• Hayes, John D. / The Nrf2 transcription factor regulates basal expression of class alpha and class Mu glutathione S-transferases in the mouse, but not necessarily their induction by cancer chemopreventive agents . (elsevier.com)
  • It was concluded that C5a and C5a desarg may play a role in lung injury by interactions with AM, inducing the secretion of acid hydrolases and proteolytic enzymes that can cause tissue damage, and by regulating the influx of other inflammatory cells into the interstitium and air spaces. (jimmunol.org)
  • Eukaryotic cells have evolved two classes of enzymes that can alter chromatin structure to control accessibility to the transcriptional machinery. (asm.org)
  • We studied the kinetics of ACTH induction of mitochondrial P450scc, P450c11 and their electron transport proteins, adrenodoxin, and adrenodoxin reductase in bovine adrenal cortex cells in primary culture. (zenodo.org)
  • Exposure of the cells to ACTH for 1-2 h was sufficient for maximal induction of the enzymes and P450scc mRNA. (zenodo.org)
  • The absence of any effect of prolonged cAMP pulses on enzyme and mRNA levels weakens the previous hypothesis that cAMP is the sole second messenger for the ACTH induction of steroidogenic enzymes in adrenal cortex cells. (zenodo.org)
  • The role of enzyme induction on metabolite formation of bis(2- methoxyethyl) ether in the rat. (cdc.gov)
  • However, in calendar 2006, we assume XenoTech will begin penetrating the enzyme induction market by selling product for an assumed ASP of $600. (thefreedictionary.com)
  • A combination of process engineering and random mutagenesis of fungal species has greatly improved hydrolytic enzyme production from industrial strains ( 3 ). (pnas.org)
  • The lysosomal enzyme secretion was accompanied by increased pinocytosis and release of proteolytic enzymes from the macrophages. (jimmunol.org)
  • Moreover, the TNF-α-TNF-Rp55 axis can promote thrombus resolution by inducing macrophages to express Plau, Mmp2 , and Mmp9 , the proteolytic enzymes that are crucial to collagenolysis and neovascularization ( 18 ). (frontiersin.org)
  • Rogan, EG , Mailander, P & Cavalieri, E 1976, ' Metabolic activation of aromatic hydrocarbons in purified rat liver nuclei: induction of enzyme activities and binding to DNA with and without monooxygenase catalyzed formation of active oxygen ', Proceedings of the National Academy of Sciences of the United States of America , vol. 73, no. 2, pp. 457-461. (elsevier.com)
  • We report here that induction of the PPARγ activator and adipogenesis forced by overexpression of adipogenic regulatory proteins is blocked upon expression of dominant-negative BRG1 or hBRM, the ATPase subunits of distinct SWI/SNF chromatin-remodeling enzymes. (asm.org)
  • These include histone-modifying enzymes, which posttranslationally modify the N-terminal and C-terminal domains (CTDs) of the individual histone proteins that comprise the nucleosome, and ATP-dependent chromatin-remodeling enzymes, which alter structure by disrupting the histone:DNA contacts of the nucleosome, thereby altering nucleosome conformation and, in some cases, altering the position of the histone octamer along the DNA (reviewed in references 28 , 42 , and 46 ). (asm.org)
  • Histones are nucleoproteins, the HAT1 subfamily proteins are both cytoplasmic enzymes that acetylate newly synthesized histone proteins. (russky.me)
  • Majority of functional enzymes are proteins, like trypsin, fumarase or papain. (wikibooks.org)
  • Model enzymes are monomeric, globular proteins. (wikibooks.org)
  • Prostate cancer is characterized by an early and near universal loss of expression of the phase 2 enzyme glutathione S -transferase (GST)-π. (aacrjournals.org)
  • Dexamethasone and prednisone in physiologic range increased angiotensin converting enzyme 7- to 16-fold in comparison to control in 3 days at maximal stimulation (4 nM steroid) in rabbit alveolar macrophages in culture. (sciencemag.org)
  • But, these agents stimulated cortisol secretion to the medium quickly, indicating that they can activate some intracellular processes while not showing any effect on enzyme induction. (zenodo.org)