpr.res.in)
These are termed xenobiotic-metabolizing enzymes (XMEs) found especially in the liver but also in the mucosa of the upper aerodigestive tract, and several are polymorphic and strongly influence individual biological responses to carcinogens. (bvsalud.org)

This enzyme participates in oxidative phosphorylation. (wikipedia.org)
The enzyme participates in the menthol-biosynthesis pathway of Mentha plants. (enzyme-database.org)
Thioredoxin reductase is another selenium-dependent enzyme that participates in the regeneration of antioxidant systems, including vitamin C. Maintaining thioredoxin in its reduced form by thioredoxin reductase is important in supporting normal cell growth and vitality (7). (nutrametrix.com)

In addition, increases in GPX, SOD3, G6PD, HK, and PFK at proteomic and transcriptomic levels suggested elevation of glycolysis and pentose phosphate pathway, synthesis of glutathione and nucleotides, and antioxidative pathway activity, whereas oxidative phosphorylation, TCA and mitochondrial energy metabolism were reduced. (frontiersin.org)

the disease includes a component of skeletal myopathy with proximal-limb muscle weakness, mild muscular atrophy, elevated plasma concentrations of creatine kinase (CK), ophthalmologic involvement, possible intellectual disability, and elevated hepatic enzyme levels. (medscape.com)

Specific activities of antioxidant enzymes in the liver and small intestine were not altered after GTE treatment except the decrease of NAD(P)H:quinone oxidoreductase activity. (olsztyn.pl)
Blood pressure, lipids, fasting glucose, liver values, antioxidant enzymes, and markers of inflammation (C-reactive protein and interleukin-6) were assessed before and after the three-month treatment period. (lifeextension.com)
Concurrently, the antioxidant enzymes superoxide dismutase (SOD) and glutathione peroxidase were higher in the supplemented groups. (lifeextension.com)

Ubiquinol-cytochrome-c reductase catalyzes the chemical reaction QH2 + 2 ferricytochrome c ⇌ {\displaystyle \rightleftharpoons } Q + 2 ferrocytochrome c + 2 H+ Thus, the two substrates of this enzyme are quinol (QH2) and ferri- (Fe3+) cytochrome c, whereas its 3 products are quinone (Q), ferro- (Fe2+) cytochrome c, and H+. (wikipedia.org)
Likewise, graduate students who receive their training in medicinal chemistry not only learn the art of organic synthesis as applied to rational design and synthesis of enzyme substrates and inhibitors (or receptor agonists and antagonists) for structure-activity relationship (SAR) analyses, but also gain an appreciation for biochemical screening and drug metabolism through their graduate coursework and potentially hands-on experience in the laboratory. (aspetjournals.org)

The coenzyme Q : cytochrome c - oxidoreductase, sometimes called the cytochrome bc1 complex, and at other times complex III, is the third complex in the electron transport chain (EC 1.10.2.2), playing a critical role in biochemical generation of ATP (oxidative phosphorylation). (wikipedia.org)

The systematic name of this enzyme class is ubiquinol:ferricytochrome-c oxidoreductase. (wikipedia.org)

The meta-analysis showed that blood concentrations of oxidative glutathione (GSSG), malondialdehyde, homocysteine, S -adenosylhomocysteine, nitric oxide, and copper were higher in children with ASD than that of HC children. (nature.com)

Trichoderma reesei superoxide dismutase (TrSOD) is a well characterized enzyme being stable between 30 and 90°C for 1 h with activity at pH between 2.6 and 9.0. (pimac.org)

At the end of three months, liver enzyme activity, systolic blood pressure, inflammatory markers and triglyceride levels were lower in both groups that received supplementary nutrients compared to the group treated with statins alone. (lifeextension.com)

The entries below are proposed additions and amendments to the Enzyme Nomenclature list . (enzyme-database.org)

Microbial tannases are mostly induced extracellular enzymes produced by submerged and solid-state fermentation. (ub.ac.id)
2005). These fungi produce sever- lected in the present study by enrichment culture, using kraft al extracellular peroxidases, laccases, and additional oxidative lignin and kraft pulping lignin-enriched streams. (lu.se)

Glutathione peroxidases are a group of selenoprotein enzymes that reduce reactive oxygen species such as hydrogen peroxide and lipid hydroperoxides to harmless products such as water and simple alcohols. (nutrametrix.com)

G6PD is an enzyme involved in the pentose monophosphate pathway. (medscape.com)
The G6PD enzyme is part of the pentose monophosphate shunt. (medscape.com)

