Enzyme of lipid biosynthetic. Medical search. Frequent questions

Functional annotation resulted in the identification of almost all genes involved in diverse lipid-metabolic pathways, including the novel fatty acid desaturase/epoxygenase, diacylglycerol acyltransferase 1 and 2, and phospholipid:diacylglycerol acyltransferases. (researchsquare.com)
However, current methods only go as far as the reconstruction of natural biosynthetic pathways in heterologous systems, lacking the effectiveness of natural hosts. (europa.eu)
Research on the regulation of biosynthetic pathways is still in its infancy. (europa.eu)
Secondary metabolites are organic molecules of low molecular weight, biosynthesized by any living being using a wide range of biosynthetic pathways, known as secondary metabolism. (mdpi.com)
In evolutionary terms, secondary metabolism is seen as a set of specialized pathways that use a varied and specialized series of enzymes. (mdpi.com)
They are part of a much larger group of compounds, the eicosanoids, which, although ubiquitous as a group, are produced by a variety of cell type-, tissue-, and species-specific biosynthetic pathways. (jci.org)
Structures of the first six prostaglandins (PGs) were established by 1962, before their individual biosynthetic pathways were studied. (jci.org)
Here, we focus on newly uncovered pathways, involving either the cyclooxygenases (COXs) or nonenzymatic chemical transformations, that lead to the formation of bioactive prostanoids and of previously unknown lipid mediators produced by COX-2. (jci.org)
The tissue-specific biosynthetic pathways that generate specific PGs are well covered in textbooks. (jci.org)
Compounds targeting cellular membrane biology and lipid biosynthetic pathways have previously shown promise as antivirals, and are actively being pursued as treatments for other conditions. (axionbiosystems.com)
Consequently, downregulation of NADPH creation is predicted to truly have a selective and two-pronged unfavorable influence on tumor success: inhibition of crucial biosynthetic pathways and decrease in the power of malignancy cells to take care of ROS. (thetechnoant.info)
NADP/H may be the primary of biosynthetic pathways for lipids, proteins, and nucleotides as substrates or cofactors. (thetechnoant.info)
It is an important building block of all cell membranes, and an important metabolite in many biosynthetic pathways. (forschung3r.ch)

Our lab studies the roles of lipid biosynthesis in this process, using pharmacological, genetic, and molecular approaches. (csun.edu)
Lipid biosynthesis is essential for cell viability and bacterial fatty acid synthetic enzymes have been suggested as antibiotic targets. (csun.edu)
p)ppGpp modulates cell size and the initiation of DNA replication in Caulobacter crescentus in response to a block in lipid biosynthesis. (csun.edu)
Through unbiased genetic screening in C. elegans, we uncovered a novel role for genes necessary for ether lipid biosynthesis in the favorable effects of biguanides. (harvard.edu)
Our study implicates promotion of ether lipid biosynthesis as a novel therapeutic target to promote healthy aging. (massgeneral.org)
Estrogen is consistently associated with increased levels of 18:0, 16:1n-7 and elongase 6, an enzyme in monounsaturated fatty acids (MUFA) biosynthesis. (uwaterloo.ca)
Structure of the essential Haemophilus influenzae UDP-diacylglucosamine pyrophosphohydrolase LpxH in lipid A biosynthesis. (duke.edu)
In most Gram-negative pathogens, the hydrolysis of UDP-2,3-diacylglucosamine to generate lipid X in lipid A biosynthesis is catalysed by the membrane-associated enzyme LpxH. (duke.edu)
Although most xyloglucans (XyGs) biosynthesis enzymes have been identified, the molecular mechanism that defines XyG branching patterns is unclear. (bvsalud.org)
This enzyme is involved in lipid-A precursor biosynthesis. (unl.edu)
Despite of the chemical diversity of phytochemicals, their biosynthesis involves a highly modular assembly of specific enzyme classes such as oxidoreductases, cytochromes P450 and glycosyltransferases. (ku.dk)
Moreover, many cell lines would need additional fatty acid derivatives, since they often do not express a normal cell's entire set of metabolic enzymes (e.g., lack of elongases) for the biosynthesis of essential metabolites. (forschung3r.ch)
In the case of steroid biosynthesis, we are identifying the specific catalytic intermediate involved in catalysis with a goal of developing novel inhibitors of these enzymes that are central targets in the treatment of hormone dependent cancers. (illinois.edu)
Peptidoglycan biosynthesis is driven by lipid transfer along enzyme-substrate affinity gradients. (ox.ac.uk)
Surprisingly, the enzyme catalyzed not only biosynthesis of PAF from lyso-PAF but also incorporation of arachidonoyl-CoA to produce PAF precursor membrane glycerophospholipids (lysophosphatidylcholine acyltransferase activity). (rhea-db.org)
2023). Ether lipid biosynthesis promotes lifespan extension and enables diverse pro-longevity paradigms in Caenorhabditis elegans. (beingmedicos.com)

