Nitric oxideAntibiotic activityNovoAcetylcholineAngiotensinSignificantlyInhibitsInhibitionInhibitorsExogenousPathwaysEndothelialLiverTorsade de poinLipidPeptideInstitutoD'IL-10AcuteEffectsActivatorDegradationSubsequentConcentrationsL'infection2017VivoNiveauUptakeIncreasesCardiovascularActivationProteinsEstudoReceptor1997EffectPatientsSangFoundCentralEnergyTypeHuman
Nitric oxide4
- Stressors increase corticoreleasing hormone, adrenocorticoreleasing hormone, cortisol and prolactin and decrease prostaglandin E2 release and vasoconstriction induced/potentiated by angiotensin II, nitric oxide, acetylcholine and serotonin. (gremjournal.com)
- In the endothelium, nitric oxide synthase (eNOS) is the enzyme that generates nitric oxide, a key molecule involved in a variety of biological functions and cancer-related events. (edu.mx)
- Conclusion: Inhibition of nitric oxide in an acute liver injury model potentiates the liver injury as evidenced by increased appearance of hepatocellular necrosis and elevated liver enzymes and bilirubin. (bvsalud.org)
- The increased bacterial translocation could be one of the mechanisms potentiating liver injury and nitric oxide may be pathophysiologically involved. (bvsalud.org)
Antibiotic activity1
- Thus the peptide represents a novel strategy to potentiate antibiotic activity against biofilms. (ubc.ca)
Novo5
- More recently it has been proposed that prostate tumor cells synthesize their own androgens through de novo steroidogenesis, which involves the step-wise synthesis of androgens from cholesterol. (harvard.edu)
- Moreover, we show that circulating cholesterol levels are directly correlated with tumoral expression of CYP17A, the critical enzyme required for de novo synthesis of androgens from cholesterol (R = 0.4073, p = 0.025) Since hypercholesterolemia does not raise circulating androgen levels and the adrenal gland of the mouse synthesizes minimal androgens, this study provides evidence that hypercholesterolemia increases intratumoral de novo steroidogenesis. (harvard.edu)
- L-alanosine-induced disruption of de novo purine biosynthesis is potentiated by methylthioadenosine phosphorylase (MTAP) deficiency. (medicalterminologydb.com)
- De novo peptide sequencing identified one Bothrops -like BPP and one new BPP sequence. (biomedcentral.com)
- Fatty acid synthase (FAS), as a key enzyme involved in de novo lipogenesis, is highly expressed in many cancers. (oncotarget.com)
Acetylcholine1
- When cholinesterases are inhibited, the action of endogenously released acetylcholine at cholinergic synapses is potentiated. (bvsalud.org)
Angiotensin4
- The bradykinin-potentiating peptides (BPPs) comprise a class of angiotensin-I converting enzyme (ACE) inhibitors. (biomedcentral.com)
- Novel natural peptide substrates for endopeptidase 24.15, neurolysin, and angiotensin-converting enzyme. (nih.gov)
- In anesthetized male Wistar rats, this peptide exhibited hypotensive actions similar to those of bradykinin (BK) when administered intravenously (i.v.), and was found to be metabolized both in vitro and in vivo by several peptidases, including the angiotensin-converting enzyme (ACE). (nih.gov)
- In addition, angiotensin II potentiates the neural liberation of catecholamines, is arrhythmogenic, promotes vascular hyperplasia and pathological myocardial hypertrophy, as well as stimulates cardiomyocytes apoptosis. (fapesp.br)
Significantly5
- The in vivo effect of HP was significantly potentiated in rabbits immunostimulated with bacterial lipopolysaccharide (LPS), but was unaffected by both the B2 receptor antagonist HOE 140 (0.1 micromol/kg) and captopril (100 microg/kg), contrary to BK. (nih.gov)
- The blood glucose level, liver function enzymes, total protein, lipid, and cholesterol levels were significantly normalized by extract treatment. (hindawi.com)
