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  • inhibitor
  • Male 20-week-old type 2 diabetic rats (OLETF) were randomly divided into 3 groups: sedentary control, resistance training (3 times a week on alternate days for 8 weeks), or resistance training with continuous infusion of a 5α-reductase inhibitor (n = 8 each group). (nih.gov)
  • Administering the 5α-reductase inhibitor in resistance-trained OLETF rats resulted in suppression of the exercise-induced effects on skeletal muscle mass, fasting glucose level, insulin sensitivity index, and GLUT-4 signaling, with a decline in muscular DHT levels. (nih.gov)
  • The emerging SGLT2 inhibitor class removes excess glucose through the urine by blocking glucose re-absorption by the kidney. (bio-medicine.org)
  • Linagliptin is an inhibitor of the enzyme, dipeptidyl peptidase-4 (DPP-4), which breaks down the incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) that are involved with regulating blood sugar. (bio-medicine.org)
  • is an inhibitor of isocitrate dehydrogenase-2 (IDH2) approved for the treatment of relapsed or refractory acute myeloid leukaemia with an IDH2 mutation. (medicinescomplete.com)
  • excess glucose
  • However, if our energy storage tank is already full (the obese state), as a result of over consumption of fuel, the excess glucose spills over into the fat-producing pathway, converts to fat, and is stored in fat cells. (juvenon.com)
  • hydrolytic
  • Gastric HCl causes hydrolysis of sucrose, while there is no hydrolytic enzyme present in gastric juice for the digestion of carbohydrates. (amazonaws.com)
  • Bifidobacteria secrete a variety of hydrolytic enzymes that act on oligosaccharides, enabling them to grow on various prebiotic oligosaccharides that function to increase probiotic bacteria in vivo ( 6 , 7 , 22 ). (asm.org)
  • regulatory
  • Thus, relative to their leaner counterparts on reduced energy diets, typical overweight ad libitum-fed rodents exhibit elevated levels of energy regulatory hormones and factors such as glucose, insulin, triglycerides, low-density lipoprotein (LDL) cholesterol and leptin, and decreased levels of adiponectin and ghrelin ( 3 , 14 ). (pnas.org)
  • DKA is caused by reduced insulin levels, decreased glucose use, and increased gluconeogenesis from elevated counter regulatory hormones, including catecholamines, glucagon, and cortisol. (amazonaws.com)
  • tissues
  • Glucose is essential to health because it is an important source of energy for the cells that make up your muscles and tissues and it is the brain's main source of fuel. (medicineshoppe.com)
  • The Relationship of Kidney Function to the Glucose Utilization of the Extraabdominal Tissues. (amazonaws.com)
  • liver
  • Blood glucose is derived from the food you eat, and is stored and produced by your liver , which breaks it down into healthy, manageable levels. (internal-medicine-centers.com)
  • Glucose is then stored as glycogen in liver and muscle.Insulin also inhibits the release of glucagon and so blocks fat being used as an energy source. (amazonaws.com)
  • Sustained Liver Glucose Release in Response to Adrenaline Can Improve Hypoglycaemic Episodes in Rats under Food Restriction Subjected to Acute Exercise. (amazonaws.com)
  • The newly manufactured insulin is subsequently secreted from the beta cell into the blood stream and delivered to our muscle, fat, and liver cells, where it binds to the membranes of these cells and opens a door, allowing glucose to enter. (juvenon.com)
  • If the pancreas is functioning normally, it produces and secretes insulin into the bloodstream, which in turn activates muscle, fat and liver cells to take in glucose from the blood. (juvenon.com)
  • molecular
  • El estudio llevado a cabo por el grupo de los Drs. Jose Manuel García Fernández y Jesús Díez, del Departamento de Bioquímica y Biología Molecular de la Universidad de Córdoba, cuya primera autora es la doctoranda María del Carmen Muñoz Marín, ha probado que Prochlorococcus es perfectamente capaz de absorber glucosa del océano. (sebbm.es)
  • levels
  • Blood glucose should be evaluated every one to two hours until the patient is stable, and the blood urea nitrogen, serum creatinine, sodium, potassium, and bicarbonate levels should be monitored every two to six hours depending on the severity of DKA.3 Cardiac monitoring may be warranted for patients with significant electrolyte disturbances. (amazonaws.com)