Most previous studies on bacterial lipid metabolism have focused on E. coli , a gamma-proteobacteria. (csun.edu)
To better understand the role of dietary FA on metabolic diseases, for the first time, a study to identify key transcription factors (TF) involved in lipid metabolism and inflammatory response by transcriptome analysis from liver samples of animal models was performed. (nature.com)
These findings demonstrated that key TF related to lipid metabolism could be modulated by dietary inclusion of soybean oil. (nature.com)
Disruptions to lipid metabolism can lead to diseases such as cancer and neurological disorders. (stjude.org)
Our laboratory wants to understand how lipid signaling is regulated, and why changes in lipid metabolism can lead to disease. (stjude.org)
In this webinar, Prof. Christopher F. Basler (Georgia State University) , identifies two small molecule inhibitors of VPS34, an enzyme involved in cell membrane dynamics, as well as two inhibitors of lipid metabolism, that can suppress SARS-CoV-2 virus replication in human cells in vitro . (axionbiosystems.com)
These results thus reveal a novel role of mTORC1-SRPK2 signaling in post-transcriptional regulation of lipid metabolism and demonstrate that SRPK2 is a potential therapeutic target for mTORC1-driven metabolic disorders. (princeton.edu)
Hepatic mRNA expression of lipid metabolism enzymes and SCFA in feces and sera were measured. (biomedcentral.com)
FOS treatment improved the liver pathology and blunted the increases in the mRNA expression levels of lipid metabolism enzymes. (biomedcentral.com)
thus, the mechanism underlying the effect of FOS on lipid metabolism in the liver or visceral fat levels cannot be examined, whereas the monosodium glutamate (MSG)-treated mouse is an appropriate animal model of NASH. (biomedcentral.com)
In particular the lipid metabolism-despite being central to cellular regulation and development-is not well explored. (biomedcentral.com)
The obtained lipid profiles are crucial in revealing the lipid metabolism of malaria parasites and identifying targets to interfere with this deadly disease. (biomedcentral.com)

Ginkgo's synthetic biology platform, enables you to develop functional proteins, enzyme biocatalysts, small molecule ingredients, and microbial strains for a variety of applications in the nutrition and wellness markets. (ginkgobioworks.com)
Using a newly developed enzyme-coupled continuous activity assay, we compare differing NAS proteins identified through multiple sequence alignments and phylogenetic analyses. (bvsalud.org)
Compared to fungal and moss NAS that comprise merely a core-NAS domain (class III), NA biosynthetic activities of the four paralogous Arabidopsis thaliana NAS proteins were far lower. (bvsalud.org)
Specifically, we investigate the membrane lipid biology of proteins as well as the functionality of ion channels and receptors. (stjude.org)
Here, we demonstrate that mTORC1 promotes lipid biogenesis via SRPK2, a key regulator of RNA-binding SR proteins. (princeton.edu)
Proteomic and lipidomic analyses revealed accumulation of lysosomal proteins, ceramide biosynthetic enzymes, and ceramides. (princeton.edu)
Central to Ras-mediated signal transduction is proper transport from the endoplasmic reticulum and subsequent stable association with the lipid bilayer of the plasma membrane where, once activated, Ras recruits downstream effector proteins leading to their subsequent activation. (illinois.edu)
Although lipids are a distinct class of biomolecules, we shall see that they often occur combined, either covalently or through weak bonds, with members of other classes of bio-molecules to yield hybrid molecules such as glycolipids , which contain both carbohydrate and lipid groups, "and lipoproteins , which contain both lipids and proteins. (medmuv.com)