- The antioxidant markers, glucolytic, and gluconeogenic enzymes were significantly ameliorated and the elevated level of kidney biomarkers in the diabetic groups was restored. (hindawi.com)
- Suppression of NADPH oxidase almost totally blocked reactive oxygen species generation while significantly potentiated the in vitro and in vivo killing of breast cancers by FAS inhibition. (oncotarget.com)
- Results:Liver enzymes increased significantly at all time intervals in acute liver injury + L-NAME compared to liver injury control groups. (bvsalud.org)
Inhibits2
- Plasminogen activator inhibitor-1 inhibits plasminogen activators and subsequent fibrinolysis potentiating thromboembolic effects. (gremjournal.com)
- It also inhibits other fungal enzymes resulting in the accumulation of toxic concentrations of hydrogen peroxide. (medicscientist.com)
Inhibition1
- The inhibition of dipeptidyl peptidase IV (DPPIV), the enzyme responsible for the degradation of incretin hormone glucagon-like peptide 1 (GLP-1), represents an effective and safe therapy for patients with type 2 diabetes mellitus. (fapesp.br)
Inhibitors1
- Targeting TNKS1/2 with small-molecule inhibitors shows promising potential to modulate the involved pathways, thereby potentiating disease intervention. (mdc-berlin.de)
Exogenous2
- This ability was highly potentiated by the addition of exogenous factor Va, which functions as a co-factor for the enzyme factor Xa. (scielo.br)
- drugs that can produce parallel blocking of potentiating effects on the responses of both exogenous transmitter and nerve stimulation Tachyphylaxis to ATP produced in the rabbit ileum resulted in a consistent depression of responses to non-adrenergic inhibitory nerve stimulation, whereas responses to adrenergic nerve stimulation remained unaffected (Burnstock et al. (uni-frankfurt.de)
Pathways1
- MTAP is a key enzyme in the adenine and methionine salvage pathways. (medicalterminologydb.com)
Endothelial1
- In conclusion, UMMD enhances the delivery and potentiates the effect of AP-Cav in the endothelial layer of rat aorta segments. (edu.mx)
Liver1
- Alananine transaminase (ALT) and aspartate transaminase (AST) are enzymes that, when elevated, can indicate liver damage, anavar show up on drug test. (dsgmerkezi.com)
Torsade de poin2
- Due to increased risk of bradycardia, AV block, and torsade de pointes, concomitant use is contraindicated. (medscape.com)
- Increased plasma levels and prolonged QT intervals of astemizole, cisapride, dofetilide, pimozide, quinidine and terfenadine which may lead to torsade de pointes. (medicscientist.com)
Lipid1
- 15 Castilho R.F., Meinicke A.R., Alemida A.M., Hermes-Lima M., Vercesi A.E. Oxidative damage of mitochondria induced by Fe(II)citrate is potentiated by Ca 2+ and includes lipid peroxidation and alterations in membrane proteins. (thieme-connect.de)
Peptide1
- To explain the broad-spectrum activity of the peptide, I hypothesized that it acted to inhibit a common stress response, and that the stringent response, mediating (p)ppGpp synthesis through the enzymes RelA and SpoT, was targeted. (ubc.ca)
Instituto1
- Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). (fapesp.br)
D'IL-102
- Une corrélation positive significative a été détectée entre les concentrations sériques de sCD40L et d'IL-10 (r = 0,85 p (who.int)
- L'évaluation des concentrations sériques d'IL-10 chez les patients positifs pour le VHC pourrait fournir un possible marqueur prédictif pour l'évolution de la maladie. (who.int)
Acute2
- Two small studies conducted in patients with a high baseline risk of acute pancreatitis concluded serial monitoring of pancreatic enzymes may be useful to guide early discontinuation of medications with known associations with pancreatitis. (bmj.com)