  • Studies29 comparing intravenous insulin with subcutaneous or intramuscular insulin have found a quicker decrease in glucose and ketone levels, but no improvement in morbidity and mortality. (amazonaws.com)
  • This is a positive effect as it lowers blood-glucose, and prevents it from reaching toxic levels. (juvenon.com)
  • For example, it has been demonstrated that people on restricted caloric diets (1,500 to 1,700 kcal/day) have lower blood pressure, lower cholesterol, lower insulin levels, and lower blood glucose. (juvenon.com)
  • blood
  • T 2 DM affects several major organs, including heart, blood vessels, nerves, eyes and kidneys leading to disabling or even life-threatening complications such as cardiac dysfunction, atherosclerosis, and nephropathy [ 7 ]. (ijbs.com)
  • The absorbed glucose is transported to portal blood from intestinal cell by specific GLUT-2 transporters (Facilitated diffusion). (amazonaws.com)
  • Without enough insulin, the glucose stays in your blood. (medicineshoppe.com)
  • This blood test indicates your average blood sugar level for the past 2 to 3 months. (medicineshoppe.com)
  • When it can't produce enough (or any) insulin, or doesn't use insulin effectively, glucose remains trapped in your blood and is unable to reach your cells. (internal-medicine-centers.com)
  • The types of insulin differ only in how quickly they begin to work and how long they continue to control blood sugar. (internal-medicine-centers.com)
  • Physiologic determinants, such as pulse pressure [difference between systolic blood pressure (SBP) and diastolic BP (DBP)], mean arterial pressure (2/3 DBP + 1/3 SBP), and double product [beats per minute (bpm) × SBP], are linked to cardiovascular outcomes. (biomedcentral.com)
  • Insulin also helps move glucose (blood sugar) into cells, where it can be stored and used for energy. (amazonaws.com)
  • A triterpene glycoside (TG) fraction isolated and purified from ethanolic extract of Gymnema sylvestre (EEGS) was investigated for blood glucose control benefit using in vitro methods. (hindawi.com)
  • Normally, the insulin-producing cells of the pancreas (beta cells) recognize high blood-glucose and respond by secreting insulin. (juvenon.com)
  • In this way, the cell loses its ability to recognize glucose in the blood. (juvenon.com)
  • First, we have an excess of blood-glucose, and second, now our cells are converting this excess fuel, in the form of glucose, to fat. (juvenon.com)
  • As described above, high body fat impairs the production of insulin, thus interfering with the removal of the blood-borne glucose we put into our bodies with a high-carbohydrate diet. (juvenon.com)
  • The blood O 2 -carrying capacity is maintained by the O 2 -regulated production of erythropoietin (EPO), which stimulates the proliferation and survival of red blood cell progenitors. (physiology.org)
  • cellular
  • However, exposure to O 2 must be limited due to the damaging effects of reactive oxygen species (ROS) on cellular macromolecules. (physiology.org)
  • All of the major physiological systems participate in complex homeostatic mechanisms that regulate O 2 supply and demand to maintain cellular oxygenation within a narrow range that balances the risks associated with O 2 deficiency and excess. (physiology.org)
  • glycemic control
  • If an inducer of UGTs (e.g., rifampin, phenytoin, phenobarbital, ritonavir) is co-administered with INVOKANA, consider increasing the dosage to 300 mg once daily in patients currently tolerating INVOKANA 100 mg once daily who have an eGFR of 60 mL/min/1.73 m 2 or greater and require additional glycemic control [see DRUG INTERACTIONS ]. (rxlist.com)
  • aerobically
  • The resulting strain grows aerobically in glucose minimal medium and can achieve near-complete carbon conservation in the production of acetyl-CoA-derived products during anaerobic fermentation. (pnas.org)
  • monosaccharides
  • The disaccharidases, maltase, sucrase-isomaltase (a bifunctional enzyme catalyzing hydrolysis of sucrose and isomaltose), lactase, and trehalase are located on the brush border of the intestinal mucosal cell where the resultant monosaccharides and others arising from the diet are absorbed. (amazonaws.com)
  • lipid
  • There are two toxic effects, one from high glucose, or glycotoxicity, and the other from high fat (lipid), or lipotoxicity. (juvenon.com)