Resolution of inflammation is an active process timely controlled by endogenous specialized pro-resolving lipid mediators (SPMs) produced locally in inflammatory loci to restrain this innate response, prevent further damages to the host, and permit return to homeostasis. (frontiersin.org)
A superfamily of pro-resolving molecules formed during self-limiting inflammation is derived from long-chain polyunsaturated fatty acids (LCPUFA), in particular lipoxin A 4 from AA, and resolvins, protectin, maresins and other specialized pro-resolving lipid mediators (SPMs) from the omega-3 LCPUFA, eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA) and docosahexaenoic acid (DHA). (fatsoflife.com)
Here we profiled intramuscular lipid mediators via liquid chromatography-tandem mass spectrometry-based metabolipidomics following myofiber injury and investigated the potential role of SPMs in skeletal muscle inflammation and repair. (jci.org)
Dynamic shifts in muscle lipid mediators following skeletal muscle injury. (jci.org)
Downstream bioactive specialized proresolving lipid mediators (SPMs) detected in muscle are also shown (light blue). (jci.org)
Lipid mediators, including PAF are produced from membrane phospholipids by enzymatic cascades. (rhea-db.org)
Cocoa polyphenols tend to reduce inflammation by regulating proinflammatory mediators and controlling processes that oxidize low density lipids (LDL) in the development of atherosclerosis 73 . (bvsalud.org)

[ 11 ] The NSDHL enzyme is located both within the membranes of the endoplasmic reticulum and on the surface of intracellular lipid storage droplets. (medscape.com)
The sphingolipid biosynthetic pathway begins in the endoplasmic reticulum, where membrane enzyme complexes catalyze the first step of the process. (stjude.org)
[ 8 ] This enzyme is located both within the membranes of the endoplasmic reticulum and on the surface of intracellular lipid storage droplets. (medscape.com)

Capitalizing on the existing expertise in reconstruction of carnosic acid in yeast, I applied an interdisciplinary approach that involve metabolic engineering, lipid biochemistry and biophysics to study the role of membrane lipid composition on the CYPs activity and the assembly of the metabolic complex involved in this pathway. (europa.eu)
The major membrane lipid class (phospholipids) decreased during gametocyte development. (biomedcentral.com)

We demonstrate that biguanides govern lifespan extension via a complex effect on the ether lipid landscape requires enzymes responsible for both ether lipid biogenesis and polyunsaturated fatty acid synthesis. (harvard.edu)

A lipid bilayer or bilayer lipid membrane (BLM) is a membrane or zone of a membrane composed of lipid molecules (usually phospholipids ). (wikidoc.org)
Support for the existence of a lipid bilayer in cell membranes came with the discovery by Alec Bangham in 1965 that phospholipids , when introduced into an aqueous environment, spontaneously form liposomes . (wikidoc.org)

The interfacial regions of model phospholipid bilayers have a thickness of 8 to 10 Å, although they can be wider in biological membranes that include lipid molecules whose head groups have complex carbohydrates, found in the gangliosides or lipopolysaccharides [1] . (wikidoc.org)
Although our primary focus is on enzymes that increase oil yields, we will also examine the contribution the enzyme phospholipid: diacylglycerol acyltransferase (PDAT) makes to lipid production because this enzyme controls the accumulation of unsaturated oil, which has important dietary implications. (openaire.eu)

Fatty acids are the main compound of lipids, which are a class of molecules present in animals and vegetal cell types. (nature.com)
New research led by investigators at Massachusetts General Hospital (MGH), a founding member of the Mass General Brigham healthcare system, reveals that metformin promotes longevity by stimulating the body's production of molecules called ether lipids, a major structural component of cell membranes. (massgeneral.org)
As the bioeconomy era unfolds, yeast emerge as robust cell factories for production of a broad range of products from medicines to small molecules, enzymes and vaccines, components of human breast milk, heme for meat substitutes, bioplastics, biomaterials and even biofuels. (europa.eu)
They concluded, correctly, that the membrane is two lipid molecules thick and proposed it is made of a bilayer. (wikidoc.org)
Lipids are amphiphilic molecules since they consist of polar head groups and non-polar fatty acid tails. (wikidoc.org)
These are small balloons of lipid bilayer which can entrap polar molecules inside them. (wikidoc.org)
They also can be described as having an internal lateral pressure or "the sponaneous radius of curvature", which defines the tendency of the lipid molecules to form curved rather than planar surfaces. (wikidoc.org)
Lipid molecules have these properties because they consist largely of long hydrocarbon tails which are lipophilic in nature as well as polar headgroups (e.g. phosphate-based functionality, and/or inositol based functionality). (medmuv.com)
Biological molecules that are insoluble in aqueous solutions and soluble in organic solvents are classified as lipids. (medmuv.com)
According to a hypothesis, polyphenol (PP) activity against several forms of cancer, proliferative diseases, inflammation and neurodegeneration is mainly exerted through the inhibiting and modulating activities against a wide range of receptors, enzymes and transcription molecules 88 . (bvsalud.org)