Amiot M.J., Riva C., Vinet A., Effects of dietary polyphenols on metabolic syndrome features in humans: a systematic review. (olsztyn.pl)
Organochlorine pesticide exposures, metabolic enzyme genetic polymorphisms and semen quality parameters among men attending an infertility clinic. (cdc.gov)

This changing in oxidation state is called redox chemistry and it allows copper to mediate some of the electron transfer reactions that are essential for things like cellular energy production (in the electron transport chain), antioxidant activity in cytoplasm, and in body fluids (in enzymes SOD 1 and SOD 3). (duke.edu)

The na- quire biotransformation by enzymes carcinogens. (who.int)
Various products of these genes are enzymes involved in the activation or degradation of carcinogens/pro-carcinogens. (bvsalud.org)

Mutations in genes concerned with production of enzymes for metabolism of tobacco products may lead to increased risk of carcinogenesis with respect to oral mucosa. (bvsalud.org)

In a systematic review and meta-analysis published in 2021, Fritzen et al ( 10 ) verified increased levels of salivary cortisol in bruxists. (spandidos-publications.com)
Genetic Polymorphisms of Pesticide-Metabolizing Enzymes and Transporters in Agricultural Workers and Thyroid Hormone Levels. (cdc.gov)
Worldwide prevalence of hepatitis B virus and hepatitis C virus among patients with cirrhosis at country, region, and global levels: a systematic review. (who.int)

When the concentration of free radicals exceeds the neutralizing capability of the body's antioxidants, these highly reactive species can damage vital molecules such as DNA, RNA, enzymes and structural proteins and large amounts of membrane lipids though peroxidation. (nutrametrix.com)

The enzyme is a member of the succinate dehydrogenase/fumarate-reductase family of enzymes [5]. (enzyme-database.org)
Fitzsimmons S.A., Workman P., Grever M., Paull K., Camalier R., Lewis A.D., Reductase enzyme expression across the National Cancer Institute Tumor cell line panel: correlation with sensitivity to mitomycin C and EO9. (olsztyn.pl)

The goal of this thesis is to establish the feasibility of textile as support material for immobilization of catalyst in the pursuit of fabrication of heterogeneous catalytic system (oxidative and reductive) for wastewater treatment. (diva-portal.org)

Nasu, S., Wicks, F.D. and Gholson, R.K. L -Aspartate oxidase, a newly discovered enzyme of Escherichia coli , is the B protein of quinolinate synthetase. (enzyme-database.org)
This work aimed to clone, express, purify and evaluate the protective effect antioxidant of this enzyme on skin cells when fused to transactivator of transcription (TAT) protein transduction domain of HIV-1 and Abalone (Ab) peptides to allow cell penetration. (pimac.org)
For metal- powerful methods to obtain and compare reaction and activation loproteins, a third method to obtain local information about the energies for suggested enzyme mechanisms and they can also provide atomic details about the protein dynamics. (lu.se)

PD-1/PD-L1 inhibitors plus carboplatin and paclitaxel compared with carboplatin and paclitaxel in primary advanced or recurrent endometrial cancer: a systematic review and meta-analysis of randomized clinical trials. (nih.gov)

This review provides a more in-depth knowledge of the research related to the biochemical characteristics of the tannase enzyme activity (in terms of molecular weight, the effect of pH, the effect of temperature, the effect of metal ions, inhibitor, and chelator), extraction, and purification methods. (ub.ac.id)

During their training, medicinal chemists are also taught to apply physical and mechanistic organic chemistry concepts (e.g., valence electrons, resonance effects, acidity, nucleophilicity, electrophilicity, etc.) to rationalize the biochemistry of enzyme-catalyzed reactions, and even understand the chemical basis for conversion of a substrate into product. (aspetjournals.org)
Ulf Ryde was born in 1963 and obtained a PhD in biochemistry methods and their possible combination with quantum chemical (enzyme kinetics and control theory) at Lund University, Sweden, methods, including a number of typical applications. (lu.se)

To identify biological markers associated with lower limb muscle (dys)function in adults with sarcopenia, a systematic literature search was conducted in AMED, CINAHL, Cochrane Library, EMBASE, Medline, PubMed, Scopus, SPORTDiscus, and Web of Science databases from inception to 17 November 2021. (lincoln.ac.uk)

To obtain detailed systematic tumor immune profile, we performed an in-depth immunoassay on 12 human urothelial carcinoma tissue samples and 14 paratumor tissue samples using mass cytometry. (biomedcentral.com)

Polymorphic genotypes of these enzymes may serve as genetic biomarkers for susceptibility to certain malignancies and therefore may help predict individual cancer risk 8 . (bvsalud.org)

