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  • peripheral blood
  • Objective: We used peripheral blood from AD patients to investigate the expression of genes related to APP-processing [(β-site APP-cleaving enzyme 1 (BACE1), presenilin1 (PSEN1), and a disintegrin and metalloproteinase family 10 (ADAM10) and 17 (ADAM17)] and the epigenetic genes sirtuin (SIRT)1-3, which regulate Aβ production. (eurekaselect.com)
  • mRNA
  • Interestingly, their findings at Mahidol University, Thiland, highlighted prominent variations in mRNA expression of enzymes, with BACE1 and SIRT2 as significant markers (with higher levels) in AD subjects. (scienmag.com)
  • intestine
  • The pancreas also produces fluid that is released through ducts into the intestine and contains enzymes and bicarbonate that are necessary for digestion of food. (nih.gov)
  • synthesis
  • Conclusion: The present findings provide evidence and support for the potential roles of these enzymes that drive Aβ synthesis and for epigenetic regulation in AD progression and development, which can possibly be considered peripheral markers of AD. (eurekaselect.com)
  • roles
  • In this paper, we will summarize a number of experimental observations that address how A β affects synaptic function, and review data obtained from genetically altered mice developed to test the feasibility of blocking APP-processing enzymes which unveiled functional roles for these enzymes in normal synaptic transmission and plasticity. (hindawi.com)
  • occurs
  • In animal cells, the first notable step in miRNA processing occurs when Drosha, a nuclear RNaseIII enzyme, excises the upper part of this RNA hairpin to generate the precursor miRNA (pre‐miRNA), which is ∼60 nt long with a 3′ 2 nt overhang ( Lee et al , 2002 , 2003 ). (embopress.org)
  • ADAM10
  • Group of enzymes including β-site APP-cleaving enzyme 1 (BACE1), presenilin1 (PSEN1), disintegrin, metalloproteinases MMP10 (ADAM10), MMP17 (ADAM17) and NAD-dependent deacetylase sirtuin-1 were identified to have a major role in the progression of Aβ formation. (scienmag.com)
  • major
  • Therefore, inhibiting the activity of these enzymes has surfaced as one of the major disease-modifying approaches for AD [ 4 ]. (hindawi.com)
  • activity
  • The aim of this study was to determine variation in the activity of stearoyl-CoA desaturase enzyme and endogenous precursors of unsaturated fatty acids in cow's milk during the grazing season. (sggw.pl)
  • Dietary specialization is associated with differences in level and activity of gut enzymes and transporters ( 2 ). (pnas.org)
  • Function
  • Abnormalities in synaptic function resulting from the absence or inhibition of the A β -producing enzymes suggest that A β itself may have normal physiological functions which are disrupted by abnormal accumulation of A β during AD pathology. (hindawi.com)
  • We will also discuss a body of work, which investigates how synaptic function is affected by currently available therapies that target APP-processing enzymes. (hindawi.com)
  • The pathway requires the function of a previously unidentified amidohydrolase enzyme that converts adenosylcobinamide to adenosylcobyric acid, a bona fide intermediate of the de novo coenzyme B(12) biosynthetic route. (nih.gov)
  • Several recent studies have already suggested a potential role for UDP-Glc in plant growth and development, and UDP-Glc has also been suggested as a signaling molecule, in addition to its precursor function. (frontiersin.org)
  • Substrate specificities of these enzymes are discussed, along with structure-function relationships, based on their crystal structures and homology modeling. (frontiersin.org)
  • blood
  • Regulatory subunit of the blood coagulation factor X- and IX-activating enzyme. (uniprot.org)
  • Blood samples were collected from patients with AD, and the regulation as well as genes expression of enzymes involved in APP-processing was monitored. (scienmag.com)
  • environment
  • The existence of a pathway for salvaging the coenzyme B(12) precursor dicyanocobinamide (Cbi) from the environment was established by genetic and biochemical means. (nih.gov)
  • usually
  • This information usually correlates with the presence of an EC (Enzyme Commission) number in the 'Names and taxonomy' section. (uniprot.org)