Temporal expression patterns of oat avenanthramides and lipid biosynthetic genes were concordant with previous studies of avenanthramide biosynthetic enzyme activity and lipid accumulation. (usda.gov)
The experiments reveal that genes that Increase production of ether lipids are required to extend lifespan in response to the biguanides. (massgeneral.org)
Inactivation of the genes that encode for these enzymes completely prevented the longevity-promoting effects of biguanides. (massgeneral.org)

The Lipid A 1-Phosphatase, LpxE, Functionally Connects Multiple Layers of Bacterial Envelope Biogenesis. (duke.edu)
A single enzyme catalyzes both platelet-activating factor production and membrane biogenesis of inflammatory cells. (rhea-db.org)
Under resting conditions, the enzyme prefers arachidonoyl-CoA and contributes to membrane biogenesis. (rhea-db.org)
Thus, our findings provide a novel concept that a single enzyme catalyzes membrane biogenesis of inflammatory cells while producing a prophlogistic mediator in response to external stimuli. (rhea-db.org)

Genome-wide transcriptome analysis reveals that lipid biosynthetic enzymes are among the downstream targets of mTORC1-SRPK2 signaling. (princeton.edu)

Collectively, these results demonstrate that iron overload induces lysosomal accumulation and impairs lysosomal function, likely due to iron-induced lipid peroxides that can inhibit lysosomal enzymes. (princeton.edu)
We will use rape plants where the activity of individual enzymes in the biosynthetic pathway have been changed and quantify the effects on overall oil accumulation. (openaire.eu)

The lipid bilayer is a critical component of all biological membranes , including cell membranes , and so is absolutely essential for all life on Earth. (wikidoc.org)
There is enormous demand for lipids due to parasite growth inside the host cell [developing organelles (e.g. nucleus, mitochondria, food vacuoles and apicoplast) surrounded by membranes and accumulating lipids in lipid bodies] and subsequent replication. (biomedcentral.com)
Additionally, new lipid structures also appear inside the host cell: the parasite is surrounded by a parasitophorous vacuole membrane [ 24 ] and new parasite induced membranous structures (Maurer's clefts and transport vesicles) emerge, which play an important role in trafficking of parasite virulence factors to the surface of infected red blood cell (iRBC) membranes. (biomedcentral.com)

Conformational dynamics plays an important role in enzyme catalysis, allosteric regulation of protein functions and assembly of macromolecular complexes. (duke.edu)
Our research group, Dynamic Metabolons , are working on the plasticity of biosynthetic membrane protein complexes termed metabolons for the production of phytochemicals. (ku.dk)
Formation of enzyme complexes, metabolons, facilitate direct transfer of substrates and intermediates between sequential enzymes, which results in increased flux and avoid release of toxic or labile intermediates. (ku.dk)
In the organism, liposoluble nutrients such as cholesterol, fatty acids and lipophilic vitamins reach the cells by means of specific apolipoproteins which form complexes with the lipids, the so-called lipoproteins (LPs), and which recognize specific membrane receptors expressed by the cells. (forschung3r.ch)

The team also found that increasing ether lipid synthesis alone (by overexpressing a single, key ether lipid biosynthetic enzyme called fard-1 ) was sufficient to extend C. elegans' lifespan, orchestrating a metabolic stress defense response through a factor called SKN-1, which is the worm counterpart to the mammalian protein Nrf. (massgeneral.org)
Because our studies focused solely on interventions in C. elegans , further studies in mammalian models (such as human cells and mice), epidemiological observation, and rigorous clinical trials are required to determine the viability of promoting ether lipid synthesis to promote human health-span and lifespan. (massgeneral.org)
Sphingolipids are one of the major membrane lipids in mammalian cells. (stjude.org)

The ratio integrates resolution and inflammation processes using lipid mediator levels that can be determined by an ELISA method in readily collected saliva. (fatsoflife.com)
One key pro-inflammatory mediator is leukotriene B 4 (LTB 4), which is produced by macrophages from arachidonic acid (AA) through the activity of the 5-lipoxygenase enzyme, very early in the inflammatory process. (fatsoflife.com)
Platelet-activating factor (PAF) is a potent proinflammatory lipid mediator eliciting a variety of cellular functions. (rhea-db.org)