Our body uses selenium-dependent enzymes known as selenoproteins to neutralize reactive oxygen species as well as reactive nitrogen species. (nutrametrix.com)

The enzyme has a preference for NADPH as the reductant, with NADH being a poor substitute [2]. (enzyme-database.org)
This enzyme differs from EC 1.1.1.105 , retinol dehydrogenase, which prefers NAD + and NADH. (enzyme-database.org)

Evidence from systematic experiments was gathered for the case of immobilization of an inorganic catalyst (zerovalent iron-Fe0) and a biocatalyst (glucose oxidase -GOx) on textile support. (diva-portal.org)

G6PD deficiency leads to free radical-mediated oxidative damage to red blood cells, which in turn causes hemolysis. (medscape.com)
Research on this topic may be of great procedures were approved by the Eth- Results interest since oxidative damage has ics Review Committee of the National been proposed as a pathogenic mecha- Research Centre. (who.int)

RÉSUMÉ L'objectif de la présente étude était d'évaluer l'efficacité d'un programme d'exercice sur tapis roulant électronique sur le malondialdéhyde, en tant que marqueur de la peroxydation lipidique et sur une enzyme antioxydante, le glutathion peroxydase, chez des adolescents atteints du Syndrome de Down. (who.int)

Further, given the scale at which ART is being used in pregnancy, it is important that systematic monitoring of adverse events and pregnancy and birth outcomes is implemented because even small changes in risk have the potential to translate into many pregnancies and babies affected. (natap.org)

More systematic studies of molecular epidemiology, toxico- and pharmaco-genomics, elucidating the mechanisms of regulation, expression, induction, and activity of antioxidant/detoxifying enzymes, and the possible role of inflammatory mediators, promise a better understanding of this pathologically increased sensitivity to low-level chemical stimuli, and a solid basis for effective individualized antioxidant- and/or chelator-based treatments. (niscpr.res.in)

Alcohol also interferes with proper inflammatory responses by disturbing the enzymatic processing of TNFα by TNFα Converting Enzyme (TACE) and abrogating TNFα/TACE function [ 11 , 12 ]. (cdc.gov)

Some of the enzymes which generate aromatic radicals that break down most prominent bacterial strains found were isolated and tax- the complex linkages present in lignin to compounds of lower onomically identified using 16S ribosomal RNA (rRNA) se- molecular weight. (lu.se)

The aim of our systematic review was to assess the effects of selenium supplementation on Hashimoto's thyroiditis. (karger.com)
Boušová I., Matoušková P., Bártíková H., Szotáková B. Hanušová V., Tománková V., Anzenbacherová E., Lišková B., Anzenbacher P., Skálová L., Influence of diet supplementation with green tea extract on drug-metabolizing enzymes in a mouse model of monosodium glutamate-induced obesity. (olsztyn.pl)

In Mali, screening for certain viruses such as dengue, Zika, and Rift Valley fever is not systematic at the national blood transfusion center (CNTS). (bvsalud.org)

The 3T3 cells were exposed to the oxidant agent tert-butyl hydroperoxide (tBH) and evaluated for ROS generation, in the presence or not of the recombinant enzymes. (pimac.org)

Studies on the feeding habits of Lygus disponsi Linnavuori (Hemiptera: Miridae) and the injury to its host plant V. Phenolic compounds, acid phosphatae and oxidative enzymes in artificially injured tissue of sugar beet leaf. (amnh.org)

The ability of the enzyme to use both O 2 and fumarate in cofactor reoxidation enables it to function under both aerobic and anaerobic conditions [5]. (enzyme-database.org)

In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). (yeastgenome.org)

Anatomy4

Organisms75

Diseases1

Chemicals and Drugs38

Analytical, Diagnostic and Therapeutic Techniques and Equipment16

Psychiatry and Psychology9

Phenomena and Processes34

Disciplines and Occupations12

Anthropology, Education, Sociology and Social Phenomena4

Technology, Industry, Agriculture4

Humanities11

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Named Groups1

Health Care23

Geographicals13

Increased oxidative stress2

Stress29

Induce oxidative1

Xenobiotic metabol3

Participates3

Mitochondrial1

Hepatic1

Antioxidant enzymes3

Substrates2

Phosphorylation1

Oxidoreductase1

Nitric oxide1

Superoxide dismutase1

Liver1

Nomenclature1

Extracellular2

Lipid1

Pentose2

Metabolic2

Oxidation1

Carcinogens2

Metabolism1

Levels3

Proteins1

Reductase2

Catalytic1

Protein3

Clinical1

Biochemical1

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Tumor1

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Reactive1

NADH2

Glucose1

Damage2

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High1