- Early discontinuation of medication was not advised for lower-risk patients because some medications cause transient elevations of pancreatic enzymes that do not progress to acute pancreatitis. (bmj.com)
Effects4
- It does not inhibit arginyl aminopeptidase (aminopeptidase B). Amastatin has been found to potentiate the central nervous system effects of oxytocin and vasopressin in vivo. (wikipedia.org)
- Recombinant human alpha fetoprotein synergistically potentiates the anti-cancer effects of 1'-S-1'-acetoxychavicol acetate when used as a complex against. (oncotarget.com)
- Potentially Fatal: May potentiate and prolong sedative and hypnotic effects of midazolam and triazolam. (medicscientist.com)
- Our results suggest that occupational exposure to styrene has genotoxic effects that are potentiated by the GSTT1 gene deletion. (unipi.it)
Activator1
- We demonstrate for the first time at the cellular level that heat-activated ionic currents were potentiated after exposure to the cAMP activator forskolin in rat nociceptive neurons. (jneurosci.org)
Degradation1
- Die Apoptose in akut abgestoßenen allogenen Herztransplantaten (Rattenmodell) war von einer erhöhten Bax-Expression und einer totalen, posttranslationalen Degradation des antiapoptotischen Bcl-2 in ein spezifisches Degradationsprodukt durch eine Serinprotease gekennzeichnet. (uni-frankfurt.de)
Subsequent2
- Tissue factor (TF) is a 47-kDa membrane-bound protein that serves as a receptor and co-factor for the enzyme factor VIIa (FVIIa), with subsequent formation of the extrinsic tenase complex that converts factor X (FX) to FXa (2). (scielo.br)
- however, subsequent studies demonstrated no utility of serial ultrasound or serial monitoring of pancreatic enzymes in the early detection of DIP. (bmj.com)
Concentrations4
- It required higher concentrations of BKM120 and BGT226 to reach the same level of apoptosis in these estrogen-deprived cells, but adding fulvestrant (which down-regulates the estrogen receptor) strongly potentiated cell death. (cancernetwork.com)
- Les concentrations sériques de sCD40L circulant et d'interleukine 10 circulante ont été analysées à l'aide de la méthode immuno-enzymatique chez 30 patients positifs pour le VHC avec un CHC, chez 30 patients patients positifs pour le VHC avec une cirrhose du foie, et chez 30 volontaires d'âge correspondant en bonne santé avec des anticorps anti-VHC négatifs servant de groupe témoin. (who.int)
- Les concentrations sériques de sCD40L ont montré des niveaux statistiquement élevés chez les patients atteints d'un CHC associé au VHC par rapport aux concentrations sériques d'AFP. (who.int)
- Les concentrations sériques de sCD40L avaient une valeur diagnostique plus élevée chez les patients atteints d'un CHC que les concentrations sériques d'AFP. (who.int)
L'infection1
- L'étude a conclu que le sCD40L est un outil précieux pour le diagnostic et le dépistage précoces de l'infection à VHC et du CHC, ainsi que pour le suivi de routine des patients cirrhotiques positifs pour le VHC. (who.int)
20172
- Betont reduction Foot pp. control management Bedeutung des Wissens beim gesellschaftlichen Aufbau einer Wirklichkeit, biosynthesis der unknowable Konstruktivismus grain Akzent auf have Bedeutung der Kommunikation bei dem Aufbau der Wirklichkeit( Knoblauch 1995, Knoblauch 2013 root 2017, Reichertz 2009 practice 2017). (xn--drpverein-rahe-vpb.de)
- Neste estudo foi realizada a análise qualitativa da mídia de 727 notícias de jornais impressos, datados de 2015 a 2017. (bvsalud.org)
Vivo1
- Using the in vivo LNCaP PCa xenograft model, previous data from our group demonstrated that a hypercholesterolemia diet potentiates prostatic tumor growth via induction of angiogenesis. (harvard.edu)
Niveau2