Remarkably, loss of the ether lipid biosynthetic machinery also mitigates lifespan extension attributable to dietary restriction, target of rapamycin (TOR) inhibition, and mitochondrial electron transport chain inhibition. (harvard.edu)
Furthermore, overexpression of a single, key ether lipid biosynthetic enzyme, fard-1/FAR1, is sufficient to promote lifespan extension. (harvard.edu)

We propose that the specificity of XXT3, XXT4, and XXT5 is directed toward the prior synthesis of the acceptor substrate by the other two enzymes, XXT1 and XXT2. (bvsalud.org)
Genetic or pharmacological inhibition of SRPK2 blunts de novo lipid synthesis, thereby suppressing cell growth. (princeton.edu)
This will enable us to quantify the limitations imposed by different enzymes of the pathway and, furthermore, will provide information to underpin logical steps in genetic manipulation leading to plants with increased oil synthesis and storage capabilities. (openaire.eu)
This suggests that dietary or pharmacologic intervention to promote ether lipid synthesis might one day represent a strategy to treat aging and aging-related diseases. (beingmedicos.com)

Our major efforts are focused on isolating and characterizing the reactive intermediates of the P450 catalytic cycle, the modes of molecular recognition of enzyme for its substrate and the details of inter-protein electron and proton transfer. (illinois.edu)

The cytochromes P450 are members of a class of enzymes known oxygenases, as the incorporate an oxygen atom from atmospheric dioxygen into a substrate molecule. (illinois.edu)
We show that dimerization of MraY is coupled with binding of the carrier lipid substrate undecaprenyl phosphate (C55-P). Further, we demonstrate the use of native MS for biosynthetic reaction monitoring and find that the passage of substrates and products is controlled by the relative binding affinities of the different membrane enzymes. (ox.ac.uk)

In fact, compounds specific to bacterial fatty acid biosynthetic compounds have been generated. (csun.edu)

We found that the tricarboxylic acid cycle-associated enzyme α-ketoglutarate (α-KG) dehydrogenase (KGDH) entered the nucleus, where it interacted with various JMJs to regulate α-KG-dependent histone demethylations by JMJs, and thus controlled genome-wide gene expression in plants. (bvsalud.org)
Growth on CO requires the enzyme carbon monoxide dehydrogenase (CODH) that catalyzes the reversible conversion between CO and CO 2 . (hindawi.com)

This fluid lipid bilayer cross section is made up entirely of phosphatidyl choline . (wikidoc.org)
The bilayer is composed of two layers of lipids arranged so that their hydrocarbon tails face one another to form an oily core held together by Van der Waals interactions, while their charged heads face the aqueous solutions on either side of the membrane. (wikidoc.org)
The properties of the bilayer are influenced by a variety of factors, including the lipid composition, temperature and membrane pressure. (wikidoc.org)
The thickness of the hydrocarbon core region is about 27 Å for the model bilayer formed by DOPC lipid whose acyl chains have eighteen carbon atoms and a single double bond (di(C18:1)PC) [2] . (wikidoc.org)
The thickness of a lipid bilayer increases by 0.8 Å per each additional carbon atom of the lipid tail in the liquid crystalline state, or by 1.1 Å in the gel state (these numbers should be multiplied by 2 because the bilayer has two leaflets). (wikidoc.org)

Here, by applying native mass spectrometry, we elucidate the effects of lipid substrates on the PG membrane enzymes MraY, MurG, and MurJ. (ox.ac.uk)

VLCFAs consist of 20 or more carbon atoms and are the key components of the cell membrane and cuticular lipids in plants 9 . (nature.com)

Hormone biosynthetic cancer targets. (illinois.edu)
Maintenance of bacterial cell shape and resistance to osmotic stress by the peptidoglycan (PG) renders PG biosynthetic enzymes and precursors attractive targets for combating bacterial infections. (ox.ac.uk)

The functional enrichment analysis detected TF linked to lipid homeostasis and inflammatory response, such as RXRA , EGFR , and SREBP2 precursor. (nature.com)
Upon acute inflammatory stimulation with lipopolysaccharide, the activated enzyme utilizes acetyl-CoA more efficiently and produces PAF. (rhea-db.org)

Dietary fatty acids (FA) are components of the lipids, which contribute to membrane structure, energy input, and biological functions related to cellular signaling and transcriptome regulation. (nature.com)
Lipids are vital for both cellular structure and function. (stjude.org)
They represent 10% to 20% of cellular lipids, and in certain specialized tissues, such as myelin sheaths, they can account for ~25% of the lipids. (stjude.org)

