• IDO induction has been correlated with induction of GTP-cyclohydrolase, the key enzyme in pteridine biosynthesis. (nih.gov)
  • In pteridine biosynthesis pathway, Catsup negatively regulates the activity of GTP Cyclohydrolase I (GTPCH), preventing GTPCH catalyzed biosynthesis of TH cofactor required for TH catalytic activity and regulation, tetrahydrobiopterin (BH4). (wikipedia.org)
  • Pralatrexate is a folate analog that inhibits folate metabolism, thus impeding the synthesis of amino acids and nucleic acid. (drugbank.com)
  • IDO induction also occurs in vivo during rejection of allogeneic tumors, indicating a possible role for this enzyme in the tumor rejection process. (nih.gov)
  • A direct role for IDO in pteridine synthesis has not been shown, and this parallel induction may reflect coordinate regulation of genes induced by IFN-gamma. (nih.gov)
  • Additionally, Catsup plays an important role in regulation of dopamine synthesis, and the mutations in Catsup gene can lead to hyperactivity of Catsup-regulated enzymes TH, GTPCH, and VMAT, as well as to increases in dopamine (DA) and tetrahydrobiopterin (BH4) levels. (wikipedia.org)
  • A process for the synthesis of quinazolinone containing compounds which may be useful for the treatment of cancer, is hereby disclosed. (justia.com)
  • Catsup co-localizes with enzymes TH and VMAT to dopaminergic neuron cell bodies and synaptic termini. (wikipedia.org)
  • Derivatives of the dimethylisoalloxazine (7,8-dimethylbenzo[g]pteridine-2,4(3H,10H)-dione) skeleton. (bvsalud.org)
  • Flavin derivatives serve an electron transfer function as ENZYME COFACTORS in FLAVOPROTEINS. (bvsalud.org)
  • Additionally, Catsup plays an important role in regulation of dopamine synthesis, and the mutations in Catsup gene can lead to hyperactivity of Catsup-regulated enzymes TH, GTPCH, and VMAT, as well as to increases in dopamine (DA) and tetrahydrobiopterin (BH4) levels. (wikipedia.org)
  • In pteridine biosynthesis pathway, Catsup negatively regulates the activity of GTP Cyclohydrolase I (GTPCH), preventing GTPCH catalyzed biosynthesis of TH cofactor required for TH catalytic activity and regulation, tetrahydrobiopterin (BH4). (wikipedia.org)
  • Pteridines metabolism and its regulation in normal and pathological conditions have not been extensively investigated due to the difficulty of their quantification. (hmdb.ca)