Protein StabilityDrug StabilityEnzyme StabilityProtein DenaturationThermodynamicsProtein FoldingMolecular Sequence DataKineticsAmino Acid SequenceMutationProteinsModels, MolecularProtein ConformationRNA StabilityDiaminesTemperatureProtein BindingRNA, MessengerLiverUbiquitinationHalf-LifeHydrogen-Ion ConcentrationBase SequenceProtein Structure, TertiaryCell LineElectrophoresis, Polyacrylamide GelCircular DichroismProteasome Endopeptidase ComplexProteolysisProtein Structure, SecondaryHot TemperatureAcetyl-CoA HydrolaseOrnithine DecarboxylaseEscherichia coliCycloheximideEnzyme InductionAmino AcidsAcetyl-CoA C-AcyltransferaseUbiquitinGuanidineMolecular WeightProtein EngineeringAmino Acid SubstitutionLesch-Nyhan SyndromeSubstrate SpecificityRecombinant ProteinsMutagenesis, Site-DirectedBinding SitesEnzymesProtein UnfoldingPurine-Pyrimidine Metabolism, Inborn ErrorsIsomerasesEnoyl-CoA HydrataseProgesterone ReductaseIsoenzymesProcollagen-Proline DioxygenaseUbiquitin-Protein LigasesSpectrometry, FluorescenceCarboxy-LyasesBlotting, WesternGene Expression Regulation, EnzymologicCalorimetry, Differential ScanningTranscription, GeneticProtein BiosynthesisCatalysisRats, Inbred StrainsSequence Homology, Amino Acidbeta-N-AcetylhexosaminidasesChromatography, GelProtein Processing, Post-TranslationalUreaMultienzyme ComplexesHEK293 CellsImmunodiffusion3-Hydroxyacyl CoA DehydrogenasesDNAImmunoblottingCloning, MolecularOxidoreductasesCells, CulturedHydrogen BondingTime FactorsMuramidaseSolventsGlucosidasesPhosphorylationDactinomycinTransition TemperatureEnzyme ActivationMicrosomes, LiverMutation, MissenseModels, ChemicalStatic ElectricityHydroxymethylglutaryl CoA ReductasesStructure-Activity RelationshipCell Line, TumorMacromolecular SubstancesMutant ProteinsBlotting, NorthernFibroblasts