The group is also involved in targeting antimicrobial production to lipid rafts, attempting to increase production levels, by engineering biosynthetic enzymes with Raft-related tags. (rafts4biotech.eu)

The enzyme was induced by bacterial endotoxin (lipopolysaccharide), which was suppressed by dexamethasone treatment. (rhea-db.org)

It is described as a housekeeping enzyme, being responsible for cell-to-cell signaling, tissue homeostasis, and cytoprotection. (medscape.com)

Metabolic engineering of Escherichia coli to produce a monophosphoryl lipid A adjuvant. (duke.edu)

The proteolytic enzyme cathepsin D had impaired maturation. (princeton.edu)

Very long-chain fatty acids (VLCFAs) possess more than twenty carbon atoms and are the major components of seed storage oil, wax, and lipids. (nature.com)

Their distinct biosynthetic activity includes an endoperoxidase synthase reaction that oxygenates and cyclizes polyunsaturated fatty acid precursors (eg, arachidonic acid) to form prostaglandin G 2 (PGG2), and a peroxidase reaction that converts PGG2 to prostaglandin H 2 (PGH2), as shown below. (medscape.com)

Cannabis derivatives produce their CNS effect through activation of the endocannabinoid system, a recently discovered signalling system comprising specific receptors, their intrinsic lipid ligands and the associated enzymatic machinery (transporters, biosynthetic and degradative enzymes). (eurekaselect.com)

Regardless of the etiology, a deficiency of cyclooxygenase (COX), a key regulatory enzyme in the synthetic pathway of eicosanoid production, results in beneficial and detrimental physiologic conditions relative to imbalances of the eicosanoids. (medscape.com)

However, the gene expression and activity of antioxidative enzymes had no differences between wild type and the zcf29zcf29 mutant. (ncl.edu.tw)
Iron-loading of cultured iPS-RPE cells increased lysosomal abundance, impaired proteolysis, and reduced the activity of a subset of lysosomal enzymes, including lysosomal acid lipase and acid sphingomyelinase. (princeton.edu)
He localized the biologic activity to a fraction of lipid soluble acids that he termed "prostaglandin," hypothesizing that these substances originate in the prostate gland. (medscape.com)

Purpose: Plasmalogens (Plgs) are highly abundant lipids in the retina, and their deficiency leads to severe abnormalities during eye development. (bvsalud.org)

The research group of Dr Daniel López will be responsible for the coordination of the project and the construction of synthetic lipid rafts in Bacillus subtilis. (rafts4biotech.eu)
The "Genetics of Biofilms" laboratory led by Dr Jean-Marc Ghigo in the microbiology department will provide its expertise in biofilm genetics to construct synthetic lipid rafts in first line of E. coli . (rafts4biotech.eu)

For the drug metabolizing P450s, we seek to understand the molecular mechanisms of drug-drug interaction and the role of protein dynamics in linking the allosteric and catalytic sites of the enzymes. (illinois.edu)
Overall, we provide a molecular view of how PG membrane enzymes convey lipid precursors through favourable binding events and highlight possible opportunities for intervention. (ox.ac.uk)

The most important features are the nature of the lipid head groups and the length and degree of saturation of the hydrocarbon chains. (wikidoc.org)
There are several different families or classes of lipids but all derive their distinctive properties from the hydrocarbon nature of a major portion of their structure. (medmuv.com)

The findings, which are published in eLife , suggest that boosting production of ether lipids in humans may support healthy aging and reduce the impact of aging-related diseases. (massgeneral.org)

Choline kinase alpha is an enzyme that in humans is encoded by the CHKA gene. (wikipedia.org)

The protein encoded by this gene is the initial enzyme in the sequence and may play a regulatory role. (wikipedia.org)
Although a G protein-coupled PAF receptor and degradation enzymes have been cloned and characterized, the PAF biosynthetic enzyme, aceyl-CoA:lyso-PAF acetyltransferase, has not been identified. (rhea-db.org)
The enzyme is a 60-kDa microsomal protein with three putative membrane-spanning domains. (rhea-db.org)

The biosynthetic pathway leading to the potent antioxidant carnosic acid involves several successive oxidation events catalyzed by two cytochrome P450 enzymes (CYPs). (europa.eu)

CHILD syndrome is caused by an X-linked dominant mutation in the NSDHL gene encoding for an enzyme in the cholesterol biosynthetic pathway. (medscape.com)

Anatomy20

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