- Ainsi, chez les hommes âgés, le manque de testostérone est plus fréquent avec le déclin de la production testiculaire ou des sécrétions au niveau des testicules, anavar show up on drug test. (dsgmerkezi.com)
- Resultats et Discussion: Il n'a pas ete retrouve une association significative entre l'allele Arginine du codon 72 de p53 et la predisposition au cancer du col de l'uterus (p=0;354) de meme qu'il n'a pas ete retrouve de correlation entre l'allele Arginine et les types de lesions histologiques observees au niveau du col de l'uterus. (bvsalud.org)
Uptake2
- We demonstrate tumoral expression of cholesterol uptake genes as well as the spectrum of steroidogenic enzymes necessary for androgen biosynthesis from cholesterol. (harvard.edu)
- 1970). enzymes that inactivate the transmitter and/or uptake systems for the transmitter or its breakdown products When ATP was added to a perfusion fluid recycled through the vasculature of the stomach, very little ATP remained, but the perfusate contained substantially increased amounts of adenosine and inosine, as well as some ADP and AMP (Burnstock et al. (uni-frankfurt.de)
Increases1
- Increases risk of torsades de pointes. (medscape.com)
Cardiovascular1
- Pro-inflammatory interleukin-1 genotypes potentiate the risk of coronary artery disease and cardiovascular events mediated by oxidized phospholipids and lipoprotein(a). (cdc.gov)
Activation2
- In contrast, prothrombin activation was not observed when cells were previously incubated with DEGR-factor Xa, an inactive derivative of the enzyme. (scielo.br)
- The result, often, is hyper-activation of the enzyme. (cancernetwork.com)
Proteins1
- The enzymes that are responsible for adding phosphate groups to proteins are known as "kinases" . (clinicaleducation.org)
Estudo1
- O estudo mostra que os conceitos mais recentes de promoção da saúde atrelados ao estresse são pouco discutidos na mídia impressa. (bvsalud.org)
Receptor1
- The effect of the psoralen derivatives from radix Angelicae dahuricae on retinoid X receptor- α enzymes transcriptional regulation was reported [ 4 ] and this in turn plays key roles in various biological processes including diabetes and obesity. (hindawi.com)
19971
- It caused decreased basal TSH levels (De Mendonca et al, 1997) . (poisonfluoride.com)
Effect1
- This extract and some linear furanocoumarins exhibited carbohydrate metabolizing enzymes inhibitory effect. (hindawi.com)
Patients2
- May potentiate sleep apnea in some patients, anavar show up on drug test. (dsgmerkezi.com)
- RÉSUMÉ L'objectif de l'étude était d'évaler l'importance clinique du ligand de CD40 soluble (sCD40L) chez des patients atteints d'un carcinome hépatocellulaire (CHC) associé au virus de l'hépatite C (VHC). (who.int)
Sang2
- En effet, en vieillissant, la quantité de testostérone dans le sang diminue naturellement et de manière progressive, allant jusqu'à une carence. (dsgmerkezi.com)
- l'ADN a ete extrait a partir de sang total preleve sur tube EDTA. (bvsalud.org)
Found2
- Toxins with hemorrhagic and myonecrotic activity are generally found in the venoms of the Viperidae family due to synergic action of proteolytic enzymes, such as metalloproteinases and serine proteinases 4 . (nature.com)
- Regarding only snake venoms, several high mass enzymes have been found to be glycosylated. (springer.com)
Central1
- También se usan por sus efectos en el corazón y en el sistema nervioso central. (bvsalud.org)
Energy1
- They are also essential for the function of a variety of membrane-intercalated and membrane-bound enzymes, and they afford cells with an important energy storage system. (clinicaleducation.org)
Type1
- Le diabète de type 2, sustanon 250 uk. (dsgmerkezi.com)
Human1
- The RAS-regulated RAF-MEK1/2-ERK1/2 signalling pathway is frequently de-regulated in human cancer. (babraham.ac.uk)